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| 1 | Protective effect of naringenin on acetic acid-induced ulcerative colitis in rats显示文摘AIM:To evaluate the ameliorative effect of naringenin(NG)during ulcerative colitis(UC)in rats.METHODS:Rats were treated with three different doses(25,50 and 100 mg/kg per day)of NG and a single dose of mesalazine(MES,300 mg/kg per day)for seven days prior to ulcerative colitis induction by4%acetic acid(AA).Twenty four hours after AA rectal administration,animals were scarified and the colonic tissues were dissected.Colonic mucus content was estimated using Alcian blue dye binding technique.In colon tissues,levels of total glutathione sulphadryls(T-GSH),non-protein sulphadryls(NP-SH)and thiobarbituric acid reactive substances(TBARS)were evaluated.The activities of the antioxidant enzymes,catalase(CAT)and superoxide dismutase(SOD)were measured.Concentrations of nucleic acids(DNA and RNA)and total protein were also estimated in colon tissues.Colonic levels of tumor necrosis factor-(TNF-),interleukin-1(IL-1),interleukin-6(IL-6),prostaglandin E2(PGE2)and nitric oxide(NO)were estimated.In cross section of colitis tissue the histopathological changes were observed.RESULTS:Colonic mucus content was decreased in AA compared to controls(587.09±65.59 mg/kg vs941.78±68.41 mg/kg,P<0.001).AA administration markedly reduced T-GSH(5.25±0.37 nmol/L vs 3.04±0.24 nmol/L,P<0.01),NP-SH(3.16±0.04 nmol/L vs 2.16±0.30 nmol/L,P<0.01),CAT(6.77±0.40 U/mg vs 3.04±0.2 U/mg,P<0.01)and SOD(3.10±0.11U/mg vs 1.77±0.18 U/mg,P<0.01)while TBARS,TNF-,IL-1,IL-6,PGE2 and NO levels(15.09±3.84nmol/L vs 59.90±16.34 nmol/L,P<0.01;113.56±1.91 pg/mg vs 134.24±4.77 pg/mg,P<0.01;209.20±36.38 pg/mg vs 422.19±31.47 pg/mg,P<0.01;250.83±25.09 pg/mg vs 638.58±115.9 pg/mg,P<0.01;248.19±36.98 pg/mg vs 541.74±58.34 pg/mg,P<0.01 and 81.26±2.98 mmol/g vs 101.90±10.73 mmol/g,P<0.001)were increased in colon of rats with UC compared controls respectively.Naringenin supplementation,significantly and dose dependently increased the colonic mucus content.The elevated TBARS levels were significantly decreased(39.35±5.86nmol/L,P<0.05;26.74±3.17 nmol/L,P<0.01 nmol/L and 17.74±2.69 nmol/L,P<0.01)compared to AA(59.90±16.34 nmol/L)group while the decreased levels of T-GSH and NP-SH and activities of CAT and SOD found increased by NG treatments in dose dependent manner.The decreased values of nucleic acids and total protein in AA group were also significantly(P<0.01)increased in all three NG supplemented groupsrespectively.NG pretreatment inhibited the TNF-levels(123.76±3.76 pg/mg,122.62±3.41 pg/mg and121.51±2.61 pg/mg vs 134.24±4.78 pg/mg,P<0.05)compared to AA group,respectively.Interleukins,IL-1 and IL-6 levels were also decreased in NG50+AA(314.37±16.31 pg/mg and 292.58±23.68 pg/mg,P<0.05)and NG100+AA(416.72±49.62 pg/mg and 407.96±43.87 pg/mg,P<0.05)when compared to AA(352.46±8.58 pg/mg and 638.58±115.98pg/mg)group.Similar decrease(P<0.05)was seen in PGE2and NO values when compared to AA group.The group pretreated with MES,as a reference drug,showed significant(P<0.01)protection against the changes induced in colon tissue by AA administration respectively.CONCLUSION:In present study,NG produced antioxidant and anti-inflammatory effects demonstrating protective effect in inflammatory bowel disease. | Salim S Al-Rejaie Hatem M Abuohashish Maher M Al-Enazi Abdullah H Al-Assaf Mihir Y Parmar Mohammed M Ahmed | 2013 | World Journal of Gastroenterology2013，19，34： | 20 |
| 2 | Reverse en-gineering of turbine blades based on design intent 显示文摘 | Mohaghegh K Sadeghi M H Abdullah A | 2007 | International Journal of Advanced Manufacturing Tech-nology2007，32，5： | 1 |
