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| 1 | A unique sequence in the N-terminal regulatory region controls the nuclear localization of KLF8 by cooperating with the C-terminal zinc-fingers显示文摘Kr 眉 p 像像素的因素 8 (KLF8 ) 抄写因素在房间周期前进起一个关键作用, oncogenic 转变,对间充质的转变和侵略上皮。然而,它的原子本地化信号(NLS ) 没被识别。有另外的 KLF monopartite NLS (mNLS ) 和 C2H2 锌手指(ZF ) 的 KLF8 份额,哪个被显示了是为一些另外的 KLF 的 NLS。在这份报告,用指导 PCR 的 mutagenesis 和 immunofluorescent 显微镜学,我们显示出 mNLSs,任何单个 ZF 的删除,或变化的那混乱 Zn2+ 有约束力或联系 DNA 主题没影响 KLF8 的原子本地化。删除 > 然而,从 C 终点的 1.5 ZF 引起了 KLF8 的细胞质的累积。令人惊讶地,氨基酸(aa ) 的删除 151-200 区域几乎从原子核消除了 KLF8。有 PKC 禁止者的 S165A, K171E 或 K171R 变化,或处理导致了部分细胞质的累积。Co-immunoprecipitation 证明 KLF8 与 importin- 交往了,这个相互作用要求了 ZF 主题。aa 1-150 或 201-261 区域的删除独自没改变原子本地化。BrdU 加入和 cyclin D1 倡导者酶试金作为野类型的 KLF8 证明在原子本地化的 KLF8 异种有缺陷者不能支持 DNA 合成或 cyclin D1 倡导者激活。一起拿,这些结果建议 KLF8 有二 NLS,一包围 S165 和 K171 并且另外的是二双人脚踏车 ZF,它为 KLF8 原子本地化和它的细胞的功能的规定是批评的。 | Tina S Mehta Heng Lu Xianhui Wang Alison M Urvalek Kim-Hang H Nguyen Farah Monzur Jojo D Hammond Jameson Q Ma Jihe Zhao | 2009 | Cell Research2009，19，9： | 10 |
| 2 | Terahertz pulse imaging in archaeology显示文摘在这份报纸介绍的工作在芝加哥大学在东方研究所被执行,在从他们的永久收集的目标上:一具古老的埃及鸟木乃伊和三个古老的闪族语的侵蚀的铜合金目标。我们使用了便携式的、联合纤维的兆兆赫(THz ) 时间域分光镜的成像系统,它允许我们在传播和思考几何学测量标本,和基于时间、基于频率的现在想象模式。结果证实 THz 成像能提供互补信息给那的更早的证据从计算断层摄影术(XRCT ) 木乃伊扫描的 X 光检查可获得,给低密度区域的更好的可视化。另外,我们证明 THz 成像能在金属人工制品区分使矿物化的层。 | J. Bianca JACKSON Julien LABAUNE Rozenn BAILLEUL-LESUER Laura D'ALESSANDRO Alison WHYTE John W. BOWEN Michel MENU Gerard MOUROU | 2015 | Frontiers of Optoelectronics2015，8，1： | 3 |
| 3 | Effect of Ginkgo biloba (EGb 761) and aspirin on platelet aggregation and platelet function analysis among older adults at risk of cardiovascular disease: a randomized clinical trial显示文摘 | Christopher D Gardner James L Zehnder Alison J Rigby Joel R Nicholus John W Farquhar | 2007 | Blood Coagulation & Fibrinolysis2007，，8： | 2 |
| 4 | Methods of Operative Fixation of the Acromio-Clavicular Joint: A Biomechanical Comparison显示文摘 | Alison J McConnell Daniel J Yoo Rad Zdero Emil H Schemitsch Michael D McKee | 2007 | Journal of Orthopaedic Trauma2007，，4： | 2 |
| 5 | CD133:molecule of the moment显示文摘 | Mizrak D Brittan M Alison MR | 2008 | J Pathol2008，214，： | 1 |
| 6 | The prognostic significance of thrombocytosis in epithelial ovarian carcinoma显示文摘 | Andrew J Li Alison C Madden Ilana Cass Ronald S Leuchter Leo D Lagasse Beth Y Karlan | 2003 | Gynecologic Oncology2003，，1： | 1 |
| 7 | Educating undergraduate medical students about oncology : a literature review 显示文摘 | Judith C Jane D Alison J | 2006 | J Clin Oncol2006，24，12： | 1 |
