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| 1 | Effect of harmless acute pancreatitis score, red cell distribution width and neutrophil/lymphocyte ratio on the mortality of patients with nontraumatic acute pancreatitis at the emergency department显示文摘BACKGROUND: Harmless acute pancreatitis score(HAPS), neutrophile/lymphocyte ratio and red blood cell distribution width(RDW) are used to determine the early prognosis of patients diagnosed with nontraumatic acute pancreatitis in the emergency department(ED).METHODS: Patients diagnosed with acute pancreatitis(K 85.9) in the ED according to the ICD10 coding during one year were included in the study. Patients with chronic pancreatitis and those who had missing data in their files were excluded from the study. Patients who did not have computed tomography(CT) in the ED were not included in the study.RESULTS: Ultimately, 322 patients were included in the study. The median age of the patients was 53.1(IQR=36–64). Of the patients, 68.1%(n=226) had etiological causes of the biliary tract. The mortality rate of these patients within the first 48 hours was 4.3%(n=14). In the logistic regression analysis performed by using Balthazar classification, HAPS score, RDW, neutrophile/lymphocyte ratio, age, diabetes mellitus and systolic blood pressure, the only independent variable in determining mortality was assigned as Balthazar classification(OR: 15; 95% CI: 3.5 to 64.4).CONCLUSIONS: HAPS, neutrophile/lymphocyte ratio and RDW were not effective in determining the mortality of nontraumatic acute pancreatitis cases within the first 48 hours. The only independent variable for determining the mortality was Balthazar classifi cation. | Bedia Gülen Ertan Sonmez Serpil Yaylaci Mustafa Serinken Cenker Eken Ali Dur Figen Tunali Turkdogan ?zgür S?güt | 2015 | World Journal of Emergency Medicine2015，6，1： | 13 |
| 2 | Environmental risk factors for inflammatory bowel diseases: Evidence based literature review显示文摘AIM: To advances in genetics and immunology have contributed to the current understanding of the pathogenesis of inflammatory bowel diseases(IBD). METHODS: The current opinion on the pathogenesis of IBD suggests that genetically susceptible individuals develop intolerance to dysregulated gut microflora(dysbiosis) and chronic inflammation develops as a result of environmental insults. Environmental exposures are innumerable with varying effects during the life course of individuals with IBD. Studying the relationship between environmental factors and IBD may provide the missing link to increasing our understanding of the etiology and increased incidence of IBD in recent years with implications for prevention, diagnosis, and treatment. Environmental factors are heterogeneous and genetic predisposition, immune dysregulation, or dysbiosis do not lead to the development of IBD in isolation. RESULTS: Current challenges in the study of environmental factors and IBD are how to effectively translate promising results from experimental studies to humans in order to develop models that incorporate the complex interactions between the environment, genetics, immunology, and gut microbiota, and limited high quality interventional studies assessing the effect of modifying environmental factors on the natural history and patient outcomes in IBD.CONCLUSION: This article critically reviews the current evidence on environmental risk factors for IBD and proposes directions for future research. | Ayokunle T Abegunde Bashir H Muhammad Owais Bhatti Tauseef Ali | 2016 | World Journal of Gastroenterology2016，22，27： | 11 |
| 3 | Update on the applications and limitations of alpha-fetoprotein for hepatocellular carcinoma显示文摘Alpha-fetoprotein(AFP)is an oncofetal glycoprotein that has been used as a tumor marker for hepatocellular carcinoma(HCC)in combination with ultrasound and other imaging modalities.Its utility is limited because of both low sensitivity and specificity,and discrepancies among the different methods of measurements.Moreover,its accuracy varies according to patient characteristics and the AFP cut-off values used.Combination of AFP with novel biomarkers such as AFP-L3,Golgi specific membrane protein(GP73)and des-gamma-carboxyprothrombin significantly improved its accuracy in detecting HCC.Increased AFP level could also signify severity of hepatic destruction and subsequent regeneration and is commonly observed in patients with acute and chronic liver conditions and cirrhosis.Hereditary and other non-hepatic disorders can also cause AFP elevation. | Hira Hanif Mukarram Jamat Ali Ammu T Susheela Iman Waheed Khan Maria Alejandra Luna-Cuadros Muzammil Muhammad Khan Daryl Tan-Yeung Lau | 2022 | World Journal of Gastroenterology2022，28，2： | 9 |
