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| 1 | 他汀、高密度脂蛋白胆固醇与冠状动脉粥样硬化消退显示文摘背景:他汀类药物可以降低低密度脂蛋白胆固醇(low—density lipoprotein cholesterol,LDL—C)水平并减缓冠状动脉粥样硬化的进展。然而,对于他汀类药物所致高密度脂蛋白胆固醇(high—density lipoprotein cholesterol,HDL—C)变化与疾病进展的关系,目前仍无相关数据描述。目的:了解LDL—C和HDL—C水平变化与动脉粥样硬化的相互关系。设计、地点及患者:对4项前瞻性随机试验(1999~2005年在美国、北美、欧洲和澳大利亚进行)的原始数据进行事后分析。其中1455例经血管造影证实的冠心病患者在接受他汀治疗(18个月或24个月)时进行了系列血管内超声扫描。所有超声分析均在相同的核心实验室中进行。主要观测指标:脂蛋白水平变化与冠状动脉粥样斑块体积的相互关系。结果:他汀治疗期间,LDL—C平均(SD)水平从124.0(38.3)mg,/dL(3.2[0.99]mmol/L)降至87.5(28.8)mg,/dL(2.3[0.75]mmol/L)(下降23.5%;P〈0.001),HDL—C水平从42.5(11.0)mg/dL(1.1[0.28]mmol/L)升至45.1(11.4)mg/dL(1.2[0.29]mmol/L)(上升7.5%;P〈0.001)。LDL—C与HDL—C比值从平均(SD)3.0(1.1)降至2.1(0.9)(下降26.7%;P〈0.001)。这些变化同时伴随平均(SD)百分粥样斑块体积的增加(从39.7%[9.8%]增至40.1%[9.7%])(增加0.5%[3.9%];P=0.001)以及平均(SD)总粥样斑块体积的减小(2.4[23.6]mm^3;P〈0.001)。在单变量分析中,LDL—C、总胆固醇、非HDL胆固醇、载脂蛋白B以及载脂蛋白B与载脂蛋白A-1比值平均水平和治疗引起的变化与动脉粥样硬化进展速率显著相关,而治疗所致HDL—C变化则与动脉粥样斑块体积负相关。在多变量分析中,平均LDL—C水平(β系数,0.11[95%可信区间,0.07~0.15])以及HDL—C升高(β系数,-0.26[95%可信区间,-0.41--0.10])依然为动脉粥样硬化消退的独立预测因子。动脉硬化显著消退(动脉粥样斑块体积减少≥5%)见于治疗期间LDL—C水平低于均值(87.5mg/dL)和HDL—C升高百分比大于均值(7.5%;P〈0.001)的患者。临床事件的发生未见显著差异。结论:在LDL—C显著降低以及HDL上升〉7.5%时,他汀治疗与冠状动脉粥样硬化消退相关。这些结果提示他汀治疗的获益源自致动脉粥样硬化脂蛋白的降低以及HDL.C的升高。尽管血脂水平的这些变化与动脉粥样硬化消退相关,但是后者是否可以转化为临床事件的显著减少,并改善临床预后仍有待进一步研究确定。 | Stephen J. Nicholls, MBBS, PhD E. Murat Tuzcu, MD IIke Sipahi, MD Adam W. Grasso, MD Paul Schoenhagen, MD Tingfei Hu, MS Kathy Wolski, MPH Tim Crowe, BS Milind Y. Desai, MD Stanley L. Hazen, MD, PhD Samir R. Kapadia, MD Steven E. Nissen, MD 李呈亿(译) | 2007 | 美国医学会杂志(中文版)2007，26，3： | 48 |
| 2 | Magnitude of modulation of gene expression in aneuploid maize depends on the extent of genomic imbalance显示文摘Aneuploidy has profound effects on an organism,typically more so than polyploidy,and the basis of this contrast is not fully understood.A dosage series of the maize long arm of chromosome 1(1L)was used to compa re relative global gene expression in diffe rent types and degrees of aneuploidy to gain insights into how the magnitude of genomic imbalance as well as hypoploidy affects global gene expression.While previously available methods require a selective examination of specific genes,RNA sequencing provides a whole-genome view of gene expression in aneuploids.Most studies of global aneuploidy effects have concentrated on individual types of aneuploids because multiple dose aneuploidies of the same genomic region are difficult to produce in most model genetic organisms.The genetic toolkit of maize allows the examination of multiple ploidies and 1-4 doses of chromosome arms.Thus,a detailed examination of expression changes both on the varied chromosome arms and elsewhere in the genome is possible,in both hypoploids and hyperploids,compared with euploid controls.Previous studies observed the inverse trans effect,in which genes not varied in DNA dosage were expressed in a negative relationship to the varied chromosomal region.This response was also the major type of changes found globally in this study.Many genes varied in dosage showed proportional expression changes,though some were seen to be partly or fully dosage compensated.It was also found that the effects of aneuploidy were progressive,with more severe aneuploids producing effects of greater magnitude. | Adam F·Johnson Jie Hou Hua Yang Xiaowen Shi Chen Chen Md Soliman Islam Tieming Ji Jianlin Cheng James A·Birchler | 2020 | Journal of Genetics and Genomics2020，47，2： | 3 |
