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| 1 | Non invasive blood flow measurement in cerebellum detects minimal hepatic encephalopathy earlier than psychometric tests显示文摘AIM: To assess whether non invasive blood flow measurement by arterial spin labeling in several brain regions detects minimal hepatic encephalopathy. METHODS: Blood flow(BF) was analyzed by arterial spin labeling(ASL) in different brain areas of 14 controls, 24 cirrhotic patients without and 16 cirrhotic patients with minimal hepatic encephalopathy(MHE). Images were collected using a 3 Tesla MR scanner(Achieva 3T-TX, Philips, Netherlands). Pulsed ASL was performed. Patients showing MHE were detected using the battery Psychometric Hepatic Encephalopathy Score(PHES) consisting of five tests. Different cognitive and motor functions were also assessed: alterations in selective attention were evaluated using the Stroop test. Patients and controls also performed visuo-motor and bimanual coordination tests. Several biochemical parameters were measured: serum pro-inflammatory interleukins(IL-6 and IL-18), 3-nitrotyrosine, cGMP and nitrates+nitrites in plasma, and blood ammonia. Bivariate correlations were evaluated.RESULTS: In patients with MHE, BF was increased in cerebellar hemisphere(P = 0.03) and vermis(P = 0.012) and reduced in occipital lobe(P = 0.017). BF in cerebellar hemisphere was also increased in patients without MHE(P = 0.02). Bimanual coordination was impaired in patients without MHE(P = 0.05) and much more in patients with MHE(P < 0.0001). Visuo-motor coordination was impaired only in patients with MHE(P < 0.0001). Attention was slightly affected in patients without MHE and more strongly in patients with MHE(P< 0.0001). BF in cerebellar hemisphere and vermis correlated with performance in most tests of PHES [(number connection tests A(NCT-A), B(NCT-B)and line tracing test] and in the congruent task of Stroop test. BF in frontal lobe correlated with NCT-A. Performance in bimanual and visuomotor coordination tests correlated only with BF in cerebellar hemisphere. BF in occipital lobe correlates with performance in the PHES battery and with CFF. BF in cerebellar hemisphere correlates with plasma cGMP and nitric oxide(NO) metabolites. BF in vermis cerebellar also correlates with NO metabolites and with 3-nitrotyrosine. IL-18 in plasma correlates with BF in thalamus and occipital lobe.CONCLUSION: Non invasive BF determination in cerebellum using ASL may detect MHE earlier than the PHES. Altered NO-cGMP pathway seems to be associated to altered BF in cerebellum. | Vicente Felipo Amparo Urios Carla Giménez-Garzó Omar Cauli Maria-Jesús Andrés-Costa Olga González Miguel A Serra Javier Sánchez-González Roberto Aliaga Remedios Giner-Durán Vicente Belloch Carmina Montoliu | 2014 | World Journal of Gastroenterology2014，20，33： | 12 |
| 2 | Thermodynamic and topological instability approaches for forecasting glass-forming ability in the ternary Al-Ni-Y system 显示文摘 | DE OLIVEIRA M F ALIAGA L C R BOLFARINI C BOTTA W J KIMINAMI C S | 2008 | J Alloys Comp2008，464，： | 1 |
| 3 | Identification and quantification of DNA adducts in the oral tissues of mice treated with the environmental carcinogen dibenzo pyrene by HPLC-MS/MS 显示文摘 | Zhang S M Chert K M Aliaga C | 2011 | Chem Res Toxicol2011，24，8： | 1 |
| 4 | Utility of interenal Doppler ultrasound in the diagnosis of renal artery stenosis显示文摘 | Ripollés T Aliaga R Morote V | | 0，，01： | 1 |
| 5 | Flotation of high-grade fluorite in a short column under negative bias regime显示文摘 | Aliaga W Sampaio C H Brum I A S | 2006 | Minerals En- gineering2006，19，13： | 1 |
| 6 | Effects of the high-efficacy 5-HT1A receptor agonist,F 13640 in the formalin pain model:a c-Fos study显示文摘 | BURITOVA J LARRUE S ALIAGA M | 2005 | Eur J Pharmacol2005，514，23： | 1 |
| 7 | Identification and quantification of DNA adducts in the oral tissues of mice treated with the environmental carcinogen dibenzo pyrene by HPLC-MS/MS 显示文摘 | Zhang S M Chen K M Aliaga C | 2011 | Chemical Research in Toxicology2011，24，8： | 1 |
| 8 | The effect of selection for growth rate and slaughter age on carcass composition and meat quality traits in rabbits显示文摘 | HERNNDEZ P ALIAGA S PLA M | 2004 | Journal of Animal Science2004，82，11： | 1 |
| 9 | Flotation of high-grade fluorite in a short column under negative bias regime显示文摘 | Aliaga W Sampaio C H Brum I A S | 2006 | Minerals Engineering2006，19，13： | 1 |
| 10 | Flotation of high-grade fluorite in a short column un- der negative bias regime显示文摘 | ALIAGA W SAMPAIO C H BRUM I A S | 2006 | Minerals Engineering2006，19，13： | 1 |
| 11 | Effects of atrazine on microbial activity in semiarid soil显示文摘 | MORENOA J L ALIAGA A NAVARRO S | 2007 | Applied Soil Ecology2007，35，1： | 1 |
| 12 | Surface chemistry of room temperature ionic liquids 显示文摘 | ALIAGA C SANTOS C S BALDELLI S | 2007 | Physical Chemistry Chemical Physics2007，9，： | 1 |
| 13 | Effects or cows, milks on nutritive utilization phosphorus in rats with intestinal of caM- resection显示文摘 | Campos of goats' um and M S Lopez Aliaga I Alferez M J | 2003 | Br J Nutr2003，90，1： | 1 |
| 14 | Effects of the high-efficacy 5-HT1A receptor agonist, F13640 in the formalin pain model: a c-Fos study 显示文摘 | BURITOVA J LARRUEA S ALIAGA M | 2005 | Eur J Pharmacol2005，514，23： | 1 |
| 15 | Flotation ofhigh-grade fluorite in a short column under negative bias regime显示文摘 | ALIAGA W SAMPAIO C H BRUM I A S | 2006 | Minerals Engineering2006，19，13： | 1 |
| 16 | Diagnostic yield and safety of CT scans in ICU显示文摘 | Aliaga M ForeI JM De Bourmont S | 2015 | Intensive Care Med2015，41，3： | 1 |
| 17 | Flotation of high-grade fluorite in a short column under negative bias regime显示文摘 | Aliaga W Sampaio C H Brum I A S | 2006 | Minerals Engineering2006，19，13： | 1 |
| 18 | Flotation of high-grade fluorite in a short column under negative bias regime显示文摘 | W Aliaga C H Sampaio I A S Brum | 2006 | Minerals engineering2006，19，13： | 1 |
| 19 | Flotation of high-grade fluorite in a short column under negative bias regime 显示文摘 | Aliaga W Sampaio C H Brum I A S | 2006 | Minerals Engineering2006，19，13： | 1 |
| 20 | Immunodominant role of CCHA subunit of Concholepas hemocyanin is associated with unique biochemical properties显示文摘 | María Inés Becker Alejandra Fuentes Miguel Del Campo Augusto Manubens Esteban Nova Harold Oliva Fernando Faunes María Antonieta Valenzuela Marcelo Campos-Vallette Alvaro Aliaga Jorge Ferreira Alfredo E. De Ioannes Pablo De Ioannes Bruno Moltedo | 2008 | International Immunopharmacology2008，，3： | 1 |
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