|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | B型利钠肽预测心力衰竭患者死亡和心血管事件的效用:系统性综述显示文摘 | Jenny A Doust Eva Pietrzak Annette Dobson Paul Glasziou 付晓霞 | 2005 | 英国医学杂志中文版2005，8，4： | 3 |
| 3 | Exogenous cytokinin application to Actinidia chinensis var. deliciosa ‘Hayward’ fruit promotes fruit expansion through water uptake显示文摘Exogenous application of a cytokinin-like compound forchlorfenuron(CPPU)can promote fruit growth,although often at the expense of dry matter(DM),an important indicator of fruit quality.Actinidia chinensis var.deliciosa‘Hayward’fruit are very responsive to CPPU treatments,but the mechanism underlying the significant fruit weight increase and associated decrease in DM is unclear.In this study,we hypothesised that CPPU-enhanced growth increases fruit carbohydrate demand,but limited carbohydrate supply resulted in decreased fruit DM.During fruit development,CPPU effects on physical parameters,metabolites,osmotic pressure and transcriptional changes were assessed under conditions of both standard and a high carbohydrate supply.We showed that CPPU increased fruit fresh weight but the dramatic DM decrease was not carbohydrate limited.Enhanced glucose and fructose concentrations contributed to an increase in soluble carbohydrate osmotic pressure,which was correlated with increased water accumulation in CPPU-treated fruit and up-regulation of water channel aquaporin gene PIP2.4 at 49 days after anthesis.Transcipt analysis suggested that the molecular mechanism contributing to increased glucose and fructose concentrations was altered by carbohydrate supply.At standard carbohydrate supply,the early glucose increase in CPPU fruit was associated with reduced starch synthesis and increased starch degradation.When carbohydrate supply was high,the early glucose increase in CPPU fruit was associated with a general decrease in starch synthesis but up-regulation of vacuolar invertase and fructokinase genes.We conclude that CPPU affected fruit expansion by increasing the osmotically-driven water uptake and its effect was not carbohydrate supply-limited. | Simona Nardozza Helen L Boldingh Mark W Wohlers Andrew P Gleave Zhiwei Luo Guglielmo Costa Elspeth A MacRae Michael J Clearwater Annette C Richardson | 2017 | Horticulture Research2017，4，1： | 2 |
| 4 | Nanorover for Mars 显示文摘 | BRIAN W ANNETTE N RICK W A | 1997 | Space Technology1997，17，3： | 1 |
| 5 | Predictors of survival for esophageal cancer patients with and without celiac axis lymphadenopathy: impact of staging endosonography显示文摘 | Mohamad A Eloubeidi Michael B Wallace Brenda J Hoffman Margaret B Leveen Annette Van Velse Robert H Hawes Carolyn E Reed | 2001 | The Annals of Thoracic Surgery2001，，1： | 1 |
| 6 | Mesenchymal stem cells for the treatment of neurodegenerative disease显示文摘 | Nanette Joyce Geralyn Annett Louisa Wirthlin Scott Olson Gerhard Bauer Jan A Nolta | 2010 | Regen Med2010，，6： | 1 |
| 7 | TLRT/8 triggering exerts opposing effects in acute versus latent HIV infection显示文摘 | Erika S Annette A Helene J | 2006 | J Immunol2006，176，5： | 1 |
| 8 | Oxidation of^6-to^5 by peroxomonosulfate in strong and weak acid solutions,an example of zero-order kinetics显示文摘 | Annette L N Robert C B Geoffrey A L | 1998 | J Chem Soc Dalton Trans1998，，5： | 1 |
