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| 1 | Direct anterior total hip arthroplasty: Literature review of variations in surgical technique显示文摘The direct anterior approach to the hip has been suggested to have several advantages compared to previously popular approaches through its use of an intra-muscular and intra-nervous interval betweenthe tensor fasciae latae and sartorius muscles. Recent increased interest in tissue-sparing and minimallyinvasive arthroplasty has given rise to a sharp increase in the utilization of direct anterior total hip arthroplasty. A number of variations of the procedure have been described and several authors have published their experiences and feedback to successfully accomplishing this procedure. Additionally, improved understanding of relevant soft tissue constraints and anatomic variants has provided improved margin of safety for patients. The procedure may be performed using speciallydesigned instruments and a fracture table, however many authors have also described equally efficacious performance using a regular table and standard arthroplasty tools. The capacity to utilize fluoroscopy intraoperatively for component positioning is a valuable asset to the approach and can be of particular benefit for surgeons gaining familiarity. Proper management of patient and limb positioning are vital to reducing risk of intra-operative complications. An understanding of its limitations and challenges are also critical to safe employment. This review summarizes the key features of the direct anterior approach for total hip arthroplasty as an aid to improving the understanding of this important and effective method for modern hip replacement surgeons. | Keith P Connolly Atul F Kamath | 2016 | World Journal of Orthopedics2016，7，1： | 33 |
| 2 | 寰枢椎脱位中西医结合诊治指南(2019)显示文摘《寰枢椎脱位中西医结合诊疗指南》由中国中西医结合学会脊柱医学专业委员会遵照循证医学原则和专家共识制定,为骨科医师提供AAD临床诊疗的学术性指导意见。主要内容包括AAD的诊断标准、中医辨证、临床分型、治疗策略和方法。 | 无 谭明生 Atul Goel Kuniyoshi Abumi Zhang Fangyi 董福慧 郝定均 赵勇 | 2020 | 中国骨伤2020，33，1： | 15 |
| 3 | Direct anterior total hip arthroplasty:Comparative outcomes and contemporary results显示文摘Direct anterior total hip arthroplasty has become increasingly more popular among arthroplasty surgeons,in large part due to the use of an intramuscular interval and desire to reduce soft tissue damage.Several studies have now been published comparing the anterior intramuscular to other commonly used approaches,and many studies have published complication rates on large series of patients.Review of comparative studies indicates direct anterior hips tend towards shorter hospital stays and high rates of patients discharged to home.Although some studies show evidence of early benefit in functional outcomes,there is no strong evidence that the anterior approach provides any long term functional improvements compared to other approaches.Additionally,evidence to support reduced damage to soft tissue may not translate to certain clinical significance.Rates of intra-operative femur fracture,operative time and blood loss rates are notably higher for those developing familiarity with this approach.However,when surgeons have performed a modest number of procedures,the complication rates tend to markedly decrease in most studies to levels comparable to other approaches.Accuracy of component positioning also favors the anterior approach in some studies.This review summarizes the available literature comparing the direct anterior to other approaches for total hip arthroplasty and provides a comprehensive summary of common complications. | Keith P Connolly Atul F Kamath | 2016 | World Journal of Orthopedics2016，7，2： | 14 |
| 4 | Implication of the intestinal microbiome in complications of cirrhosis显示文摘The intestinal microbiome(IM) is altered in patients with cirrhosis,and emerging literature suggests that this impacts on the development of complications.The Pub Med database was searched from January 2000 to May 2015 for studies and review articles on the composition,pathophysiologic effects and therapeutic modulation of the IM in cirrhosis.The following combination of relevant text words and MeS H terms were used,namely intestinal microbiome,microbiota,or dysbiosis,and cirrhosis,encephalopathy,spontaneous bacterial peritonitis,hepatorenal syndrome,variceal bleeding,hepatopulmonary syndrome,portopulmonary hypertension and hepatocellular carcinoma.The search results were evaluated for pertinence to the subject of IM and cirrhosis,as well as for quality of study design.The