|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Efficacy of intramuscular diclofenac and fluid replacement in prevention of post-ERCP pancreatitis显示文摘AIM:To assess the efficacy of intramuscular diclofenac and fluid replacement for prevention of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis.METHODS: A prospective, placebo-controlled study was conducted in 80 patients who underwent ERCP. Patients were randomized to receive parenteral diclofenac at a loading dose of 75 mg followed by the infusion of 5-10 mL/kg per hour isotonic saline over 4 h after the procedure, or the infusion of 500 mL isotonic saline as placebo. Patients were evaluated clinically, and serum amylase levels were measured 4, 8 and 24 h after the procedure.RESULTS: The two groups were matched for age, sex, underlying disease, ERCP findings, and type of treatment. The overall incidence of pancreatitis was 7.5% in the diclofenac group and 17.5% in the placebo group (12.5% in total). There were no significant differences in the incidence of pancreatitis and other variables between the two groups. In the subgroup analysis, the frequency of pancreatitis in the patients without sphincter of Oddi dysfunction (SOD) was significantly lower in the diclofenac group than in the control group (P=0.047).CONCLUSION: Intramuscular diclofenac and fluid replacement lowered the rate of pancreatitis in patients without SOD. | Altug Senol Ulku Saritas Halil Demirkan | 2009 | World Journal of Gastroenterology2009，15，32： | 20 |
| 2 | Handheld high-throughput plasmonic biosensor using computational on-chip imaging显示文摘We demonstrate a handheld on-chip biosensing technology that employs plasmonic microarrays coupled with a lens-free computational imaging system towards multiplexed and high-throughput screening of biomolecular interactions for point-of-care applications and resource-limited settings.This lightweight and field-portable biosensing device,weighing 60 g and 7.5 cm tall,utilizes a compact optoelectronic sensor array to record the diffraction patterns of plasmonic nanostructures under uniform illumination by a single-light emitting diode tuned to the plasmonic mode of the nanoapertures.Employing a sensitive plasmonic array design that is combined with lens-free computational imaging,we demonstrate label-free and quantitative detection of biomolecules with a protein layer thickness down to 3 nm.Integrating large-scale plasmonic microarrays,our on-chip imaging platform enables simultaneous detection of protein mono-and bilayers on the same platform over a wide range of biomolecule concentrations.In this handheld device,we also employ an iterative phase retrieval-based image reconstruction method,which offers the ability to digitally image a highly multiplexed array of sensors on the same plasmonic chip,making this approach especially suitable for high-throughput diagnostic applications in field settings. | Arif E Cetin Ahmet F Coskun Betty C Galarreta Min Huang David Herman Aydogan Ozcan Hatice Altug | 2014 | Light(Science & Applications)2014，3，1： | 6 |
| 3 | 一名无精症和开咬合畸形男性体内的额外标记染色体15显示文摘额外标记染色体15(sSMC[15])是最常见的标记染色体,通常认为如果不包含Prader-Willi/Angelman综合症关键区(Prader-Willi/Angelman syndrome critical region,PWACR),这一标记染色体就无关紧要。较大标记的关键区域的临床意义在几乎所有与标记染色体15相关的报告中都被提及,较小的标记仅与轻微畸形、无精症、习惯性流产相关。然而,这些不包含PWACR的小额外标记染色体15也可能决定某一基因表现型。我们在一个遗传学门诊对一名无精症病人进行畸形检查,根据标准的细胞遗传学方法进行外周血淋巴染色体分析,还对Y染色体微缺失进行了核仁组织区(NOR)连接、C-连接、荧光原位杂交(Fluorescence in situ hybridization,FISH)以及分子学研究。临床评估确定为畸形特征伴有无精症及重度“安氏Ⅱ类1分类开咬合畸形”。分子细胞遗传结果显示有小额外标记染色体15存在,此外,Y染色体微缺失分析显示无精症不是Y染色体微缺失的结果。额外标记染色体15和下颌不规则的症状同时出现在这一病例中,这可能只是巧合,但也可能标明了一个不仅只是无精症的特定表现型,其特征包括不育、颧骨发育不全、下颌不规则、瘢痕瘤形成以及轻微畸形特征。 | Altug Koc Odul Onur Mehmet Ali Ergun E. Ferda Pergin | 2009 | Asian Journal of Andrology2009，11，5： | 4 |