| 9 | Characterization of Damaged Skin by Imedance Spec- troscopy: Mechanical Damage 显示文摘 | White Erick A Orazem Mark E Bunge Annette L | 2013 | Pharmaceutical Research2013，30，8： | 1 |
| 10 | Cognitive existential coupletherapy for newly diagnosed prostate cancer patients and their part-ners:A descriptive pilot study显示文摘 | Collins A L Bloch S Annette F | 2011 | Psycho-oncology2011，10，2： | 1 |
| 11 | Cheese flavour development by enzymatic conversions of peptides and amino acids显示文摘 | Gerrit S Annette V Eman A | 2000 | Food Research International2000，33，3： | 1 |
| 12 | The effects of vapreotide, a somatostatin analogue, on gastric acidity, gallbladder emptying and hormone release after 1 week of continuous subcutaneous infusion in normal subjects显示文摘 | MARC A R JURGEN D ANNETTE Z | 1999 | Brit J Clin Pharmacol1999，47，： | 1 |
| 13 | Computer modeling and intraoperative navigation in maxillofacial surgery 显示文摘 | Annette M Pham Amir A Rafii Marc C | 2007 | Otolaryngology-Head and Neck Surgery (S1043-1810)2007，137，4： | 1 |
| 14 | Design considerations for 12-pulse diode rectifier systems operating under voltage unbalance and pre-existing voltage distortion with some corrective measures显示文摘 | Daudi A Rendusara Annette yon Jouanne Prasad N Enjeti Derek A Paice | | 0，，06： | 1 |
| 15 | Thermal denaturation and coagulation of whey proteins: effect of sugars显示文摘 | GARRETT J M STAIRS R A ANNETT R G | 1988 | Journal of Dairy Science1988，71，： | 1 |
| 16 | 测定血清S100蛋白用于诊断克-雅病:前瞻性病例对照研究显示文摘目的:分析克-雅病(Creutzfeldt-Jakob dis-ease,CJD)患者及对照组血清中脑特异性 S100蛋白浓度。设计:前瞻性病例对照研究。研究单位:国家 CJD 监测站。研究对象:224例疑为 CJD 的转诊患者及35例无痴呆的对照病例。主要结果测定:CJD 患者、其他疾病引起的痴呆患者及对照组血清 S100浓度。结果:224例疑为 CJD 的患者中,65例经病理证实确诊;6例有基因突变而肯定诊断;43例很可能患 CJD;36例可能患 CJD;74例患有其他疾病。108例为肯定或很可能 CJD 患者,其血清 S100浓度中位数为395 pg/ml(SD 387 pg/ml)。这明显高于患其他疾病的74例患者(S100浓度中位数为109pg/ml,SDl77pg/ml;P=0.0001)。以213pg/ml为界值,S100测定用于 CJD 诊断的敏感性为77.8%(95%的可信区间为66.8%~85.2%),特异性为81.1%(70.3%~89.3%)。在 Kaplan-Meier 曲线上,不同浓度 S100患者的存活时间差异有显著性(P=0.023)。结论:S100血清浓度测定是一种有价值的工具,在 CJD 的鉴别诊断中,较测定脑脊液更有价值。尚需更多的研究以确定连续测定是否有助于提高此病的诊断准确性。 | Markus Otto Jens Wiltfang Ekkehard Schtz Ingo Zerr Anke Otto Annette Pfahlberg Olaf Gefeller Manfred Uhr Armin Giese Thomas Weber Hans A Kretzschmar Sigrid Poser 张星虎 | 1998 | 英国医学杂志中文版1998，0，1： | 1 |
| 17 | Optimal energy storage sizing and control for wind power applications 显示文摘 | Ted K A Brekken Alex Yokoehi Annette Von Jouanne | 2011 | IEEE Transaction on Sustainable Energy2011，3，32： | 1 |
| 18 | Multichannel CT:evaluating the spine in postoperative patients with orthopedic hardware显示文摘 | Annette C Douglas A Kenneth A | 2006 | Radiographics2006，26，1： | 1 |
| 19 | Vaccination of mice with plasmids expressing processed capsid protein of foot-and-mouth disease virus-Importance of dominant and subdominant epitopes for antigenicity and protection 显示文摘 | Tine H F Annette M B Bent A | 2007 | Vaccine2007，25，： | 1 |
| 20 | Angiopoietin-2 overexpression in morris hepatoma results in increased tumor perfusion and induction of critical angioge-nesis-promoting genes显示文摘 | Pierre K Johannes H Annette A | | 0，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员