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| 1 | Pegylated interferon-alpha plus taurine in treatment of rat liver fibrosis显示文摘AIM: To investigate the antif ibrotic effects of peginterferon- alpha 2b and taurine on oxidative stress markers and hepatocellular apoptosis. METHODS: Sixty rats with CCl4-induced liver fibrosis were divided into 4 groups (n = 15). Group 1 was left for spontaneous recovery (SR). Groups 2-4 received peginterferon-alpha 2b, taurine, and their combination, respectively, for four weeks. Histological f ibrosis scores, histomorphometric analysis, tissue hydroxyproline, tissue MDA, GPx and SOD activities were determined. Activated stellate cells and hepatocellular apoptosis were also evaluated. RESULTS: The degree of f ibrosis decreased in all treatment groups compared to spontaneous recovery group. Taurine alone and in combination with peginterferon-alpha 2b reduced oxidative stress markers, but peginterferon-alpha 2b alone did not. Apoptotic hepatocytes and activated stellate cells were higher in groups 2-4 than in group 1. Combined taurine and peginterferon-alpha 2b further reduced fibrosis and increased activated stellate cell apoptosis, but could not improve oxidative stress more than taurine alone.CONCLUSION: Peginterferon-alpha 2b exerts anti- f ibrotic effects on rat liver fibrosis. It seems ineffective against oxidative stress in vivo. Peginterferon-alpha 2b in combination with taurine seems to be an antif ibrotic strategy. | Ilker Tasci Mehmet Refik Mas Sevil Atalay Vural Salih Deveci Bilgin Comert Gunay Alcigir Nuket Mas Cemal Akay Mithat Bozdayi Cihan Yurdaydin Hakan Bozkaya Ozden Uzunalimoglu Ahmet Turan Isik Harun M Said | 2007 | World Journal of Gastroenterology2007，13，23： | 7 |
| 2 | Sound radiation from an impact-excited clamped circular plate in an infinite ba f fle显示文摘 | Akay A Latcha M | 1983 | Journal of the Acoustical Society of America1983，74，2： | 1 |
| 3 | Estimation of tibiofemoral static zero position during dynamic drop landing显示文摘 | Ida H Nagano Y Akai M | 2013 | The Knee2013，20，5： | 1 |
| 4 | Electrochemical hydrogen storage performance of Mg-Ti-Zr-Ni alloys显示文摘 | ANIK M AKAY I O'ZDEMIR G | 2009 | International Journal of Hydrogen Energy2009，34，24： | 1 |
| 5 | Expression of g!omerular plasminogen activator inhibitor type 1 in glomerulonephri- tis 显示文摘 | Hamano K lwano M Akai Y | 2002 | Am J Kidney Dis2002，39，6： | 1 |
| 6 | An outcome measure for Japanese people with chronic low back pain:an introduction and validation study of Japan low back pain evaluation questionnaire显示文摘 | Shirado O Doi T Akai M | 2007 | Spine2007，32，26： | 1 |
| 7 | Fiscal decentralization contributes to economic growth: evidence from state-level cross-section data for the United States 显示文摘 | Akai N Sakata M | 2002 | Journal of Urban Economics2002，52，1： | 1 |
| 8 | Role of positively charged amino acids in the M2D transmembrane helix ot' ktr/Trk/HKT type cation transporters显示文摘 | Kato N Akai M Zulkifli L | 2007 | Chan nels2007，1，16： | 1 |
| 9 | Dynamic change and influence of osteoporotic back pain with vertebral fracture on related activities and social participation:evaluating reliability and validity of a newly developed outcome measure显示文摘 | Doi T Akai M Endo N | 2013 | J Bone Miner Metab2013，31，6： | 1 |
| 10 | Measurement of tangential contact hysteresis during microslip显示文摘 | Filippi S Akay A Gola M M | 2004 | Journal of Tribology2004，126，3： | 1 |
| 11 | Carotid atherosclerosis and cardiovascular risk factors in hemodialysis and peritoneal dialysis patients显示文摘 | Yilmaz FM Akay H Duranay M | 2007 | Clin Biochem2007，40，18： | 1 |
| 12 | Dederichs, Theory of Hyperfine Interactions in Metals 显示文摘 | Akai H Akai M Blugel S | 1990 | Prog Theor Phys Suppl1990，101，： | 1 |
| 13 | A newly development warm extrusion technique for compacting amorphous alloy powders显示文摘 | TAKAGI M AKAI M | 1988 | Mater Sci Eng1988，98，： | 1 |
| 14 | Gasification of hazelnut shells in a downdraft gasifier显示文摘 | Dogru M Howarth C R Akay G | 2002 | Energy2002，27，5： | 1 |
| 15 | Jetting and fibre degradation in injection moulding of glass-fibre reinforced polyamides显示文摘 | Akay M Barkley D | 1992 | Joumal of Materials Science1992，27，21： | 1 |
| 16 | Support vector machines combined with feature selection for breast cancer diagnosis 显示文摘 | Akay M F | 2009 | Expert Systems with Applications2009，36，2： | 1 |
| 17 | Vitiligo after hematopoietic cell transplantation:six cases and review of the literature显示文摘 | Sanli H Akay BN Arat M | 2008 | Dermatology2008，216，4： | 1 |
| 18 | Fiscal decentralization contributes to economic growth: Evidence from state-level cross-section data for the United States 显示文摘 | Akai N Sakata M | 2002 | Journal of Urban Economics2002，52，1： | 1 |
| 19 | Noninvasive acoustic detection of coronary artery disease:a comparative study of signal processing methods显示文摘 | Akay M Welkowitz W | 1993 | IEEE Trans Biomed Eng1993，40，6： | 1 |
| 20 | Crystal structure of dichlorozinc ( Ⅱ ) homodinuclear complex methanol solvate显示文摘 | Atakol O Tatar L Akay M A | 1999 | Anal Sci1999，15，： | 1 |
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