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| 1 | Viral hepatitis prevalence in patients with active and latent tuberculosis显示文摘AIM: To assess the prevalence of hepatitis B virus(HBV) and hepatitis C virus(HCV) infection and association with drug induced liver injury(DILI) in patients undergoing anti-tuberculosis(TB) therapy.METHODS: Four hundred and twenty nine patients with newly diagnosed TB- either active disease or latent infection- who were due to commence antiTB therapy between September 2008 and May 2011 were included. These patients were prospectively tested for serological markers of HBV, HCV and human immunodeficiency virus(HIV) infections- hepatitis B core antigen(HBc Ag), hepatitis B surface antigen(HBs Ag), hepatitis B e antigen, Ig G and Ig M antibody to HBc Ag(anti-HBc), HCV Ig G antibody and HIV antibody using a combination of enzyme-linked immunosorbent assay, Western blot assay and polymerase chain reaction techniques. Patients were reviewed at least monthly during the TB treatment initiation phase. Liver function tests were measured prior to commencement of antiTB therapy and 2-4 wk later. Liver function tests were also performed at any time the patient had significant nausea, vomiting, rash, or felt non-specifically unwell. Fisher's exact test was used to measure significance in comparisons of proportions between groups. A P value of less than 0.05 was considered statistically significant.RESULTS: Of the 429 patients, 270(62.9%) had active TB disease and 159(37.1%) had latent TB infection. 61(14.2%) patients had isolated anti-HBc positivity, 11(2.6%) were also HBs Ag positive and 7(1.6%) were HCV-antibody positive. 16/270 patients with active TB disease compared to 2/159 patients with latent TB infection had markers of chronic viral hepatitis(HBs Ag or HCV antibody positive; P = 0.023). Similarly the proportion of HBs Ag positive patients were significantly greater in the active vs latent TB infection group(10/43 vs 1/29, P = 0.04). The prevalence of chronic HBV or HCV was significantly higher than the estimated United Kingdom prevalence of 0.3% for each. We found no association between DILI and presence of serological markers of HBV or HCV. Three(5.3%) patients with serological markers of HBV or HCV infection had DILI compared to 25(9.5%) patients without; P = 0.04.CONCLUSION: Viral hepatitis screening should be considered in TB patients. DILI risk was not increased in patients with HBV/HCV. | Hesam Ahmadi Nooredinvand David W Connell Mahmoud Asgheddi Mohammed Abdullah Marie O'Donoghue Louise Campbell Melissa I Wickremasinghe Ajit Lalvani Onn Min Kon Shahid A Khan | 2015 | World Journal of Gastroenterology2015，21，29： | 7 |
| 2 | Tectonostratigraphic controls on turbidite depositional processes in Brunei显示文摘 | Allman W P Tromp J P Abdullah I | 2000 | AAPG Bulletin2000，84，9： | 1 |
| 3 | A survey on routing techniques in underwater wireless sensor networks显示文摘 | Ayaz M Nubaig I Abdullah A | 2011 | Journal of Network and Computer Application2011，34，6： | 1 |
| 4 | Optimized intrusion detection mechanism using soft computing techniques显示文摘 | Ahmad I Abdullah A AJghamdi A | 2013 | Telecommunication Systems2013，52，4： | 1 |
| 5 | Elec- tromigration noise measurements using a novel AC/DC water -level noise measurement system 显示文摘 | ABDULLAH M Y CHARLES I' CHEN Songming | 1997 | IEEE Transactions on Electron Devices1997，44，1： | 1 |
| 6 | Photocatalytic treatment of 4-chlorophenol in aqueous ZnO suspensions:intermediates,influence of dosage and inorganic anions显示文摘 | Gaya U I Abdullah A H Zainal Z | 2009 | Journal of Hazardous Materials2009，168，1： | 1 |
| 7 | Floating roof storage tank boilover 显示文摘 | Shaluf I M Abdullah S A | 2011 | Journal of Loss Prevention in the Process Industries2011，24，： | 1 |
| 8 | Heterogeneous photocatalytic degradation of organic contaminants over Titanium dioxide:A review of fundamentals,progress and problems显示文摘 | Gaya U I Abdullah A H | 2008 | Journal of Photochemistry and Photobiology C:Photochemistry Reviews2008，9，1： | 1 |
| 9 | Heterogeneous photocatalytic degradation of organic contaminants over titanium dioxide: a review of fundamentals, progress and problems 显示文摘 | Gaya U I Abdullah A H | 2008 | Journal of Photochemistry and Photobiology C: Photochemistry Reviews2008，9，1： | 1 |
| 10 | Photocatalytic treatment of 4-chlorophenol in aqueous ZnO suspensions: intermediates, influence of dosage and inorganic anions 显示文摘 | Gaya U I Abdullah A H Zainal Z Hussein M Z | 2009 | Journal of Hazardous Materials2009，168，1： | 1 |
| 11 | The implicit killer box method for the one dimen- sional time fractional diffusion equation显示文摘 | AL-SHIBANI F S MD A I ISMAIL ABDULLAH F A | 2012 | J of Applied Mathematics Bioinformatics2012，2，3： | 1 |
| 12 | Peak-valley segmentation algorithm for kurtosis analysis and classification of fatigue time series data 显示文摘 | Nopiah Z M Khairir M I Abdullah S | 2009 | European Journal of Scientific Research2009，29，1： | 1 |
| 13 | Characterization of Ti02-chitosaniglass photocatalyst for the removal of a monoazo dye via photodegradation-adsorption process显示文摘 | Zainal Z Hui L K Hussein M Z Abdullah A H Hamadneh I R | 2009 | Jour?nal of Hazardous Materials2009，164，1： | 1 |
| 14 | Evolution of incipient nephropathy in type 2 diabetes mellitus 显示文摘 | Lemley KV Abdullah I Myers BD | 2000 | Kidey lnt2000，58，3： | 1 |
| 15 | Modelling and simulation single layer anti-reflective coating of ZnO and ZnS for silicon solar cells using Silvaco software 显示文摘 | H Abdullah A Lennie I Ahmad | 2009 | Journal of Applied Sciences2009，9，6： | 1 |
| 16 | Heterogeneous photocatalytic degradation of organic contaminants over titanium dioxide: A review of fundamentals, progress and problems 显示文摘 | Gaya U I Abdullah A H | 2008 | J Photochem Photobiol C:Photochem Rev2008，9，1： | 1 |
| 17 | Photocatalytic degradation of 17 β- oestradiol, oestriol and 17α- ethynyloestradiol in water monitored using fluorescence spectroscopy 显示文摘 | COLEMAN H M Abdullah M I | 2005 | Applied Catalysis B: Environmental2005，55，： | 1 |
| 18 | Photo- catalytic treatment of 4--chlorophenol in aqueous ZnO sus- pensions: Intermediates, influence of dosage and inorganic anions 显示文摘 | Gaya U I Abdullah A H Zainal Z Hussein M Z | 2009 | J Hazard Mater2009，168，： | 1 |
| 19 | Diffusion tensor magnetic resonance imaging as molecular diagnostic tool for leukoaraiosis显示文摘 | MohdTaib N H Wan Abdullah A K Shuaib I L | 2014 | Asian Pacific Journal of Tropical Disease2014，4，3： | 1 |
| 20 | Doppler emboli signals vary according to stroke subtype显示文摘 | Georgiadis D Abdullah I | 1994 | Stroke1994，25，： | 1 |
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