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| 1 | Insulin like growth factor-1 increases fatty liver preservation in IGL-1 solution显示文摘AIM: To investigate the benefits of insulin like growth factor-1 (IGF-1) supplementation to serum-free institut georges lopez-1 (IGL-1) solution to protect fatty liver against cold ischemia reperfusion injury. METHODS: Steatotic livers were preserved for 24 h in IGL-1 solution supplemented with or without IGF-1 and then perfused 'ex vivo ' for 2 h at 37℃. We examined the effects of IGF-1 on hepatic damage and function (transaminases, percentage of sulfobromophthalein clearance in bile and vascular resistance). We also studied other factors associated with the poor tolerance of fatty livers to cold ischemia reperfusion injury such as mitochondrial damage, oxidative stress, nitric oxide, tumor necrosis factor-α (TNF-α) and mitogen-activated protein kinases.RESULTS: Steatotic livers preserved in IGL-1 solutionsupplemented with IGF-1 showed lower transaminase levels, increased bile clearance and a reduction in vascular resistance when compared to those preserved in IGL-1solution alone. These benefits are mediated by activation of AKT and constitutive endothelial nitric oxide synthase (eNOS), as well as the inhibition of inflammatory cytokines such as TNF-α. Mitochondrial damage and oxidative stress were also prevented.CONCLUSION: IGL-1 enrichment with IGF-1 increasedfatty liver graft preservation through AKT and eNOS activation, and prevented TNF-α release during normothermic reperfusion. | Mohamed Amine Zaouali Susagna Padrissa-Altés Ismail Ben Mosbah Hassen Ben Abdennebi Olivier Boillot Antoni Rimola Dalila Saidane-Mosbahi Joan Roselló-Catafau | 2010 | World Journal of Gastroenterology2010，16，45： | 6 |
| 2 | Acute liver failure secondary to severe systemic disease from fatal hemophagocytic lymphohistiocytosis:Case report and systematic literature review显示文摘AIM To systematically review liver disease associated with hemophagocytic lymphohistiocytosis(HLH),propose reasonable contraindications for liver transplantation for liver failure in HLH,and report an illustrative case.METHODS Systematic review according to PRISMA guidelines of hepatic manifestations of HLH using computerizedliterature search via PubMed of articles published since 1980 with keywords('hemophagocytic lymphohistiocytosis' or 'HLH') AND('liver' or 'hepatic'). Two authors independently performed literature search and incorporated articles into this review by consensus. Illustrative case report presented based on review of medical chart,and expert re-review of endoscopic photographs,radiologic images,and pathologic slides. RESULTS A 47-year-old Caucasian male,was hospitalized with high-grade pyrexia,rash,total bilirubin = 45 g/dL,moderately elevated hepatic transaminases,ferritin of 3300 ng/dL,leukopenia,and profound neutropenia(absolute neutrophil count < 100 cells/mm3). Viral serologies for hepatitis A,B,and C were negative. Abdominal computed tomography scan and magnetic resonance imaging revealed no hepatic or biliary abnormalities. Pathologic analysis of liver biopsy revealed relatively well-preserved hepatic parenchyma without lymphocytic infiltrates or macrophage invasion,except for sparse,focal hepatocyte necrosis. Bone marrow biopsy and aspirate revealed foamy macrophages engulfing mature and precursor erythrocytes,consistent with HLH. Interleukin-2 receptor(CD25) was highly elevated,confirming diagnosis of HLH according to Histiocytic Society criteria. Patient initially improved after high-dose prednisone therapy. Patient was judged not to be a liver transplant candidate despite model for end stage liver disease(MELD) score = 33 because liver failure was secondary to severe systemic disease from HLH,including septic shock,focal centrilobular hepatocyte necrosis from hypotension,bone marrow failure,and explosive immune activation from HLH. The patient eventually succumbed to overwhelming sepsis,progressive liver failure,and disseminated intravascular coagulopathy. Systematic review reveals liver injury is very common in HLH,and liver failure can sometimes occur. Data on liver transplantation for patients with HLH are very limited,and so far the results have shown a generally much worse prognosis than for other liver transplant indications. Liver transplantation should not be guided solely by MELD score,but should include liver biopsy results and determination whether liver failure is from intrinsic liver injury vs multisystem(extrahepatic) organ failure from HLH.CONCLUSION This case report illustrates that liver transplantation may not be warranted when liver failure associated with HLH is primarily from multisystem failure from HLH. Liver biopsy may be very helpful in determining the severity and pathophysiology of the liver disease. | Mitchell S Cappell Ismail Hader Mitual Amin | 2018 | World Journal of Hepatology2018，10，9： | 5 |
