|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Postpartum depression:A systematic review of the genetics involved显示文摘Postpartum depression is one of the most prevalent psychopathologies. Its prevalence is estimated to be between 10% and 15%. Despite its multifactorial etiology, it is known that genetics play an important role in the genesis of this disorder. This paper reviews epidemiological evidence supporting the role of genetics in postpartum depression(PPD). The main objectives of this review are to determine which genes and polymorphisms are associated with PPD and discuss how this association may occur. In addition, this paper explores whether these genes are somehow related to or even the same as those linked to Major Depression(MD). To identify gaps in the current knowledge that require investigation, a systematic review was conducted in the electronic databases Pub Med, LILACS and Sci ELO using the index terms 'postpartum depression' and 'genetics'. Literature searches for articles in peerreviewed journals were made until April 2014. PPD was indexed 56 times with genetics. The inclusion criteria were articles in Portuguese, Spanish or English that were available by institutional means or sent by authors upon request; this search resulted in 20 papers. Genes and polymorphisms traditionally related to MD, which are those involved in the serotonin, catecholamine, brain-derived neurotrophic factor and tryptophan metabolism, have been the most studied, and some have been related to PPD. The results are conflicting and some depend on epigenetics, which makes the data incipient. Further studies are required to determine the genes that are involved in PPD and establish the nature of the relationship between these genes and PPD. | Tiago Castro e Couto Mayra Yara Martins Brancaglion António Alvim-Soares Lafaiete Moreira Frederico Duarte Garcia Rodrigo Nicolato Humberto Corrêa Regina Amélia Lopes P Aguiar Henrique Vitor Leite | 2015 | World Journal of Psychiatry2015，5，1： | 5 |
| 2 | Influence of donor age on the differentiation and division capacity of human adipose-derived stem cells显示文摘BACKGROUND Human adipose-derived stromal/stem cells(hASCs)are one of the most useful types of mesenchymal stromal/stem cells,which are adult multipotent cells with great therapeutic potential for the treatment of several diseases.However,for successful clinical application,it is critical that high-quality cells can be obtained.Diverse factors seem to be able to influence cell quality and performance,especially factors related to donors’intrinsic characteristics,such as age.Nevertheless,there is no consensus regarding this characteristic,and there is conflicting information in the literature.AIM To investigate the growth kinetics and differentiation potential of adipose-derived stem cells isolated from the lipoaspirates of elderly and young donors.METHODS hASCs were harvested from liposuctioned adipose tissue obtained from female donors(aged 20-70 years).Cells were distributed into two groups according to age range:old hASCs(oASCs,≥55 years,n=9)and young hASCs(yASCs,≤35 years,n=9).For each group,immunophenotypic characterization was performed by flow cytometry.Population doubling time was assessed over seven days.For adipogenic potential evaluation,lipid deposits were assessed after 7 d,14 d and 21 d of adipogenic induction.Osteogenic potential was verified by analyzing cell mineralization after 14 d,21 d and 28 d of osteogenic induction.mRNA expression of PPARγ2,CEBPA and Runx2 were detected by quantitative reverse transcription polymerase chain reaction.RESULTS hASCs were successfully obtained,cultured,and grouped according to their age:yASCs(26.33±4.66 years old)and oASCs(64.78±4.58 years old).After maintenance of the cells in culture,there were no differences in morphology between cells from the young and old donors.Additionally,both groups showed classical immunophenotypic characteristics of mesenchymal stem/stromal cells.The average doubling time indicated that yASCs(4.09±0.94 d)did not significantly differ from oASCs(4.19±1.29 d).Concerning differentiation potential,after adipogenic and osteogenic induction,yASCs and oASCs were able to differentiate to greater levels than the noninduced control cells.However,no differences were found in the differentiation efficiency of yASCs and oASCs in adipogenesis or osteogenesis.Additionally,the mRNA expression of PPARγ2,CEBPA and Runx2 were similar in yASCs and oASCs.CONCLUSION Our findings suggest that age does not seem to significantly affect the cell division or adipogenic or osteogenic differentiation ability of adipose-derived stem cells isolated from lipoaspirates. | Cintia DS Horinouchi María Julia Barisón Anny W Robert Crisciele Kuligovski Alessandra M Aguiar BrunoDallagiovanna | 2020 | World Journal of Stem Cells2020，12，12： | 2 |