| 8 | The American phytopathological society molecular evidence that the extracellular cutinase PbcIs required for pathogenicity of pyrenopeziza brassicae on oilseed显示文摘 | Li D H Alison M A Johnstone K | 2003 | RapMPMI2003，16，6： | 1 |
| 9 | Antiepileptie drugs:Are women aware of interactions with oral contraceptivesand potential teratogenicity?显示文摘 | Alison M P Anne R D Kritzer J | 2009 | Epilepsy & Behavior2009，4，14： | 1 |
| 10 | Nucleotide sequence and analysis and comparison of the structural genes for Shiga-like toxin i and Shiga-like toxin Ⅱ encoded by bacteriophages from Escherichia coli 933显示文摘 | MATTHEW P J ROGER J H ALISON D O | 1987 | FEMS Microbiology Letters1987，44，10： | 1 |
| 11 | Hepatotoxicity in an African antiretroviral therapy cohort: the effect of tuberculosis and hepatitis B显示文摘 | Christopher J Hoffmann Salome Charalambous Chloe L Thio Desmond J Martin Lindiwe Pemba Katherine L Fielding Gavin J Churchyard Richard E Chaisson Alison D Grant | 2007 | AIDS2007，，10： | 1 |
| 12 | Dissolved organic carbon and nitrogen relationships in forest litter as affected by nitrogen deposition 显示文摘 | Alison H M John D A | 2000 | Soil biology and biochemistry2000，32，： | 1 |
| 13 | Cultivar and environment effects on annual ryegrass forage yield,yield distribution,and nutritive value显示文摘 | Redfearn D D Venuto B C Pitman W D Alison M W Ward J D | 2002 | Crop Science2002，42，6： | 1 |
| 14 | Fertlizer nitrogen isotope signatures 显示文摘 | ALISON S B SIMON D K | 2007 | Isotopes in Environmental and Health Studies2007，43，： | 1 |
| 15 | The many fac- ets of Notch ligands 显示文摘 | Brendan D souza Alison Miyamoto Gerry Weinmaster | 2008 | Oncogene2008，127，38： | 1 |
| 16 | Relationship among nigrostriatal denervation,parkinsonism,and dyskinesias in the MPTP primate model显示文摘 | DONATO A DI MONTE M D ALISON MCCORMACK | 2000 | Mov Disord2000，15，3： | 1 |
| 17 | A Case Study of Organizational Capac- ity in Nonprofit Community Sport 显示文摘 | Katie M Alison D | 2009 | Journal of Sport Man- agement2009，，45： | 1 |
| 18 | Renal hypoplasia: lessons from Pax2 显示文摘 | Alison D Jacklyn Q and Paul G | 2006 | Pediatr Nephrol2006，21，1： | 1 |
| 19 | HIV transmission and high rates of late diagnoses among adults aged 50 years and over显示文摘 | Ruth D Smith Valerie C Delpech Alison E Brown Brian D Rice | 2010 | AIDS2010，，13： | 1 |
| 20 | Extracellular Matrix Associated Protein CYR61 is Linked to Prostate Cancer Development显示文摘 | Katherine B. D’Antonio Antoun Toubaji Roula Albadine Alison M. Mondul Elizabeth A. Platz George J. Netto Robert H. Getzenberg | 2010 | The Journal of Urology2010，，4： | 1 |
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