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| 1 | Trends in Acute Myocardial Infarction in Young Patients and Differences by Sex and Race, 2001 to 2010显示文摘 | Aakriti Gupta Yongfei Wang John A. Spertus Mary Geda Nancy Lorenze Chileshe Nkonde-Price Gail D’Onofrio Judith H. Lichtman Harlan M. Krumholz | 2014 | Journal of the American College of Cardiology2014，，： | 1 |
| 2 | A solar reactor for bio-diesel production from Pongamia oil: Studies on transesterfication process parameters and energy efficiency显示文摘Over exploitation of non-renewable energy reserves will lead to increase in price of petroleum fuels.Therefore there is a need for suitable and sustainable substitutes(renewable resource) for conventional fuels.In this study,an efficient and environmental friendly method for production of bio-diesel from Pongamia(Karanja) oil has been developed using a solar reactor.During the experimental study,the maximum temperature attained by the pongamia oil during the transesterification process was 64.1℃.The transesterification reaction was studied by varying different parameters such as reactant flow rate(5-20 L·h^(-1)),stirring speed(150-450 r·min^(-1)),catalyst mass loading(0.5%-2%) and methanol to oil ratio(3:1 to15:1).The maximum biodiesel yield was 83.11% at a flow rate of 5 L·h^(-1),stirring speed of 350 r·min^(-1),a methanol to oil ratio of 15:1,catalyst mass loading of 1% and reaction time of 270 min.The physical and chemical properties of biodiesel was analyzed as per American Society for Testing Materials(ASTM) standards and it had density of 938 kg·m^(-3),viscosity(28.7×10^(-6) m~2·s^(-1)),acid value(9.45 mg KOH·(g oil)^(-1))and flash point(215℃).The energy efficiency of solar heating process was determined by comparing the net energy ratio of direct heating process and solar heating process.For solar heating the net energy ratio(NER) was found to be 31.85 against 5.73 for direct heating.Similarly,net energy efficiency index was calculated for 10 kg production scale and was found to be increasing when scaled up which means that the solar heating process is more effective even in scaled up production. | Subbaiyan Naveen Kannappan Panchamoorthy Gopinath Rajagopal Malolan Ramesh Sai Jayaraman Krishnan Aakriti Jayaseelan Arun | 2021 | Chinese Journal of Chemical Engineering2021，34，12： | 0 |
| 3 | Influence of non-alcoholic fatty liver disease on non-variceal upper gastrointestinal bleeding:A nationwide analysis显示文摘BACKGROUND Non-alcoholic fatty liver disease(NAFLD)is the leading cause of liver disease globally with an estimated prevalence of 25%,with the clinical and economic burden expected to continue to increase.In the United States,non-variceal upper gastrointestinal bleeding(NVUGIB)has an estimated incidence of 61-78 cases per 100000 people with a mortality rate of 2%-15%based on co-morbidity burden.AIM To identify the outcomes of NVUGIB in NAFLD hospitalizations in the United States.METHODS We utilized the National Inpatient Sample from 2016-2019 to identify all NVUGIB hospitalizations in the United States.This population was divided based on the presence and absence of NAFLD.Hospitalization characteristics,outcomes and complications were compared.RESULTS The total number of hospitalizations for NVUGIB was 799785,of which 6%were found to have NAFLD.NAFLD and GIB was,on average,more common in younger patients,females,and Hispanics than GIB without NAFLD.Interestingly,GIB was less common amongst blacks with NAFLD.Multivariate logistic regression analysis was conducted,controlling for the multiple covariates.The primary outcome of interest,mortality,was found to be significantly higher in patients with NAFLD and GIB[adjusted odds ratio(aOR)=1.018(1.013-1.022)].Secondary outcomes of interest,shock[aOR=1.015(1.008-1.022)],acute respiratory failure[aOR=1.01(1.005-1.015)]and acute liver failure[aOR=1.016(1.013-1.019)]were all more likely to occur in this cohort.Patients with NAFLD were also more likely to incur higher total hospital charges(THC)[$2148($1677-$2618)];however,were less likely to have a longer length of stay[0.27 d(0.17-0.38)].Interestingly,in our study,the patients with NAFLD were less likely to suffer from acute myocardial infarction[aOR=0.992(0.989-0.995)].Patients with NAFLD were not more likely to suffer acute kidney injury,sepsis,blood transfusion,intubation,or dialysis.CONCLUSION NVUGIB in NAFLD hospitalizations had higher inpatient mortality,THC,and complications such as shock,acute respiratory failure,and acute liver failure compared to those without NAFLD. | Aakriti Soni Anuroop Yekula Yuvaraj Singh Nitish Sood Dushyant Singh Dahiya Kannu Bansal GM Abraham | 2023 | World Journal of Hepatology2023，15，1： | 0 |
| 4 | Detection of colorectal adenomas using artificial intelligence models in patients with chronic hepatitis C显示文摘BACKGROUND Hepatitis C virus is known for its oncogenic potential,especially in hepatocellular carcinoma and non-Hodgkin lymphoma.Several studies have shown that chronic hepatitis C(CHC)has an increased risk of the development of colorectal cancer(CRC).AIM To analyze this positive relationship and develop an artificial intelligence(AI)-based tool using machine learning(ML)algorithms to stratify these patient populations into risk groups for CRC/adenoma detection.METHODS To develop the AI automated calculator,we applied ML to train models to predict the probability and the number of adenomas detected on colonoscopy.Data sets were split into 70:30 ratios for training and internal validation.The Scikit-learn standard scaler was used to scale values of continuous variables.Colonoscopy findings were