| 4 | All-silicon carrier accumulation modulator based on a lateral metal-oxide-semiconductor capacitor显示文摘In silicon photonics, the carrier depletion scheme has been the most commonly used mechanism for demonstrating high-speed electro-optic modulation. However, in terms of phase modulation efficiency, carrieraccumulation-based devices potentially offer almost an order of magnitude improvement over those based on carrier depletion. Previously reported accumulation modulator designs only considered vertical metal-oxidesemiconductor(MOS) capacitors, which imposes serious restrictions on the design flexibility and integratability with other photonic components. In this work, for the first time to our knowledge, we report experimental demonstration of an all-silicon accumulation phase modulator based on a lateral MOS capacitor. Using a Mach–Zehnder interferometer modulator with a 500-μm-long phase shifter, we demonstrate high-speed modulation up to 25 Gbit∕s with a modulation efficiency(V_πL_π) of 1.53 V·cm. | KAPIL DEBNATH DAVID J.THOMSON WEIWEI ZHANG ALI Z.KHOKHAR CALLUM LITTLEJOHNS JAMES BYERS LORENZO MASTRONARDI MUHAMMAD K.HUSAIN KOUTA IBUKURO FREOERIC Y.GARDES GRAHAM T,REED SHINICHI SAITO | 2018 | Photonics Research2018，6，5： | 6 |
| 5 | 左心质量与脑磁共振成像和认知功能的关系显示文摘左心室质量(1eft ventricularmass,LVM)被证实可以作为长期暴露于数个危险因素下时造成的靶器官损害的评估标准。有关中年LVM和晚期认知表现之间联系的资料很少。纳入StrongHeart研究(SHS,1993—1995)及其附属的CDCAI(脑血管病及其对美国印第安人的影响)研究(2010—2013)中721名成年研究对象(平均基础年龄56岁),这些人群心血管病风险较高。 | 黄洁 叶鹏 Haring B Omidpanah A Suchy Dicey AM Best LG Verney SP Shibata DK Cole SA Ali T Howard BV Buchwald D Devereux RB | 2017 | 中华高血压杂志2017，25，10： | 4 |
| 6 | Environmental Isotopic Characterization of Groundwater and Surface Water in Northeast Missan Province,South Iraq显示文摘The present work studies the environmental isotopes assess groundwater characteristics of the different parts of the main aquifer in the northeast Missan Province in south of Iraq.Water samples of groundwater and surface water were collected for two dry and wet seasons during the water year of 2011–2012.The study shows that most of the groundwater in the aquifer falls above the global meteoric water line,and all the samples fall below the Mediterranean meteoric water line,indicating that these samples are a mixture of two water types.The tritium content of these samples supports this conclusion.The overall conclusion of this study indicates that there are two sources of groundwater recharge in the studied area:the ephemeral streams(Teeb and Dewerge) and major precipitation sources.According to the tritium levels at or below one tritium unit(TU) obtained from the water,supply wells are highly confined or 'not vulnerable'.Overall,the 3H results imply that recent recharge has taken place during the last four to five decades.In the recharge area,the high tritium content in the southern part of the Teeb area suggests that the recharge originates from rapid infiltration of surface runoff.Therefore,the groundwater resources in the study area should be protected from contamination,because it will influence the aquifer in a relatively short period of time if any contamination enters the recharge areas of the aquifer. | Hussein Badr GHALIB Ali Riza SGüT | 2014 | Acta Geologica Sinica(English Edition)2014，88，4： | 4 |
| 7 | Histone deacetylase inhibitor pre-treatment enhances the efficacy of DNA-interacting chemotherapeutic drugs in gastric cancer显示文摘BACKGROUND The prognosis of gastric cancer continues to remain poor,and epigenetic drugs like histone deacetylase inhibitors(HDACi)have been envisaged as potential therapeutic agents.Nevertheless,clinical trials are facing issues with toxicity and efficacy against solid tumors,which may be partly due to the lack of patient stratification for effective treatments.To study the need of patient stratification before HDACi treatment,and the efficacy of pre-treatment of HDACi as a chemotherapeutic drug sensitizer.METHODS The expression activity of class 1 HDACs and histone acetylation was examined in human gastric cancer cells and tissues.The potential combinatorial regime of HDACi and chemotherapy drugs was defined on the basis of observed drug binding assays,chromatin remodeling and cell death.RESULTS In the present study,the data suggest that the differential increase in HDAC activity and the expression of class 1 HDACs are associated with hypoacetylation of histone proteins