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| 1 | Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations显示文摘 | Thompson MC Fuller C Hogg TL Dalton J Finkelstein D Lau CC Chintagumpala M Adesina A Ashley DM KeUie SJ Taylor MD Curran T Gajjar A Gilbertson RJ | 2006 | 中国神经肿瘤杂志2006，4，1： | 17 |
| 2 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 3 | QTLs conditioning early growth in a soybean population segregation for growth habit 显示文摘 | Mian M A R Ashley D A Vencill WK et at | 1998 | Theoretical and Applied Genetics1998，97，8： | 1 |
| 4 | Spratt the evolutionary history of methicillin-resistant Staphylococcus anreus (MRSA)显示文摘 | Enright D Ashley Robinson | 2002 | PNAS2002，99，11： | 1 |
| 5 | Clinical detection of sarcopenic obesity by bioelectrical impedance analysis显示文摘 | Heber D Ingles S Ashley JM | | 0，，3： | 1 |
| 6 | Environmental mobility of antimony around mesothermal stibnitedeposits, New South Wales, Australia and southern New Zealand 显示文摘 | ASHLEY P M CRAW D GRAHAM B P | 2003 | Journal of Geochemical Exploration2003，77，1： | 1 |
| 7 | An additional QTL for water use efficiency in soybean显示文摘 | MAIN M A R ASHLEY D BAILEY M A | 1998 | Crop Sci1998，38，： | 1 |
| 8 | Capecitabine and oxaliplatin foradvanced esophagogastric cancer显示文摘 | Cunningham D Okines AF Ashley S | 2010 | NEngl J Med2010，358，1： | 1 |
| 9 | Optimal Power Flow by Newton Approach显示文摘 | SUN D I ASHLEY B BREWER B | 1984 | IEEE Transactions on Power Apparatus and Systems1984，103，10： | 1 |
| 10 | Melecularmarkers associated with water use efficiency and leafash in soybean显示文摘 | MIAN M A R BAILEY M A ASHLEY D D | 1996 | Crop Sci1996，36，： | 1 |
| 11 | A practical scientific app roach to riparian vegetation rehabilitation in Australia显示文摘 | Ashley A W Wayne D E | 2003 | Journal of Environmental Management2003，68，4： | 1 |
| 12 | Determination of 10 carcinogenic polyeyclic aromatic hydrocarbons in mainst-ream cigarette smoke显示文摘 | Ding Y S Ashley D L Watson C H | 2007 | J Agri & Food Chem2007，55，： | 1 |
| 13 | Analysis of volatile organic compounds in mainstream cigarette smoke显示文摘 | Polzin G M Kosa-Maines R E Ashley D L | 2007 | Environmental Science & Technology2007，41，4： | 1 |
| 14 | Synthesis and biological evaluation of c-aminophosphonates as potent, subtype-selectivesphingosine 1-phosphate receptor qagonists and antagonists 显示文摘 | Frank W Foss Jr Ashley H Snyder Michael D Davis | 2007 | Bioorg Med Chem2007，15，2： | 1 |
| 15 | Sustainable livelihoods : Lessons from ear- ly experience显示文摘 | Ashley C Carney D | 1999 | London : Department for International Devel- opment1999，，： | 1 |
| 16 | Outpatient management of patients with low-risk upper-gastrointestinal haemorrhage: multicentre validation and prospective evaluation显示文摘 | AJ Stanley D Ashley HR Dalton C Mowat DR Gaya E Thompson U Warshow M Groome A Cahill G Benson O Blatchford W Murray | 2009 | The Lancet2009，，9657： | 1 |
| 17 | Methods for Researching Gear Whine in Automotive TransaxIes显示文摘 | ASHLEY L D DONALD R H | 1997 | SAE1997，，1： | 1 |
| 18 | Influence of top- ping and side pruning on cotton yield and other characteristics显示文摘 | BENNETT O L Ashley D A Doss B D | 1965 | Agronomy Journal1965，67，： | 1 |
| 19 | Bone marrow-generated den dritic cells pulsed with tumor extracts or tunor RNA induce antitumor immunity against central nervous system tumors显示文摘 | Ashley D M Faiola B Nair S | 1997 | J Exp Med1997，186，7： | 1 |
| 20 | High-dose methotrexate for primary CNS lymphoma in the elderly显示文摘 | Ng S Rosenthal MA Ashley D | 2000 | Neuro-oncol2000，2，1： | 1 |
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