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| 1 | Hepatitis B and C virus-induced hepatitis: Apoptosis, autophagy, and unfolded protein response显示文摘AIM: To investigate the co-incidence of apoptosis, autophagy, and unfolded protein response(UPR) in hepatitis B(HBV) and C(HCV) infected hepatocytes.METHODS: We performed immunofluorescence confocal microscopy on 10 liver biopsies from HBV and HCV patients and tissue microarrays of HBV positive liver samples. We used specific antibodies for LC3β, cleaved caspase-3, BIP(GRP78), and XBP1 to detect autophagy, apoptosis and UPR, respectively. AntiHCV NS3 and anti-HBs antibodies were also used to confirm infection. We performed triple blind counting of events to determine the co-incidence of autophagy(LC3β punctuate), apoptosis(cleaved caspase-3), and unfolded protein response(GRP78) with HBV and HCV infection in hepatocytes. All statistical analyses were performed using SPSS software for Windows(Version 16 SPSS Inc, Chicago, IL, United States). P-values < 0.05 were considered statistically significant. Statistical analyses were performed with Mann-Whitney test to compare incidence rates for autophagy, apoptosis, and UPR in HBV- and HCV-infected cells and adjacent noninfected cells.RESULTS: Our results showed that infection of hepatocytes with either HBV and HCV induces significant increase(P < 0.001) in apoptosis(cleavage of caspase-3), autophagy(LC3β punctate), and UPR(increase in GRP78 expression) in the HCV- and HBVinfected cells, as compared to non-infected cells of the same biopsy sections. Our tissue microarray immunohistochemical expression analysis of LC3β in HBV^(Neg) and HBV^(Pos) revealed that majority of HBVinfected hepatocytes display strong positive stainingfor LC3β. Interestingly, although XBP splicing in HBVinfected cells was significantly higher(P < 0.05), our analyses show a slight increase of XBP splicing was in HCV-infected cells(P > 0.05). Furthermore, our evaluation of patients with HBV and HCV infection based on stage and grade of the liver diseases revealed no correlation between these pathological findings and induction of apoptosis, autophagy, and UPR.CONCLUSION: The results of this study indicate that HCV and HBV infection activates apoptosis, autophagy and UPR, but slightly differently by each virus. Further studies are warranted to elucidate the interconnections between these pathways in relation to pathology of HCV and HBV in the liver tissue. | Behzad Yeganeh Adel Rezaei Moghadam Javad Alizadeh Emilia Wiechec Seyed Moayed Alavian Mohammad Hashemi Bita Geramizadeh Afshin Samali Kamran Bagheri Lankarani Martin Post Payam Peymani Kevin M Coombs Saeid Ghavami | 2015 | World Journal of Gastroenterology2015，21，47： | 13 |
| 2 | w显示文摘一系列新 2,5-disubstituted-1,3,4-oxadiazole 和 1,2,4-triazole 衍生物被酸一种肺结核特效药的 heterocyclization 综合 1 和 thiosemicarbazide 衍生物 2。而且,非循环的 C-nucleoside 类似物被反应被他们的相应的糖 hydrazones 的环合与醋性的酐准备。准备混合物的抗菌剂活动被评估,一些综合混合物对真菌揭示了好活动。 | EI-Sayed, Wael A. Ali, Omar M Hendy, Hend A AbdeI-Rahman, Adel A.-H.t | 2012 | Chinese Journal of Chemistry2012，30，1： | 9 |
| 3 | 施用不同配比蚯蚓粪对海南耕地砖红壤肥力特性的影响显示文摘为研究蚯蚓粪对砖红壤的培肥和改良效果,采用海南耕地砖红壤为材料进行室内培养试验,按照蚯蚓粪与干土的质量比分别设置为CK(0)、V1(1∶11)、V2(1∶5)、V3(1∶3)和V4(1∶2),共5个处理,培养52 d后,分别测定各处理土壤的p H值、全氮、全磷、全钾、碱解氮、速效磷、速效钾、有效钠、有效镁和有效钙的含量。结果表明,砖红壤p H值提高0.77~1.64个单位;全磷、全钾、碱解氮和速效磷含量均随蚯蚓粪添加量的增加显著提高(P<0.05),其中全磷和全钾较CK分别增加0.88~3.22倍和1.67~2.65倍,碱解氮和速效磷含量的最大增加量分别为1.66和10.7倍。V1处理土壤全氮和有效钠含量低于CK,随蚯蚓粪添加量的增多,V4处理土壤全氮和有效钠含量较CK分别增加3.43倍和66.19%;V1和V2处理速效钾含量低于CK,V3和V4处理分别高于CK 6.9%和14.9%;但蚯蚓粪添加量对土壤有效镁含量的影响差异不显著。因此,蚯蚓粪作为有机肥料施入砖红壤,可以提高砖红壤p H,砖红壤全态和有效养分含量随添加量的提高而增加,对于砖红壤地区培肥地力和改良土壤具有重要的实用价值。 | 单颖 赵凤亮 邹刚华 李玮 Adel M R A Abdelaziz | 2017 | 华北农学报2017，32，A01： | 8 |
