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| 1 | Tumor size as a prognostic factor in patients with advanced gastric cancer in the lower third of the stomach显示文摘AIM: To explore the impact of tumor size on outcomes in patients with advanced gastric cancer in the lower third of the stomach. METHODS: We retrospectively analyzed the clinical records of 430 patients with advanced gastric cancer in the lower third of the stomach who underwent distal subtotal gastrectomy and D2 lymphadenectomy in our hospital from January 1998 to June 2004. Receiver-operating characteristic (ROC) curve analysis was used to determine the appropriate cutoff value for tumor size, which was measured as maximum tumor diameter. Based on this cutoff value, patients were divided into two groups: those with large-sized tumors (LSTs) and those with small-sized tumors (SSTs). The correlations between other clinicopathologic factors and tumor size were investigated, and the 5-year overall survival (OS) rate was compared between the two groups. Potential prognostic factors were evaluated by univariate KaplanMeier survival analysis and multivariate Cox's propor-tional hazard model analysis. The 5-year OS rates in the two groups were compared according to pT stage and pN stage. RESULTS: The 5-year OS rate in the 430 patients with advanced gastric cancer in the lower third of the stomach was 53.7%. The mean ± SD tumor size was 4.9 ± 1.9 cm, and the median tumor size was 5.0 cm. ROC analysis indicated that the sensitivity and specificity results for the appropriate tumor size cutoff value of 4.8 cm were 80.0% and 68.2%, respectively (AUC=0.795, 95%CI: 0.751-0.839, P=0.000). Using this cutoff value, 222 patients (51.6%) had LSTs (tumor size ≥ 4.8 cm) and 208 (48.4%) had SSTs (tumor size<4.8 cm). Tumor size was significantly correlated with histological type (P=0.039), Borrmann type (P=0.000), depth of tumor invasion (P=0.000), lymph node metastasis (P=0.000), tumor-nodes metastasis stage (P=0.000), mean number of metastatic lymph nodes (P=0.000) and metastatic lymph node ratio (P=0.000). Patients with LSTs had a significantly lower 5-year OS rate than those with SSTs (37.1% vs 63.3%, P=0.000). Univariate analysis showed that depth of tumor invasion (c 2=69.581, P=0.000), lymph node metastasis (c 2=138.815, P=0.000), tumor size (c 2=78.184, P=0.000) and metastatic lymph node ratio (c 2=139.034, P=0.000) were significantly associated with 5-year OS rate. Multivariate analysis revealed that depth of tumor invasion (P=0.000), lymph node metastasis (P=0.019) and tumor size (P=0.000) were independent prognostic factors. Gastric cancers were divided into 12 subgroups: pT2N0; pT2N1; pT2N2; pT2N3; pT3N0; pT3N1; pT3N2; pT3N3; pT4aN0; pT4aN1; pT4aN2; and pT4aN3. In patients with pT2-3N3 stage tumors and patients with pT4a stage tumors, 5-year OS rates were significantly lower for LSTs than for SSTs (P<0.05 each), but there were no significant differences in the 5-year OS rates in LST and SST patients with pT23N0-2 stage tumors (P > 0.05). CONCLUSION: Using a tumor size cutoff value of 4.8cm, tumor size is a prognostic factor in patients with pN3 stage or pT4a stage advanced gastric cancer located in the lower third of the stomach. | Hong-Mei Wang, Chang-Ming Huang, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Jun Lu, Department of Gastric Surgery, Affiliated Union Hospital of Fujian Medical University, Fuzhou 350001, Fujian Province, China Author contributions: Wang HM and Huang CM conceived of the study, analyzed the data, and drafted the manuscript Zheng CH, Li P and Xie JW helped revise the manuscript critically for important intellectual content Wang JB, Lin JX and Lu J helped collect data and design the study and all authors read and approved the final manuscript. | 2012 | World Journal of Gastroenterology2012，18，38： | 15 |