in tumors compared to normal adjacent mucosa tissue samples of gastric cancer.The data highlights for the first time that pretreatment of HDACi results in an increased amount of DNA-bound drugs associated with enhanced histone acetylation,chromatin relaxation and cell cycle arrest.Fraction-affected plots and combination index-based analysis show that pre-HDACi chemo drug combinatorial regimes,including valproic acid with cisplatin or oxaliplatin and trichostatin A with epirubicin,exhibit synergism with maximum cytotoxic potential due to higher cell death at low combined doses in gastric cancer cell lines.CONCLUSION Expression or activity of class 1 HDACs among gastric cancer patients present an effective approach for patient stratification.Furthermore,HDACi therapy in pretreatment regimes is more effective with chemotherapy drugs,and may aid in predicting individual patient prognosis. | Ramchandra Vigay Amnekar Shafqat Ali Khan Mudasir Rashid Bharat Khade Rahul Thorat Poonam Gera Shailesh V Shrikhande Duane T Smoot Hassan Ashktorab Sanjay Gupta | 2020 | World Journal of Gastroenterology2020，26，6： | 3 |
| 8 | Evaluation of the safety and effectiveness of direct oral anticoagulants and low molecular weight heparin in gastrointestinal cancer-associated venous thromboembolism显示文摘BACKGROUND Gastrointestinal cancer(GICA)is associated with a higher incidence of venous thromboembolism(VTE)compared to other solid tumors,moreover,recurrent VTE and major bleeding(MB)complications during anticoagulation treatment have an associated increase rate.GICA-VTE remains a challenging clinical scenario with MB concerns for utilization of direct oral anticoagulants(DOAC),especially with active cancer therapies.AIM To evaluate patient risk factors,effectiveness(VTE)and safety(MB)of DOACs and low molecular weight heparin(LMWH)in patients with active GICA-VTE.METHODS A retrospective chart review of patients receiving DOACs and LMWH with GICA and symptomatic or incidental VTE treated at comprehensive cancer center from November 2013 to February 2017 was performed.Inclusion criteria included active GI cancer diagnosed at any stage or treatment+/-6 mo of VTE diagnosis,whom were prescribed 6 mo or more of DOACs or LMWH.The Chi-squared test was used for overall and the Fisher exact test for pairwise comparisons of the proportions of patients experiencing recurrent VTE and MB events.Odds ratios were used to compare the relative odds of the occurrence of the outcome given exposure to the risk factor.RESULTS A total of 144 patients were prescribed anticoagulation,in which 106 fulfilled inclusion criteria apixaban(27.3%),rivaroxaban(34.9%)and enoxaparin(37.7%),and 38 were excluded.Patients median age was 66.5 years at GICA diagnosis and 67 years at CAVTE event,with 62%males,80%Caucasian,70%stage IV,pancreatic cancer(40.5%),30%Khorana Score(≥3 points),and 43.5%on active chemotherapy.Sixty-four percent of patients completed anticoagulation therapy(range 1 to 43 mo).Recurrent VTE at 6 mo was noted in 7.5%(n=3),6.8%(n=2)and 2.7%(n=1)of patients on enoxaparin,apixaban and rivaroxaban,respectively(all P=NS).MB at 6 mo were 5%(n=2)for enoxaparin,6.8%(n=2)for apixaban and 21.6%(n=8)for rivaroxaban(overall P=0.048;vs LMWH P=0.0423;all other P=NS).Significant predictors of a primary or secondary outcome for all anticoagulation therapies included:Active systemic treatment(OR=5.1,95%CI:1.3-19.3),high Khorana Score[≥3 points](OR=5.5,95%CI:1.7-17.1),active smoker(OR=6.7,95%CI:2.1-21.0),pancreatic cancer(OR=6.8,95%CI:1.9-23.2),and stage IV disease(OR=9.9,95%CI:1.2-79.1).CONCLUSION Rivaroxaban compared to apixaban and enoxaparin had a significantly higher risk of MB on GICA-VTE patients with equivocal efficacy. | Alejandro Recio-Boiles Sumana Veeravelli Jessica Vondrak Hani M Babiker Aaron J Scott Rachna T Shroff Hitendra Patel Emad Elquza Ali McBride | 2019 | World Journal of Gastrointestinal Oncology2019，11，10： | 3 |
