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| 1 | All-cause hospitalizations for inflammatory bowel diseases:Can the reason for admission provide information on inpatient resource use?A study from a large veteran affairs hospital显示文摘Background:Inflammatory bowel diseases(IBDs) are group of chronic inflammatory illnesses with a remitting and relapsing course that may result in appreciable morbidity and high medical costs secondary to repeated hospitalizations.The study's objectives were to identify the reasons for hospitalization among patients with IBDs,and compare inpatient courses and readmission rates for IBD-related admissions versus non-IBD-related admissions.Methods:A retrospective chart review was performed on all patients with IBD admitted to the Minneapolis Veterans Affairs(VA) Medical Center between September 2010 and September 2012.Results:A total of 111 patients with IBD were admitted during the 2-year study period.IBD flares/complications accounted for 36.9% of the index admissions.Atherothrombotic events comprised the second most common cause of admissions(14.4%) in IBD patients.Patients with an index admission directly related to IBD were significantly younger and had developed IBD more recently.Unsurprisingly,the IBD admission group had significantly more gastrointestinal endoscopies and abdominal surgeries,and was more likely to be started on medication for IBD during the index stay.The median length of stay(LOS) for the index hospitalization for an IBD flare or complication was 4(2–8) days compared with 2(1–4) days for the other patients(P=0.001).A smaller percentage of the group admitted for an IBD flare/complication had a shorter ICU stay compared with the other patients(9.8% vs.15.7%,respectively); however,their ICU LOSs tended to be longer(4.5 vs.2.0 days,respectively,P=0.17).Compared to the other admission types,an insignificantly greater percentage of the group whose index admission was related to an IBD flare or complication had at least one readmission within 6 months of discharge(29% versus 21%; P=0.35).The rate of admission was approximately 80% greater in the group whose index admission was related to an IBD flare or complication compared to the other types of admission(rate ratio 1.8,95% confidence interval 0.96 to 3.4),although this difference did not reach statistical significance(P=0.07).Conclusion:Identifying the reasons for the patients' index admission,IBD flares versus all other causes,may provide valuable information concerning admission care and the subsequent admission history. | Ashish Malhotra K.C.Mandip Aasma Shaukat Thomas Rector | 2016 | Journal of Medical Colleges of PLA(China)2016，31，3： | 2 |
| 2 | Endoscopic and Medical Therapy for Chronic Radiation Proctopathy: A Systematic Review显示文摘 | Brian Hanson Roderick MacDonald Aasma Shaukat | 2012 | Diseases of the Colon & Rectum2012，，： | 2 |
| 3 | A Comparison of Image Processing Techniques for Optical Interference Fringe Analysis显示文摘我们在场为移动的分析的不同技术的比较并且在光干扰穗倾斜。穗中心,氡变换,和 Gaussian 近似方法被用于穗分析。我们测量了在二个相关的穗模式之间的 tilt 和移动。错误在倾斜测量是大约 2% ,并且很少纳米的顺序的排水量被穗移动分析测量。在这些技术之间的比较关于百分比错误被分析。 | Muhammad FAROOQ Aasma ASLAM Babar HUSSAIN Ghazanfar HUSSAIN Masroor IKRAM | 2015 | Photonic Sensors2015，5，4： | 2 |
| 4 | Transcription factor-based gene therapy to treat glioblastoma through direct neuronal conversion显示文摘Objective:Glioblastoma(GBM)is the most prevalent and aggressive adult primary cancer in the central nervous system.Therapeutic approaches for GBM treatment are under intense investigation,including the use of emerging immunotherapies.Here,we propose an alternative approach to treat GBM through reprogramming proliferative GBM cells into non-proliferative neurons.Methods:Retroviruses were used to target highly proliferative human GBM cells through overexpression of neural transcription factors.Immunostaining,electrophysiological recording,and bulk RNA-seq were performed to investigate the mechanisms underlying the neuronal conversion of human GBM cells.An in vivo intracranial xenograft mouse model was used to examine the neuronal conversion of human GBM cells.Results:We report efficient neuronal conversion from human GBM cells by overexpressing single neural transcription factor Neurogenic differentiation 1(Neuro D1),Neurogenin-2(Neurog2),or Achaete-scute homolog 1(Ascl1).Subtype characterization showed that the majority of Neurog2-and Neuro D1-converted neurons were glutamatergic,while Ascl1 favored GABAergic neuron generation.The GBM cell-converted neurons not only showed pan-neuronal markers but also exhibited neuron-specific electrophysiological activities.Transcriptome analyses revealed that neuronal genes were activated in glioma cells after overexpression of neural transcription factors,and different signaling pathways were activated by different neural transcription factors.Importantly,the neuronal conversion of GBM cells was accompanied by significant inhibition of GBM cell proliferation in both in vitro and in vivo models.Conclusions:These results suggest that GBM cells can be reprogrammed into different subtypes of neurons,leading to a potential alternative approach to treat brain tumors using in vivo cell conversion technology. | Xin Wang Zifei Pei Aasma Hossain Yuting Bai Gong Chen | 2021 | Cancer Biology & Medicine2021，18，3： | 2 |
