|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Mesenchymal stem cells secretome:The cornerstone of cell-free regenerative medicine显示文摘Mesenchymal stem cells(MSCs)are the most frequently used stem cells in clinical trials due to their easy isolation from various adult tissues,their ability of homing to injury sites and their potential to differentiate into multiple cell types.However,the realization that the beneficial effect of MSCs relies mainly on their paracrine action,rather than on their engraftment in the recipient tissue and subsequent differentiation,has opened the way to cell-free therapeutic strategies in regenerative medicine.All the soluble factors and vesicles secreted by MSCs are commonly known as secretome.MSCs secretome has a key role in cell-to-cell communication and has been proven to be an active mediator of immunemodulation and regeneration both in vitro and in vivo.Moreover,the use of secretome has key advantages over cell-based therapies,such as a lower immunogenicity and easy production,handling and storage.Importantly,MSCs can be modulated to alter their secretome composition to better suit specific therapeutic goals,thus,opening a large number of possibilities.Altogether these advantages now place MSCs secretome at the center of an important number of investigations in different clinical contexts,enabling rapid scientific progress in this field. | Alberto González-González Daniel García-Sánchez Monica Dotta JoséC Rodríguez-Rey Flor M Pérez-Campo | 2020 | World Journal of Stem Cells2020，12，12： | 2 |
| 3 | Clinical significance of'anti-HBc alone'in human immunodeficiency virus-positive patients显示文摘AIM:To determine the prevalence and clinical relevance of isolated antibodies to hepatitis B core antigen as the only marker of infection('anti-HBc alone')among human immunodeficiency virus(HIV) type-1 infected patients.Occult hepatitis B infection frequency was also evaluated. METHODS:Three hundred and forty eight histories from 2388 HIV-positive patients were randomly reviewed.Patients with serological markers of hepatitis B virus(HBV)infection were classified into three groups:past hepatitis,'anti-HBc alone'and chronic hepatitis.Determination of DNA from HBV,and RNA and genotype from hepatitis C virus(HCV)were performed on'anti-HBc alone'patients. RESULTS:One hundred and eighty seven(53.7%) HIV-positive patients had markers of HBV infection: 118 past infection(63.1%),14 chronic hepatitis (7.5%)and 55'anti-HBc alone'(29.4%).Younger age[2.3-fold higher per every 10 years younger;95% confidence intervals(CI)1.33-4.00]and antibodies to HCV infection[odds ratio(OR)2.87;95%CI 1.10-7.48]were factors independently associated with the'anti-HBc alone'pattern.No differences in liver disease frequency were detected between both groups. Serum levels of anti-HBs were not associated with HCV infection(nor viral replication or HCV genotype),or with HIV replication or CD4 level.No'anti-HBc alone' patient tested positive for HBV DNA. CONCLUSION:'Anti-HBc alone'prevalence in HIVpositive patients was similar to previously reported data and was associated with a younger age and with antibodies to HCV infection.In clinical practice,HBV DNA determination should be performed only in those patients with clinical or analytical signs of liver injury. | M~aTeresa Pérez-Rodríguez Bernardo Sopea Manuel Crespo Alberto Rivera Teresa González del Blanco Antonio Ocampo César Martínez-Vázquez | 2009 | World Journal of Gastroenterology2009，15，10： | 2 |
| 4 | System dynamics urban sustainability model for Puerto aura in Puebla,Mexico显示文摘 | Jorge A Duran E Alberto P C | 2009 | Systemic Practice and Action Research2009，22，2： | 1 |
| 5 | Olefin inversion, protection of the sulfide function in the stereospecific synthesis of trans-thiacyclooct-4-ene显示文摘 | Anda C Alberto G Salvatore P | 1980 | J Org Chem1980，45，： | 1 |
| 6 | System dynamics urban sustainability model for Puerto Aurain Puebla, Mexico 显示文摘 | JORGE A DURAN E ALBERTO P C | 2009 | Systemic Practice and Action Research2009，22，2： | 1 |
| 7 | Genetic analysis of the Aegilops longissima 3S chromosome carrying the Pm13 resistance gene显示文摘 | Alberto C Renato D Enrico P etal | 2003 | Euphytica2003，130，： | 1 |
| 8 | Existence results and the monotone iterative technique for systems of nonlinear fractional differential equations显示文摘 | Wang G T Ravi P Alberto C | 2012 | Applied Mathematics Letters2012，25，6： | 1 |
| 9 | Isolation and identification of Ornithobacterium rhinotracheale from commercial turkey flocks in the upper Midwest 显示文摘 | Donald C Roepke Alberto Back Daniel P Shaw | 1998 | Avian Dis1998，42，1： | 1 |
| 10 | Genetic analysis of the Aegilops longissima 3S chromosome carrying t he Pm13 resistance gene显示文摘 | Alberto C Renato D Enrico P | 2003 | Euphytica2003，130，： | 1 |
| 11 | Decline in rotavirus hospi- talizations and health care visits for childhood diarrhea following ro- tavirus vaccination in E1 salvador 显示文摘 | Yen C Guardado JA Alberto P | 2011 | Pediatric Infectious Disease Journal2011，30，： | 1 |
| 12 | Pituitary macroadenomas:preoperative evaluation of consistency with diffusion-weighted MR imaging-initial experience显示文摘 | Alberto P Francesca C Carlo F | 2006 | Radiology2006，239，1： | 1 |
| 13 | Behavioral response to selected feed attractants and stimulants in Pacific white shrimp, Litopenaeus vannamei 显示文摘 | ALBERTO J P N MARCELO V C S FRANCISCO F A - N | 2006 | Aquaculture2006，260，： | 1 |
| 14 | The crack surface anomalous scaling and its connection with the size-scale effects显示文摘 | Alberto C Simone P | 2005 | International Journal of Fracture2005，133，： | 1 |
| 15 | Hollow fiber modules for orange juice aroma recovery using pervaporation显示文摘 | Andrew S Alberto C H Cristiano P B | 2002 | Desalination2002，148，13： | 1 |
| 16 | Influence of bioparticle size on the degradation of partially soluble wastewater in an anaerobic sequencing batch biofilm reactor (ASBBR) with mechanical stirring显示文摘 | Samantha C P Suzana M R Jose Alberto D R | 2005 | Bioresource Technology2005，96，6： | 1 |
| 17 | Growth of immature peach embryos in response to media, ovule supportmethod,and ovule perforation显示文摘 | Alberto C Q P Pinto Q Suzanne M | 1994 | Horticultural Science1994，29，9： | 1 |
| 18 | A fast and cost-effective approach to develop and map EST -SSR markers: oak as a case study 显示文摘 | Durand J Bodenes C Chancerel E Frigerio J M Vendramin G Sebastiani F Buonamici A Gailing 0 Koelewijn H P Villani F Mattioni C Cherubini M Goicoechea P G Herran A Ikaran Z Cabane C Ueno S Alberto F Dumoulin P Y Guichoux E Daruvar A Kremer A Plomion C | 2010 | BMCGenomics2010，11，： | 1 |
| 19 | Steps toward high specific activity labeling of biomolecules for therapeutic application: Preparation of precursor ^(+) and synthesis of tailor - made bifunctional ligand systems 显示文摘 | Schibli R Schwarzbach R Alberto R Ortner K Schmalle H Dumas C Egli A Schubiger P A | 2002 | Bioconjugate Chem2002，13，4： | 1 |
| 20 | Recovery of Functional Impairment after Acute Illness and Mortality: One-Year Follow-Up Study显示文摘 | Baztán Juan J Gálvez César P Socorro Alberto | 2009 | Gerontology2009，，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员