| 3 | Limited, local, extracolonic spread of mucinous appendiceal adenocarcinoma after perforation with formation of a malignant appendix-to-sigmoid fistula: Case report and literature review显示文摘A 68-year-old man presented with progressive right lower quadrant abdominal pain and tenderness without rebound tenderness, and with constipation during the prior 9 mo. Abdomino-pelvic computed tomography and magnetic resonance imaging demonstrated a dilated appendix forming a fistula to the sigmoid colon. Open laparotomy revealed a bulky abdominal tumor involving appendix, cecum, and sigmoid, and extending up to adjacent viscera, without ascites or peritoneal implants. The abdominal mass was removed en bloc, including resection of sigmoid colon, cecum(with preservation of ileocecal valve), appendix, right vas deferens, testicular vessels, and minimal amounts of anterior abdominal wall; and shaving off of small parts of the walls of the urinary bladder and small bowel. Gross and microscopic pathologic examination revealed an appendix-to-sigmoid malignant fistula secondary to perforation of mucinous adenocarcinoma of the appendix with minimal local spread(stage T4). However, the surgical margins were clear, all 13 resected lymph nodes were cancer-free, and pseudomyxoma peritonei or peritoneal implants were not present. The patient did well during 1 year of follow-up with no clinical or radiologic evidence of local recurrence, metastases, or pseudomyxoma peritonei despite presenting with extensive stage T4 cancer that was debulked without administering chemotherapy, and despite presenting with malignant appendiceal perforation. This case illustrates the non-aggressive biologic behavior of this low-grade malignancy. The fistula may have prevented free spillage of cancerous cells and consequent distant metastases by containing the appendiceal contents largely within the colon. | Seifeldin Hakim Mitual Amin Mitchell S Cappell | 2016 | World Journal of Gastroenterology2016，22，38： | 4 |
| 4 | TLR8激动剂GS-9688在慢性乙型肝炎中的治疗潜力——抗病毒和调节介质的重塑显示文摘GS-9688(Selgantolimod)是一种用于治疗慢性乙型肝炎的Toll样受体8(TLR8)激动剂,目前正处于临床研究阶段。GS-9688的抗病毒活性之前已经在感染HBV的肝细胞中进行了体外评估,并在慢性乙型肝炎的土拨鼠模型中进行了体内评估。该研究评估了GS-9688增强应答有助于病毒控制和调节介质的潜力。 | AMIN OE COLBECK EJ DAFFIS S 阿米那·阿不力孜 华瑞 | 2021 | 临床肝胆病杂志2021，37，3： | 4 |
| 5 | Role of platelet-albumin-bilirubin score in predicting re-bleeding after band ligation for acute variceal hemorrhage显示文摘Platelet-albumin-bilirubin(PALBI)score was proposed by Roayaie et al with modification of previously studied albumin-bilirubin score to include platelet as an indicator of portal hypertension in 2015.Predictive value of this score was recently tested by Elshaarawy et al for re-bleeding in patients presenting with acute variceal hemorrhage.We did a similar study at our center(n=170)to look at incidence of re-bleeding after band ligation defined as drop in 2 units of hemoglobin and witnessed melena or hematemesis within 2 wk of the procedure.We calculated PALBI scores for all patients based on lab values prior to the procedure.Of 25.3%had re-bleeding episodes,area under receiver operating characteristic curve for PALBI as predictor of re-bleeding was 0.601(95%confidence interval:0.502-0.699).PALBI score showed moderate accuracy at predicting re-bleeding in our population. | Muhammad S Faisal Tavankit Singh Hina Amin Jamak Modaresi Esfeh | 2020 | World Journal of Hepatology2020，12，10： | 3 |
| 6 | Using fuzzy-AHP and parametric technique to assess soil fertility status in Northeast of Iran显示文摘A good understanding of the levels and distribution patterns of soil properties and/or quality indicators is a prerequisite for developing sustainable agricultural land management programs. Traditional assessments of these parameters of soil fertility status are somewhat costly, in both economics and time aspects. Different modelling techniques have been proposed as a useful tool for determination of soil quality indicators and development of soil fertility maps, but to what extent these results are reliable remains under-quantified in many regions worldwide. To address this uncertainty, Fuzzy-Analytical Hierarchy Process(Fuzzy-AHP) and Parametric analyses were conducted to ascertain the soil fertility status of a semiarid region in the Northeast of Iran for some selected crops: alfalfa, corn silage, potato, sugar beet, tomato and wheat. The Fuzzy-AHP and Parametric techniques using soil suitability indices were estimated for each crop and each soil delineation was achieved by Ordinary Kriging. The Technique for Order of Preference by Similarity to Ideal Solution(TOPSIS) was used as a compensatory method to allow tradeoffs