| 4 | Association between facet joint osteoarthritis and the Oswestry Disability Index显示文摘AIM:To investigate the correlation of facet joint osteoarthritis(FJOA) at lumbar levels L4/L5 and L5/S1 and the Oswestry Disability Index(ODI).METHODS:The study involved lumbar MRIs of 591 patients with a mean age of 47.3 years.The MRIs of the lumbar spine were performed on a 1.5 Tesla scanner(Magnetom Avanto,Siemens AG,Erlangen,Germany) using a dedicated receive only spine coil.After initial blinding,each dataset was evaluated by 2 board certified radiologist with more than 5 years experience in musculoskeletal imaging.In total 2364 facet joints were graded.Degenerative changes of the facet joints were evaluated according to the 4-point scale as proposed by Weishaupt et al Functional status was assessed using the ODI.The index is scored from 0 to 100 and interpreted as follows:0%-20%,minimaldisability; 20%-40%,moderate disability; 40%-60%,severe disability; 60%-80%,crippled; 80%-100%,patients are bedbound.Spearman's coefficient of rank correlation was used for statistical analysis,with significance set at P < 0.05.RESULTS:In total 2364 facet joints at lumbar levels L4/5 and L5/S1 were analysed in 591 individuals.FJOA was present in 97%(L4/L5) and 98%(L5/S1).At level L4/5(left/right) 17/15(2.9%/2.5%) were described as grade 0,146/147(24.7%/24.9%) as grade 1,290/302(49.1%/51.1%) as grade 2 and 138/127(23.4%/21.5%) as grade 3.At level L5/S1(left/right) 10/11(1.7%/1.9%) were described as grade 0,136/136(23.0%/23.0%) as grade 1,318/325(53.8%/55.0%) as grade 2 and 127/119(21.5%/20.1%) as grade 3.Regarding the ODI scores,patients' disability had a minimum of 0% and a maximum of 91.11% with an arithmetic mean of 32.77% ± 17.02%.The majority of patients(48.39%) had moderate functional disability(21%-40%).There was no significant correlation between FJOA and ODI on both sides of lumbar level L4/5 and on the left side of lumbar level L5/S1.A weak positive correlation was evaluated between ODI and FJOA on the right side of lumbar level L5/S1.CONCLUSION:The missing correlation of FJOA and ODI confirms our clinical experience that imaging alone is an insufficient approach explaining low back pain.Clinical correlation is imperative for an adequate diagnostic advance in patients with low back pain. | Adel Maataoui Thomas J Vogl Marcus Middendorp Konstantinos Kafchitsas M Fawad Khan | 2014 | World Journal of Radiology2014，6，11： | 6 |
| 5 | Protective role of PI3-kinase/Akt/eNOS signaling in mechanical stress through inhibition of p38 mitogenactivated protein kinase in mouse lung显示文摘 | Xin-qi PENG Mahendra DAMARLA Jarrett SKIRBALL Stephanie NONAS Xiao-ying WANG Eugenia J HAN Emile J HASAN Xuan CAO Adel BOUEIZ Rachel DAMICO Rubin M TUDER Alfred M SClUTO Dana R ANDERSON Joe GNGARCIA David A KASS Paul M HASSOUN Jun-tian ZHANG | 2010 | Acta Pharmacologica Sinica2010，31，2： | 6 |
| 6 | Correlation of lumbar lateral recess stenosis in magnetic resonance imaging and clinical symptoms显示文摘AIM To assess the correlation of lateral recess stenosis(LRS) of lumbar segments L4/5 and L5/S1 and the Oswestry Disability Index(ODI).METHODS Nine hundred and twenty-seven patients with history of low back pain were included in this uncontrolled study.On magnetic resonance images(MRI) the lateral recesses(LR) at lumbar levels L4/5 and L5/S1 were evaluated and each nerve root was classified into a 4-point grading scale(Grade 0-3) as normal,not deviated,deviated