|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 抑郁症的非药物治疗:系统性综述与证据图显示文摘背景抑郁症非药物治疗的疗效比较目前仍然不清楚。方法我们对一些系统性综述作了概述,回顾了随机对照试验(RCT),比较抑郁症非药物治疗的有效性和认知行为治疗(CBT)。对多个电子数据库在2016年2月之前发表的所有文献进行了检索,不限制语言。成对的评阅人进行资料纳入、数据提炼并评估偏倚的风险。在适用的时候进行了荟萃分析。结果我们收录了367项RCT,纳入了约2000名患者,进行了11种治疗,导出17项独立的头对头比较。通过标准化的量表评估,发现CBT、自然疗法、行为干预与躯体活动干预可以降低抑郁的严重程度。然而,这些非药物干预的相对疗效仍然缺乏。这些干预对临床缓解和复发的效果不清楚。CBT的发生率比抗抑郁药物更低。局限性由于证据缺乏一致性、证据不清或偏倚风险高,导致证据的质量只是低到中等,限制了我们研究结果的可信度。结论抑郁症的非药物治疗能减少抑郁症状,在轻度到重度抑郁症患者中,应当合并抗抑郁药物治疗,一同进行。对于非药物治疗的选择,应当根据患者的价值观、偏好、临床和社会因素来与患者共同作出决定。 | Wigdan H Farah Mouaz Alsawas Maria Mainou Fares Alahdab Magdoleen H Farah Ahmed T Ahmed Essa A Mohamed Jehad Almasri Michael R Gionfriddo Ana Castaneda-Guarderas Khaled Mohammed Zhen Wang Noor Asi Craig N Sawchuk Mark D Williams Larry J Prokop M Hassan Murad Annie LeBlanc | 2017 | 英国医学杂志中文版2017，20，11： | 2 |
| 2 | Influence of donor age on the differentiation and division capacity of human adipose-derived stem cells显示文摘BACKGROUND Human adipose-derived stromal/stem cells(hASCs)are one of the most useful types of mesenchymal stromal/stem cells,which are adult multipotent cells with great therapeutic potential for the treatment of several diseases.However,for successful clinical application,it is critical that high-quality cells can be obtained.Diverse factors seem to be able to influence cell quality and performance,especially factors related to donors’intrinsic characteristics,such as age.Nevertheless,there is no consensus regarding this characteristic,and there is conflicting information in the literature.AIM To investigate the growth kinetics and differentiation potential of adipose-derived stem cells isolated from the lipoaspirates of elderly and young donors.METHODS hASCs were harvested from liposuctioned adipose tissue obtained from female donors(aged 20-70 years).Cells were distributed into two groups according to age range:old hASCs(oASCs,≥55 years,n=9)and young hASCs(yASCs,≤35 years,n=9).For each group,immunophenotypic characterization was performed by flow cytometry.Population doubling time was assessed over seven days.For adipogenic potential evaluation,lipid deposits were assessed after 7 d,14 d and 21 d of adipogenic induction.Osteogenic potential was verified by analyzing cell mineralization after 14 d,21 d and 28 d of osteogenic induction.mRNA expression of PPARγ2,CEBPA and Runx2 were detected by quantitative reverse transcription polymerase chain reaction.RESULTS hASCs were successfully obtained,cultured,and grouped according to their age:yASCs(26.33±4.66 years old)and oASCs(64.78±4.58 years old).After maintenance of the cells in culture,there were no differences in morphology between cells from the young and old donors.Additionally,both groups showed classical immunophenotypic characteristics of mesenchymal stem/stromal cells.The average doubling time indicated that yASCs(4.09±0.94 d)did not significantly differ from oASCs(4.19±1.29 d).Concerning differentiation potential,after adipogenic and osteogenic induction,yASCs and oASCs were able to differentiate to greater levels than the noninduced control cells.However,no differences were found in the differentiation efficiency of yASCs and oASCs in adipogenesis or osteogenesis.Additionally,the mRNA expression of PPARγ2,CEBPA and Runx2 were similar in yASCs and oASCs.CONCLUSION Our findings suggest that age does not seem to significantly affect the cell division or adipogenic or osteogenic differentiation ability of adipose-derived stem cells isolated from lipoaspirates. | Cintia DS Horinouchi María Julia Barisón Anny W Robert Crisciele Kuligovski Alessandra M Aguiar BrunoDallagiovanna | 2020 | World Journal of Stem Cells2020，12，12： | 2 |