IM in cirrhosis is characterized by a decreased proportion of Bacteroides and Lactobacilli,and an increased proportion of Enterobacteriaceae compared to healthy controls.Except for alcoholic cirrhosis,the composition of the IM in cirrhosis is not affected by the etiology of the liver disease.The percentage of Enterobacteriaceae increases with worsening liver disease severity and decompensation and is associated with bacteremia,spontaneous bacterial peritonitis and hepatic encephalopathy.Lactulose,rifaximin and Lactobacillus-containing probiotics have been shown to partial y reverse the cirrhosis associated enteric dysbiosis,in conjunction with improvement in encephalopathy.The IM is altered in cirrhosis,and this may contribute to the development of complications associated with end-stage liver disease.Therapies such as lactulose,rifaximin and probiotics may,at least partially,reverse the cirrhosisassociated changes in the IM.This,in turn,may prevent or alleviate the severity of complications. | Mamatha Bhat Bianca M Arendt Venkat Bhat Eberhard L Renner Atul Humar Johane P Allard | 2016 | World Journal of Hepatology2016，8，27： | 13 |
| 5 | Cytokine- and chemokine-induced inflammatory colorectal tumor microenvironment: Emerging avenue for targeted therapy显示文摘Colorectal cancer(CRC)is a predominant life-threatening cancer,with liver and peritoneal metastases as the primary causes of death.Intestinal inflammation,a known CRC risk factor,nurtures a local inflammatory environment enriched with tumor cells,endothelial cells,immune cells,cancer-associated fibroblasts,immunosuppressive cells,and secretory growth factors.The complex interactions of aberrantly expressed cytokines,chemokines,growth factors,and matrix-remodeling enzymes promote CRC pathogenesis and evoke systemic responses that affect disease outcomes.Mounting evidence suggests that these cytokines and chemokines play a role in the progression of CRC through immunosuppression and modulation of the tumor microenvironment,which is partly achieved by the recruitment of immunosuppressive cells.These cells impart features such as cancer stem cell-like properties,drug resistance,invasion,and formation of the premetastatic niche in distant organs,promoting metastasis and aggressive CRC growth.A deeper understanding of the cytokineand chemokine-mediated signaling networks that link tumor progression and metastasis will provide insights into the mechanistic details of disease aggressiveness and facilitate the development of novel therapeutics for CRC.Here,we summarized the current knowledge of cytokine-and chemokine-mediated crosstalk in the inflammatory tumor microenvironment,which drives immunosuppression,resistance to therapeutics,and metastasis during CRC progression.We also outlined the potential of this crosstalk as a novel therapeutic target for CRC.The major cytokine/chemokine pathways involved in cancer immunotherapy are also discussed in this review. | Ajaz A.Bhat Sabah Nisar Mayank Singh Bazella Ashraf Tariq Masoodi Chandra P.Prasad Atul Sharma Selma Maacha Thasni Karedath Sheema Hashem Syed Besina Yasin Puneet Bagga Ravinder Reddy Michael P.Frennaux Shahab Uddin Punita Dhawan Mohammad Haris Muzafar A.Macha | 2022 | Cancer Communications2022，42，8： | 8 |
| 6 | Bernese periacetabular osteotomy for hip dysplasia: Surgical technique and indications显示文摘For young, active patients with healthy hip cartilage, pelvic osteotomy is a surgical option in to address hip pain and to improve mechanical loading conditions related to dysplasia. Hip dysplasia may lead to arthrosis at an early age due to poor coverage of the femoralhead and abnormal loading of the joint articulation. In patients with symptomatic dysplasia and closed triradiate cartilage(generally over age 10), including adolescents and young adults(generally up to around age 40), the Bernese periacetabular osteotomy(PAO) is a durable technique for addressing underlying structural deformity. The PAO involves a modified Smith-Petersen approach. Advantages of the Bernese osteotomy include preservation of the weight-bearing posterior column of the hemi-pelvis, preservation of the acetabular blood supply, maintenance of the hip abductor musculature, and the ability to effect powerful deformity correction about an ideal center of rotation. There is an increasing body of evidence that preservation of the native hip can be improved through pelvic osteotomy. In contrast to hip osteotomy and joint preservation, the role of total hip arthroplasty in young, active patients with correctable hip deformity remains controversial. Moreover, the durability of hip replacement in young patients is inherently limited. Pelvic osteotomy should be considered the preferred method to address correctable structural deformity of the hip in the young, active patient with developmental dysplasia. The Bernese PAO is technically demanding, yet offers reproducible results with good long-term survivorship in carefully selected patients with preserved cartilage and the ability to meet the demands of rehabilitation. | Atul F Kamath | 2016 | World Journal of Orthopedics2016，7，5： | 7 |