| 4 | Kefir treatment ameliorates dextran sulfate sodium-induced colitis in rats显示文摘AIM: To investigate the preventive effect of kefir on colitis induced with dextran sulfate sodium(DSS) in rats.METHODS: Twenty-four male Wistar-albino rats were randomized into four groups: normal control,kefircontrol,colitis,and kefir-colitis groups. Rats in the normal and kefir-control groups were administered tap water as drinking water for 14 d. Rats in the colitis and kefir-colitis groups were administered a 3% DSS solution as drinking water for 8-14 d to induce colitis. Rats in the kefir-control and kefir-colitis groups were administered 5 m L kefir once a day for 14 d while rats in the normal control and colitis group were administered an identical volume of the placebo(skim milk) using an orogastric feeding tube. Clinical colitis was evaluated with reference to the disease activity index(DAI),based on daily weight loss,stool consistency,and presence of bleeding in feces. Rats were sacrificed on the 15 th day,blood specimens were collected,and colon tissues were rapidly removed. Levels of myeloperoxidase(MPO),tumor necrosisfactor(TNF)-α,interleukin(IL)-10,malondialdehyde,and inducible nitric oxide synthase(i NOS) were measured in colon tissue.RESULTS: The DAI was lower in the kefir-colitis group than in the colitis group(on the 3rd and 5th days of colitis induction; P < 0.01). The DAI was also significantly higher in the colitis group between days 2 and 6 of colitis induction when compared to the normal control and kefir-control groups. The DAI was statistically higher only on the 6th day in the kefircolitis group when compared to that in the normal control groups. Increased colon weight and decreased colon length were observed in colitis-induced rats. Mean colon length in the colitis group was significantly shorter than that of the kefir-control group. Kefir treatment significantly decreased histologic colitis scores(P < 0.05). MPO activity in the colitis group was significantly higher than in the kefir-control group(P < 0.05). Kefir treatment significantly reduced the DSS colitis-induced TNF-α increase(P < 0.01). No statistically significant differences were observed among groups for IL-10 and MDA levels. Colon tissue i NOS levels in the colitis group were significantly higher than those in the control and kefir-colitis groups(P < 0.05).CONCLUSION: Kefir reduces the clinical DAI and histologic colitis scores in a DSS-induced colitis model,possibly via reduction of MPO,TNF-α,and i NOS levels. | Altug Senol Mehmet Isler Recep Sutcu Mete Akin Ebru Cakir Betul M Ceyhan M Cem Kockar | 2015 | World Journal of Gastroenterology2015，21，46： | 3 |
| 5 | Penile length and somatometric parameters: a study in healthy young Turkish men显示文摘这研究的目的是决定平均阴茎长度并且在一组年轻、健康的土耳其语的人调查在阴茎长度和 somatometric 参数之间的关系。1132 个人的一个总数在学习被包括。这些题目的年龄,高度和重量被记录。阴茎长度处于松驰、拉长的状态被测量。在阴茎长度和 somatometric 参数之间的关联被分析。这些题目的吝啬的年龄是 20.3 卤 0 .9 年。处于松驰、拉长的状态的吝啬的阴茎长度是 9.3 卤 1 .3 和 13.7 卤 1 .6 厘米,分别地(P < 0.001 ) 。在松驰、拉长的阴茎长度之间有积极关联(r=0.800, P < 0.001 ) 。吝啬的阴囊的体积是 22.0 卤 2 .8 cm3。弱积极关联在阴茎长度和吝啬的阴囊的体积之间被检测(为松驰的阴茎长度的 r=0.143 和为拉长的阴茎长度的 r=0.140, P < 0.001 为两个) 。同样,弱积极关联在阴茎长度之间被发现(松驰、拉长) 并且高度,重量和身体团索引,分别地(P < 0.001,为所有) 。这些结果证明 somatometric 参数与阴茎长度被相关。我们相信进一步的研究将关于原因的关系提供更多的信息。 | Yllmaz Asian Ali Atan Ali Oemur Aydm Varol Nalcacloglu Altug Tuncel Ates Kadloglu | 2011 | Asian Journal of Andrology2011，13，2： | 3 |