| 3 | Quantitative analysis offlavour precursors and pyruvate levels in different tissues and cultivars ofonion(Allium cepa)显示文摘 | JAMES R B GRAHAM K M ANNIE N | 1999 | Food Chemistry1999，64，2： | 1 |
| 4 | Polymer - supported chiral Co (salen) complexes : Synthetic applications and mechanis- tic investigations in the hydrolytic kinetic resolution of ter- minal epoxides 显示文摘 | Annis D A Jacobsen E N | 1999 | J Am Chem Soc1999，121，17： | 1 |
| 5 | Release and regeneration of protoplasts from the fungus Trichothecium roseum显示文摘 | N Balasubramanian G Annie Juliet P Snkalaivani D Lalithakumari | 2003 | Canadian Journal of Microbiology2003，49，： | 1 |
| 6 | First struc- tural characterisation of an amino phosphonate monoes- ter metal complex 显示文摘 | ANNIE B S W CHOI N FAILLA S | 1994 | Journal of the chemical soci- ety-dalton transactions1994，，22： | 1 |
| 7 | Statistical modelling of fatigue crack growth in a nickelbased superalloy显示文摘 | Yang J N Salivar G C Annis C G | 1983 | Engineering fracture Mechanics1983，18，： | 1 |
| 8 | Effects of self-disclosure on relational intimacy in Facebook显示文摘 | Park N Jin B Annie Jin S.A | | 0，，05： | 1 |
| 9 | Risk Factors and Causes of Death in MEN1 Disease. A GTE (Groupe d’Etude des Tumeurs Endocrines) Cohort Study Among 758 Patients显示文摘 | Pierre Goudet Arnaud Murat Christine Binquet Christine Cardot-Bauters Annie Costa Philippe Ruszniewski Patricia Niccoli Fabrice Ménégaux Georges Chabrier Fran?oise Borson-Chazot Antoine Tabarin Philippe Bouchard Brigitte Delemer Alfred Beckers Claire Boni | 2010 | World Journal of Surgery2010，，2： | 1 |
| 10 | ADAMTS-1 mediates the release of antiangiogenic polypeptides from TSP1 and 2显示文摘 | LEE N V SATO M ANNIS D S | 2006 | EMBO J2006，25，22： | 1 |
| 11 | Risk Factors and Causes of Death in MEN1 Disease. A GTE (Groupe d’Etude des Tumeurs Endocrines) Cohort Study Among 758 Patients显示文摘 | Pierre Goudet Arnaud Murat Christine Binquet Christine Cardot-Bauters Annie Costa Philippe Ruszniewski Patricia Niccoli Fabrice Ménégaux Georges Chabrier Fran?oise Borson-Chazot Antoine Tabarin Philippe Bouchard Brigitte Delemer Alfred Beckers Claire Boni | 2010 | World Journal of Surgery2010，，2： | 1 |
| 12 | Role of vascular endothelial growth factor receptor 1 and vascular endothelial growth factor receptor 2 in the vasodilator response to vascular endothelial growth factor in the neonatal piglet lung显示文摘 | SOPHIE N JOHANNE B | 2005 | Cri Care Med2005，33，4： | 1 |
| 13 | Release and regeneration of protoplasrs from the fungus Trichothecium roseum显示文摘 | N Balasubramanian G annie P Srikalaivani | 2003 | Canadian Journal of Microbiology2003，49，4： | 1 |
| 14 | ADAMTS1 mediates the release of antiangiogenic polypeptides from TSP1 and 2 显示文摘 | LEE N V SATO M ANNIS D S | 2006 | EMBO J2006，25，22： | 1 |
| 15 | Prevention of form-deprivation myopia with pirenzepine: a study of drug delivery and distribution 显示文摘 | Cottriall CL McBrien N A Annies R | 1999 | Ophthalmic Physiol Opt1999，19，4： | 1 |