among the selected criteria. Our results demonstrated that from the Fuzzy-AHP analysis, the soil fertility indices ranged from moderate to high for production of alfalfa;from low to high for production of corn silage and sugar beet;moderate to high for production of potato and tomato;and from low to moderate for production of wheat. However, the parametric analysis showed soil fertility classes ranging from very low to high for production of all the selected crops. High correlations were also observed between soil fertility indices predicted by both models. Similarly, the capacities of both models to predict soil fertility status for production of the selected crops were also highly correlated. The preference for the cultivation of the selected crops based on the Fuzzy-AHP analysis was sugar beet > corn silage > wheat > alfalfa > tomato > potato. On the other hand, using Parametric techniques, the crops preferences for cultivation ranked as corn silage > wheat > alfalfa > sugar beet > tomato > potato. We concluded that the findings would help to develop sustainable plans of cultivation based on patterns related to soil fertility classes depending on each crop’s requirement. | Ali KESHAVARZI Henry Oppong TUFFOUR Ali BAGHERZADEH Leo Paapa TATTRAH Vinod KUMAR Amin GHOLIZADEH Jesús RODRIGO-COMINO | 2020 | Journal of Mountain Science2020，17，4： | 3 |
| 7 | Effects of vanadium complexes with organic ligands on glucose metabolism: a comparison study in diabetic rats显示文摘 | Reul B A Amin S S Buchet J P | 1999 | Br J Pharmacol1999，126，2： | 2 |
| 8 | GIS-based irrigation water management for precision farming of rice显示文摘Precision farming aims to manage production inputs over many small management zones rather than on large zones.It is difficult to manage inputs at extremely fine scales,especially in the case of the rice irrigation system.However,site-specific irrigation management can potentially improve the overall water management in comparison to irrigated areas of hundreds of hectares.A critical element of the irrigation scheduling and management is the accurate estimation of irrigation supplies and its proper allocation for the irrigation offtake structures based on the actual planted areas.All irrigation scheduling procedures consist of monitoring indicators that determine the need for irrigation.The final decision depends on the irrigation criterion,strategy and goal.Irrigation scheduling is the decision of when and how much water to apply to a field.The amount of water applied is determined by using a criterion to determine irrigation need and a strategy to prescribe how much water to apply in any situation.The right amount of daily irrigation supply and monitoring at the right time within the discrete irrigation unit is essential to improve the irrigation water management of a scheme.This paper presents the GIS capability to achieve the goal in the view of irrigation strategy and goal with special reference to precision farming of rice.The GIS-based water management model was developed for the scheduling daily irrigation water deliveries and regular monitoring of irrigation delivery performance.The“Scheduling”program computes the right amount of irrigation deliveries based on crop water requirements.The“Monitoring”program gives information on the uniformity of water distribution and the shortfall or excess.The displayed results allow the manager to view maps,tables and graphs in a comprehensible form to ease decision making that where the irrigation amount will be delivered as the season progresses.GIS was used as a useful tool to assist the irrigation water management program in the context of precision farming. | Rowshon M K Amin M S M | 2010 | International Journal of Agricultural and Biological Engineering2010，3，3： | 2 |
| 9 | Mesuaferrea stem bark extract induces apoptosis and inhibits metastasis in human colorectal carcinoma HCT 116 cells, through modulation of multiple cell signalling pathways显示文摘Considering the great potential of natural products as anticancer agents, the present study was designed to explore the molecular mechanisms responsible for anticancer activities of Mesua ferrea stem bark extract against human colorectal carcinoma. Based on MTT assay results, bioactive sub-fraction(SF-3) was selected for further studies using HCT 116 cells. Repeated column chromatography resulted in isolation of less active α-amyrin from SF-3, which was identified and characterized by GC-MS and HPLC methods. α-amyrin and betulinic acid contents of SF-3 were measured by HPLC methods. Fluorescent assays revealed characteristic apoptotic features, including cell shrinkage, nuclear condensation, and marked decrease in mitochondrial membrane potential in SF-3 treated cells. In addition, increased levels of caspases-9 