| 3 | Trajectory-tracking and path- following of underactuated autonomous vehicles with parametric modeling uncertainty 显示文摘 | AGUIAR A P HESPANHA J P | 2007 | IEEE Transactions on Automatic Control2007，52，8： | 1 |
| 4 | Trajectory-tracking and path-following of underactuated autonomous vehicles with parametric modeling uncertainty显示文摘 | Aguiar A Hespanha J P | 2007 | IEEE Trans on Automation Control2007，52，8： | 1 |
| 5 | Metal-chelatingcompounds produced by ectomycorrhizal fungi collected from pineplantations显示文摘 | MACHUCA A PEREIRA G AGUIAR A | 2007 | Letters in Applied Microbiology2007，44，1： | 1 |
| 6 | Trajectory-tracking and path-following of underaetuated autonomous vehicles with parametric modeling uncertainty 显示文摘 | Aguiar A P Hespanha J P | 2007 | IEEE Transactions on Automatic Control2007，52，： | 1 |
| 7 | Trajectory-tracking and path-following of underactuated autonomous vehicles with parametric modeling uncertainty显示文摘 | Aguiar A P Hespanha J P | 2007 | Automatic Control IEEE Transactions on2007，52，8： | 1 |
| 8 | Peritumoral brain edema in benign meningiomas: correlation with clinical, radiologic, and surgical factors and possible role on recurrence显示文摘 | Simis A Pires de Aguiar PH Leite CC | 2008 | Surg Neurol2008，70，： | 1 |
| 9 | Slowmagic-angle coil spinning: a high-sensitivity and high-resolution NMR strategy for microscopic biologicalspecimens显示文摘 | WONG A AGUIAR P M SAKELLARIOU D | 2010 | Magnetic Resonance in Medicine2010，63，2： | 1 |
| 10 | Trajectory-tracking and path-following of underactuated autonomous vehicles with parametric modeling un- certainty显示文摘 | Aguiar A P Hespanha J P | 2007 | IEEE Transactions on Automatic Control2007，52，8： | 1 |
| 11 | Friedel-Crafts acylaiton of anisole with acetic anhydride over silica-supported hetempolyphostungstic acid (HPW/SiO2 )显示文摘 | CARDOSO L A M ALVES W It GONZAGA A R E AGUIAR L M G ANDRADE H M C | 2004 | J Mol Catal A2004，209，12： | 1 |
| 12 | Internal suture technique for improving projection and stability in secondary gluteoplasty显示文摘 | JAIMOVICH C A ALMEIDA M W AGUIAR L F | 2010 | Aesthet Surg J2010，30，3： | 1 |
| 13 | Encapsulation of insulin-cyelodextrin complex in PLGA microspheres: a new approach for prolonged puhnonary insulin delivery显示文摘 | Aguiar M M Rodrigues J M Silva Cunba A | 2004 | Microencapsul2004，21，5： | 1 |
| 14 | Best cases from the AFIP:congenital intracranial teratoma显示文摘 | SANDOW B A DORY C E AGUIAR M A | 2004 | Radiographics2004，24，4： | 1 |
| 15 | Antimalarial activity and mechanisms of action of two novel 4- aminoquinolines against chloroquine-resistant parasites 显示文摘 | AGUIAR A C C SANTOS R D M FIGUEIREDO F J B | 2012 | PLoS One2012，7，37： | 1 |
| 16 | World catalog of the Stephanidae (Hymenoptera: Stephanoidea)显示文摘 | Aguiar A P | 2004 | Zootaxa2004，753，： | 1 |
| 17 | Microwave Promoted Suzuki Reactions between Aroyl Chlorides and Boronic Acids Catalyzed by Het- erogeneous and Homogeneous Phosphine-free Palla- dium Catalysts 显示文摘 | DANIELA DE L M AGUIAR L C ANTUNES O A | 2011 | J of Organomet Chem2011，696，1516： | 1 |
| 18 | Long-term complications in totally implantable venous access devices: randomized study comparing subclavian and internal jugular vein puncture 显示文摘 | Ribeiro R C Abib S C Aguiar A S | 2012 | Pediatr Blood Cancer2012，58，2： | 1 |
| 19 | Role of mast cells and pro-inflammatory mediators on the intestinal secretion induced by cholera toxin显示文摘 | Marcos F.G Rocha José E.P Aguiar José J.C Sidrim Raimundo B Costa Regina F.G Feitosa Ronaldo A Ribeiro Aldo A.M Lima | 2003 | Toxicon2003，，2： | 1 |
| 20 | Optimisation of a solid-phase microextraction/HPLC/Diode Array method for multiple pesticide screening in lettuce显示文摘 | Melo A Aguiar A Mansilha C | 2012 | Food chemistry2012，130，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员