| 16 | Polymer-supported chiral Co(Salen) complexes:Synthetic applications and mechanistic investigations in the hydrolytic kinetic resolution of terminal epoxides显示文摘 | ALLEN ANNIS D JACOBSEN E N | 1999 | J Am Chem Soc1999，121，17： | 1 |
| 17 | Image restoration usingwavelet based image fusion 显示文摘 | Anni U G Alice N C Mangesh D N | 2011 | International Journal cff Engi- neering Science and Technology2011，3，2： | 1 |
| 18 | Polymer-supported chiral co(Salen) complexes:synthetic application and mechanistic investigation in the hydrolytic kinetic resolution of terminal epoxides显示文摘 | Annis D A Jacobsen E N | 1999 | J Am Chem Soc1999，121，： | 1 |
| 19 | HCV-specific immune responses induced by CIGB-230 in combination with IFN-α plus ribavirin显示文摘AIM:To analyze hepatitis C virus(HCV)-specific immune responses in chronically infected patients under triple therapy with interferon-α(IFN-α)plus ribavirin and CIGB-230.METHODS:CIGB-230 was administered in different schedules with respect to IFN-αplus ribavirin therapy.Paired serum and peripheral blood mononuclear cells(PBMC)samples from baseline and end of treatment were analyzed.The HCV-specific humoral response was tested by enzyme-linked immunosorbent assay,neutralizing antibodies were evaluated by cell culture HCV neutralization assays,PBMC proliferation was assayed by carboxyfluorescein succinimidyl ester staining and IFN-γsecretion was assessed by enzyme-linked immunospot.Data on virological and histological response and their association with immune variables are also provided.RESULTS:From week 12 to week 48,all groups of patients showed a significant reduction in mean leukocyte counts.Statistically significant reductions in antibody titers were frequent,but only individuals immunized with CIGB-230 as early add-on treatment sustained the core-IgG response,and the neutralizing antibody response was enhanced only in patients receiving CIGB-230.Cell-mediated immune responses also tended to decline,but significant reductions in IFN-γsecretion and total absence of core-specific lymphoproliferation were exclusive of the control group.Only CIGB-230-immunized individuals showed de novo induced lymphoproliferative responses against the structural antigens.Importantly,it was demonstrated that thequality of the CIGB-230-induced immune response depended on the number of doses and timing of administration in relation to the antiviral therapy.Specifically,the administration of 6 doses of CIGB-230 as late addon to therapy increased the neutralizing antibody activity and the de novo core-specific IFN-γsecretion,both of which were associated with the sustained virological response.CONCLUSION:CIGB-230,combined with IFN-α-based therapy,modifies the immune response in chronic patients.The study provides evidence for the design of more effective therapeutic vaccine interventions against HCV. | Yalena Amador-Caizares Gillian Martínez-Donato Liz lvarez-Lajonchere Claudia Vasallo Mariacarla Dausá Daylen Aguilar-Noriega Carmen Valenzuela Ivette Raíces Jean Dubuisson Czeslaw Wychowski Zurina Cinza-Estévez Marlén Castellanos Magdalys Núez Anny Armas Yaimé González Ismariley Revé Ivis Guerra ngel Pérez Aguiar Santiago Dueas-Carrera | 2014 | World Journal of Gastroenterology2014，20，1： | 1 |
| 20 | Endoplasmic reticulum localized Bcl-2 prevents apoptosis when redistribution of cytochrome c is a late event显示文摘 | Annis MG Zamzami N Zhu W | 2001 | Oncogene2001，20，16： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员