| 7 | Three distinct global estimates of historical land-cover change and land-use conversions for over 200 years显示文摘地球的陆地盖子广泛地由于人的活动和自然原因随着时间的过去被转变了。以前的全球研究集中了于开发主导的人的陆地使用活动的空间、时间的模式(例如,农田, pastureland,城市的土地,木头收获) 。基于过程的建模研究采用不同策略由使用数据与一张潜在的植被地图在联合设置的这些陆地使用在陆地盖子估计变化,并且随后为影响评价使用这个信息。然而,由于在土地的未说明的变化盖住(源于两个间接人为、自然的原因),在 land-use/cover ( LUC )的异质在格子房间之中的变换甚至为一样的陆地使用活动,并且无常与潜在的植被在与从遥感观察获得的结果相比是实质地不同的陆地盖子估计印射和人的陆地使用结果的历史的估计联系了。这里,我们在场含蓄地说明从这些无常产生以便提供与卫星一致的陆地盖子的历史的估计的差别的一个方法估计最近的年。由于在历史的农业陆地使用的无常,我们与数据设置产生历史的陆地封面变化和内在的 LUC 变换的三不同估计的普通木头收获和城市的土地在联合使用农田和 pastureland 的三广泛地接受的全球估计。因此,这些不同历史的重建提供不同生态系统经历了变化到的无常和程度的大量嘴巧的地区性的估计。年度陆地盖子地图和 LUC 变换地图在 0.5 点被报导 ? | Prasanth MEIYAPPAN Atul K. JAIN | 2012 | Frontiers of Earth Science2012，6，2： | 6 |
| 8 | A substitution mutation in OsPELOTA confers bacterial blight resistance by activating the salicylic acid pathway显示文摘We previously reported a spotted-leaf mutant pelota(originally termed HM_(47)) in rice displaying arrested growth and enhanced resistance to multiple races of Xanthomonas oryzae pv. oryzae. Here, we report the mapbased cloning of the causal gene OsPELOTA(originally termed spl^(HM47)). We identified a single base substitution from T to A at position 556 in the coding sequence of OsPELOTA, effectively mutating phenylalanine to isoleucine at position 186 in the translated protein sequence. Both functional complementation and over-expression could rescue the spotted-leaf phenotype. OsPELOTA, a paralogue to eukaryotic release factor 1(eRF_1), shows high sequence similarity to Drosophila Pelota and also localizes to the endoplasmic reticulum and plasma membrane.OsPELOTA is constitutively expressed in roots, leaves,sheaths, stems, and panicles. Elevated levels of salicylic acid and decreased level of jasmonate were detected in the pelota mutant. RNA-seq analysis confirmed that genes responding to salicylic acid were upregulated in the mutant. Our results indicate that the rice PELOTA protein is involved in bacterial leaf blight resistance by activating the salicylic acid metabolic pathway. | Xiao-Bo Zhang Bao-Hua Feng Hui-Mei Wang Xia Xu Yong-Feng Shi Yan He Zheng Chen Atul Prakash Sathe Lei Shi Jian-Li Wu | 2018 | Journal of Integrative Plant Biology2018，60，2： | 5 |
| 9 | Energy loss at bends in the pneumatic conveying of fly ash显示文摘An accurate estimation of the total pressure drop of a pipeline is important to the reliable design of a pneumatic conveying system.The present paper presents results from an investigation into the modelling of the pressure drop at a bend in the pneumatic conveying of fly ash.Seven existing bend models were used(in conjunction with solids friction models for horizontal and vertical straight pipes,and initial acceleration losses) to predict the total pipeline pressure drop in conveying fly ash(median particle diameter:30 μm;particle density:2300 kg/m^3;loose-poured bulk density:700 kg/m^3) in three test rigs(pipelines with dimensions of 69 mm inner diameter(I.D.) × 168 m length:105 mm I.D.× 168 m length;69 mm I.D.× 554 m length).A comparison of the pneumatic conveying characteristics(PCC) predicted using the seven bend models and experimental results shows that the predicted total pipeline PCC and trends depend on the choice of bend model.While some models predict trends that agree with the experimental results,other models predicted greater bend pressure drops for the dense phase of fly ash than for the dilute phase.Models of Pan,R.(1992).Improving scale-up procedures for the design of pneumatic conveying systems.Doctoral dissertation,University of Wollongong,Australia.Pan,R.,& Wypych,P.W.(1998).Dilute and dense phase pneumatic conveying of fly ash.In Proceedings of the sixth International Conference on Bulk Materials Storage and Transportation(pp.183-189),Wollongong,NSW,Australia and Chambers,A.J.,& Marcus,R.D.(1986).Pneumatic conveying calculations.In Proceedings of the second International Conference on Bulk Materials Storage and Transportation(pp.49-52).Wollongong,Australia reliably predicted the bend losses for systems conveying fly ash over a large range of air flows. | Naveen Tripathi Atul Sharma S.S.Mallick P.W.Wypych | 2015 | Particuology2015，13，4： | 5 |
