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| 1 | Concurrent systemic AA amyloidosis can discriminate primary sclerosing cholangitis from IgG4-associated cholangitis显示文摘Chronic hepatobiliary inflammatory diseases are not widely acknowledged as underlying disorders of systemic AA amyloidosis,except epidemic schistosomiasis.Among them,primary sclerosing cholangitis (PSC) might initiate amyloid A protein deposition in diverse tissues,giving rise to systemic amyloidosis,due to a progressive and unresolved inflammatory process,and its possible association with inflammatory bowel diseases.Nevertheless,only one such case has been reported in the literature to date.We report a 69-year-old Japanese woman with cirrhosis who was diagnosed with PSC complicated with systemic AA amyloidosis,without any evidence of other inflammatory disorders.As a result of cholestasis in conjunction with biliary strictures and increased serum IgG4,the presence of IgG4 + plasma cells was examined systemically,resulting in unexpected documentation of Congo-red-positive amyloid deposits,but not IgG4 + plasma cells,in the liver,stomach and salivary glands.Elevated serum IgG4 is the hallmark of IgG4-related disease,including IgG4-associated cholangitis,but it has also been demonstrated in certain patients with PSC.Amyloid A deposits in multiple organs associated with an indolent clinical course that progresses over many years might have a diagnostic value in discriminating PSC from IgG4-associated cholangitis. | Takehiro Kato Atsumasa Komori Sung-Kwan Bae Kiyoshi Migita Masahiro Ito Yasuhide Motoyoshi Seigo Abiru Hiromi Ishibashi | 2012 | World Journal of Gastroenterology2012，18，2： | 11 |
| 2 | Fenofibrate-induced liver injury显示文摘TO THE EDITOR
Fenofibrate is a member of such fibrate class agents as bezafibrate and it work as a ligand of PPARα, and also shows a potent triglyceride-lowering effect. The elevation of aminotransferase levels has been frequently observed after the administration of fenofibrate and this phenomenon is considered to be non-pathological because fenofibrate activates the gene expression of the aminotransferases. Recently, fenofibrate has been used not only for hypercholesterolemia but also for primary biliary cirrhosis (PBC)[1,2]. However, the occurrence of liver injury induced by fenofibrate has not yet been reported written in the English literature. We herein report a rare case of liver injury due to the oral use of this drug. | Kazufumi Dohmen Chun Yang Wen Shinya Nagaoka Koji Yano Seigo Abiru Toshihito Ueki Atsumasa Komori Manabu Daikoku Hiroshi Yatsuhashi Hiromi Ishibashi | 2005 | World Journal of Gastroenterology2005，11，48： | 7 |
| 3 | Cytokine gene polymorphisms in Japanese patients with hepatitis B virus infection—association between TGF-β1 polymorphisms and hepatocellular carcinoma显示文摘 | Kiyoshi Migita Seiji Miyazoe Yumi Maeda Manabu Daikoku Seigo Abiru Tshihito Ueki Koji Yano Shinya Nagaoka Takehiro Matsumoto Kazuhiko Nakao Keisuke Hamasaki Hiroshi Yatsuhashi Hiromi Ishibashi Katsumi Eguchi | 2004 | Journal of Hepatology2004，，4： | 3 |
| 4 | mPGES-1 expression in non-cancerous liver tissue impacts on postoperative recurrence of HCC显示文摘AIM:To investigate whether microsomal prostaglandin E synthase-1 (mPGES-1) expression in hepatocellular carcinoma (HCC) and in non-cancerous liver affects HCC prognosis after hepatectomy. METHODS: The relationship between patient clinical prof iles, tumor factors, surgical determinants, and mPGES-1 expression and the recurrence-free survival rate were examined in 64 patients who underwent curative hepatectomy between March 2003 and December 2006. RESULTS: The scores for mPGES-1 expression were higher in well differentiated and moderately differentiated HCC tissues than in poorly differentiated HCC tissues (well differentiated, 5.1 ± 2.7; moderately differentiated, 5.1 ± 1.7; poorly differentiated, 3.0 ± 1.8). In noncancerous liver tissues, the mPGES-1 levels were higher in injured liver tissues than in normal tissues. Cirrhotic