|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Non-pharmacological management of pediatric functional abdominal pain disorders:Current evidence and future perspectives显示文摘Functional abdominal pain disorders(FAPDs) are an important and prevalent cause of functional gastrointestinal disorders among children, encompassing the diagnoses of functional dyspepsia, irritable bowel syndrome, abdominal migraine, and the one not previously present in Rome Ⅲ, functional abdominal pain not otherwise specified. In the absence of sufficiently effective and safe pharmacological treatments for this public problem, non-pharmacological therapies emerge as a viable means of treating these patients, avoiding not only possible side effects, but also unnecessary prescription, since many of the pharmacological treatments prescribed do not have good efficacy when compared to placebo. Thus, the present study provides a review of current and relevant evidence on non-pharmacological management of FAPDs, covering the most commonly indicated treatments, from cognitive behavioral therapy to meditation, acupuncture, yoga, massage, spinal manipulation, moxibustion, and physical activities. In addition, this article also analyzes the quality of publications in the area, assessing whether it is possible to state if non-pharmacological therapies are viable, safe, and sufficiently well-based for an appropriate and effective prescription of these treatments. Finally, it is possible to observe an increase not only in the number of publications on the non-pharmacological treatments for FAPDs in recent years, but also an increase in the quality of these publications. Finally, the sample selection of satisfactory age groups in these studies enables the formulation of specific guidelines for this age group, thus avoiding the need for adaptation of prescriptions initially made for adults, but for children use. | Maria Luísa Cordeiro Santos Ronaldo Teixeira da Silva Júnior Breno Bittencourt de Brito Filipe Antônio França da Silva Hanna Santos Marques Vinícius Lima de SouzaGonçalves Talita Costa dos Santos Carolina Ladeia Cirne Natália Oliveira e Silva Márcio Vasconcelos Oliveira Fabrício Freire de Melo | 2022 | World Journal of Clinical Pediatrics2022，11，2： | 2 |
| 2 | 'Effect of tillage on fractal indices describing soil surface microrelief of a Brazilian Alfisol显示文摘 | Vi~lal'V~izquez E /Vliranda J G V Alves M C | 2006 | Geoderma2006，134，3： | 1 |
| 3 | Inflammation,T-cell phenotype and inflammatory cytokines in chronic kidney disease patients under hemodialysis and its relationship to resistance to recombinanthuman erythropoietin therapy显示文摘 | Costa E Lima M Alves JM | 2008 | Clin Immunol2008，28，： | 1 |
| 4 | RBS lattice site location and damage recovery studies in GaN 显示文摘 | Alves E DaSilva M F Soares J C | 1999 | MRS Internet J Nitride Semiconductor Res1999，4，1： | 1 |
| 5 | The effects of dy- namic hyperinflation on CT emphysema measurements in patients with COPD显示文摘 | Alves GR Marchiori E Irion KL | 2014 | Eur J Radiol2014，83，12： | 1 |
| 6 | Scaling of structures subject to impact loads when using a power law constitu- tive equation显示文摘 | Oshiro R E Alves M | 2009 | Solids Struct2009，，4： | 1 |
| 7 | Prognostic implications of tumor-infiltrating lymphocytes in association with programmed cell death ligand 1 expression in remnant gastric cancer显示文摘Objective:Remnant gastric cancer(RGC)is usually associated with a worse prognosis.As they are less common and very heterogeneous tumors,new prognostic and reliable determinants are required to predict patients’clinical course for RGC.This study aimed to investigate the tumor-infiltrating lymphocytes(TILs)and programmed cell death ligand 1(PD-L1)status as prognostic biomarkers in a cohort of patients with RGC to develop an immunerelated score.Methods:Patients with gastric cancer(GC)who underwent curative intent gastrectomy were retrospectively investigated.RGC resections