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| 1 | Sex-specific differences in white matter microvascular integrity after ischaemic stroke显示文摘background and purpose Functional outcomes after ischaemic stroke are worse in women,despite adjusting for differences in comorbidities and treatment approaches.White matter microvascular integrity represents one risk factor for poor long-term functional outcomes after ischaemic stroke.The aim of the study is to characterise sex-specific differences in microvascular integrity in individuals with acute ischaemic stroke.Methods A retrospective analysis of subjects with acute ischaemic stroke and brain MRI with diffusion-weighted(DWI)and dynamic-susceptibility contrast-enhanced(DSC)perfusion-weighted imaging obtained within 9 hours of last known well was performed.In the hemisphere contralateral to the acute infarct,normal-appearing white matter(NAWM)microvascular integrity was measured using the K_(2) coefficient and apparent diffusion coefficient(ADC)values.Regression analyses for predictors of K_(2) coefficient,DWI volume and good outcome(90-day modified Rankin scale(mRS)score<2)were performed.results 105 men and 79 women met inclusion criteria for analysis.Despite no difference in age,women had increased NAWM K_(2) coefficient(1027.4 vs 692.7×10^(-6)/s;p=0.006).In women,atrial fibrillation(β=583.6;p=0.04)and increasing NAWM ADC(β=4.4;p=0.02)were associated with increased NAWM K_(2) coefficient.In multivariable regression analysis,the K_(2) coefficient was an independent predictor of DWI volume in women(β=0.007;p=0.01)but not men.Conclusions In women with acute ischaemic stroke,increased NAWM K_(2) coefficient is associated with increased infarct volume and chronic white matter structural integrity.Prospective studies investigating sex-specific differences in white matter microvascular integrity are needed. | Mark R Etherton Ona Wu Pedro Cougo Svetlana Lorenzano Hua Li Lisa Cloonan Mark J R J Bouts Arne Lauer Ken Arai Eng H Lo Steve K Feske Karen L Furie Natalia S Rost | 2019 | Stroke & Vascular Neurology2019，4，4： | 2 |
| 2 | The small GTPase Rho3 and the diaphanous/formin For3 function in polarized cell growth in fission yeast显示文摘 | Nakano K Imai J Arai R | 2002 | Journal of Cell Science2002，115，23： | 1 |
| 3 | Magnetic resonance angiography e-valuation of the bone tunnel and graft following ACL reconstructionwith a hamstring tendon autograft显示文摘 | Terauchi R Arai Y Hara K | 2014 | Knee Surg Sports TraumatolArthrosc2014，1，： | 1 |
| 4 | ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe显示文摘 | MATSUYAMA A ARAI R YASHIRODA Y | 2006 | Nat Biotechnol2006，24，： | 1 |
| 5 | The small GT-Pase Rho4 is involved in controlling cell morphology and septation in fission yeast显示文摘 | Nakano K Mutoh T Arai R | 2003 | Genes Cells2003，8，4： | 1 |
| 6 | Mechanism and kinetics of cellobiose decomposition in sub-and supercritical water显示文摘 | KABYEMELA B M TAKIGAWA M ADSCHIRI T MALALUAN R M ARAI K | 1998 | Ind Eng Chem Res1998，37，2： | 1 |
| 7 | Marked increase in serum KL-6 and surfaetant protein D levels during the first 4 weeks after treatment predicts poor prognosis in patients with active interstitial pneumonia associated with polymyositis/ dermatomyositis显示文摘 | Arai S Kurasawa K Maezawa R | 2013 | Mod Rheumatol2013，23，5： | 1 |
| 8 | Cytokeratin expression of engrafted three-dimensional culture tissues using epithelial cells derived from porcine periodontal ligaments显示文摘 | YAMADA R KITAJIMA K ARAI K | 2014 | J Oral Pathol Med2014，43，8： | 1 |
| 9 | Glucose and fructose decomposition in subcritical and supercritical water:Detailed reaction pathway,mechanisms,and kinetics显示文摘 | KABYEMELA B M ADSCHIRI T MALALUAN R M ARAI K | 1999 | Ind Eng Chem Res1999，38，8： | 1 |
| 10 | In vitro activation of mouse macrophage by propolis extract powder显示文摘 | Moriyasu J ARAI S Motoda R | 1994 | Biotherapy1994，，8： | 1 |
| 11 | Chlorogentisylquinone,a new neutral sphingomyelinase inhibitor,produced by a marine fungus显示文摘 | Uchida R Tomoda H Arai M | 2001 | J Antibiot (Tokyo)2001，54，11： | 1 |
| 12 | 查看详情显示文摘 | Fang Z Sato T Smith R L J Inomata H Arai K Kozinski J A | | 0，，09： | 1 |
| 13 | Differential subcellular location of mitochondria in rat serotonergic neurons depends on the presence and the absence of monoamine oxidase type B显示文摘 | Arai R Karasawa N Kurokawa K | 2002 | Neuroscience2002，114，： | 1 |
| 14 | Asymmetric syn-selective Henry reaction catalyzed by the sulfonyldiamine-CuC1- pyridine system显示文摘 | Arai T Takashita R Endo Y | 2008 | J Org Chem2008，73，： | 1 |
| 15 | Transverse skeletal and dental asymmetry in adults with unilateral lingual posterior crossbite显示文摘 | Langberg B J Arai K Miner R M | 2005 | Am J Orthod Dentofacial Orthop2005，127，1： | 1 |
| 16 | Alterations in sarcoplasmic reticulum gene expression in human heart failure:A possible mechanism for alterations in systolic and diastolic properties of the failing myocardium 显示文摘 | Arai M Alpert N R Maclennan D H | 1993 | Circ Res1993，72，： | 1 |
| 17 | Can secondary degeneration accelerate the formation of neurofibrillary tangles? A case of hemispheric infarction showing asymmetric degeneration of the substantia nigra, red nuclei, inferior olivary nuclei and dentate nuclei with concomitant changes of progressive supranuclear palsy显示文摘 | Matsumoto R Oda M Arai N | 1999 | Acta Neuropathol1999，97，2： | 1 |
| 18 | A chromosome study on two cyprinid fishes,Acrosso- cheilus labiatus and Pseudorasbora pumila pumila, with notes on Eurasian Cyprinids and their karyotypes 显示文摘 | Arai R | 1982 | Bull Nat Sci Mus Ser A1982，8，3： | 1 |
| 19 | Cellulose hydrolysis in subcritical and supercritical water显示文摘 | SASAKI M KABYEMELA B MALAUAN R MALALUAN R HIROSE S TAKEDA N ADSCHIRI T ARAI K | 1998 | J Supercrit Fluids1998，13，13： | 1 |
| 20 | Production of androgenetic diploid loach Misgurmus anguillicaudatus from UV irradiation eggs of the first cleavage 显示文摘 | Masaoka T Arai K Suzuki R | 1995 | Fish Sci1995，61，4： | 1 |
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