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| 1 | Effect of crocin carotenoid on BDNF and CREB gene expression in brain ventral tegmental area of morphine treated rats显示文摘Objective: To investigate the effect of crocin carotenoid on BNDF and CREB gene expression in the brain ventral tegmental area(VTA) and the serum level of BDNF in morphine-treated rats compared to control. Methods: In this study, 40 male Wistar rats(200-250 g) were used in 5 experimental groups: 1) non morphine treat rats(control); 2) non morphine-treated rats with 25 mg/kg crocin carotenoid(i.p., for 21 d); 3) morphine treated rats(10 mg/kg twice a day, s.c., 21 d); 4 and 5) morphine-treated rats with 12.5 and 25 mg/kg crocin carotenoid, respectively. By the end of research, BDNF and CREB expression was determined by real-time-PCR method. ELISA analysis was also applied for assessing the serum BDNF level. Results: The data indicated that morphine treatment could cause a significant decrease in BDNF and CREB gene expression(P<0.01 and P<0.001, respectively) in brain VTA as well as serum level of BDNF(P<0.01) in comparison to control group. Treatment with 25 mg/kg crocin carotenoid caused a significant enhancement in BDNF and CREF gene expression(P<0.01 and P<0.05, respectively) and serum level of BDNF(P<0.01) in morphine-treated rats in comparison to morphine-treated group. Conclusions: Regarding to obtained results, crocin carotenoid can inhibit unfavorable effects of morphine on the neural system to some extent through enhancing BDNF and CREB gene expression in brain VTA and serum level of BDNF. | Marzieh Rezai Mehdi Mahmoodi Ayat Kaeidi Mojgan Noroozi Karimabad Alireza Khoshdel Mohammad Reza Hajizadeh | 2018 | Asian Pacific Journal of Tropical Biomedicine2018，8，8： | 5 |
| 2 | Protective effects of Balanites aegyptiaca extract, melatonin and ursodeoxycholic acid against hepatotoxicity induced by methotrexate in male rats显示文摘Objective: To compare the degree of ameliorative effects of Melatonin(MEL), Ursodeoxycholic acid(UDCA) and Balanites aegyptiaca(BA) against hepatotoxicity induced by MTX for one month. Methods: Eighty adult male rats(Sprague Dawely) weighing(190±10g), were randomly divided into eight equal groups: Control, MTX, MEL, BA, UDCA, MTX+MEL, MTX+BA, MTX+UDCA. Liver function biomarker enzymes, liver tissue oxidative stress parameters, together with total antioxidant capacity and tumor necrosis factor(TNF-α) were determined. Histopathological and immunohistochemistry examinations for TNF-α were also done. Results: MTX showed significant increase in alanine transaminase(ALT), aspartate transaminase(AST), alkaline phosphatase(ALP), gamma glutamyl transferase(GGT), total and direct bilirubin, as well as TNF-α levels, oxidized glutathione(GSSG), malodialdehyde(MDA) and nitric oxide(NO). whereas, total protein, albumin, total antioxidant capacity, reduced glutathione(GSH), glutathione peroxidase(GPx), glutathione reductase(GR), glutathione S-transferase(GST), superoxide dismutase(SOD) and catalase(CAT) levels were significantly decreased in MTX treated group. These alterations were improved by MEL and BA treatment, whereas no improvement was noticed in UDCA treatment. Conclusions: BA may be as promising as MEL in the hepatoprotection against MTX toxicity through their antioxidant and radical scavenging activities. In addition, it is not recommended to co-administer UDCA with MTX as it enhanced inflammation and damage to the liver. | Ayat OS Montasser Hanan Saleh Omar A.Ahmed-Farid Aida Saad Mohamed-Assem S.Marie | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，6： | 2 |
| 3 | Role of eIF4E on epithelial-mesenchymal transition,invasion,and chemoresistance of prostate cancer cells显示文摘Dear Editor,Prostate cancer(PCa)is the most common cancer and second leading cause of cancer death for men in the United States[1].PCa with similar Gleason score has been reported to show substantial interpatient heterogeneity and differential prostate cancer-specific mortality rate[2].Such heterogeneity in PCa often results in different therapeutic responses among patients,including therapy resistance,therapeutic failure,relapse,and metastasis[3].Numerous oncogenes,such as eukaryotic translation initiation factor 4E(eIF4E),have been reported to be involved in epithelial-mesenchymal transition(EMT)and/or drug resistance in PCa[4].We previously demonstrated