| 9 | Preventive health measures in inflammatory bowel disease显示文摘We aim to review the literature and provide guidance on preventive health measures in inflammatory bowel disease(IBD). Structured searches were performed in Pub Med,MEDLINE,EMBASE,Web of Science and Cochrane Library from January 1976 to June 2016 using the following keywords:(inflammatory bowel disease OR Crohn's disease OR ulcerative colitis) AND(health maintenance OR preventive health OR health promotion). Abstracts of the articles selected from each of these multiple searches were reviewed,and those meeting the inclusion criteria(that is,providing data regarding preventive health or health maintenance in IBD patients) were recorded. Reference lists from the selected articles were manually reviewed to identify further relevant studies. Patients with IBD are at increased risk of developing adverse events related to the disease course,therapeutic interventions,or non-adherence to medication. Recent studies have suggested that IBD patients do not receive preventive services with the same thoroughness as patients with other chronic diseases. Preventive health measures can avert morbidity and improve the quality of life of patients with IBD. Gastroenterologists and primary care physicians(PCPs) should have an up to date working knowledge of preventive health measures for IBD patients. A holistic approach and better communication between gastroenterologists and PCPs with explicit clarification of roles will prevent duplication of services and streamline care. | Ayokunle T Abegunde Bashir H Muhammad Tauseef Ali | 2016 | World Journal of Gastroenterology2016，22，34： | 2 |
| 10 | Risk of post-operative complications associated with anti-TNF therapy in inflammatory bowel disease显示文摘There have been increasing concerns regarding the safety of perioperative anti-tumour necrosis factor (anti-TNF) α agents. We performed a literature review to evaluate the post-operative complications associated with perioperative anti-TNF use in patients with inflammatory bowel disease. A comprehensive review was performed with a literature search utilizing Pub Med, Cochrane, OVID and EMBASE databases according to published guidelines. To date, there are only data for infliximab. There are three published studies which have assessed post-operative complications with perioperative infliximab use in patients with Crohn' s disease (CD), four studies in ulcerative colitis (UC) patients, and one study on both CD and UC patients. Two out of the three studies in CD patients showed no increased post-operative complications associated with perioperative infliximab. Two out of four studies in UC patients also did not show an increase in post-operative complications, and the combined study with CD and UC patients did not show an increased risk as well. Studyresults could not be combined secondary to significant differences in study designs, patient population and definition of their endpoints. There appears to be a risk of post-operative complications associated with TNF therapy in some patients. Based on these data, careful patient selection and prospective data collection should be performed. | Tauseef Ali Laura Yun David T Rubin | 2012 | World Journal of Gastroenterology2012，18，3： | 2 |
| 11 | 肥胖Zucker大鼠肾脏血管紧张素Ⅱ2型受体及Mas受体共定位,且功能相互依赖显示文摘血管紧张素Ⅱ2型受体(angiotensinⅡtype 2receptor,AT_2R)与Mas受体(the receptor Mas,MasR)作用复杂,但均具有相似的前利钠作用,尤其是在肥胖/糖尿病大鼠肾脏中AT_2R表达及利钠作用增强。根据一些报道提示的这些受体之间的潜在正相互作用,研究者在肥胖大鼠中验证肾脏AT_2R及MasR生理上相互作用、相互依赖地刺激细胞信号转导及促进利钠作用的假设。 | Patel SN Ali Q Samuel P Steckelings UM Hussain T 赵狄 练桂丽 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 12 | Complication of reperfusion in acute aortic artery occlusion following saddle embolization orginating from an atrial myxoma显示文摘 | Ali T Castro J Young CR | 2004 | Vascular2004，12，3： | 1 |
| 13 | Development of a small RGD peptide fibrinogen receptor antagonist with potent anti - aggregatory activity in vitro显示文摘 | SamanenJ Ali F Romoff T etal | 1991 | J Med Chem1991，34，： | 1 |
| 14 | Effects of an endoscope on peristaltic flow of a micropolar fluid显示文摘 | Hayat T Ali N | 2008 | Mathe- matical and Computer ModeUing2008，48，55： | 1 |
| 15 | Extrapelvic endometriosis presenting as unusual swellings of the buttick and thigh显示文摘 | Ali T Mohammed F Hoford R | 2001 | West Indian Med J2001，50，： | 1 |
| 16 | Depression and quality of life in cancer patients with and without pain:The role of pain beliefs显示文摘 | Azadeh T Ali M Rasool R | 2008 | BMC Cancer2008，8，： | 1 |
| 17 | Gill net selectivity in Lake Nubia fisheries 显示文摘 | Ali M T Abu-Gideiril Y B | 1984 | Hydrobiologia1984，110，： | 1 |
| 18 | Central blood pressure better predicts eardiovasvular events than does peripheral blood pressure: the strong heart study显示文摘 | ROMAN MJ KIZER JR ALI T | 2005 | Circulation2005，112，： | 1 |
| 19 | Relay Architectures for 3GPP LTE - Advanced 显示文摘 | Peters Steven Ali Y Panah Kien T Truong | 2009 | EURASIP Journal on Wireless Communications and Networking2009，，2009： | 1 |
| 20 | Natural convection radiation interaction in boundary layer flow over horizontal surface显示文摘 | Ali M M Chen T S Armaly B | 1984 | A/AA J1984，22，： | 1 |
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