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	题名	作者	年代	出处	被引量
1	Non invasive blood flow measurement in cerebellum detects minimal hepatic encephalopathy earlier than psychometric tests显示文摘AIM: To assess whether non invasive blood flow measurement by arterial spin labeling in several brain regions detects minimal hepatic encephalopathy. METHODS: Blood flow(BF) was analyzed by arterial spin labeling(ASL) in different brain areas of 14 controls, 24 cirrhotic patients without and 16 cirrhotic patients with minimal hepatic encephalopathy(MHE). Images were collected using a 3 Tesla MR scanner(Achieva 3T-TX, Philips, Netherlands). Pulsed ASL was performed. Patients showing MHE were detected using the battery Psychometric Hepatic Encephalopathy Score(PHES) consisting of five tests. Different cognitive and motor functions were also assessed: alterations in selective attention were evaluated using the Stroop test. Patients and controls also performed visuo-motor and bimanual coordination tests. Several biochemical parameters were measured: serum pro-inflammatory interleukins(IL-6 and IL-18), 3-nitrotyrosine, cGMP and nitrates+nitrites in plasma, and blood ammonia. Bivariate correlations were evaluated.RESULTS: In patients with MHE, BF was increased in cerebellar hemisphere(P = 0.03) and vermis(P = 0.012) and reduced in occipital lobe(P = 0.017). BF in cerebellar hemisphere was also increased in patients without MHE(P = 0.02). Bimanual coordination was impaired in patients without MHE(P = 0.05) and much more in patients with MHE(P < 0.0001). Visuo-motor coordination was impaired only in patients with MHE(P < 0.0001). Attention was slightly affected in patients without MHE and more strongly in patients with MHE(P< 0.0001). BF in cerebellar hemisphere and vermis correlated with performance in most tests of PHES [(number connection tests A(NCT-A), B(NCT-B)and line tracing test] and in the congruent task of Stroop test. BF in frontal lobe correlated with NCT-A. Performance in bimanual and visuomotor coordination tests correlated only with BF in cerebellar hemisphere. BF in occipital lobe correlates with performance in the PHES battery and with CFF. BF in cerebellar hemisphere correlates with plasma cGMP and nitric oxide(NO) metabolites. BF in vermis cerebellar also correlates with NO metabolites and with 3-nitrotyrosine. IL-18 in plasma correlates with BF in thalamus and occipital lobe.CONCLUSION: Non invasive BF determination in cerebellum using ASL may detect MHE earlier than the PHES. Altered NO-cGMP pathway seems to be associated to altered BF in cerebellum.	Vicente Felipo Amparo Urios Carla Giménez-Garzó Omar Cauli Maria-Jesús Andrés-Costa Olga González Miguel A Serra Javier Sánchez-González Roberto Aliaga Remedios Giner-Durán Vicente Belloch Carmina Montoliu	2014	World Journal of Gastroenterology2014，20，33：	12
2	Automatic extraction of manhattan-world building masses from 3D laser range scans显示文摘	Vanegas C A Aliaga D G Benes B	2012	IEEE Transactions on Visualization and Computer Graphics2012，18，10：	1
3	Automatic Extraction of Manhattan-World Building Masses from 3D Laser Range Scans显示文摘	Carlos A Vanegas Daniel G Aliaga Bedrich Benes	2012	IEEE Trans on Visualization and Computer Graphics2012，18，10：	1
4	Breast cancer models to study the expression of estrogen receptors with small animal PET imaging 显示文摘	ALIAGA A ROUSSEAU J A OUELLETTE R	2004	Nucl Med Biol2004，31，6：	1
5	Histopathology of psoriasis treated with zinc pyrithione 显示文摘	Aliaga A	2001	Am J De-rmatopathol2001，23，2：	1
6	A combination therapy of calcipotriol cream and PUVA reduces the UVA dose and improves the response of psoriasis vulgaris显示文摘	Torras H Aliaga A Lopez-Estebaranz JL	2004	J Dermatolog Treat2004，15，2：	1
7	Flotation of high-grade fluorite in a short column under negative bias regime显示文摘	Aliaga W Sampaio C H Brum I A S	2006	Minerals En- gineering2006，19，13：	1
8	Interactive reconfiguration of urban layouts 显示文摘	ALIAGA D G BENS B VANEGAS C A	2008	IEEE Computer Graphics and Applications2008，28，4：	1
9	Smooth D G,Lastua transitionsin Texture-Based Simplification显示文摘	Aliaga A A	1998	Computer& Graphics1998，22，5：	1
10	A small animal positron emission tomography study of the effect of chemo- therapy and hormonal therapy on the uptake of 2-deoxy-2- fluoro-D-glucose in murine models of breast cancer 显示文摘	Aliaga A Rousseau JA Cadorette J	2007	Mol Imaging Biol2007，9，3：	1
11	Kinetics and mechanism of the reaction of a nitroxide radical (Tempol) with a phenolic antioxidant 显示文摘	Aliaga C Lissi E A Augusto O	2003	Free Radical Research2003，37，3：	1
12	Microcultivation ofanaerobic bacteria single cells entrapped in alginate mi- crobeads 显示文摘	Borner R A Aliaga M T Mattiasson B	2013	Biotechno Lett2013，35，3：	1
13	BDT:an easy-to-use front-end application for automation of massive docking tasks and complex docking strategies with AutoDock显示文摘	Vague M Anna A Aliagas C	2006	Bioinformatics2006，22，14：	1
14	Modeling the appearance and behavior of urban spaces 显示文摘	VANEGAS C A ALIAGA D G WONKA P MULLER P WADDELL P A WATSON B	2010	Computer Graphics Forum2010，29，1：	1
15	A combination ther- apy of ealeipotriol cream and PUVA reduces the UVA dose and im- proves the response of psoriasis vulgaris 显示文摘	Torras H Aliaga A L6pez-Estebaranz JL	2004	J Dermatolog Treat2004，15，2：	1
16	Histopathology of psoriasis treated with zinc pyrithione显示文摘	Aliaga A	2001	Am J Dermatopathol2001，23，2：	1
17	Flotation of high-grade fluorite in a short column under negative bias regime显示文摘	Aliaga W Sampaio C H Brum I A S	2006	Minerals Engineering2006，19，13：	1
18	Style grammars for interactive visualization of architecture显示文摘	Aliaga D Rosen G Bekins P A	2007	IEEE Transactions on Visualization and Computer Graph- ics2007，13，4：	1
19	Functionalization of Ag nanoparticles with the bis-acridinium lucigenin as a chemical assembler in the detection of persis- tent organic pollutants by surface-enhanced Raman scattering 显示文摘	Guerrini L Aliaga A E Carcamo J	2008	Analytica Chimica Acta2008，624，：	1
20	Inverse design of urban procedural models 显示文摘	VANEGAS C A GARCIA-DORADO I ALIAGA D G BENES B WADDELL P	2012	ACM Transactions on Graphics2012，31，6：	1

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