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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | MR-guided interventional breast procedures Considering vacuum biopsy in particular 显示文摘 | Heinig A Amaya B | 2002 | Eur J Radiol2002，42，： | 1 |
| 3 | RANi-mediated silencing of the myo- inositol phosphate synthase gene (GmMIPS) in trans-genic soybean inhibited seed development and reduced phytate content 显示文摘 | Nunes A C S Vianna G R Cuneo F Amaya F J Capdeville G Rech E L Arogao F J L | 2006 | P[anta2006，224，1： | 1 |
| 4 | A common meehanism controls the life cycle and architecture of plants显示文摘 | Ratcliffe O J Amaya I Vincent C A | 1998 | Development1998，125，： | 1 |
| 5 | Biochemical and mutational analysis of glutamine synthetase type Ⅲ from the rumen anaerobe Ruminococcus albus 8显示文摘 | AMAYA K R KOCHERGINSKAYA S A MACKIE R I | 2005 | Bacteriology2005，187，21： | 1 |
| 6 | Research into material selection for down-hole tubing in severe sour service显示文摘 | AMAYA H YAMAMOTO E NARITA A | 2001 | Corrosion2001，，01： | 1 |
| 7 | gehaviour of nano particle (ultrafine) titanium dioxide pigments and stabilisers on thephotooxidative stability of water based acrylic and isocyanate based acrylic coatings显示文摘 | Norman S A Miehele E Amaya O | 2002 | Polym Degradation Stability2002，78，3： | 1 |
| 8 | Variation quality of characteristies associated with some spring 1B/1R translocation wheats显示文摘 | Pefia R J Amaya A Rajarams | 1990 | Cereal Sci1990，12，： | 1 |
| 9 | Variation in quality characteristics associated with some spring 1B/1R translocation wheats显示文摘 | Pena R J Amaya A Rajaram S | 1990 | Journal of Cereal Science1990，12，： | 1 |
| 10 | Replacement of fish meal in practical diets for the pacific white shrimp (Litope- naeus vannamei)reared under pond conditions 显示文摘 | AMAYA E A DAVIS D A ROUSE D B | 2007 | Aquaculture2007，，262： | 1 |
| 11 | The strawbeery gene FaGAST affects plant growth through inhibition of cell elongation显示文摘 | DE LA FUENTE J I AMAYA I CASTILLEJO C SANCHEZ-SEVILLA J F QUESADA M A BOTELLA M A VALPUESTA V | 2006 | Journal of Experimental Botany2006，57，10： | 1 |
| 12 | Experimental demonstration of subcarrier multiplexed quantum key distribution system显示文摘 | J Mora A Ruiz-Alba W Amaya | 2012 | Opt Lett2012，37，11： | 1 |
| 13 | Regulation of lipoprotein lipase activity in rainbow trout ( On- corhynchus mykiss) tissues显示文摘 | AMAYA A SANCHEZ-GURMAEHES J GUTIERREZ J | 2006 | Gen Comp Endocrino2006，146，3： | 1 |
| 14 | The migration of olfactory ensheathing cells during development and regeneration 显示文摘 | Ekberg JA Amaya D Mackay-Sim A | 2012 | Neurosig- nals2012，20，3： | 1 |
| 15 | Variation in quality characteristics associated with some spring 1B/1R translocation wheats显示文摘 | Pena R J Amaya A Rajaram S | 1990 | Journal of Cereal Science1990，12，： | 1 |
| 16 | Effects of a leukocyte depleting arterial line filter on perioperative morbidity in patients undergoing cardiac surgery : a controlled randomized trial 显示文摘 | Lcal-Noval SR Amaya R Herruzo A | 2005 | Ann Thorae Surg2005，80，4： | 1 |
| 17 | The transtheoretical model and cervical screening, its application among culturally diverse communities in Queensland, Australia 显示文摘 | Margaret K Amaya G Pascale A | 1999 | Ethn Health1999，4，4： | 1 |
| 18 | Activated carbon briquettes from biomass materials 显示文摘 | Amaya A Medero N Tancredi N | 2007 | Bioresource Technology2007，98，： | 1 |
| 19 | The role of tissue factor pathway inhibitor in tumor growth and metastasis显示文摘 | Amirkhosravi A Meyer T Amaya M | 2007 | Semin Thromb Hemost2007，33，7： | 1 |
| 20 | Reactive Oxygen species activate NF:B (p65) and p53 and induce apoptosis in RVFVinfected liver cells显示文摘 | Narayanan A Amaya M Voss K | 2014 | Virology2014，449，： | 1 |
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