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| 1 | Diabetic nephropathy:Is it time yet for routine kidney biopsy?显示文摘Diabetic nephropathy(DN)is one of the most important long-term complications of diabetes.Patients with diabetes and chronic kidney disease have an increased risk of all-cause mortality,cardiovascular mortality,and kidney failure.The clinical diagnosis of DN depends on the detection of microalbuminuria.This usually occurs after the first five years from the onset of diabetes,and predictors of DN development and progression are being studied but are not yet implemented into clinical practice.Diagnostic tests are useful tools to recognize onset,progression and response to therapeutic interventions.Microalbuminuria is an indicator of DN,and it is considered the only noninvasive marker of early onset.However,up to now there is no diagnostic tool that can predict which patients will develop DN before any damage is present.Pathological renal injury is hard to predict only with clinical and laboratory findings.An accurate estimate of damage in DN can only be achieved by the histological analysis of tissue samples.At the present time,renal biopsy is indicated on patients with diabetes under the suspicion of the presence of nephropathies other than DN.Results from renal biopsies in patients with diabetes had made possible the classification of renal biopsies in three major groups associated with different prognostic features:diabetic nephropathy,non-diabetic renal disease(NDRD),and a superimposed non-diabetic condition on underlying diabetic nephropathy.In patients with type 2 diabetes with a higher degree of suspicion for NDRD,it is granted the need of a renal biopsy.It is important to identify and differentiate these pathologies at an early stage in order to prevent progression and potential complications.Therefore,a more extensive use of biopsy is advisable. | Maria L Gonzalez Suarez David B Thomas Laura Barisoni Alessia Fornoni | 2013 | World Journal of Diabetes2013，4，6： | 29 |
| 2 | A new method for as- sessing 24-h blood pressure variability after excluding the contri- bution of nocturnal blood pressure fall显示文摘 | Grzegorz B Alessia G Katarzyna S | 2007 | J Hypertens2007，25，10： | 1 |
| 3 | Generation of reactive oxygen species after exhaustive aerobic and isometric exercise显示文摘 | Alessia H M Hagerman A E Fulkerson B K | 2000 | Med Sci Sports Exerc2000，32，9： | 1 |
| 4 | Molecular composition and ftmctional properties of f-channels in murine embryonic stem cell-de- rivedpacemaker cells 显示文摘 | Andrea B Alessia C Daniela C | 2009 | Journal of Molecular and Cellular Cardiology2009，46，： | 1 |
| 5 | Interplay between miR-155,AT1RA1166Cpolymorphism,and AT1R expression in young untreated hypertensives显示文摘 | GIULIO C ITALIA P ALESSIA B | 2011 | Am J Hypertens2011，24，： | 1 |
| 6 | Discovery of raltegravir,a potent,selective orally bioavailable HIV-integrase inhibitor for the treatment of HIV-AIDS infection显示文摘 | VINCENZO S ALESSIA P FABIO B | 2008 | J Med Chem2008，51，18： | 1 |
| 7 | Identification of plas- raids by PCR-based replicon typing显示文摘 | Alessandra C Alessia B Laura V | 2005 | Journal of Microbiologi- cal Methods2005，63，： | 1 |
| 8 | Solitary erythematous, tender plaque of the heel in a young infant 显示文摘 | Sabina V Alma I Alessia B | 2013 | Dermatology Online Journal2013，19，9： | 1 |
| 9 | How early is the atherosclerotic risk in rheumatoid arthritis? 显示文摘 | Elena B Alessia A Onelia B | 2010 | Autoimmun Rev2010，9，10： | 1 |
| 10 | Interplay between miR-155,AT1RA1166C polymorphism,and AT1R expression in young untreated hypertensives显示文摘 | Giulio C Italia P Alessia B | 2011 | Am J Hypertens2011，24，2： | 1 |
| 11 | Estrogen neuroprotection: the involvement of the Bcl-2 binding protein BNIP2显示文摘 | Silvia B Elisabetta V Alessia B | 2001 | Brain Research Reviews2001，37，： | 1 |
| 12 | Histdines are responsible for Zinc protentiation of the current in KDC1 carrot chanels 显示文摘 | Critiana P Monica B Alessia N | 2004 | Biophysical Joural2004，86，1： | 1 |
| 13 | MOF-Regulated Acetylation of MSL-3 in the Drosophila Dosage Compensation Complex显示文摘 | Alessia B Thomas K Jop H K | 2003 | Molecular Cell2003，11，： | 1 |
| 14 | Preparation and Reactivity of Mixed-- Ligand Ruthenium (11) Hydride Complexes wih Phosphites and Polypyridyls显示文摘 | Gabriele A Stefano A Alessia B | 2004 | norg Chem2004，43，： | 1 |
| 15 | Endowing carbon nano- tubes with biological and biomedical properties by chemical modifi- cations显示文摘 | Alessia B Cecilia M Tatiana DR | 2013 | Adv Drug Deliv Rev2013，65，15： | 1 |
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