livers had higher mPGES-1 levels than livers with chronic hepatitis (normal livers, 3.3 ± 0.7; chronic hepatitic livers, 5.4 ± 1.9; cirrhotic livers, 6.4 ± 1.6). A univariate analysis revealed that the recurrence-free survival rate was signif icantly lower in patients with vascular invasion,a higher mPGES-1 level in non-cancerous liver tissue,a larger tumor diameter (≥5 cm), and a lower serum albumin level (≤3.7 g/dL). The mPGES-1 expression in HCC tissues did not correlate well with postoperative recurrence. A multivariate analysis demonstrated that the presence of vascular invasion and higher mPGES-1 levels were statistically significant independent predictors for early postoperative recurrence of HCC.CONCLUSION: Increased mPGES-1 expression in noncancerous liver tissues is closely associated with the early recurrence of HCC after curative resection. | Koichi Nonaka Hikaru Fujioka Yasushi Takii Seigo Abiru Kiyoshi Migita Masahiro Ito Takashi Kanematsu Hiromi Ishibashi | 2010 | World Journal of Gastroenterology2010，16，38： | 2 |
| 5 | Export of soluble sugars and increase in membrane permeabili-ty of gladiolus florets during senescence显示文摘 | Abiru S Fijishige N | 1993 | J Jpn Soc Hort1993，62，： | 1 |
| 6 | Contractile mech - anisms of gallbladder filling and emptying in dog显示文摘 | Abiru H Sarna SK Condon RE | 1994 | Gastroen - terology1994，106，6： | 1 |
| 7 | Aspirin and NS-398 inhibit hepatocyte growth factor-induced invasiveness of human hepatoma cells 显示文摘 | Abiru S Nakao K Ichikawa T | 2002 | Hepatology2002，35，5： | 1 |
| 8 | Application of tyramide signal amplification system to immunohistochemistry:a potent method to locatize antigens that are not detected by ordinary method显示文摘 | Toda Y Kono K Abiru H | 1999 | Patholo Int1999，49，5： | 1 |
| 9 | Expression of microsomal prostaglandin E synthase-1 in human hepatocelluar carcinoma显示文摘 | Takii Y Abiru S Fujioka H | | 0，，07： | 1 |
| 10 | Serum cytokines and soluble cytokine receptor levels in patients with nonalcoholic steatohelyatitis 显示文摘 | Abiru S M igita K Maeda Y | 2005 | Liver Intern2005，26，1： | 1 |
| 11 | PACAP has a neurotrophie effect on cultured basal forebrain cholinergic neurons from adult rats显示文摘 | Yuhara A Nishio C Abiru Y | 2001 | Brain Res Dev Brain Res2001，131，12： | 1 |
| 12 | Prime role for an insulin epitope in the development of type 1 diabetes in nod mice 显示文摘 | Nakayama M Abiru N Moriyama H | 2005 | Nature2005，435，7039： | 1 |
| 13 | Early expression of antiinsulin autoantibodies of humans and the nod mouse evidence for early determination of subsequent diabetes 显示文摘 | Yu LP Robles DT Abiru N | 2000 | P Natl Acad Sci USA2000，97，4： | 1 |
| 14 | Application of tyramide signal amplification system to immunohistochemistry: a potent method to locatize antigens that are not detected by ordinary method显示文摘 | Toda Y Kono K Abiru H | 1999 | Patholo Inter1999，49，5： | 1 |
| 15 | Insulin response after treatment depends on fasting plasma glucose level in NIDDM 显示文摘 | Matsumoto K Akazawa S Abiru N | 1994 | Diabetes Res Clin Pract1994，26，1： | 1 |
| 16 | Distinct IA-2 autoantibody epitope recognition between childhood-onset and adult-onset type 1 diabetes显示文摘 | Kawasaki E Sera Y Abiru N | 2002 | Ann N Y Acad Sci2002，958，： | 1 |
| 17 | Distinct role of T helper type 17 immune response for Graves' hyperthyroidism in mice with different genetic baekgrounds显示文摘 | Horie I Abiru N Saitoh o | 2011 | Autoimmunity2011，44，2： | 1 |
| 18 | CDg+CD122+ T cells, a newly identified regulatory T subset, negatively regulate Graves' hyperthyroidism in a murine model显示文摘 | Saitoh O Abiru N Nakahara M | 2007 | Endocrinolo gy2007，148，12： | 1 |
| 19 | Strain difference in an al-lergic-asthma model in rats显示文摘 | Misawa M Takenouchi K Abiru T | 1987 | Jpn J Pharmacol1987，45，1： | 1 |
| 20 | Thelper type 17 immune response plays an indispensable role for development of iodineinduced autoimmune thyroiditis in nonobese diabetic-H2h4 mice显示文摘 | Horie I Abiru N Nagayama Y | | 0，，11： | 1 |
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