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| 1 | 应用组织型纤溶酶原激活物行静脉溶栓治疗急性缺血性卒中的时间窗延长——美国心脏协会/美国卒中协会的科学建议显示文摘美国心脏协会卒中委员会发布了关于急性缺血性卒中的现行治疗指南,其中包括应用重组组织型纤溶酶原激活物(rt—PA)行静脉溶栓的建议。尽管该药对改善神经功能预后有一定的疗效,但由于患者通常在发病3h后方能到达医院,往往已经超过了用药的时间窗。因此,大部分缺血性卒中患者未能接受rt—PA治疗。目前研究认为,增加rt—PA治疗例数的最可能方法就是延长治疗时间窗。 | del Zoppo G J Saver J L Jauch E C Adams H P Jr. | 2009 | 中国脑血管病杂志2009，6，8： | 8 |
| 2 | Axial strain enhances osteotomy repair with a concomitant increase in connexin43 expression显示文摘The mechanical environment is known to influence fracture healing. We speculated that connexin43(Cx43) gap junctions, which impact skeletal homeostasis, fracture healing and the osteogenic response to mechanical load,may play a role in mediating the response of the healing bone to mechanical strain. Here, we used an established rat fracture model, which uses a 2 mm osteotomy gap stabilized by an external fixator, to examine the impact of various cyclical axial loading protocols(2%, 10%, and 30% strain) on osteotomy healing. We examined the presence of Cx43 in the osteotomy-healing environment and assessed how mechanical strain modulates Cx43 expression patterns in the callus. We demonstrated that increased cyclical axial strain results in increased radiographic and histologic bone formation. In addition, we show by immunohistochemistry that Cx43 is abundantly expressed in the healing callus, with the expression most robust in samples exposed to increased cyclical axial strain. These data are consistent with the concept that an increase in Cx43 expression by mechanical load may be part of the mechanisms by which mechanical forces enhances fracture healing. | Rishi R Gupta Hyunchul Kim Yu-Kwan Chan Carla Hebert Leah Gitajn David J Yoo Robert V O’Toole Adam H Hsieh Joseph P Stains | 2015 | Bone Research2015，3，2： | 2 |
| 3 | Measurements of acute cerebral infarction: a clinical examination scale 显示文摘 | Brott T Adams H P Jr Olinger C P | 1989 | Stroke1989，20，7： | 1 |
| 4 | Sensitive de- tection of occult breast cancer by the reverse - transcriptase poly- merase chain reaction显示文摘 | DATI?A Y H ADAMS P T DROBYKI W R_ | 1994 | J Clin Oncol1994，12，6： | 1 |
| 5 | Guidelines for the early management of patients with ischemic stroke : 2005 guidelines update : a scientific statement from the Stroke Council of the American Harct Assoeiation/American Stroke Assoeiation显示文摘 | Adams H P Adams R Del Zoppo G | 2005 | Stroke2005，36，1： | 1 |
| 6 | Guidelines for the early management of adults with ischemic stroke : a guideline from the American Heart Association/American Stroke Association Stroke Coun- cil, Clinical Cardiology Council, Cardiovascular Radiology and Inter- vention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: the American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists 显示文摘 | Adams H P Jr del-Zoppo G Alberts M J | 2007 | Stroke2007，38，5： | 1 |
| 7 | Guidelines for the early management of adults withischemic stroke: a guideline from the American Heart Association/American Stroke Association StrokeCouncil, ClinicalCardiology Council, CardiovascularRadiology and Inter vent ion Council, and theAtherosclerotic Peripheral VascularDisease andQualityof CareOutcomeinResearchlnterdisciplinary Working Groups:the American Academy of Neurologyaffirms the value of this guideline as an educationaltool for neurologists 显示文摘 | ADAMS H P JR DEL ZOPPO G ALBER TS M J | 2007 | Stroke2007，38，： | 1 |
| 8 | Postoperative pain management in orthopaedic patients: no differences in pain score,but improved stress control by epidural anaesthesia显示文摘 | Adams H A Saatweber P Schmitz C S | 2002 | Eur J Anaesthesiol2002，19，9： | 1 |
| 9 | Autoimmune ovarian inflammation triggered by proinflammatory(Th1) T cells is compatible with normal ovarian function in mice显示文摘 | Begawan H Adams S Terranova P | 1999 | Biol Reprod1999，61，3： | 1 |
| 10 | Climate change and the integrity of science 显示文摘 | Gleick P H Adams R M Amasino R M | 2010 | Science2010，328，5979： | 1 |
| 11 | Baseline NIH Stroke Scale score strongly predicts outcome after stroke: A report of the Trial of Org 10172 in Acute Stroke Treatment(TOAST)显示文摘 | ADAMS H P J R DAVIS P H LEIRA E C | 1999 | Neurology1999，53，1： | 1 |
| 12 | Electrical impedance tomography of human brain function using reconstruction algorithms based on the finite element method 显示文摘 | ANDREW P B ADAM D L RICHARD H B | 2003 | Neurolmage2003，20，2： | 1 |
| 13 | Sequence analysis demostrate that Onion yellow dwarf virus isolates from China contain a P3 region much larger than other potyvirus显示文摘 | Chen J Adams M J Zheng H Y Chen J P | 2003 | Archives of Virology2003，148，： | 1 |
| 14 | Postoperative pain management in orthopaedic patients:no differences in pain score,but improved stress control by epidural anaesthesia显示文摘 | Adams H A Saatweber P Schmitz C S | 2002 | Eur J Anaesthesiol2002，19，9： | 1 |
| 15 | Hypoxia induces the expression of a 43-kDa protein( PROXY-1 ) in normal and malignant cells 显示文摘 | Park H Adams MA Lachat P | 2000 | Biochem Biophys Res Commun2000，276，： | 1 |
| 16 | Polymyalgia rheumatica and in- ed 2 12 37 terspinous FDG uptake on PET/CT显示文摘 | Adams H Raijmakers P Smulders Y | | Clin Nuclear M0，，5： | 1 |
| 17 | Molecular characterization of segments 1 to 6 of Rice black-streaked dward virus from China provides the complete genome显示文摘 | Zhang H M Chen J P Adams M J | 2001 | Archives of Virology2001，146，12： | 1 |
| 18 | Insertion of microneedles into skin: measurement and prediction of insertion force and needle fracture force 显示文摘 | DAVIS S P LANDIS B J ADAMS Z H | 2004 | Journal of Biomechanics2004，37，8： | 1 |
| 19 | Postoperative pain management in orthopaedic patients: no differences in pain score, but improved stress control by epidurai anaesthesia显示文摘 | Adams H A Saatweber P Schmitz C S et ai | 2002 | Eur J Anaesth2002，19，： | 1 |
| 20 | Ovulation-inducing factor: aprotein component of llama seminal plasma显示文摘 | Ratto M H HuancaW Adams G P | 2010 | Reprod Biol Endo-crinol2010，8，： | 1 |
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