| 6 | Double-layer graphene for enhanced tunable infrared plasmonics显示文摘Graphene is emerging as a promising material for photonic applications owing to its unique optoelectronic properties.Graphene supports tunable,long-lived and extremely confined plasmons that have great potential for applications such as biosensing and optical communications.However,in order to excite plasmonic resonances in graphene,this material requires a high doping level,which is challenging to achieve without degrading carrier mobility and stability.Here,we demonstrate that the infrared plasmonic response of a graphene multilayer stack is analogous to that of a highly doped single layer of graphene,preserving mobility and supporting plasmonic resonances with higher oscillator strength than previously explored single-layer devices.Particularly,we find that the optically equivalent carrier density in multilayer graphene is larger than the sum of those in the individual layers.Furthermore,electrostatic biasing in multilayer graphene is enhanced with respect to single layer due to the redistribution of carriers over different layers,thus extending the spectral tuning range of the plasmonic structure.The superior effective doping and improved tunability of multilayer graphene stacks should enable a plethora of future infrared plasmonic devices with high optical performance and wide tunability. | Daniel Rodrigo Andreas Tittl Odeta Limaj F Javier García de Abajo Valerio Pruneri Hatice Altug | 2017 | Light(Science & Applications)2017，6，1： | 3 |
| 7 | 真空辅助熔模铸造制备A6063/SiC-B_4C混杂复合材料(英文)显示文摘采用真空辅助熔模铸造技术制备A6063/SiC-B4C混杂复合材料。首先,采用平均粒径分别为60μm和55μm、质量比为85%和15%的SiC和B4C粉末制备圆柱形的SiC-B4C预制块。然后,将预制块放入圆柱形石膏粘结块熔模中,在真空辅助铸造机中将A6063铝熔体浸渗到预制块中。采用阿基米德方法测定预制块中的孔隙度。对制备的复合材料进行硬度测试、图像分析、SEM观察和EDX成分分析。结果表明,采用真空辅助熔模铸造技术,铝熔体能将够成功地浸渗到预制块中。 | Alptekin KISASOZ Kerem Altug GULER Ahmet KARAASLAN | 2012 | Transactions of Nonferrous Metals Society of China2012，22，7： | 2 |
| 8 | Investigation of carbon contamination in lost foam castings of low carbon steel显示文摘Lost foam casting(LFC) process is a special casting method in which polymeric foam patterns with refractory coatings are utilized as a mould component. In this work, four types of foam: expandable polyethylene(EPE), expandable polypropylene(EPP) and expandable polystyrene(EPS) foams with two different densities were employed as pattern materials. LFC and conventional green sand mould casting methods were used to cast a low carbon steel, A216 Grade WCB. Both casting processes were carried out at 1,580 °C. Chemical analysis results showed that the carbon contamination level was high and was influenced by pattern type. Metallographic investigations revealed a significant increase in the percentage of pearlite phase in all LFC samples. Densities of manufactured samples were calculated in order to evaluate porosity of the products. It was determined that the densities of the LFC samples were lower than the green sand mould cast reference sample(RS). Vickers hardness tests were also carried out and increments in hardness values with increased carbon content was observed. | Oznur Kilic Serhat Acar Alptekin Kisasoz Kerem Altug Guler | 2018 | China Foundry2018，15，5： | 2 |