| 10 | Epidemiology of electrical burns and its impact on quality of life-the developing world scenario显示文摘BACKGROUND Electrical burns are devastating injuries and can cause deep burns with significant morbidity and delayed sequelae.Epidemiological data regarding the etiology,socioeconomic differences and geographic variation are necessary to assess the disease burden and plan an effective preventive strategy.These severe injuries often lead to amputations and thus hamper quality of life in the long term AIM To identify the population at maximum risk of sustaining electrical burns.We also studied the impact of electrical burns on these patients in terms of quality of life as well as return to work.METHODS The study was conducted at a tertiary referral teaching hospital over a period of eighteen months.All patients with a history of sustaining electrical burns and satisfying the inclusion criteria were included in the study.All relevant epidemiological parameters and treatment details were recorded.The patients were subsequently followed up at 3 mo,6 mo and 9 mo.The standardized Brief Version of the Burn Specic Health Scale(BSHS-B)was adopted to assess quality of life.Statistical analysis was conducted using IBM SPSS statistics(version 22.0).A P value of<0.05 was considered statistically significant.RESULTS A total of 103 patients were included in the study.The mean age of the patients was 31.83 years(range 18-75 years).A significant majority(91.3%)of patients were male.The mean total body surface area(TBSA)in these patients was 21.1%.In most of the patients(67%),the injury was occupation-related.High voltage injuries were implicated in 72.8%of patients.Among the 75 high voltage burn patients,31(41%)required amputation.The mean number of surgeries the patients underwent in hospital was 2.03(range 1 to 4).The quality of life parameters amongst the patients sustaining high voltage electrical burns were poorer when compared to low voltage injuries at all follow-up intervals across nine domains.In eight of these domains,the difference was statistically significant.Similarly,the scores among the amputees were poorer when compared to non-amputees.The difference was statistically significant in six domains.CONCLUSION Electrical burns remain a problem in the developing world.Most injuries are occupation-related.The quality of life in patients with high voltage burns and amputees remains poor.Work resumption was almost impossible for amputees.These patients could not regain pre-injury status.Steps should be taken to create awareness and to implement an effective preventive strategy to safeguard against electrical injuries. | Giriraj Gandhi Atul Parashar Ramesh K Sharma | 2022 | World Journal of Critical Care Medicine2022，11，1： | 3 |
| 11 | Characterization of a Novel Gain-of-Function Spotted-Leaf Mutant with Enhanced Disease Resistance in Rice显示文摘We here reported the identification and characterization of a novel gain-of-function spotted-leaf 26 (Spl26) mutant from an ethylmethylsulfone (EMS)-induced rice cultivar IR64. Spl26 displayed reddish- brown lesions that firstly appeared on the leaf tips at the early tillering stage and spread gradually downward to cover the whole leaf blades that wilted subsequently. The lesion development was light- dependent under natural conditions. Spl26 exhibited impaired photosynthetic capacity with decreased chlorophyll content and lowered photosynthetic parameters which ultimately led to the poor performance of agronomic traits. Severe cell death occurred in Spl26 in accompany with increased malonaldehyde level and membrane ion leakage rate, elevated reactive oxygen species (ROS) accumulation, altered ROS scavenging activities, increased DNA fragmentation and decreased soluble protein levels. Defense responses were activated in Spl26 with enhanced resistance to rice bacterial blight, up-regulation of defense response genes and altered endogenous hormone levels. The spotted-leaf phenotype is controlled by a single dominant nuclear gene localized to a 305 kb region between RM5490 and InDel42 on the short arm of chromosome 7. The data suggested that Spl26 is a novel gain-of-function spotted-leaf mutant with enhanced bacterial disease resistance and immunity-associated premature leaf senescence and would provide the basis for cloning of the target gene. | CHEN Ting CHEN Zheng Atul Prakash SATHE ZHANG Zhihong LI Liangjian SHANG Huihui TANG Shaoqing ZHANG Xiaobo WU Jianli | 2019 | Rice science2019，26，6： | 3 |