used as the gold standard and deep learning architecture was used to train six ML models for prediction.A Flask(customizable Python framework)application programming interface(API)was used to deploy the trained ML model with the highest accuracy as a web application.Finally,Heroku was used for the deployment of the web-based API to http://gffzz173cc124733e4edfswkpquo9fpv5v6cp0.ffgz.tsg.suse.edu.cn Of 415 patients,206 had colonoscopy results.On internal validation,the Bernoulli naive Bayes model predicted the probability of adenoma detection with the highest accuracy of 56%,precision of 55%,recall of 55%,and F1 measure of 54%.Support vector regressor predicted the number of adenomas with the least mean absolute error of 0.905.CONCLUSION Our AI-based tool can help providers stratify patients with CHC for early referral for screening colonoscopy.Along with providing a numerical percentage,the calculator can also comment on the number of adenomatous polyps a gastroenterologist can expect,prompting a higher adenoma detection rate. | Yuvaraj Singh Maya Gogtay Anuroop Yekula Aakriti Soni Ajay Kumar Mishra Kartikeya Tripathi GM Abraham | 2023 | World Journal of Hepatology2023，15，1： | 0 |
| 5 | Infuence of gut microbiome on the human physiology显示文摘Trillions of microbes harbor the gastrointestinal tract and co-exist peacefully with the human host.Microbial diversity and composition among individuals depend upon human age,diet,and environmental factors.The dynamic population of the gut microbiome,majorly consisting of Bacteroidetes and Firmicutes,forms a complex ecological community.The collective metabolic activities and interaction of gut microbiota with the host exert a marked infuence on human physiology.The gut microbiota help to perform various functions,such as maintenance of intestinal mucosal integrity,production of antimicrobial peptides,protection against foreign invaders,and immunity development.In addition,they also provide essential nutrients,such as enzymes and vitamins,and also take part in metabolite synthesis,which infuences both cognitive and behavioral functions of the human host.Homeostatic equilibrium among gut microorganisms,and between the microbes and intestinal interface of the host allows the maintenance of benefcial microbiota.Any alteration or dysbiosis in gut microbial composition,due to a sedentary lifestyle or intake of an unbalanced diet,plays a crucial role in the development of diseases like systemic infammation,insulin resistance,auto-immune and metabolic disorders.This review summarizes our current understanding of the gut microbial organization,its importance in the fundamental biological processes and the pathogenesis of various human diseases and infections,and also the prognostic,diagnostic,and therapeutic potential of the gut microbiota. | Aakriti Srivastava Muhil Raj Prabhakar Anee Mohanty Sumer Singh Meena | 2022 | Systems Microbiology and Biomanufacturing2022，2，2： | 0 |
| 6 | Peptic ulcer disease in non-alcoholic fatty liver disease hospitalizations:A new challenge on the horizon in the United States显示文摘BACKGROUND Peptic ulcer disease(PUD)is frequently seen in patients with liver cirrhosis.However,current literature lacks data on PUD in non-alcoholic fatty liver disease(NAFLD)hospitalizations.AIM To identify trends and clinical outcomes of PUD in NAFLD hospitalizations in the United States.METHODS The National Inpatient Sample was utilized to identify all adult(≥18 years old)NAFLD hospitalizations with PUD in the United States from 2009-2019.Hospitalization trends and outcomes were highlighted.Furthermore,a control group of adult PUD hospitalizations without NAFLD was also identified for a comparative analysis to assess the influence of NAFLD on PUD.RESULTS The total number of NAFLD hospitalizations with PUD increased from 3745 in 2009 to 3805 in 2019.We noted an increase in the mean age for the study population from 56 years in 2009 to 63 years in 2019(P<0.001).Racial differences were also prevalent as NAFLD hospitalizations with PUD increased for Whites and Hispanics,while a decline was observed for Blacks and Asians.The all-cause inpatient mortality for NAFLD hospitalizations with PUD increased from 2%in 2009 to 5%in 2019(P<0.001).However,rates of Helicobacter pylori(H.pylori)infection and upper endoscopy decreased from 5%in 2009 to 1%in 2019(P<0.001)and from 60%in 2009 to 19%in 2019(P<0.001),respectively.Interestingly,despite a significantly higher comorbidity burden,we observed lower inpatient mortality(2%vs 3%,P=0.0004),mean length of stay(LOS)(11.6 vs 12.1 d,P<0.001),and mean total healthcare cost(THC)($178598 vs$184727,P<0.001)for NAFLD hospitalizations with PUD compared to non-NAFLD PUD hospitalizations.Perforation of the gastrointestinal tract,coagulopathy,alcohol abuse,malnutrition,and fluid and electrolyte disorders were identified to be independent predictors of inpatient mortality for NAFLD hospitalizations with PUD.CONCLUSION Inpatient mortality for NAFLD hospitalizations with PUD increased for the study period.However,there was a significant decline in the rates of H.pylori infection and upper endoscopy for NAFLD hospitalizations with PUD.After a comparative analysis,NAFLD hospitalizations with PUD had lower inpatient mortality,mean LOS,and mean THC compared to the non-NAFLD cohort. | Dushyant Singh Dahiya Vinay Jahagirdar Hassam Ali Manesh Kumar Gangwani Muhammad Aziz Saurabh Chandan Amandeep Singh Abhilash Perisetti Aakriti Soni Sumant Inamdar Madhusudhan R Sanaka Mohammad Al-Haddad | 2023 | World Journal of Hepatology2023，15，4： | 0 |
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