| 9 | Nanoplasmonic mid-infrared biosensor for in vitro protein secondary structure detection显示文摘Plasmonic nanoantennas offer new applications in mid-infrared(mid-IR)absorption spectroscopy with ultrasensitive detection of structural signatures of biomolecules,such as proteins,due to their strong resonant near-fields.The amide I fingerprint of a protein contains conformational information that is greatly important for understanding its function in health and disease.Here,we introduce a non-invasive,label-free mid-IR nanoantenna-array sensor for secondary structure identification of nanometer-thin protein layers in aqueous solution by resolving the content of plasmonically enhanced amide I signatures.We successfully detect random coil to crossβ-sheet conformational changes associated withα-synuclein protein aggregation,a detrimental process in many neurodegenerative disorders.Notably,our experimental results demonstrate high conformational sensitivity by differentiating subtle secondary-structural variations in a nativeβ-sheet protein monolayer from those of crossβ-sheets,which are characteristic of pathological aggregates.Our nanoplasmonic biosensor is a highly promising and versatile tool for in vitro structural analysis of thin protein layers. | Dordaneh Etezadi John B Warner IV Francesco S Ruggeri Giovanni Dietler Hilal A Lashuel Hatice Altug | 2017 | Light(Science & Applications)2017，6，1： | 2 |
| 10 | T6热处理对触变锻造加低过热铸造制备的A356和A380铝合金的影响(英文)显示文摘研究T6热处理对触变锻造A356和A380铝合金的影响。采用低过热铸造(LSC)技术制备用于触变锻造的样品。为了获得等轴晶粒并防止枝晶生长,将样品在高于液相温度20°C时进行浇铸,将浇铸坯料再加热不同时间(20~80 min)后进行触变锻造,变形量为50%,再将触变锻造后的A356和A380铝合金样品进行T6热处理。用光学显微镜、能量弥散X射线谱仪、扫描电镜和布氏硬度仪对经触变锻造、固溶处理和时效处理后样品的显微组织和硬度变化进行检测。结果表明,T6热处理后合金的显微组织更均匀,并分别在A356和A380坯料中形成了新的析出相Mg_2Si和Al_2Cu。相应地,经过人工时效后,样品的硬度大幅度提高,A356铝合金的硬度达到HB 93,A380铝合金的硬度达到HB 120。 | Ridvan GECU Serhat ACAR Alptekin KISASOZ Kerem ALTUG GULER Ahmet KARAASLAN | 2018 | Transactions of Nonferrous Metals Society of China2018，28，3： | 2 |
| 11 | Fano resonant ring/disk plasmonic nanocavities on conducting substrates for advanced biosensing显示文摘 | Cetin A E Altug H | 2012 | ACS Nano2012，，6： | 1 |
| 12 | Increasing driving safety with a multiple vehicle detection and tracking system using ongoing vehicle shadow information显示文摘 | AYTEKIN B ALTUG E | 2010 | IEEE International Conference on Systems Man and Cybernetics2010，25，4： | 1 |
| 13 | Effects of pattern coating and vacuum assistance on porosity of aluminium lost foam castings显示文摘 | Kerem Altug Guler Alptekin Kisasoz Ahmet Karaaslan | 2014 | Russ J Non-Ferrous Met2014，55，5： | 1 |
| 14 | The influence of subthalamic nucleus deep brain stimulation on physical,emotional,cognitive functions and daily living activities in patients with Parkinson's disease显示文摘 | Altug F Acar F Acar G | 2011 | Turk Neurosurg2011，21，2： | 1 |
| 15 | Oral versus intravenousibuprofen for patent ductus arteriosus closure: A randomisedcontrolled trial in extremely low birthweight infants显示文摘 | Erdeve O Yurttutan S Altug N | 2012 | Arch DisChild Fetal Neonatal Ed*2012，97，4： | 1 |
| 16 | Photonic crystal nanocavity array laser显示文摘 | Altug H Vukovic J | 2005 | Optics Express2005，13，： | 1 |
| 17 | Enan- tiospecific ( + )-and ( -)-germacrene D synthases, cloned from goldenrod, reveal a functionally active va- riant of the universal isoprenoid-biosynthesis aspartate- rich motif显示文摘 | PROSSER I ALTUG I G PHILLIPS A L | 2004 | Arch Biochem Biophys2004，432，2： | 1 |
| 18 | Evidence for the involvement of peroxynitrite in ischaemic preconditioning in rat isolated hearts显示文摘 | Altug S Demiryurek AT Kane KA | 2000 | Br J Pharmacol2000，130，： | 1 |
| 19 | Treatment rationale and study design for a phaseⅢ,double-blind,placebo-control ed study of maintenance pemetrexed plus best supportive care versus best supportive care immediately following induction treatment with pemetrexed plus cisplatin for advanced n显示文摘 | Paz-Ares LG Altug S Vaury AT | | 0，，： | 1 |
| 20 | EKF Based Attitude Estimation and Stabilizationof a Quadrotor UAV Using Vanishing Points in Catadioptric Images显示文摘 | Tarhan M Altug E | 2011 | Journal of Intelligent and Robotic Systems2011，62，34： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员