| 2 | 显示文摘 | Mirror on the Wall: You're Omnidirectional After All | 1998 | Science1998，282，： | 1 |
| 3 | Three natural zircon standards for U-Th-Pb, Lu-Hf, trace element and REE analyses显示文摘 | Wiedenbeck M Alle P Corfu F | 1995 | Creostan- dards Newsletter1995，19，1： | 1 |
| 4 | Three Natural Zircon Standards for U-Th-Pb, Lu-Hf, Trace Element and REE Analyses 显示文摘 | Wiedenbeck M Alle P Corfu F | 1995 | Geostandards Newsletter1995，19，1： | 1 |
| 5 | Telomere length is shorter in healthy offspring of subjects with coronary artery disease: support for the telomere hypothesis显示文摘 | Brouilette SW Whittaker A Stevens SE van der Harst P Good- all AH Samani NJ | 2008 | Heart2008，94，4： | 1 |
| 6 | Therapeutic po- tential of vasopressin receptor antagonists 显示文摘 | All F Guglin M Vaitkevicius P | 2007 | Drugs2007，67，6： | 1 |
| 7 | Three natural zircon standards for U-Th-Pb, Lu-Hf, trace element and REE analyses显示文摘 | Wiedenbeck M Alle P Corfu F | 1995 | Geostandards Newsletter1995，19，： | 1 |
| 8 | Hastening, delaying, or averting sudden death of quantum entanglement 显示文摘 | RAU A R P ALl M ALBER G | 2008 | Europhys Lett2008，，40： | 1 |
| 9 | Molecular and antigenic comparison of Ehrllchia canis isolates from dogs, ticks, and a human in Venezuela显示文摘 | Unver All Miriam P Nelson O | 2001 | J Clin Microbiol2001，39，： | 1 |
| 10 | Effect of silicate fertilizer on reducing methane emission during rice cultivation显示文摘 | All M A Lee C H Kin P J | 2008 | Biology and Fertility of Soils2008，44，59： | 1 |
| 11 | Exercise preconditioning reduces neuronal apoptosis in stroke by up-regulating heat shock protein-70 (heat shock protein-72) and extracellular- signal-regulated-kinase 1/2显示文摘 | Liebeh B Papapetrou P All A | 2010 | Neuroscience2010，166，4： | 1 |
| 12 | Chemorheology of t her mal: An overview显示文摘 | all ey P J Mackay M E | 1996 | Poly mer Engineeri ng and Science1996，36，5： | 1 |
| 13 | Application of isotope dilution for precise measurement of Zr/Hf and 176Hf/177Hf ratios by mass spectrometry (ID-TIMS/ID-MC-ICP-MS) 显示文摘 | David K Birck J L Telouk P Allègre C J | 1999 | Chem Geol1999，157，12： | 1 |
| 14 | Evaluation of silicate iron slag amend ment on reducing methane emission from flood water rice farming 显示文摘 | All M A Oh J H Kim P J | 2008 | Agriculture Ecosystems and Environment2008，12，821： | 1 |
| 15 | Three natural zircon standards for U-Th-Pb, Lu-Hfm trace element and REE analyses 显示文摘 | Widenbeck M Alle P Corfu F | 1995 | Geostandards and GeoanalyticalResearch1995，19，1： | 1 |
| 16 | Assessment of the Zr/Hf fractionation in oceanic basalts and continental materials during petrogenetic processes显示文摘 | K David P Schiano C.J Allègre | 2000 | Earth and Planetary Science Letters2000，，3： | 1 |
| 17 | Three natural zircon standards for U-Th-Pb, Lu-Hf, trace element and REE analyses 显示文摘 | Wiedenbeck M Alle P Corfu F | 1995 | Geostand newsl1995，19，： | 1 |
| 18 | Bioinformatics and management sci- ence: Some common tools and techniques显示文摘 | All E A Susan P H | 2004 | Operations Research2004，52，2： | 1 |
| 19 | Towards a conceptual framework for assessing the effectiveness of digital game- based learning显示文摘 | All A Nu Ez Castellar E P Van Looy J | 2015 | Computers & Education2015，88，： | 1 |
| 20 | Three natural zircon standards for U-Th-Pb, Lu-Hf, trace ele- ment and REE analyses 显示文摘 | WIEDENBECK M ALLE P CORFU F | 1995 | Geostandards and Geoana- lyrical Research1995，19，： | 1 |
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