| 5 | Occurrence of clinical mastitis in Primiparous Estonian dairy cows in different housing conditions显示文摘 | Kalmus P Viltrop A Aasmae B | 2006 | Acta Vet Stand2006，48，1： | 1 |
| 6 | Variation in Detection of Adenomas and Polyps by Colonoscopy and Change Over Time With a Performance Improvement Program显示文摘 | Aasma Shaukat Cristina Oancea John H. Bond Timothy R. Church John I. Allen | 2009 | Clinical Gastroenterology and Hepatology2009，，12： | 1 |
| 7 | Occurrence of clini- cal mastitis in Primiparous Estonian dairy cows in differ- ent housing conditions显示文摘 | Kalmus P Viltrop A Aasmae B | 2006 | Acta Vet Stand2006，48，1： | 1 |
| 8 | Occurrence of clinical mastitis in primiparous Estonian dairy cows in different housing conditions显示文摘 | KALMUS P VILTROP A AASMAE B | 2006 | Acta Vet Scand2006，48，1： | 1 |
| 9 | Occurrence of clinical mastitis in primiparous Estonian dairy cows in different housing conditions显示文摘 | Kalmus P Viltrop A Aasmae B | | 0，，01： | 1 |
| 10 | Occur- clinical mastitis in primiparous Estonian dairy cows in different housing conditions显示文摘 | Kalmus P rence of Viltrop A Aasmae B | 2006 | Acta Vet Scand2006，48，1： | 1 |
| 11 | Occurrence of Clinical Mastitis in Primiparous Estonian Dairy Cows in Different Housing Conditions 显示文摘 | Kalmus P Viltrop A Aasmae B | 2006 | Acta Vet Scand2006，48，1： | 1 |
| 12 | Effects of drug-polymer dispersions on solubility and in vitro diffusion of artemisinin across a polydimethylsiloxane membrane显示文摘Artemisinin(ART) is a sesquiterpene lactone with an endo-peroxide bridge that is thought to be responsible for its antimalarial activity.It has low oral bioavailability because of aqueous insolubility,which leads to local toxicity at the site of aggregation.The present work focused on increasing its solubility and evaluating its permeation across a model membrane to mimic transdermal delivery that bypasses the hepatic metabolism.For this purpose,physical mixtures(PM),solid dispersions(SD) and lyophilized dispersions(LD) with different drug-polymer ratios(1:0.5,1:1,1:2,1:4 and 1:9) were prepared using the hydrophilic polymer polyvinylpyrrolidone(PVP).Drug-polymer dispersions were characterized using X-ray diffraction(XRD) and Fourier transform infrared spectroscopy(FTIR).Solubility was measured in three solvents:de-ionized water,phosphate buffered saline(PBS) and methanol.The toluene-water partition coefficient was evaluated and compared with the literature and calculated logP values.In vitro diffusion of ART was studied across a polydimethylsiloxane membrane from a saturated solution of drug-polymer dispersions.XRD patterns showed a gradual decrease in crystallinity of ART with increasing polymer concentration,while FTIR confirmed no interactions between ART and PVP.Solubility was increased up to 4-,5-and 8-fold for LD in water,PBS and methanol,respectively.The logP for toluene-water was 2.65 ± 0.3,which is in good agreement with literature and calculated logP values.Permeation was enhanced,which is attributed to the decrease in crystallinity and increase in wettability of the drug.The ART flux was significantly higher than that of pure ART(0.12 ± 0.01) with increasing PVP concentration for SD and LD formulations.In conclusion,drug-polymer dispersions with PVP improve the pharmaceutical properties of ART in the order LD>SD>PM. | SHAHZAD Yasser SHAH Syed Nisar Hussain ANSARI Muhammad Tayyab RIAZ Romana SAFDAR Aasma HUSSAIN Talib MALIK Madeeha | 2012 | Chinese Science Bulletin2012，57，14： | 1 |
| 13 | Occurrence ofclinical mastitis in primiparous Estonian dairy cows indifferent housing conditions 显示文摘 | Kalmus P’Viltrop A Aasmae B | 2006 | Acta Vet Scand2006，48，1： | 1 |
| 14 | Multiplex RTPCR assay for the differential diagnosis of alveolar rhabdomyosarcoma and Ewing's sarcoma显示文摘 | AASMA K SHURTLEFF A S | 1995 | Am J Pathol1995，146，3： | 1 |
| 15 | Review of Epidemiology, Diagnosis, and Treatment of Invasive Mould Infections in Allogeneic Hematopoietic Stem Cell Transplant Recipients显示文摘 | Zahida Bhatti Aasma Shaukat Nikolaos G. Almyroudis Brahm H. Segal | 2006 | Mycopathologia2006，，1： | 1 |
| 16 | Evaluation of electrocoagulation for the pre-treatment of coal seam water 显示文摘 | Graeme J Millar Jack Lin Aasma Arshad | 2014 | Journal of Water Process Engineering2014，4，5： | 1 |
| 17 | Occurrence of clinical mastitis in primiparous Estonian dairy cows in different housing conditions显示文摘 | Kalmus P Viltrop A Aasmae B | 2006 | Acta Vet Scand2006，48，1： | 1 |
| 18 | Occurrence of clinical mastitis in primiparous Estonian dairy cows in different housing conditions显示文摘 | Kalmus P Viltrop A Aasmae B | 2006 | Acta Vet Scand2006，48，1： | 1 |
| 19 | Occurrence of clinical mastiffs in primiparous Estonian dairy cows in different housing conditions显示文摘 | KALMUS P VILTROP A AASMAE B | 2006 | Acta Vet Scand2006，48，1： | 1 |
| 20 | Occurrence of clinical mastitis in primiparous Estonian dairy cows in different housing conditions显示文摘 | Kalmus P Vittrop A Aasmae B | 2006 | Acta Vet Stand2006，48，1： | 1 |
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