with histological diagnosis of gastric adenocarcinoma were enrolled in the study.The risk score based on immune parameters was developed using binary logistic regression analysis.RGCs were divided into high-risk(HR),intermediate-risk(IR),and low-risk(LR)groups based on their immune score.The markers(CD3+,CD4+/CD8+T cells and PD-L1)were selected for their potential prognostic,therapeutic value,and evaluated by immunohistochemistry(IHC).Results:A total of 42 patients with RGC were enrolled in the study.The score based on immune parameters exhibited an accuracy of 79%[the area under the receiver operating characteristic curve(AUC)=0.79,95%confidence interval(95%CI),0.63-0.94,P=0.002],and the population was divided into 3 prognostic groups:10(23.8%)patients were classified as LR,15(35.7%)as IR,and 17(40.5%)as HR groups.There were no differences in clinicopathological and surgical characteristics between the three groups.In survival analysis,HR and IR groups had worse disease-free survival and overall survival rates compared to the LR group.In the multivariate analysis,lymph node metastasis and the immune score risk groups were independent factors related to worse survival.Conclusions:A scoring system with immune-related markers was able to distinguish prognostic groups of RGC associated with survival.Accordingly,tumor-infiltrating immune lymphocytes and PD-L1 status may serve as a potential prognostic biomarker for patients with RGC. | Marina Alessandra Pereira Marcus Fernando Kodama Pertille Ramos André Roncon Dias Leonardo Cardili Rafael Dyer Rodrigues de Moraes Renan Ribeiro E Ribeiro Venancio Avancini Ferreira Alves Bruno Zilberstein Evandro Sobroza de Mello Ulysses Ribeiro Jr | 2022 | Chinese Journal of Cancer Research2022，34，6： | 1 |
| 8 | Increased amount of nitric oxidein exhaled air of asthmatics显示文摘 | Alving K Weitzberg E Lundberg J M | 1993 | Eur Respir 11993，6，9： | 1 |
| 9 | The Noxa/ Mcl-1 axis regulates susceptibility to apoptosis under glu- cose limitation in dividing T cells 显示文摘 | ALVES N L DERKS I A BERK E | 2006 | Immunity2006，24，6： | 1 |
| 10 | Increased amount of nitric oxide in exhaled air of asthmatics显示文摘 | Alving K Weitzberg E Lundberg JM | | 0，，09： | 1 |
| 11 | Transparent thin film transistors based on indium oxide semiconductor显示文摘 | Lavareda G de Carvalho.C.N Fortunato E Ramos A.R Alves E Conde O and Amaral A | | 0，，23： | 1 |
| 12 | Is poststroke depression a major depression显示文摘 | da Rocha e Silva CE Alves Brazil MA Matos do Nascimento E | 2013 | Cere- brovasc Dis2013，35，4： | 1 |
| 13 | Increased amount of nitric oxide in exhaled air of asthmatics显示文摘 | Alving K Weitzberg E Lundberg JM | 1993 | Eur Respir J1993，6，9： | 1 |
| 14 | Theoretical optical parameters for Ⅲ-nitride semiconductors显示文摘 | Silva Pinto E de Paiva R de Carvalho L C Alves H W L Alves J L A | 2003 | Microelectronics Journal2003，34，： | 1 |
| 15 | Optimization of Alkaline Pretreatment of Coffee Pulp for Production of Bioethanol显示文摘 | Menezes E G T Carmo J R Alves J L F | 2014 | Biotechnol Prog2014，30，2： | 1 |
| 16 | Free and Conjugated Biogenic Amines in Green and Roasted Coffee Beans显示文摘 | Casal S Mendes E Alves M R | 2004 | Journal of Agricul- tural and Food Chemistry2004，，20： | 1 |
| 17 | Slug is overexpressed in gastric carcinomas and may act synergistically with SIP1 and Snail in the down-regulation of E cadherin显示文摘 | Castro Alves C Rosivatz E Schott C | 2007 | J Pathol2007，211，7： | 1 |
| 18 | A mechanistic view of mitochondrial death decision pores显示文摘 | Belizario J E Alves J Occhiucci J M | 2007 | Braz J Med Biol Res2007，40，8： | 1 |
| 19 | Gelling properties of extruded yam (Dioscorea alata) starch显示文摘 | Alves R M L Grossmann M V E Silva R S S F | 1999 | Food Chemistry1999，67，2： | 1 |
| 20 | Increased amount of nitricoxide in exhaled air of asthmatics 显示文摘 | Alving K Weitzberg E Lundberg JM | 1993 | Eur Respir J1993，6，9： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员