| 3 | Frequency Domain Identifica- tion of Transfer Function Model of a Disk Drive Actuator显示文摘 | ABDULLAH A M LEE T H | 2002 | Mechatronics2002，，12： | 1 |
| 4 | Heavy metals (Cd, Cu, Cr, Pb and Zn) in Meretrix meretrix roding, water and sediments from estuaries in sabah, North Borneo显示文摘 | ABDULLAH M H SIDI J ARIS A Z | 2007 | International Journal of Environmental & Science Education2007，2，3： | 1 |
| 5 | Photocatalytic treatment of 4-chlorophenol in aqueous ZnO suspensions:intermediates,influence of dosage and inorganic anions显示文摘 | Gaya U I Abdullah A H Zainal Z | 2009 | Journal of Hazardous Materials2009，168，1： | 1 |
| 6 | Serum lipid profile on admission for ischemic stroke:failure to meet National Cholesterol Education Program Adult Treatment Panel(NCEP-ATPIII)guidelines显示文摘 | SMITH E E ABDULLAH A R AMIRFARZAN H | 2007 | Neurology2007，68，9： | 1 |
| 7 | Prevalence and emerging resistance of Moraxella catarrhalis in lower respiratory tract infections in Karachi显示文摘 | Abdullah FE Ahuja KR Kumar H | 2013 | J Pak Med Assoc2013，63，11： | 1 |
| 8 | Optimization of rapid prototyping pa- rameters for production of flexible ABS object 显示文摘 | Lee B H Abdullah J Khan Z A | 2005 | Journal of Materials Processing Technology2005，169，1： | 1 |
| 9 | Microwave electromagnetic and absorption properties of some LiZn ferrites 显示文摘 | YUSOFF N ABDULLAH M H | 2004 | J Magn Magn Mater2004，269，： | 1 |
| 10 | A survey of wireless sensor network approaches and their energy consumption for monitoring farm fields in precision agriculture显示文摘 | ANISI M H ABDUL-SALAAM G ABDULLAH A H | 2014 | Precision Agriculture2014，16，2： | 1 |
| 11 | Microwave electromagnetic and absorption properties of some LiZn ferrites 显示文摘 | Yusoff A N Abdullah M H | 2004 | Journal of Magnetism and Magnetic Materials2004，269，： | 1 |
| 12 | Effects of feeding high forage diets and supplemental fat on feed intake and lactation per- formance in dairy cows 显示文摘 | Abdullah M Young J W Tyler H D | 2000 | Asian-Aust J Anita Sci2000，13，4： | 1 |
| 13 | A holistic approach for optimal designof air quality monitoring network expansion in an urban area显示文摘 | Abdullah M Tahir H | 2010 | Atmospheric Environment2010，44，3： | 1 |
| 14 | Thyroid-stimulating hormone and cyclic AMP activate p38 mitogenactivated protein kinase cascade:involvement of protein kinase A,rac1,and reactive oxygen species显示文摘 | POMERANCE M ABDULLAH H B KAMERJI S | 2000 | J Biol Chem2000，275，40： | 1 |
| 15 | Urban soil pollution inDamascus, Syria: concentrations and patterns of heavy metals in thesoils of the Damascus显示文摘 | Moller A Muller H W Abdullah A | 2005 | Ghouta Geoderma2005，124，12： | 1 |
| 16 | An adaptive local binarization method for document images based on a novel thresholding method and dynamic windows显示文摘 | Bataineh B Abdullah S N H S Omar K | 2011 | Pattern Recognition Letters2011，32，14： | 1 |
| 17 | Reverse engineering of turbine blades based on design intent 显示文摘 | MOHAGHEGH K SADEGHI M H ABDULLAH A | 2007 | International Journal Advanced Manufacturing Technology2007，32，6： | 1 |
| 18 | Exercise training increase ERK2 activity in skeletal muscle of obese Zucker rats显示文摘 | Abdullah A O Tob H Desmond G H | 2001 | Appl Physiol2001，90，： | 1 |
| 19 | Histopathology of susceptible and resistant capsicum annuum cultivars infected with Ralstonia solanacearum 显示文摘 | Rahman M A Abdullah H Vanhaecke M | 1999 | J of Phytopathol1999，147，： | 1 |
| 20 | Removal of NH 4 +-N ion in drinking water treatment using locally isolated hetertrophic nitrifier显示文摘 | HASAN H A ABDULLAH S R S KOFLI N T | 2012 | Desalination and Water Treatment2012，50，123： | 1 |
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