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| 1 | Alcoholic hepatitis: The pivotal role of Kupffer cells显示文摘Kupffer cells play a central role in the pathogenesis of alcoholic hepatitis(AH). It is believed that alcohol increases the gut permeability that results in raised levels of serum endotoxins containing lipopolysaccharides(LPS). LPS binds to LPS-binding proteins and presents it to a membrane glycoprotein called CD14, which then activates Kupffer cells via a receptor called tolllike receptor 4. This endotoxin mediated activation of Kupffer cells plays an important role in the inflammatory process resulting in alcoholic hepatitis. There is no effective treatment for AH, although notable progress has been made over the last decade in understanding the underlying mechanism of alcoholic hepatitis. We specifically review the current research on the role of Kupffer cells in the pathogenesis of AH and the treatment strategies. We suggest that the imbalance between the pro-inflammatory and the anti-inflammatory process as well as the increased production of reactive oxygen species eventually lead to hepatocyte injury, the final event of alcoholic hepatitis. | Duminda B Suraweera Ashley N Weeratunga Robert W Hu Stephen J Pandol Richard Hu | 2015 | World Journal of Gastrointestinal Pathophysiology2015，6，4： | 3 |
| 2 | Bone marrow- generated dendritic cells pulsed with tumor extracts or tumor RNA induc ed antitumor immunity against central nervous system tumors显示文摘 | Ashley DM Faiola B Nair S | 1997 | J Exp Med1997，186，7： | 2 |
| 3 | 2009年南极冰穹A的双色天光背景统计和分析显示文摘天光背景是天文台址的一个重要指标。利用2009年位于南极冰穹A的CSTAR望远镜两个波段的观测数据,对南极冰穹A的天光背景进行了统计和分析。结果表明约74%的g波段天光背景的ADU值小于每像素100/s;90.5%的r波段的天光背景的ADU值小于每像素100/s。在不考虑大气消光的情况下,定标后的结果为2009年冰穹A的观测数据中天光背景亮度的中值:g波段为19.9 mag/arcsec2,r波段为20.1 mag/arcsec2。 | 宗伟凯 付建宁 牛家树 Ashley Michael C B 宫雪非 Lawrence J S 刘强 Luong-Van Daniel Pennypacker C R Storey John W V 王灵芝 王力帆 杨惠根 袁祥岩 York Donald G 朱镇熹 | 2014 | 天文研究与技术2014，11，1： | 2 |
| 4 | The effects of ω3 fatty acids and coenzyme Q10 on blood pressure and heart rate in chronic kidney disease: a randomized controlled trial显示文摘 | Trevor A Mori Valerie Burke Ian B Puddey Ashley B Irish Christine A Cowpland Lawrence J Beilin Gursharan K Dogra Gerald F Watts | 2009 | Journal of Hypertension2009，，9： | 1 |
| 5 | Environmental mobility of antimony around mesothermal stibnitedeposits, New South Wales, Australia and southern New Zealand 显示文摘 | ASHLEY P M CRAW D GRAHAM B P | 2003 | Journal of Geochemical Exploration2003，77，1： | 1 |
| 6 | Optimal Power Flow by Newton Approach显示文摘 | SUN D I ASHLEY B BREWER B | 1984 | IEEE Transactions on Power Apparatus and Systems1984，103，10： | 1 |
| 7 | Cystatin C and cystatin glomerular filtration rate as markers of early renal disease in Asian Indian subjects with glucose intolerance(CURES-32)显示文摘 | Surendar J Anuradha S Ashley B | 2009 | Metab Syndr Relat Disord2009，7，5： | 1 |
| 8 | Early response to platinum-based first-line chemotherapy in non-small cell lung cancer may predict survival显示文摘 | Sirohi B Ashley S Norton A | 2007 | J Thorac Oncol2007，2，8： | 1 |
| 9 | Urachal anomalies:a lon- gitudinal study of uraehal remnants in children and adults显示文摘 | Ashley R A Inman B A Routh J C | 2007 | JUrol2007，178，4： | 1 |
| 10 | Effects of inhaled nitric oxide on the anesthetized, mechanically ventilated, large white pig显示文摘 | Ashley Z Jugg B Brown RF | 2002 | Inhal Toxicol2002，14，11： | 1 |
| 11 | Influence of top- ping and side pruning on cotton yield and other characteristics显示文摘 | BENNETT O L Ashley D A Doss B D | 1965 | Agronomy Journal1965，67，： | 1 |
| 12 | Bone marrow-generated den dritic cells pulsed with tumor extracts or tunor RNA induce antitumor immunity against central nervous system tumors显示文摘 | Ashley D M Faiola B Nair S | 1997 | J Exp Med1997，186，7： | 1 |
| 13 | Nuclear trafficking of Dro- sophila Frizzled-2 during synapse development requires the PDZ protein dGRIP 显示文摘 | Ataman B Ashley J Gorczyca D | 2006 | Proc Natl Acad Sci USA2006，103，： | 1 |
| 14 | Using the blood concentration of 2, 5 - dimethylfuran as a marker for smoking显示文摘 | Ashley D L Bonin M A Hamar B | 1996 | International Archives of occupational and Environmental Health1996，68，3： | 1 |
| 15 | Cystatin C and cystatin glo- merular filtration rate as markers of early renal disease in Asian Indi- an subjects with glucose intolerance ( CURES-32 ) 显示文摘 | Surendar J Anuradha S Ashley B | 2009 | Metab Syndr Relat Disord2009，7，5： | 1 |
| 16 | AMPK and the neuroendocrine regulation of appetite and energy expenditure显示文摘 | Stark R Ashley S E Andrews Z B | 2013 | Molecular and Cellular Endocrinology2013，366，2： | 1 |
| 17 | Cystatin C and cystatin glomerular filtration rate as markers of early renal disease in Asian Indian subjects with glucose intolerance ( CURES - 32) 显示文摘 | Surendar J Anuradha S Ashley B | 2009 | Metab Syndr Relat Disord2009，7，5： | 1 |
| 18 | Craniopharyngiomas a long-term results following limited surgery and radiotherapy显示文摘 | Rajan B Ashley S Gormon C | 1999 | Radiother Oncol1999，26，： | 1 |
| 19 | Full genome sequence of peste des petits ruminants virus,a member of the morbillivirus genus显示文摘 | Dalan B Ashley B Pradyot D | 2005 | Virus Res2005，110，12： | 1 |
| 20 | Urachal car cinoma- clinicopathologic features and long term out- comes of an aggressive malignancy显示文摘 | Ashley R A Inman B A Sebo T J | 2006 | Cancer2006，107，4： | 1 |
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