| 12 | Effect of binder amount on the development of coal-binder interface and its relationship with the strength of the carbonized coal-binder composite显示文摘Production of high-strength carbonized coal composites from non-caking coals only with possible application as coke is presented.A binder and a non-caking coal were mixed in different ratios and carbonized at 1000C to produce coal-binder composites.Two binders,one from coal origin and other from oil origin were used.Effect of coal-binder mixing ratio and base coal particle size on the fracture strength of composites was investigated.Bonding of binder with the coal particles at coal-binder interface and development of connected carbon matrix were primarily responsible for the strength of the carbonized coal composites.The trend of change in fracture strength as a function of coal-binder fraction was similar for both the binders.However,for same coal-binder mixing ratio,binder type strongly affected the maximum strength achieved.Fracture strength was found to be primarily dependent on the coal-binder mixing ratio and base coal particle size.The main finding of this study is that the irrespective of binder type,for a given base coal particle size there was only one coal-binder mixing ratio at which the maximum strength was obtained.The binder fraction at which the highest strength observed was correlated to the carbon matrix connectivity index. | Atul Sharma Naoto Sakimoto Toshimasa Takanohashi | 2018 | Carbon Resources Conversion2018，1，2： | 3 |
| 13 | Recurrence of lymphangioleiomyomatosis: Nine years after a bilateral lung transplantation显示文摘Lymphangioleiomyomatosis(LAM) is a rare, slowly progressive lethal lung disease primary afflicting young women. LAM is characterized by proliferation of abnormal smooth muscle cells that target the lungs, causing cystic destruction and eventual respiratory failure leading to death. Recent ten year mortality due to end stage LAM has been reported to be approximately 10%-20%, but may vary. The decline in lung function in LAM is gradual, occurring at a rate of about 3% to 15% per year but can vary from patient to patient. But recently therapy with mammalian target of rapamycin(m TOR) inhibitors such as sirolimus has shown promising results in the stabilization of lung function and reduction of chylous effusions in LAM. Lung transplantation is a viable option for patients who continue to have decline in lung function despite m TOR therapy. Unique issues that may occur post-transplant in a recipient with LAM include development of chylous effusion and a risk of recurrence. We describe a case of LAM recurrence in a bilateral lung transplant recipient who developed histological findings of LAM nine years after transplantation. | Khawaja S Zaki Zahra Aryan Atul C Mehta Olufemi Akindipe Marie Budev | 2016 | World Journal of Transplantation2016，6，1： | 3 |
| 14 | Post splenectomy related pulmonary hypertension显示文摘Splenectomy predisposes patients to a slew of infectious and non-infectious complications including pulmonary vascular disease. Patients are at increased risk for venous thromboembolic events due to various mechanisms that may lead to chronic thromboembolic pulmonary hypertension(CTEPH). The development of CTEPH and pulmonary vasculopathy after splenectomy involves complex pathophysiologic mechanisms, some of which remain unclear. This review attempts to congregate the current evidence behind our understanding about the etio-pathogenesis of pulmonary vascular disease related to splenectomy and highlight the controversies that surround its management. | Atul V Palkar Abhinav Agrawal Sameer Verma Asma Iftikhar Edmund J Miller Arunabh Talwar | 2015 | World Journal of Respirology2015，5，2： | 3 |
| 15 | Hydrodesulfurization of coal tar pitch using Pt/Al_(2)O_(3)and Pd/Al_(2)O_(3)catalysts under mild conditions显示文摘Hydrodesulfurization(HDS)of coal tar pitch(CTP)using Pt/Al_(2)O_(3)and Pd/Al_(2)O_(3)catalysts in tetrahydrofuran at 333 K and atmospheric pressure was investigated.The HDS of dibenzothiophene(DBT)proceeded over both the Pt and Pd catalysts under the mild conditions.The effects of polycyclic aromatic hydrocarbons on the HDS of DBT were examined:a naphthalene ring suppressed the HDS,while a benzene ring did not.CTP underwent HDS as well as partial hydrogenation under the mild conditions.The Pt catalyst was more active than the Pd catalyst in the HDS of CTP.The sulfur content in CTP was reduced by over 50%through the HDS process. | Kazumasa Yazu Atul Sharma | 2019 | Carbon Resources Conversion2019，2，3： | 3 |
