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| 1 | Role of eIF4E on epithelial-mesenchymal transition,invasion,and chemoresistance of prostate cancer cells显示文摘Dear Editor,Prostate cancer(PCa)is the most common cancer and second leading cause of cancer death for men in the United States[1].PCa with similar Gleason score has been reported to show substantial interpatient heterogeneity and differential prostate cancer-specific mortality rate[2].Such heterogeneity in PCa often results in different therapeutic responses among patients,including therapy resistance,therapeutic failure,relapse,and metastasis[3].Numerous oncogenes,such as eukaryotic translation initiation factor 4E(eIF4E),have been reported to be involved in epithelial-mesenchymal transition(EMT)and/or drug resistance in PCa[4].We previously demonstrated that eIF4E overexpression was involved in chemoresistance of triple-negative breast cancer and silencing eIF4E significantly inhibited cancer cell proliferation and sensitized cancer cells to chemotherapy in a patient-derived xenograft mouse model[5].In addition,eIF4E phosphorylation is known to stimulate the translation of matrix metalloproteinase 3(MMP3)and Snail mRNAs to promote EMT in PCa[6].Furthermore,the complexity and dynamic nature of EMT contributes to the heterogeneity of aggressive cancer cells[7].The precise role of eIF4E in EMT,invasion,and chemoresistance in PCa is still to be established with consideration of different subpopulations in order to develop precision medicine for PCa.In this work,we aimed to explore the role of eIF4E in EMT,invasion,and chemoresistance in PCa for establishing a promising new therapeutic strategy by regulating eIF4E expression using(1-aminoethyl)iminobis[Noleicylcysteinyl-1-aminoethyl)propionamide](ECO)/small interfering RNA(siRNA)nanoparticles previously developed in our lab[8-10]for PCa therapy in the context of tumor heterogeneity. | Xujie Liu Amita M Vaidya Da Sun Yan Zhang Nadia Ayat Andrew Schilb Zheng-Rong Lu | 2020 | Cancer Communications2020，40，2： | 2 |
| 2 | Automatic model selection for the optimization of SVM kernels? 显示文摘 | N E Ayat M Cheriet C Y Suen | 2005 | Pattern Recognition2005，38，10： | 1 |
| 3 | Automatic Modelselection for the Optimization of SVM Kernels显示文摘 | Ayat N E Cheret M Suen C Y | 2005 | Pattern Recognition2005，38，5： | 1 |
| 4 | Automatic model selection for the optimization of SVM kernels显示文摘 | Ayat N E Cheriet M Suen C Y | 2005 | Pattern Recognition2005，38，： | 1 |
| 5 | Fetal ECG extraction from a signal ECG signal using SVD and polynomial classifiers显示文摘 | AYAT M ASSALEH K NASHASH H | 2008 | Machine Learning for Signal Processing2008，，： | 1 |
| 6 | Automatic model selection for the optimization of SVM kernels 显示文摘 | Ayat N E Cheriet M Suen C Y | 2005 | Pattern Recognition2005，38，10： | 1 |
| 7 | Increase in bloodstream infection due to vancomycin-susceptible Enterococcus faecium in cancer patients: risk factors, molecular epidemiology and outcomes 显示文摘 | Gudiol C Ayats J Camoez M | 2013 | PLoSOne2013，8，74： | 1 |
| 8 | Automatic model selection for the optimization of SVM kernels显示文摘 | AYAT N E CHERET M SUEN C Y | | 0，，05： | 1 |
| 9 | Automatic model selection for the optimization of the SVM kernels 显示文摘 | Ayat N E Cheriet M Suen C Y | 2005 | Pattern Recogn Comput Sci2005，38，10： | 1 |
| 10 | Epidemiology ofmethicillin-resistant staphylococcus aureus (MRSA) bloodstreaminfection: secular trends over 19 years at a university hospital 显示文摘 | Gasch 0 Ayats J Angeles Dominguez M | 2011 | Medicine (Baltimore)2011，90，5： | 1 |
| 11 | Automatic model selection for the optimization of SVM kernels 显示文摘 | Ayat N E Cheriet M Suen C Y | 2005 | Pattern Recognition2005，38，10： | 1 |
| 12 | 显示文摘 | Ayat M Amine H Mohamed B | 2008 | Journal of Applied Polymer Science2008，109，3： | 1 |
| 13 | Automatic model selection for the optimization of the SVM kernels显示文摘 | Ayat N E Cheriet M Suen C Y | 2005 | Pattern Recognition2005，38，： | 1 |
| 14 | Physiological and biochemical changes in plants under waterlogging 显示文摘 | Irfan M Hayat S H ayat Q | 2010 | Protoplasma2010，241，： | 1 |
| 15 | Comparison ofcompression stocking with elasticbandage in reducing postoperativeedemain coronary artery bypassgraft patient显示文摘 | Khoshgoftar Zohreh RN MA AyatE s f a h a n i F a r a h R N M a r z b a nMehrab MD | 2009 | J Vasc Nurs2009，27，： | 1 |
| 16 | Comparison of compression stocking with elasticbandage in reducingpostoperative edemain coronary artery bypass graft patient显示文摘 | Khoshgoftar Zohreh R N Ayat Esfahani Farah R N MarzbanMehrab M D | 2009 | J Vase Nurs2009，27，2： | 1 |
| 17 | Accurate doppler prediction scheme for satellite orbits显示文摘 | Ayat N Mehdipour M | 2006 | Wseas Transaction on Power Systems2006，1，3： | 1 |
| 18 | Automatic model selection for the optimization of SVM kernels 显示文摘 | N E Ayat M Cheriet C Y Suen | 2005 | Pattern Recognition (S1004-731X)2005，38，0： | 1 |
| 19 | Physiological and biochemical changes in plants under waterlogging显示文摘 | IRFAN M H AYAT S H AYAT Q | 2010 | Protoplasma2010，241，： | 1 |
| 20 | Automatic model selection for the optimization of SVM kernels显示文摘 | AYAT N E CHERIET M SUEN C Y | 2005 | Pattern Recognition2005，38，： | 1 |
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