or compressed.Patient symptoms and disability were assessed using ODI.The Spearman's rank correlation coefficient was used for statistical analysis(P < 0.05).RESULTS Approximately half of the LR revealed stenosis(grade 1-3;52% at level L4/5 and 42% at level L5/S1) with 2.2% and 1.9% respectively reveal a nerve root compression.The ODI score ranged from 0%-91.11% with an arithmetic mean of 34.06% ± 16.89%.We observed a very weak statistically significant positive correlation between ODI and LRS at lumbar levels L4/5 and L5/S1,each bilaterally(L4/5 left:rho < 0.105,P < 0.01;L4/5 right:rho < 0.111,P < 0.01;L5/S1 left:rho 0.128,P < 0.01;L5/S1 right:rho < 0.157,P < 0.001).CONCLUSION Although MRI is the standard imaging tool for diagnosing lumbar spinal stenosis,this study showed only a weak correlation of LRS on MRI and clinical findings.This can be attributed to a number of reasons outlined in this study,underlining that imaging findings alone are not sufficient to establish a reliable diagnosis for patients with LRS. | Annina SplettstoBer M Fawad Khan Bernd Zimmermann Thomas J Vogl Hanns Ackermann Marcus Middendorp Adel Maataoui | 2017 | World Journal of Radiology2017，9，5： | 4 |
| 7 | Magnetic resonance imaging-based interpretation of degenerative changes in the lower lumbar segments and therapeutic consequences显示文摘Intervertebral disc degeneration and facet joint osteoarthritis of the lumbar spine are, among others, wellknown as a cause of low back and lower extremity pain. Together with their secondary disorders they set a big burden on health care systems and economics worldwide. Despite modern imaging modalities, such as magnetic resonance imaging, for a large proportion of patients with low back pain(LBP) it remains difficult to provide a specific diagnosis. The fact that nearly all the lumbar structures are possible sources of LBP, may serve as a possible explanation. Furthermore, our clinical experience confirms, that imaging alone is not a sufficient approach explaining LBP. Here, the Oswestry Disability Index, as the most commonly used measure to quantify disability for LBP, may serve as an easy-toapply questionnaire to evaluate the patient's ability to cope with everyday life. For therapeutic purposes, among the different options, the lumbar facet joint intraarticular injection of corticosteroids in combination with an anaesthetic solution is one of the most frequently performed interventional procedures. Although widely used the clinical benefit of intra-articular steroid injections remains controversial. Therefore, prior to therapy, standardized diagnostic algorithms for an accurate assessment, classification and correlation of degenerative changes of the lumbar spine are needed. | Adel Maataoui Thomas J Vogl M Fawad Khan | 2015 | World Journal of Radiology2015，7，8： | 4 |
| 8 | Drainage vs. non-drainage after cholecystectomy for acute cholecystitis:a retrospective study显示文摘Many surgeons practice prophylactic drainage after cholecystectomy without reliable evidence,this study was conducted to answer the question whether to drain or not to drain after cholecystectomy for acute calculous cholecystitis.A retrospective review of all patients who had cholecystectomy for acute cholecystitis in Aseer Central Hospital,Abha,Saudi Arabia,was conducted from April 2010 to April 2012.Data were extracted from hospital case files.Preoperative data included clinical presentation,routine investigations and liver function tests.Operative data included excessive adhesions,bleeding,bile leak,and drain insertion.Complicated