| 3 | Proximal Humerus Reconstructions for Tumors显示文摘 | Benjamin K. Potter MD Sheila C. Adams MD J. David Pitcher MD Theodore I. Malinin MD H. Thomas Temple MD | 2009 | Clinical Orthopaedics and Related Research2009，，4： | 2 |
| 4 | Complementary DNA sequencing: expressed sequence tags and human genome project显示文摘 | Kelley JM Cocayne JD | 1991 | Science1991，252，5013： | 1 |
| 5 | Normal,benign,preneoplastic, and malignant prostate cell have distinct protein expression profiles resolved by surface enhanced laser desorption/ionization mass spectrometry显示文摘 | Cazares LH Adam BL Ward MD | 2002 | Clin Cancer Res2002，8，8： | 1 |
| 6 | The sequence of human genome 显示文摘 | Venter JC Adams MD Myers EW | 2001 | Science2001，291，5507： | 1 |
| 7 | Whole-genome random sequencing and assembly of Haemophilus influenzae Rd显示文摘 | Adams MD White O | 1995 | Science1995，269，： | 1 |
| 8 | Whole - genome random sequencing and assembly of Haemophilus influenzae Rd显示文摘 | Fleischmann RD Adams MD White O | 1995 | Science1995，269，5223： | 1 |
| 9 | Improving Resectability of Hepatic Colorectal Metastases: Expert Consensus Statement显示文摘 | Eddie K. Abdalla MD René Adam MD PhD Anton J. Bilchik MD PhD Daniel Jaeck MD Jean-Nicolas Vauthey MD David Mahvi MD | 2006 | Annals of Surgical Oncology2006，，10： | 1 |
| 10 | Surgical Treatment of Resectable and Borderline Resectable Pancreatic Cancer: Expert Consensus Statement by Evans et al.显示文摘 | Reid B. Adams MD Peter J. Allen MD | 2009 | Annals of Surgical Oncology2009，，7： | 1 |
| 11 | PDE4 cAMP phosphodi esterases: modularenzymes that orchestrate signalling cross-talk, desensitization and compartmentalization显示文摘 | Houslay MD Adams DR | 2003 | Biochem2003，370，1： | 1 |
| 12 | Propofol in a medium- and long-chain triglyceride emulsion: pharmacological characteristics and potential beneficial effects显示文摘 | HEILEN HJ ADAM S ALBRECHT MD | 2002 | Anesth Analg2002，95，4： | 1 |
| 13 | The Sequence of the Human Genome 显示文摘 | Venter JC Adams MD Myers EW | 2001 | Science2001，291，5507： | 1 |
| 14 | Propofol in a medium - and long- chain triglyceride emulsion: pharmacological characteris- tics and potential beneficial effects 显示文摘 | Theilen HJ Adam S Albrecht MD | 2002 | Anesth Analg2002，95，： | 1 |
| 15 | Dipole modeling in epilepsy surgery candidates 显示文摘 | D'Have MD Adam C | 1997 | Epilepsia1997，38，： | 1 |
| 16 | Propofol in a mediue-andlong--chain triglyceride emulsion:pharmacological characterististies and potential beneficial efects显示文摘 | Theilen HJ Adam S Albrecht MD | 2002 | Anesth Anmg2002，95，4： | 1 |
| 17 | Selective Blockade of Vascular Endothelial Growth Factor Receptor 2 With an Antibody Against Tumor-Derived Vascular Endothelial Growth Factor Controls the Growth of Human Pancreatic Adenocarcinoma Xenografts显示文摘 | Shane E. Holloway MD Adam W. Beck MD Latha Shivakumar PhD Jessica Shih BS Jason B. Fleming MD Rolf A. Brekken PhD | 2006 | Annals of Surgical Oncology2006，，8： | 1 |
| 18 | Evaluation of a liquid dressing for minor nonbleeding abrasions and classⅠandⅡskin tears in the emergency department显示文摘 | Adam John Singer MD Stuart Chale MD Maria Taylor | 2015 | The Journal of Emergency Medicine2015，48，2： | 1 |
| 19 | Whole genome random sequencing and assembly of Haemophilus influenzae Rd显示文摘 | Fleischmann RD Adams MD White O | 1995 | Science1995，296，5323： | 1 |
| 20 | The sequence of the human genome显示文摘 | Venter JC Adams MD Myers EW Li PW Mural R J Sutton GG Smith HO Yandell M Evans CA Holt RA | | 0，，： | 1 |
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