that eIF4E overexpression was involved in chemoresistance of triple-negative breast cancer and silencing eIF4E significantly inhibited cancer cell proliferation and sensitized cancer cells to chemotherapy in a patient-derived xenograft mouse model[5].In addition,eIF4E phosphorylation is known to stimulate the translation of matrix metalloproteinase 3(MMP3)and Snail mRNAs to promote EMT in PCa[6].Furthermore,the complexity and dynamic nature of EMT contributes to the heterogeneity of aggressive cancer cells[7].The precise role of eIF4E in EMT,invasion,and chemoresistance in PCa is still to be established with consideration of different subpopulations in order to develop precision medicine for PCa.In this work,we aimed to explore the role of eIF4E in EMT,invasion,and chemoresistance in PCa for establishing a promising new therapeutic strategy by regulating eIF4E expression using(1-aminoethyl)iminobis[Noleicylcysteinyl-1-aminoethyl)propionamide](ECO)/small interfering RNA(siRNA)nanoparticles previously developed in our lab[8-10]for PCa therapy in the context of tumor heterogeneity. | Xujie Liu Amita M Vaidya Da Sun Yan Zhang Nadia Ayat Andrew Schilb Zheng-Rong Lu | 2020 | Cancer Communications2020，40，2： | 2 |
| 4 | Automatic model selection for the optimization of SVM kernels? 显示文摘 | N E Ayat M Cheriet C Y Suen | 2005 | Pattern Recognition2005，38，10： | 1 |
| 5 | Automatic Modelselection for the Optimization of SVM Kernels显示文摘 | Ayat N E Cheret M Suen C Y | 2005 | Pattern Recognition2005，38，5： | 1 |
| 6 | Enterococcal meningitis: a clinical study of 39 cases and review of the literature显示文摘 | Pintado V Cabellos C Moreno S Meseguer MA Ayats J Viladrich PF | 2003 | Medicine (Baltimore)2003，82，5： | 1 |
| 7 | Molecular characterization of two high-level ceftrlaxone-resistant Neisseria gonorrhoeae isolates detected in Catalonia, Spain 显示文摘 | Ctmara J Serra J Ayats J | 2012 | J Antimicrob Chemother2012，67，8： | 1 |
| 8 | High-throughput molecular diagnosis of yon Willebrand disease by next generation sequencing methods显示文摘 | Corrales I Catarino S Ayats J | 2012 | Haematologica2012，97，7： | 1 |
| 9 | Molecular characterization oftwo high-level ceftriaxone-resistant Neisseria gonorrhoeae isolatesdetected in Catalonia, Spain 显示文摘 | Camara J Serra J Ayats J | 2012 | J Antimicrob Chemother2012，67，8： | 1 |
| 10 | Automatic model selection for the optimization of SVM kernels显示文摘 | Ayat N E Cheriet M Suen C Y | 2005 | Pattern Recognition2005，38，： | 1 |
| 11 | C-erbB-2 oncoprotein in apocfine adenosis of the breast显示文摘 | Selim A G A Ayat G Clive A | 2000 | J Pathol2000，191，： | 1 |
| 12 | Unit root tests in the presence of uncertainty about the non- stochastic trend显示文摘 | Ayat L Burridge P | 2000 | Journal of Econometrics2000，95，： | 1 |
| 13 | Fetal ECG extraction from a signal ECG signal using SVD and polynomial classifiers显示文摘 | AYAT M ASSALEH K NASHASH H | 2008 | Machine Learning for Signal Processing2008，，： | 1 |
| 14 | Automatic model selection for the optimization of SVM kernels 显示文摘 | Ayat N E Cheriet M Suen C Y | 2005 | Pattern Recognition2005，38，10： | 1 |
| 15 | Evaluation of the effeet of disease duration in generalized vitiligo on its clinical response to narrowband ultraviolet B phototherapy 显示文摘 | Zahra Hallaji Maryam Ghiasi Ayat Eisadeh | 2012 | Photodermatol Photoimmunol Photomed2012，28，3： | 1 |
| 16 | Risk Factors, Clinical Characteristics, and Outcomes of Invasive Fungal Infections in Solid Organ Transplant Recipients显示文摘 | M. Bodro N. Sabé A. Gomila J. Ayats C. Baliellas J. Roca E. Melilli J. Carratalà | 2012 | Transplantation Proceedings2012，，9： | 1 |
| 17 | Increase in bloodstream infection due to vancomycin-susceptible Enterococcus faecium in cancer patients: risk factors, molecular epidemiology and outcomes 显示文摘 | Gudiol C Ayats J Camoez M | 2013 | PLoSOne2013，8，74： | 1 |
| 18 | Expression of c - erbB - 2, p53, Bcl- 2, Bax, c- myc, and Ki- 67 in apocrine metaplasia and apocrine change with in sclerosing adenosis of the breast显示文摘 | Selim AG El - Ayat G Wells CA | 2002 | Virchows Arch2002，441，5： | 1 |
| 19 | Automatic model selection for the optimization of SVM kernels显示文摘 | AYAT N E CHERET M SUEN C Y | | 0，，05： | 1 |
| 20 | Automatic model selection for the optimization of the SVM kernels 显示文摘 | Ayat N E Cheriet M Suen C Y | 2005 | Pattern Recogn Comput Sci2005，38，10： | 1 |
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