cases such as pericholecystic collections,mucocele and empyema were also reported.Patients who needed therapeutic drainage were excluded.Postoperative data included hospital stay,volume of drained fluid,time of drain removal,and drain site problems.The study included 103 patients allocated into two groups;group A(n = 38) for patients with operative drain insertion and group B(n = 65) for patients without drain insertion.The number of patients with preoperative diagnosis of acute non-complicated cholecystitis was significantly greater in group B(80%) than group A(36.8%)(P < 0.001).Operative time was significantly longer in group A.All patients who were converted from laparoscopic to open cholecystectomy were in group A.Multivariate analysis revealed that hospital stay was significantly(P < 0.001) longer in patients with preoperative complications.There was no added benefit for prophylactic drain insertion after cholecystectomy for acute calculous cholecystitis in non-complicated or in complicated cases. | Mohammed A Bawahab Walid M Abd El Maksoud Saeed A Alsareii Fahad S Al Amri Hala F Ali Abdul Rahman Nimeri Abdul Rahman M Al Amri Adel A Assiri Mohammed I Abdul Aziz | 2014 | The Journal of Biomedical Research2014，28，3： | 3 |
| 9 | 构建AP-HTPB固体推进剂松弛模量主曲线的不同方法(英文)显示文摘分析了建立高氯酸铵-端羟基聚丁二烯(AP-HTPB)固体推进剂松弛模量主曲线的三种不同方法(Williams-Landel-Ferry(WLF)方法、Arrhenius方法和基本的时间-温度叠加(TTS)方法)。通过不同温度(-40,+20,+76℃)和10%常应变下1380s的应力松弛试验得到了复合固体推进剂松弛模量。通过评估松弛模量,给出转移因子和松弛模量主曲线,最后通过确定系数(R^2)得出了最佳的拟合方法。结果表明,基本TTS方法可给出最佳拟合曲线,因为该方法不依赖外部材料常数和应用中的经验方程,而且该方法可以适用于任何黏弹性材料。但是,在应用有限元软件时,经常要求用材料常数来定义非线性黏弹性材料模型,这种情况下,目前研究结果表明,当给出合适的常数后,WLF和Arrhenius两种方法均可给出满意的结果,而且WLF方法更为准确,因此在AP-HTPB固体推进剂有限元分析中倾向于采用这种方法。 | Walid M Adel 梁国柱 | 2017 | 含能材料2017，25，10： | 3 |
| 10 | Vitamin D status and viral response to therapy in hepatitis C infected children显示文摘AIM: To study the frequency of vitamin D deficiency in patients with hepatitis C virus(HCV) infection and to evaluate the role of vitamin D supplementation in improving antiviral therapy.METHODS: Sixty-six children aged from 7-14 years(mean ± SD, 11.17 ± 2.293) diagnosed with HCV infection were matched to 28 healthy controls. Serum levels of 25(OH) D3, calcium, phosphorus, alkaline phosphatase and plasma level of parathormone were measured. Quantitative PCR for HCV was performed Bone density was determined by dual energy X-ray absorptiometry. All cases received conventional therapy, and only 33 patients received vitamin D supplementation.RESULTS: Children with HCV showed significantly increased levels of HCV RNA(P < 0.001), parathormone(P < 0.01) and decreased vitamin D levels(P < 0.05)(33.3% deficient and 43.3% insufficient) compared with controls. Abnormal bone status(Z score-1.98 ± 0.75) was found in ribs, L-spine, pelvis and total body. Cases treated with vitamin D showed significant higher early(P < 0.04) and sustained(P < 0.05) virological response. There was a high frequency of vitamin D deficiency among the Egyptian HCV children, with significant decrease in bone density. The vitamin D level should be assessed before the start of antiviral treatment with the correction of any detected deficiency. CONCLUSION: Adding vitamin D to conventional Peg/RBV therapy significantly improved the virological response and helped to prevent the risk of emerging bone fragility. | Azza A Eltayeb Madleen Adel A Abdou Amal M Abdel-aal Mostafa H Othman | 2015 | World Journal of Gastroenterology2015，21，4： | 3 |
