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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 3 | Coagonist of glucagon-like peptide-1 and glucagon receptors ameliorates kidney injury in murine models of obesity and diabetes mellitus显示文摘AIM To investigate the role of glucagon-like peptide-1(GLP-1)/glucagon receptors coagonist on renal dysfunction associated with diabetes and obesity. METHODS Chronic high-fat diet fed C57 BL/6 J mice, streptozotocintreated high-fat diet fed C57 BL/6 J mice and diabeticC57 BLKS/J db/db mice were used as models of diabetes-induced renal dysfunction. The streptozotocintreated high-fat diet fed mice and db/db mice were treated with the GLP-1 and glucagon receptors coagonist(Aib2 C24 Chimera2, 150 μg/kg, sc) for twelve weeks, while in chronic high-fat diet fed mice, coagonist(Aib2 C24 Chimera2, 150 μg/kg, sc) treatment was continued for forty weeks. Kidney function, histology, fibrosis, inflammation, and plasma biochemistry were assessed at the end of the treatment. RESULTS Coagonist treatment decreased body weight, plasma lipids, insulin resistance, creatinine, blood urea nitrogen, urinary albumin excretion rate and renal lipids. In kidney, expression of lipogenic genes(SREBP-1 C, FAS, and SCD-1) was decreased, and expression of genes involved in β-oxidation(CPT-1 and PPAR-α) was increased due to coagonist treatment. In plasma, coagonist treatment increased adiponectin and FGF21 and decreased IL-6 and TNF-?. Coagonist treatment reduced expression of inflammatory(TNF-α, MCP-1, and MMP-9) and pro-fibrotic(TGF-β, COL1 A1, and α-SMA) genes and also improved histological derangement in renal tissue.CONCLUSION Coagonist of GLP-1 and glucagon receptors alleviated diabetes and obesity-induced renal dysfunction by reducing glucose intolerance, obesity, and hyperlipidemia. | Vishal J Patel Amit A Joharapurkar Samadhan G Kshirsagar Brijesh K Sutariya Maulik S Patel Hiren M Patel Dheerendra K Pandey Rajesh H Bahekar Mukul R Jain | 2018 | World Journal of Diabetes2018，9，6： | 5 |
| 4 | Axin-mediated CKI phosphorylation of beta -catenin at Set 45:a molecular switch for the Wnt pathway显示文摘 | Amit S Hatzubai A Birman Y Andersen J S Ben Shushan E Mann M | 2002 | Genes Dev2002，16，： | 1 |
| 5 | The early prenatal sonographic diagnosis of renal agenesis :techniques and possible pitfalls显示文摘 | Bronshtein M Amit A Achiron R | 1994 | Prenat Diagn1994，14，4： | 1 |
| 6 | Inactive systemic lupus erythematosus associated with a normal stimulated Th1/Th2 eytokine secretory pattern显示文摘 | Amit M Mor A Weissgarten J | 2000 | Cytokine2000，12，9： | 1 |
| 7 | Preparation and crystal structure of NH4MnCl3 and NH4FeCl3显示文摘 | Amit M Zodkevitz A Makovsky J | 1970 | Israel Journal of Chemistry1970，8，4： | 1 |
| 8 | Preparation and crystal structures of some compounds of A3BX5 type (A=Cs,Tl,NH4,B=Mn,Fe,Co,X=Cl,Br)显示文摘 | Amit M Horowitz A Ron E | 1973 | Israel Journal of Chemistry1973，11，6： | 1 |
| 9 | linkage Disequilibrium between the Human Leukocyte Antigen Class Ⅱ Region of the Major Histocompatibility Complex and Graves' Disease: Replication Using a Population Case Control and Family-Based Study 显示文摘 | Joanne M H Amit A Jacquie D | 1998 | J Clin Endocrinol Metab1998，83，： | 1 |
| 10 | Extend surface temperature and emissivity retrieval to the mid-infrared (3-5)using the Muhispectral Thermal Imager (MTI) 显示文摘 | AMIT M A LEE K BALICK B | 2005 | Remote Sensing of Environment2005，98，： | 1 |
| 11 | Acute toxicity assessment of choline by inhalation, intraperitoneal and oral routes in Balb/c mice显示文摘 | AMIT K M NAVEEN A SHAILENDRA N G | 2009 | Regulatory Toxicology and Pharmacology2009，54，3： | 1 |
| 12 | Tissue-engineering composites of annulus fibrosus and nucleus pulposus for intervertebral disc replacement 显示文摘 | Hirokazu M Amit K Charles A | 2004 | Spine2004，29，12： | 1 |
| 13 | Inhalable large porous micro-spheres of low molecular weight heparin:in vitro and in vivo evalua-tion显示文摘 | Amit R Quamrul H M Fakhrul A | 2008 | J Controlled Release2008，128，3： | 1 |
| 14 | Single-molecule biomechanics with optical methods显示文摘 | Matthias R James A | 1999 | Science1999，283，3： | 1 |
| 15 | Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals显示文摘 | Guttman M Amit I Garber M French C Lin M.F Feldser D Huarte M Zuk O Carey B.W Cassady J.P Cabili M.N Jaenisch R Mikkelsen T.S Jacks T Hacohen N Bernstein B.E Kellis M Regev A Rinn J.L Lander E.S | | 0，，： | 1 |
| 16 | Optimal Sensor Placement for Enhancing Sensitivity to Change in Stiffness for Structural Health Monitoring 显示文摘 | Josh M Beal Amit Shukla Olga A Brezhneva | 2008 | Optimization and Engineering (S11081-007-9023-1)2008，9，2： | 1 |
| 17 | Antibacterial activity of punicagranatum显示文摘 | PRASHANTH D ASHA M K AMIT A | 2001 | Journal of Fitoterapia2001，72，2： | 1 |
| 18 | Antibacterial activity of Punica granatum显示文摘 | Prashanth D Asha M K Amit A | 2001 | Journal of Fitoterapia2001，72，2： | 1 |
| 19 | Crystal structure of a thermostable bacterial cellulose degrading enzyme显示文摘 | Juy M Amit A G Alzari P M | 1992 | Nature1992，357，6373： | 1 |
| 20 | Antibacterial activity of Punica granatum显示文摘 | Prashanth D Asha M K Amit A | | 0，，02： | 1 |
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