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| 1 | Tumor-stroma ratio as prognostic factor for survival in rectal adenocarcinoma: A retrospective cohort study显示文摘AIM To evaluate the prognostic value of the tumor-stroma ratio(TSR) in rectal cancer.METHODS TSR was determined on hematoxylin and eosin stained histological sections of 154 patients treated for rectal adenocarcinoma without prior neoadjuvant treatment in the period 1996-2006 by two observers to assessreproducibility. Patients were categorized into three categories: TSR-high [carcinoma percentage(CP) ≥ 70%], TSR-intermediate(CP 40%, 50% and 60%) and TSR-low(CP ≤ 30%). The relation between categorized TSR and survival was analyzed using Cox proportional hazards model.RESULTS Thirty-six(23.4%) patients were scored as TSR-low, 70(45.4%) as TSR-intermediate and 48(31.2%) as TSRhigh. TSR had a good interobserver agreement(κ = 0.724, concordance 82.5%). Overall survival(OS) and disease free survival(DFS) were significantly better for patients with a high TSR(P = 0.01 and P = 0.02, respectively). A similar association existed for disease specific survival(P = 0.06). In multivariate analysis, patients without lymph node metastasis and an intermediate TSR had a higher risk of dying from rectal cancer(HR = 5.27, 95%CI: 1.54-18.10), compared to lymph node metastasis negative patients with a high TSR. This group also had a worse DFS(HR = 6.41, 95%CI: 1.84-22.28). An identical association was seen for OS. These relations were not seen in lymph node metastasis positive patients. CONCLUSION The TSR has potential as a prognostic factor for survival in surgically treated rectal cancer patients, especially in lymph node negative cases. | René Scheer Alexi Baidoshvili Shorena Zoidze Marloes AG Elferink Annefleur EM Berkel Joost M Klaase Paul J van Diest | 2017 | World Journal of Gastrointestinal Oncology2017，9，12： | 3 |
| 2 | Exatramed- ullary palsmacytoma: Tumor occurrence and therapeutic concepts 显示文摘 | Alexiou C Kau R J Dietzfelbinger H | 1999 | Cancer1999，85，11： | 1 |
| 3 | Locoregional cancer treatment with magnetic drug targeting 显示文摘 | ALEXIOU C ARNOLD W KLEIN R J | 2000 | Cancer Res2000，60，23： | 1 |
| 4 | Doing competencies well:best practics in competency modeling显示文摘 | Michael A Campion Alexis A Fink Brian J Ruggeberg Linda Carr Geneva M Phillips Ronald B Odman | 2011 | Personnel Psychology2011，，22： | 1 |
| 5 | Isolation, characterization and properties of the oversulphated chondroitin sulphate proteoglycan from squid skin with peculiar glycosaminoglycan sulphation pattern显示文摘 | Karamanos Nikos K Aletras Alexis J Tsegenidis Theodore | 1992 | Eur J Biochem1992，204，： | 1 |
| 6 | Laparoscopic Liver Resection for Peripheral Hepatocellular Carcinoma in Patients With Chronic Liver Disease: Midterm Results and Perspectives显示文摘 | Daniel Cherqui Alexis Laurent Claude Tayar Stephen Chang Jeanne Tran Van Nhieu Jér?me Loriau Mehdi Karoui Christophe Duvoux Daniel Dhumeaux Pierre-Louis Fagniez | 2006 | Annals of Surgery2006，，4： | 1 |
| 7 | The health effects of non-industrial indoor air pollution 显示文摘 | BERNSTEIN J A ALEXIS N BACCHUS H | 2008 | J Allergy Clin Immunol2008，121，3： | 1 |
| 8 | Links between machining parameters and surface integrity in drilling ni-superalloy显示文摘 | Dutilh V Dessein G Alexis J | 2010 | International Journal of Advanced Materials Research2010，112，： | 1 |
| 9 | Modeling of a DC Electric Arc Furnace-Heat Transfer From the Arc 显示文摘 | Alexis J Ramirez M Trapaga G | 2000 | ISIJ International2000，40，11： | 1 |
| 10 | Definition and grading of anastomotic leakage following anterior resection of the rectum: A proposal by the International Study Group of Rectal Cancer显示文摘 | Nuh N. Rahbari Jürgen Weitz Werner Hohenberger Richard J. Heald Brendan Moran Alexis Ulrich Torbj?rn Holm W. Douglas Wong Emmanuel Tiret Yoshihiro Moriya S?ren Laurberg Marcel den Dulk Cornelis van de Velde Markus W. Büchler | 2010 | Surgery2010，，3： | 1 |
| 11 | The inflammatory response to cardiopulmonary bypass:part 1-mechanisms of pathogenesis 显示文摘 | Warren O J Smith A J Alexiou C | 2009 | Cardiothorac Vase Anesth2009，23，2： | 1 |
| 12 | Links between machin- ing parameters and surface integrity in drilling ni-superalloy 显示文摘 | Dutilh V Dessein G Alexis J | 2010 | International Journal of Advanced Materials Research2010，112，： | 1 |
| 13 | Extramedullary plasmacytoma: tumor occurrence and therapeutic concepts 显示文摘 | Alexiou C Kan R J Dietzfelbinger H | 1999 | Cancer1999，85，11： | 1 |
| 14 | Investigation to determine digestibility coefficients of various raw materials in diets for gilthead sea bream, Sparus auratns L显示文摘 | Nengas I Alexis M N Davies S J | 1995 | Aquaculture Research1995，26，： | 1 |
| 15 | FGF23 induces left ventricular hypertrophy显示文摘 | Faul Christian Amaral Ansel P Oskouei Behzad Hu Ming-Chang Sloan Alexis Isakova Tamara Gutiérrez Orlando M Aguillon-Prada Robier Lincoln Joy Hare Joshua M Mundel Peter Morales Azorides Scialla Julia Fischer Michael Soliman Elsayed Z Chen J | 2011 | Journal of Clinical Investigation2011，，11： | 1 |
| 16 | Serum levels of E-selectin, ICAM-1 and VCAM-1 in colorectal cancer patients: correlations with clinicopathological features, patient survival and tumour surgery 显示文摘 | Alexiou D Karayiannakis A J Syrigos K N | 2001 | Eur J Cancer2001，37，18： | 1 |
| 17 | Modeling of a DC electric arc furnace-heat transfer from the arc显示文摘 | Alexis J Ramirez M Trapaga G etal | 2000 | ISIJ International2000，40，11： | 1 |
| 18 | Locoregional cancer treatment with magnetic drug targeting 显示文摘 | Alexiou C Arnold W Klein R J | 2000 | Cancer Res2000，60，23： | 1 |
| 19 | Clinical significance of serum levels of E-selectin, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 in gastric cancer patients显示文摘 | Alexiou D Karayiannakis A J Syrigos K N | 2003 | Am J Gastroenterol2003，98，2： | 1 |
| 20 | Extramedullary plasmacytoma:Tumor occurrence and therapeutic concepts显示文摘 | Alexiou C Kau R J Dietzfelbinger H | 1999 | Cancer1999，85，11： | 1 |
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