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| 1 | Resolution of non-alcoholic steatohepatitis by rosuvastatin monotherapy in patients with metabolic syndrome显示文摘AIM: To investigate the effect of rosuvastatin monotherapy on non-alcoholic steatohepatitis(NASH). At present there is no effective treatment for non-alcoholic fatty liver disease or its advanced form NASH.METHODS: This prospective study included 20 biopsy proven patients with NASH, metabolic syndrome(Met S) and dyslipidaemia. Biochemical parameters of the blood of the patients and an ultrasonography of the liver were performed at baseline. Then patients receivedlifestyle advice and were treated for a 12 mo period with rosuvastatin(10 mg/d) monotherapy. Patients were re-evaluated during the study at 3 mo intervals, during which biochemical parameters of the blood were measured including liver enzymes. A repeat biopsy and ultrasonography of the liver were performed at the end of the study in all 20 patients. Changes in liver enzymes, fasting plasma glucose, serum creatinine, serum uric acid(SUA), high sensitivity C reactive protein(hs CRP) and lipid profile were assessed every 3 mo. The primary endpoint was the resolution of NASH and the secondary endpoints were the changes in liver enzyme and lipid values.RESULTS: The repeat liver biopsy and ultrasonography showed complete resolution of NASH in 19 patients, while the 20 th, which had no improvement but no deterioration either, developed arterial hypertension and substantial rise in triglyceride levels during the study, probably due to changes in lifestyle including alcohol abuse. Serum alanine transaminase, aspartate transaminase, and γ-glutamyl transpeptidase were normalised by the 3rd treatment month(ANOVA P < 0.001), while alkaline phosphatase activities by the 6th treatment month(ANOVA, P = 0.01). Fasting plasma glucose and glycated haemoglobin were significantly reduced(P < 0.001). Lipid values were normalised by the 3rd treatment month. No patient had Met S by the 9th treatment month. Body mass index and waist circumference remained unchanged during the study. Thus, changes in liver pathology and function should be attributed solely to rosuvastatin treatment. A limitation of the study is the absence of a control group.CONCLUSION: These findings suggest that rosuvastatin monotherapy could ameliorate biopsy proven NASH and resolve Met S within 12 mo. These effects and the reduction of fasting plasma glucose and SUA levels may reduce the risk of vascular and liver morbidity and mortality in NASH patients. These findings need confirmation in larger studies. | Konstantinos Kargiotis Vasilios G Athyros Olga Giouleme Niki Katsiki Evangelia Katsiki Panagiotis Anagnostis Chrysoula Boutari Michael Doumas Asterios Karagiannis Dimitri P Mikhailidis | 2015 | World Journal of Gastroenterology2015，21，25： | 18 |
| 2 | The role of ankle brachial index and carotid intima-media thickness in vascular risk stratification显示文摘 | Konstantinos Tziomalos Vasilios G Athyros Asterios Karagiannis Dimitri P Mikhailidis | 2010 | Current Opinion in Cardiology2010，，4： | 2 |
| 3 | Safety and efficacy of long-term statin treatment for cardiovascular events in patients with coronary heart disease and abnormal liver tests in the Greek Atorvastatin and Coronary Heart Disease Evaluation (GREACE) Study: a post-hoc analysis显示文摘 | Vasilios G Athyros Konstantinos Tziomalos Thomas D Gossios Theodora Griva Panagiotis Anagnostis Konstantinos Kargiotis Efstathios D Pagourelias Eleni Theocharidou Asterios Karagiannis Dimitri P Mikhailidis | 2010 | The Lancet2010，，9756： | 2 |
| 4 | Cardiovascular risk across the histological spectrum and the clinical manifestations of non-alcoholic fatty liver disease:an update显示文摘 | Vasilios G Athyros Konstantinos Tziomalos Niki Katsiki Michael Doumas Asterios Karagiannis Dimitri P Mikhailidis | 2015 | World Journal of Gastroenterology2015，，22： | 2 |
| 5 | Safety and efficacy of long-term statin treatment for cardiovascular events in patients with coronary heart disease and abnormal liver tests in the Greek Atorvastatin and Coronary Heart Disease Evaluation (GREACE) Study: a post-hoc analysis显示文摘 | Vasilios G Athyros Konstantinos Tziomalos Thomas D Gossios Theodora Griva Panagiotis Anagnostis Konstantinos Kargiotis Efstathios D Pagourelias Eleni Theocharidou Asterios Karagiannis Dimitri P Mikhailidis | 2010 | The Lancet2010，，9756： | 1 |
| 6 | Influence of loading on metal surface area for Ag/α-Al2O3 catalysts显示文摘 | ASTERIOS G BILAL S ARVIND V | 1993 | Journal of Catalysis1993，139，1： | 1 |
| 7 | Safety and efficacy of long-term statin treatment for cardiovascular events in patients with coronary heart disease and abnormal liver tests in the Greek Atorvastatin and Coronary Heart Disease Evaluation (GREACE) Study: a post-hoc analysis显示文摘 | Vasilios G Athyros Konstantinos Tziomalos Thomas D Gossios Theodora Griva Panagiotis Anagnostis Konstantinos Kargiotis Efstathios D Pagourelias Eleni Theocharidou Asterios Karagiannis Dimitri P Mikhailidis | 2010 | 2010 (9756)2010，，9756： | 1 |
| 8 | Reviewed work(s): The democratic corporation: a radical prescription for recreating corporate America and rediscovering success 显示文摘 | ASTERIOS G KEFALAS S | 1996 | The Academy of Management Review1996，21，2： | 1 |
| 9 | Macronutrients requirements of the dino? agellate protoeeratium reticulatum显示文摘 | Juan J G R Asterio S M Maradel C C G | 2009 | Harmful Algae2009，8，2： | 1 |
| 10 | Growth and biochemical characterization of microalgal biomas produced in bubble column and airlift photobioreactor: :studies in fed-batch culture显示文摘 | Asterio S M Marie Carmen C G Francisco G C | 2002 | Enzyme and Microbial Technology2002，31，： | 1 |
| 11 | The role of capsule endoscopy in the evaluation and treatment of obscure-overt gastrointestinal bleeding during daily clinical practice:a prospective multicenter study显示文摘 | Panagiotis K Georgia L Asterios G | 2014 | Scand J Gastroenterol2014，49，7： | 1 |
| 12 | Atorvastatin: safety and tolerability显示文摘 | Vasilios G Athyros Konstantinos Tziomalos Asterios Karagiannis Dimitri P Mikhailidis | 2010 | Expert Opinion on Drug Safety2010，，4： | 1 |
| 13 | Design and characterisation of the staggered herringbone mixer显示文摘 | SUET P K ASTERIOS G | 2008 | Chemical Engineering Journal2008，142，： | 1 |
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