and-3/7 levels were also observed in SF-3 treated cells. SF-3 showed promising antimetastatic properties in multiple in vitro assays. Multi-pathway analysis revealed significant down-regulation of WNT, HIF-1α, and EGFR with simultaneous up-regulation of p53, Myc/Max, and TGF-β signalling pathways in SF-3 treated cells. In addition, promising growth inhibitory effects were observed in SF-3 treated HCT 116 tumour spheroids, which give a hint about in vivo antitumor efficacy of SF-3 phytoconstituents. In conclusion, these results demonstrated that anticancer effects of SF-3 towards colon cancer are through modulation of multiple molecular pathways. | Muhammad Asif Armaghan Shafaei Aman Shah Abdul Majid Mohammed Oday Ezzat Saad S Dahham Mohamed B.Khadeer Ahamed Chern Ein Oon Amin Malik Shah Abdul Majid | 2017 | Chinese Journal of Natural Medicines2017，15，7： | 2 |
| 10 | Inter-ethnic marriages and severity of coronary artery disease:A multicenter study of Arabian Gulf States显示文摘AIM To assess the association of inter-ethnic vs intra-ethnic marriage with severity of coronary artery disease(CAD) in men undergoing angiography.METHODS We conducted a prospective multicenter,multi-ethnic,cross sectional observational study at five hospitals in Saudi Arabia and the United Arab Emirates,in which we used logistic regression analysis with and without adjustment for baseline differences. RESULTS Data were collected for 1068 enrolled patients undergoing coronary angiography for clinical indications during the period of April 1^(st),2013 to March 30^(th),2014. Ethnicities of spouses were available only for male patients. Of those enrolled,687 were married men and constituted the cohort for the present analysis. Intra-ethnic marriages were reported in 70% and inter-ethnic marriages in 30%. After adjusting for baseline differences,interethnic marriage was associated with lower odds of having significant CAD [adjusted odds ratio 0.52(95%CI:0.33,0.81)] or multi-vessel disease(MVD) [adjusted odds ratio 0.57(95%CI:0.37,0.86)]. The adjusted association with left main disease showed a similar trend,but was not statistically significant [adjusted odds ratio 0.74(95%CI:0.41,1.32)]. The association between interethnic marriage and the presence of significant CAD and MVD was not modified by number of concurrent wives(P interaction > 0.05 for both).CONCLUSION Among married men undergoing coronary angiography,inter-ethnic,as compared to intra-ethnic,marriage is associated with lower odds of significant CAD and MVD. | Amin Daoulah Salem Al-kaabi Amir Lotfi Mushabab Al-Murayeh S Ali Nasseri Waleed Ahmed Salah N Al-Otaibi Mohamed N Alama Osama E Elkhateeb Amy J Plotkin Majed M Malak Khalid Alshali Mohamed Hamzi Saleh Al Khunein Mohammed Abufayyah Alawi A Alsheikh-Ali | 2017 | World Journal of Cardiology2017，9，4： | 2 |
| 11 | Microprogation and plant regeneration of Rauwolfia serpentina by tissue culture technique显示文摘 | Ahmad S Amin M N Azad M A K | 2002 | PakistanJournal of Biological Sciences2002，5，1： | 1 |
| 12 | Estimating saturated hydraulic conductivity in spatially variable fields using neural network ensembles 显示文摘 | KAMBAN P AMIN E BING C S | 2006 | Soil Science Society of America Journal2006，70，6： | 1 |
| 13 | Hydrometallurgical treatment of Egyptian zinc lead oxide ore显示文摘 | Amine A S | 1995 | Modeling Measurement and Control1995，49，1： | 1 |
| 14 | Identification of mesenchymal progenitor calls in normal and osteoarthritic human articular cartilage显示文摘 | Alsalameh S Amin R Gemba T | 2004 | Arthritis Rheum2004，50，5： | 1 |
| 15 | Unique homologous siRNA blocks hypoxia-induced VEGF upregulation in human corneal cells and inhibits and regresses murine corneal neovascularizatlon 显示文摘 | Singh N Higgins E Amin S | 2007 | Cornea2007，26，1： | 1 |
| 16 | The impact of workplace spirituality di- mensions on organisational citizenship behaviour among nurses with the mediating effect of affective organisational commitment 显示文摘 | Kazemipour F Mohd Amin S | 2012 | J Nurs Manag2012，20，8： | 1 |
| 17 | Inter- leukin-6 and type I interferon-regulated genes and chemokines mark disease activity in dermatomyositis 显示文摘 | BILGIC H YTFERBERG S R AMIN S | 2009 | Arthritis Rheum2009，6，11： | 1 |
| 18 | The role of temperature on impact properties of kevlar/fiber glass composite laminates显示文摘 | AMIN S K REZA B MOHAMMAD M | 2006 | Composites: Part B2006，37，78： | 1 |
| 19 | Flt-1 intraceptors inhibit hypoxia-induced VEGF expression in vitro and corneal neovascularization in vivo显示文摘 | Singh N Amin S Richter E | | 0，，05： | 1 |
| 20 | Collecting duct Carcinoma versus renal medullary carcinoma: an appeal for nosologic and biological clarity显示文摘 | Amin M B Smith S C Agaimy A | 2014 | Am J Surg Pathol2014，38，7： | 1 |
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