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| 1 | Effects of adacolumn selective leukocytapheresis on plasma cytokines during active disease in patients with active ulcerative colitis显示文摘瞄准:调查在临床的活动索引的 ulcerative (UC )( 蔡) 和 IL-1ra, IL-10, IL-6 和 IL-18 的传播层次之间的关系。方法:IL-1ra, IL-10, IL-6 和 IL-18 的血层次与活跃 UC 在 31 个病人被测量,吝啬的蔡是 11.1,从 5-25 ;并且是的 12 个健康个人控制。病人们与 Adacolumn 被给粒细胞和单核白血球 adsorptive 词首字母的脱落(GMA ) 。忍受 FcgammaR 并且补充受体的白细胞被吸附到列 leucocytapheresis 搬运人。每个病人能在 8 wk 上收到多达 11 个 GMA 会议。结果:我们发现了在蔡和 IL-10 之间的强壮的关联(r = 0.827, P <
0.001 ) , IL-6 (r = 0.785, P <
0.001 ) 并且 IL-18 (r = 0.791, P <
0.001 ) 。IL-1ra 没与蔡一起被相关。后面的 GMA 治疗, 31 个病人中的 24 个完成了宽恕,所有 4 cytokines 的层次掉在健康控制里到层次。进一步, IL-1ra 和 IL-10 的血层次在从遵守了搬运人的白细胞建议版本的 60 min 在列流出和流入增加了。 | Hiroyuki Hanai Takayuki Iida Masami Yamada Yoshihiko Sato Ken Takeuchi Tatsuo Tanaka Kenji Kondo Masataka Kikuyama Yasuhiko Maruyama Yasushi Iwaoka Akiko Nakamura Kazuhisa Hirayama Abby R Saniabadi Fumitoshi Watanabe | 2006 | World Journal of Gastroenterology2006，12，21： | 8 |
| 2 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 3 | Inhibition of antithrombin by hyaluronic acid may be involved in the pathogenesis of rheumatoid arthritis显示文摘 | Chang X Yamada R Yamamoto K | | Arthritis Research & Therapy0，，： | 2 |
| 4 | Existence of global solutions for the Shigesada-Kawasaki-Teramoto model with weak cross-diffusion显示文摘 | Choi Y S Lui R Yamada Y | 2003 | Discrete Contin Dynam Systems2003，9，5： | 1 |
| 5 | Three-dimensional power Doppler sonography of tumor vascularity显示文摘 | Hirai T Ohisi H Yamada R | 1998 | J Ultrasound Med1998，17，10： | 1 |
| 6 | Highly enantioselective reduction of alkynyl ketones by a binaphtholmodified aluminum hydride reagent,asymmetric synthesis of some insect pheromones显示文摘 | Nishizawa M Yamada M Noyori R | 1981 | Tetrahedron Lett1981，，22： | 1 |
| 7 | An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis显示文摘 | TOKUHIRO S YAMADA R CHANG X | 2003 | Nat Genet2003，35，4： | 1 |
| 8 | Clinical case reports of injectable tissue-engineered bone for alveolar augmentation with simultaneous implant placement 显示文摘 | Ueda M Yamada Y Ozawa R | 2005 | Int J Periodontics Restorative Dent2005，25，： | 1 |
| 9 | Usefulness of transverse fundal incision method of cesarean section for women with placentas widely covering the entire anterior uterine wall显示文摘 | Nishida R Yamada T Akaishi R | | 0，，01： | 1 |
| 10 | Simplified nutritional screening tools for patients on maintenance hemodialysis显示文摘 | Yamada K Furuya R Takita T | 2008 | Am J Clin Nutr2008，87，7： | 1 |
| 11 | Matrix metalloproteinase-2 mediates stretch-induced activation of skeletal muscle satellite cells in a nitric oxide-dependent manner显示文摘 | Yamada M Sankoda Y Tatsumi R | 2008 | Int J Biochem Cell Biol2008，40，10： | 1 |
| 12 | Sequence-dependent anti- tumor efficacy of combination chemotherapy with nedaplatin, a new- ly developed platinum, and paclitaxel 显示文摘 | Yamada H Uchida N Maekawa R | 2001 | Cancer Lett2001，，： | 1 |
| 13 | Rising rates of macrolide-resistant Mycoplasma pneumoniae in the central United States 显示文摘 | Yamada M Buller R Bledsoe S | 2012 | Pediatr Infect Dis J2012，31，4： | 1 |
| 14 | High-pressure NMR spectroscopy for characterizing folding intermediates and denatured states of proteins显示文摘 | Kamatari Y O Kitahara R Yamada H | 2004 | Methods2004，34，1： | 1 |
| 15 | Existence of global solutions for the Shigesada-Kawasaki-Teramoto model with strongly coupled cross-diffusion显示文摘 | Choi Y S Lui R Yamada Y | 2004 | Discrete Contin Dynam Systems2004，10，3： | 1 |
| 16 | Correlation of proliferative and anti-apoptotic effects of HGF, insulin, IGF-1, IGF-2, and EGF in SV40-transformed human corneal epithelial cells 显示文摘 | Yanai R Yamada N Inui M | 2006 | Exp Eye Res2006，83，1： | 1 |
| 17 | Role of SO2 for elemental mercury removal from coal combustion flue gas by activated carbon 显示文摘 | Uddin M A Yamada T Ochiai R | 2008 | Energy & Fuel2008，，3： | 1 |
| 18 | H^+-K^+-ATPase and carbonic anhydrase Ⅱ gene expression in the developing rat fundus显示文摘 | Marino L R Muglia B H Yamada T | 1990 | Am J Physiol1990，259，11： | 1 |
| 19 | Combination chemotherapy of paclitaxel followed by nedaplatin for human ovrian cancer 显示文摘 | Uchida N Yamada H Maekawa R | 2002 | Gan to Kagaku Ryoho2002，29，11： | 1 |
| 20 | Somatostatin receptor subtypes mRNA in TSH-secreting pituitary adenomas:a ease show- ing a dramatic reduction in tumor size during short octreotide treat- ment显示文摘 | Horiguchi K Yamada M Umezawa R | 2007 | Endocr J2007，54，3： | 1 |
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