| 16 | A Comparative Assessment of Temperature Data from Different Sources for Dehradun, Uttarakhand, India显示文摘A comparative study of extreme temperature parameters from different sources is carried out by examining standardized anomalies, trends, correlation, and equivalence of datasets. Maximum temperature(T_(max))and minimum temperature(Tmin) for Dehradun, from two different sources such as computed and gridded data from Climatic Research Unit(CRU) and observed data from India Meteorological Department(IMD)are used for 1901–2012. The CRU data are compared initially with IMD, by graphical assessment of standardized anomalies. Subsequently, change points are identified by using Cumulative Sum(CUSUM)-chart technique for trend analysis. The magnitude and significance of trends are determined by applying Sen's slope test, and on the basis of these, trends are compared. Further, correlation analysis is carried out and datasets are tested for equivalence by using Wilcoxon–Mann–Whitney test. The result shows that annual standardized anomalies of CRU data follow the pattern of annual standardized anomalies of IMD data. The CRU data exhibit similar trends and are well correlated with IMD dataset. Moreover, CRU anomaly data are identical with IMD anomaly data in the recent decades. High resolution gridded CRU data have open access and may be more useful due to its spatio-temporal continuity for land areas of the world. | Atul Kant PIYOOSH Sanjay Kumar GHOSH | 2016 | Journal of Meteorological Research2016，30，6： | 3 |
| 17 | Experimental investigation into transient pressure pulses during pneumatic conveying of fine powders using Shannon entropy显示文摘 | Amit Goel Anu Mittal S.S. Mallick Atul Sharma | 2016 | Particuology2016，14，6： | 3 |
| 18 | 无创正压通气治疗睡眠呼吸障碍——北美临床应用进展显示文摘持续正压通气治疗(Positive airway pressure,PAP)是北美睡眠呼吸障碍疾病(sleep disordered breathing,SDB)最主要的一线治疗方式。PAP硬件技术的进步、随访网络的普及、合并心肺疾病等复杂患者PAP治疗模式的进展,是近年来PAP疗效和依从性不断提高的动力。本文将以问答的形式就PAP在北美临床应用的几个热点问题介绍最新研究进展及北美学者的观点。 | 李彦如 Rachel Jen Robert.L.Owens Atul Malhotra | 2015 | 中国医学文摘(耳鼻咽喉科学)2015，30，1： | 2 |
| 19 | Atrial fibrillation ablation in patients with gastroesophageal reflux disease or irritable bowel syndrome—the heart to gut connection!显示文摘 | Yeruva Madhu Reddy Dhssraj Singh Darbhamulla Nagarajan Jayasree Pillarisetti Mazda Biria Hemant Boolani Martin Emert Vineela Chikkam Kay Ryschon James Vacek Sudha Bommana Donita Atkins Atul Verma Mojtaba Olyaee Buddhadeb Dawn Dhanunjaya Lakkireddy | 2013 | Journal of Interventional Cardiac Electrophysiology2013，，3： | 2 |
| 20 | Hypothyroidism during pregnancy: Controversy over screening and intervention显示文摘Thyroid hormones are critical for foetal neurological development and maternal health. Maternal hypothyroidism during pregnancy is associated with adverse impact on health of the mother as well as the progeny. Reduced thyroid hormone levels predispose the child to develop mental retardation and cognitive delay in early life. In the mother, hypothyroidism during pregnancy is associated with spontaneous abortion, placental abruption, preterm delivery and hypertensive disorders. Therefore, screening and therapeutic intervention is justified to prevent foetal as well as maternal co-morbidities. In view of impact of such a large-scale screening and intervention program on limited healthcare resources, it is debatable if a targeted rather than universal screening program will result in comparable outcomes. In addition, there is an ongoing debate regarding best evidence-based practice for the management of isolated hypothyroxinaemia, subclinical hypothyroidism and euthyroid women with autoimmune hypothyroidism. We have carried out a review of the literature; firstly, to determine whether universal screening for asymptomatic women in early pregnancy would be cost-effective. Secondly, we have retrospectively reviewed the literature to analyse the evidence regarding the impact of therapeutic intervention in women with subclinical hypothyroidism. | Abdel Hameed Mirghani Dirar Atul Kalhan | 2018 | World Journal of Obstetrics and Gynecology2018，7，1： | 2 |
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