维普期刊资源整合服务平台（V6.5）

31篇 您的检索式：作者名="APARISI L"

选中清除导出查看参考文献查看引证文献引用追踪共2页首页上一页第1页下一页末页 /2 跳转

	题名	作者	年代	出处	被引量
1	Protein phosphatases and chromatin modifying complexes in the inflammatory cascade in acute pancreatitis显示文摘Acute pancreatitis is an inflammation of the pancreas that may lead to systemic inflammatory response syndrome and death due to multiple organ failure. Acinar cells, together with leukocytes, trigger the inflammatory cascade in response to local damage of the pancreas. Amplification of the inflammatory cascade requires up-regulation of proinflammatory cytokines and this process is mediated not only by nuclear factor κB but also by chromatinmodifying complexes and chromatin remodeling. Among the different families of histone acetyltransferases, the p300/CBP family seems to be particularly associated with the inflammatory process. cAMP activates gene expression via the cAMP-responsive element (CRE) and the transcription factor CRE-binding protein (CREB). CREB can be phosphorylated and activated by different kinases, such as protein kinase A and MAPK, and then it recruits the histone acetyltransferase co-activator CREB-binding protein (CBP) and its homologue p300. The recruitment of CBP/p300 and changes in the level of histone acetylation are required for transcription activation. Transcriptional repression is also a dynamic and essential mechanism of down-regulation of genes for resolution of inflammation, which seems to be mediated mainly by protein phosphatases (PP1, PP2A and MKP1) and histone deacetylases(HDACs) .Class HDACs are key transcriptional regulators whose activities are controlled via phosphorylationdependent nucleo/cytoplasmic shuttling. PP2A is responsible for dephosphorylation of class HDACs, triggeringnuclear localization and repression of target genes, whereas phosphorylation triggers cytoplasmic localization leading to activation of target genes. The potential benefit from treatment with phosphodiesterase inhibitors and histone deacetylase inhibitors is discussed.	Javier Escobar Javier Pereda Alessandro Arduini Juan Sastre Juan Sandoval Luis Aparisi Gerardo López-Rodas Luis Sabater	2010	World Journal of Gastrointestinal Pharmacology and Therapeutics2010，1，3：	2
2	Antibodies to carbonic anhydrase and IgG4 levels in idiopathic chronic pancreatitis:relevance for diagnosis of autoimmune pancreatitis显示文摘	APARISI L FARRE A GOMEZ-CAMBRONERO L et s	2005	Gut2005，54，5：	1
3	Interaction between cytokines and oxidative stress in acute pancreatitis显示文摘	Pereda J Sabater L Aparisi L	2006	Curr Med Chem2006，13，23：	1
4	Interaction between cytokines and oxidative stress in acute pancreatitis显示文摘	Pereda J Sabater L Aparisi L	2006	Curr Med Chem2006，13，23：	1
5	Antibodies to car- bonic anhydrase and IgG4 levels in idiopathic chronic pancreatitis: relevance for diagnosis of autoimmune pancreatitis显示文摘	Aparisi L Farre A Gomez-Cambronero L	2005	Gut2005，54，5：	1
6	Pancreatic function af- ter severe acute biliary pancreatitis: the role of necrosectomy 显示文摘	Sabater L Pareja E Aparisi L	2004	Pancreas2004，28，1：	1
7	Interaction between cytokines and oxidative stress in acute pancreatitis 显示文摘	Pereda J Sabater L Aparisi L	2006	Curr Med Chem2006，13，23：	1
8	A comparison of T control charts with variable sampling schemes as opposed to MEWMA chart显示文摘	Aparisi F Haro C L	2003	International Journal of Production Research2003，41，10：	1
9	Pancreatic function after severe acute biliary pancreatitis: the role of necrosectomy 显示文摘	Sabater L Pareja E Aparisi L	2004	Pancreas2004，28，1：	1
10	显示文摘	Aparisi L Farre A Gomez-Cambronero L	2005	Gut2005，54，5：	1
11	The Spanish Pancreatic Club recommendations for the diagnosis and treatment of chronic pancreatitis: Part 1 (diagnosis)显示文摘	J. Martínez A. Abad-González J.R. Aparicio L. Aparisi J. Boadas E. Boix G. de las Heras E. Domínguez-Mu?oz A. Farré L. Fernández-Cruz L. Gómez J. Iglesias-García K. García-Malpartida L. Guarner J. Lari?o-Noia F. Lluís A. López X. Molero O. Moreno-Pérez S.	2013	Pancreatology2013，，1：	1
12	Interaction between cytokines and oxidative stress in acute pancreatitis 显示文摘	Pereda J Sabater L Aparisi L	2006	Current medicinal chemistry2006，13，23：	1
13	Efficacy and safety of ethanol injections in 18cases of vertebral hemangioma:a mean follow-up of 2 years显示文摘	BAS T APARISI F BAS J L	2001	Spine2001，26，14：	1
14	Brodie ab-scess:MR imaging appearance in 10 patients显示文摘	Martí-BonmatíL Aparisi F Poyatos C	1998	J MagnReson Imaging1998，3，3：	1
15	Interaction between cytokines and oxidative stress in acute pancreatitis 显示文摘	Pereda J Sabater L Aparisi L	2006	Curr Med Chem2006，13，23：	1
16	Antibodies to carbonic anhydrase and IgG4 levels in idiopathic chronic pancreatitis: relevance for diagnosis of autoimmune pancreatitis显示文摘	Aparisi L Farre A Gomez-Cambronero L	2005	Gut2005，54，5：	1
17	Eosinophilic granuloma: MRI manifestations 显示文摘	Beltran J Aparisi F Bonmati L M	1993	Skeletal Radiol1993，22，3：	1
18	Brodie abscess: MR imaging appearance in 10 patients显示文摘	Marti--Bonmati L Aparisi F Povatos C	1998	J Magn Reson Imaging1998，3，3：	1
19	Exocrine pancreatic changes following acute attack of biliary pancreatitis 显示文摘	Pareja E Artigues E Aparisi L	2002	Pancreatology2002，2，47：	1
20	Antibodies to carbonic anhydrase and IgG4 levels in idiopathic chronic pancreatitis: relevance for diagnosis of autoimmune pancreatitis显示文摘	APARISI L FARRE A GOMEX-CAMBRONERO L	2005	Gut2005，54，：	1

返回顶部每页显示：

共2页首页上一页第1页下一页末页 /2 跳转

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

用户提示