| 11 | Place of the reposition flap in the treatment of distal amputations of the fingers显示文摘远侧的手指切断与远侧的碎片质量提出一个治疗学的问题。培植仍然是参考处理为功能并且手的美学恢复。这研究的利息是在近似树桩作为不同 hedging 技术的一种选择建议 reposition 拍动,处于 revascularization 是不可能的许多状况。它由一种 pedicled 本地人 flap.MethodsThe 技术在骨头碎片和它的范围的 osteosynthesis 在于重新定位拍动通过在 Nabeul 编的 13 个病人的研究在 2003 和 2016 之间回顾地被评估矫形部门。为每个病人,敏感,肉 trophicity, interphalangeal 活动性,数字长度,钉子的外观和放射学的巩固是 evaluated.ResultsThe 重新定位拍动保留 p3 的超过 80% 长度。这个过程与规则化比较改进钉子美学。在肉或关节作为这种技术的功能学习了的远侧的 inter-phalangeal (剧降) 的活动性的敏感没有重要差别。然而,在快破折号的平均测试有重要差别(350 对 500 为规则化).ConclusionThe 重新定位拍动似乎是在 trans-p3 手指切断,远侧的碎片不在是 revascularizable 的上下文的规则化的一种好选择。它允许更好的美学和功能的结果。 | Mohamed Ali Sbai Mayssa El M'chirgui Riadh Maalla Adel Khorbi | 2017 | Chinese Journal of Traumatology2017，20，4： | 2 |
| 12 | COVID-19 and hepatic injury: cellular and molecular mechanisms in diverse liver cells显示文摘The coronavirus disease 2019(COVID-19)represents a global health and economic challenge.Hepatic injuries have been approved to be associated with severe acute respiratory syndrome coronavirus(SARS-CoV-2)infection.The viral tropism pattern of SARS-CoV-2 can induce hepatic injuries either by itself or by worsening the conditions of patients with hepatic diseases.Besides,other factors have been reported to play a crucial role in the pathological forms of hepatic injuries induced by SARS-CoV-2,including cytokine storm,hypoxia,endothelial cells,and even some treatments for COVID-19.On the other hand,several groups of people could be at risk of hepatic COVID-19 complications,such as pregnant women and neonates.The present review outlines and discusses the interplay between SARS-CoV-2 infection and hepatic injury,hepatic illness comorbidity,and risk factors.Besides,it is focused on the vaccination process and the role of developed vac-cines in preventing hepatic injuries due to SARS-CoV-2 infection. | Fares E M Ali Mostafa K Abd El-Aziz Mahmoud M Ali Osama M Ghogar Adel G Bakr | 2023 | World Journal of Gastroenterology2023，29，3： | 2 |
| 13 | Chitosan polymer as bioactive coating and film against Aspergillus niger contamination显示文摘 | ISSAM S T ADELE M G ADELE C P | 2005 | Journal of Food Science2005，70，2： | 1 |
| 14 | Planarian GSK3s are in- volved in neural regeneration显示文摘 | Adell T Marsal M Sal6 E | 2008 | Development Genes and Evolution2008，218，2： | 1 |
| 15 | Assessment of monitored energy use and thermal comfort conditions in mosques in hot-humid climates 显示文摘 | MOHAMM ADS A + Homoud ADEL A Abdou I SM AIL M Bu- daiw i | 2009 | Energy and Buildings2009，41，6： | 1 |
| 16 | Acquired protein C deficiency in a child with acute myelogenous leukemia, splenic, renal, and intestinal infarction显示文摘 | Roula A Farah Khalil S Jalkh Hussein Z Farhat Paul E Sayad Adel M Kadri | 2011 | Blood Coagulation & Fibrinolysis2011，，2： | 1 |
| 17 | DNA immunization of dairy cows with the clumping factor A of Staph- ylococcus aureus显示文摘 | ADEL N M NOUR EL-DIN LULZIM SHKRETA BRIAN G TALBOT | 2006 | Vaccine2006，24，： | 1 |
| 18 | The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17b-estradiol and phytoestrogens in breast cancer cells显示文摘 | Maggiolini M Adele V Giovanna F | 2004 | J Biol Chem2004，279，27： | 1 |
| 19 | Short communication : Influence of microbial inoculation and co - composting material on the evolution of humic - like substances during composting of horticultural wastes 显示文摘 | Vargas - Garcia M adel Carmen Suarez - Estrella F Francisca Lopez M a Jose | 2006 | Process Biochemistry2006，41，6： | 1 |
| 20 | Extension of PIV to super resolution using PTV 显示文摘 | Adel Stitou M L Riethmuller | 2001 | Measurement Science and Technology2001，，12： | 1 |
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