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| 1 | Folic acid supplementation inhibits recurrence of colorectal adenomas:A randomized chemoprevention trial显示文摘AIM: To determine whether folic acid supplementation will reduce the recurrence of colorectal adenomas, the precursors of colorectal cancer, we performed a double-blind placebo-controlled trial in patients with adenomatous polyps. METHODS: In the current double-blind, placebo-controlled trial at this VA Medical Center, patients with colorectal adenomas were randomly assigned to receive either a daily 5 mg dose of folic acid or a matched identical placebo for 3 years. All polyps were removed at baseline colonoscopy and each patient had a follow up colonoscopy at 3 years. The primary endpoint was a reduction in the number of recurrent adenomas at 3 years. RESULTS: Of 137 subjects, who were eligible after confirmation of polyp histology and run-in period to conform compliance, 94 completed the study; 49 in folic acid group and 45 in placebo group. Recurrence of adenomas at 3-year was compared between the two groups. The mean number of recurrent polyps at 3-year was 0.36 (SD, 0.69) for folic acid treated patients compared to 0.82 (SD, 1.17) for placebo treated subjects, resulting in a 3-fold increase in polyp recurrence in the placebo group. Patients below 70 years of age and those with left-sided colonicadenomas or advanced adenomas responded better to folic acid supplementation. CONCLUSION: High dose folic acid supplementation is associated with a signif icant reduction in the recurrence of colonic adenomas suggesting that folic acid may be an effective chemopreventive agent for colorectal neoplasia. | Richard Jaszewski Sabeena Misra Martin Tobi Nadeem Ullah Jo Ann Naumoff Omer Kucuk Edi Levi Bradley N Axelrod Bhaumik B Patel Adhip PN Majumdar | 2008 | World Journal of Gastroenterology2008，14，28： | 10 |
| 2 | Lipoxygenase from soybeana显示文摘 | Axelrod B Cheesbrough T M Leakso S | 1981 | Meibods in Enzymology1981，7，： | 2 |
| 3 | Small-focus integral fiber lenses:modeling with the segmented beam-propagation method and nearfield characterization显示文摘 | Axelrod N Lewis A Yosef N B | | 0，，： | 1 |
| 4 | Lipoxygenase from soybeans 显示文摘 | Axelrod B Cheesbrough T M Laakso S | 1981 | Methods Enzymol1981，71，： | 1 |
| 5 | Novel AC-DC and DC-DC converters with a diode-capacitor multiplier显示文摘 | BERKOVICH Y AXELROD B | 2004 | IEEE Transactions on Aerospace and Electronic Systems2004，40，4： | 1 |
| 6 | Consensus statement on the definition of orthostatic hypotension,neurally mediated syncope and the postural tachycardia syndrome显示文摘 | Freeman R Wieling W Axelrod F B | 2011 | Clin Auton Res2011，21，2： | 1 |
| 7 | Insulin-like growth factorI inhibition with pasireotide decreases cell proliferation and increases apoptosis in pre-malignant lesions of the breast:a phase 1 proof of principle trial显示文摘 | Singh B Smith JA Axelrod DM | 2014 | Breast Cancer Res2014，16，6： | 1 |
| 8 | Lipoxygenase from soybeans 显示文摘 | Axelrod B | 1981 | Meth Enzymol1981，71，： | 1 |
| 9 | Consensus statement on the definition of orthostatic hypotension,neurally mediated syncope and the postural tachycardia syndrome显示文摘 | Freeman R Wieling W Axelrod F B | 2011 | Clin Auton Res2011，21，2： | 1 |
| 10 | Isolation of an isozyme of soybean lipoxygenase 显示文摘 | Christopher J Pistorius E Axelrod B | 1970 | Biochimica et Bio- physica Acta1970，198，1： | 1 |
| 11 | Antigen Presention Cells and Bone Allotransplantation显示文摘 | Axelrod T Temandes B | 1985 | Clin Orthop1985，197，： | 1 |
| 12 | Lipoxgenase from soybenns显示文摘 | Axelrod B | 1981 | Methods in enzymology1981，，7： | 1 |
| 13 | Isolation of a third isoenzyme of soybean lipoxygenase 显示文摘 | Christopher J P Pistorius E K Axelrod B | 1972 | Biochimica et Biophysica Acta1972，284，1： | 1 |
| 14 | Lipoxygenase from soybeans显示文摘 | AXELROD B CHEESBROUGH T M LAASKO S | 1981 | Methods Enzymol1981，71，： | 1 |
| 15 | Potential clindamycin resistance in clindamycin-susceptible,erythromycin-resistant Staphylococcus aureus;report of clinical failure显示文摘 | Levin T P Suh B Axelrod P | 2005 | Antimicrob Agents Chemother2005，49，8： | 1 |
| 16 | Novel AC - DC and DC - DC converters with a diode -capacitor multiplier显示文摘 | BERKOVICH Y AXELROD B | 2004 | IEEE Transac- tions on Aerospace and Electronic Systems2004，40，4： | 1 |
| 17 | Potential clindamycin resistance in clindamycin-susceptible, erythromyein-resistant Staphylococcus aureus:report of clinical failure显示文摘 | Levin T P Suh B Axelrod P | 2005 | Antimicrob Agents Chemother2005，49，： | 1 |
| 18 | Lipoxygenasefrom soybeans显示文摘 | AXELROD B CHEESBROUGH T M LAAKSO S | 1981 | Methods in Enzymology1981，71，： | 1 |
| 19 | Plant lipoxygenases 显示文摘 | Shibata D Axelrod B | 1995 | Journal of Lipid Mediators and Cell Signalling1995，12，2： | 1 |
| 20 | Lipoxygenase from soybeans in Enzymology显示文摘 | AXELROD B CHEESBROUGH T M LESKSO S | 1981 | (7): 443-4511981，，7： | 1 |
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