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| 1 | Capecitabine and irinotecan with and without bevacizumab for advanced colorectal cancer patients显示文摘AIM:To investigate the efficacy and safety of capecitabine plus irinotecan±bevacizumab in advanced or metastatic colorectal cancer patients. METHODS:Forty six patients with previously untreated,locally-advanced or metastatic colorectal cancer(mCRC) were recruited between 2001-2006 in a prospective open-label phaseⅡtrial,in German community-based outpatient clinics.Patients received a standard capecitabine plus irinotecan(CAPIRI) or CAPIRI plus bevacizumab(CAPIRI-BEV) regimen every 3 wk. Dose reductions were mandatory from the first cycle in cases of>grade 2 toxicity.The treatment choice of bevacizumab was at the discretion of the physician.Theprimary endpoints were response and toxicity and secondary endpoints included progression-free survival and overall survival. RESULTS:In the CAPIRI group vs the CAPRI-Bev group there were more female than male patients(47% vs 24%) ,and more patients had colon as the primary tumor site(58.8%vs 48.2%) with fewer patients having sigmoid colon as primary tumor site(5.9%vs 20.7%) .Grade 3/4 toxicity was higher with CAPIRI than CAPIRI-Bev:82%vs 58.6%.Partial response rates were 29.4%and 34.5%,and tumor control rates were 70.6%and 75.9%,respectively.No complete responses were observed.The median progression-free survival was 11.4 mo and 12.8 mo for CAPIRI and CAPIRI-Bev,respectively.The median overall survival for CAPIRI was 15 mo(458 d) and for CAPIRI-Bev 24 mo(733 d) .These differences were not statistically different.In the CAPIRI-Bev,group,two patients underwent a full secondary tumor resection after treatment,whereas in the CAPIRI group no cases underwent this procedure. CONCLUSION:Both regimens were well tolerated and offered effective tumor growth control in this outpatient setting.Severe gastrointestinal toxicities and thromboembolic events were rare and if observed were never fatal. | Markus Moehler Martin F Sprinzl Murad Abdelfattah Carl C Schimanski Bernd Adami Werner Godderz Klaus Majer Dimitri Flieger Andreas Teufel Juergen Siebler Thomas Hoehler Peter R Galle Stephan Kanzler | 2009 | World Journal of Gastroenterology2009，15，4： | 10 |
| 2 | A new prognostic histopathologic classification of nasopharyngeal carcinoma显示文摘Background:The current World Health Organization(WHO) classification of nasopharyngeal carcinoma(NPC) con?veys little prognostic information.This study aimed to propose an NPC histopathologic classification that can poten?tially be used to predict prognosis and treatment response.Methods:We initially developed a histopathologic classification based on the morphologic traits and cell differentia?tion of tumors of 2716 NPC patients who were identified at Sun Yat?sen University Cancer Center(SYSUCC)(training cohort).Then,the proposed classification was applied to 1702 patients(retrospective validation cohort) from hospitals outside SYSUCC and 1613 patients(prospective validation cohort) from SYSUCC.The efficacy of radiochemotherapy and radiotherapy modalities was compared between the proposed subtypes.We used Cox proportional hazards models to estimate hazard ratios(HRs) with 95% confidence intervals(CI) for overall survival(OS).Results:The 5?year OS rates for all NPC patients who were diagnosed with epithelial carcinoma(EC;3708 patients),mixed sarcomatoid?epithelial carcinoma(MSEC;1247 patients),sarcomatoid carcinoma(SC;823 patients),and squamous cell carcinoma(SCC;253 patients) were 79.4%,70.5%,59.6%,and 42.6%,respectively(P < 0.001).In mul?tivariate models,patients with MSEC had a shorter OS than patients with EC(HR = 1.44,95% CI = 1.27–1.62),SC(HR = 2.00,95% CI = 1.76–2.28),or SCC(HR = 4.23,95% CI = 3.34–5.38).Radiochemotherapy significantly improved survival compared with radiotherapy alone for patients with EC(HR 49–0.75),and possibly for those with SCC(HR = 0.67,95% CI = 0.56–0.80),MSEC(HR = 0.58,95% CI = 0..74–1.28).= 0.63;95% CI = 0.40–0.98),but not for patients with SC(HR = 0.97,95% CI = 0Conclusions:The proposed classification offers more information for the prediction of NPC prognosis compared with the WHO classification and might be a valuable tool to guide treatment decisions for subtypes that are associ?ated with a poor prognosis. | Hai-Yun Wang Yih-Leong Chang Ka-Fai To Jacqueline S.G.Hwang Hai-Qiang Mai Yan-Fen Feng Ellen T.Chang Chen-Ping Wang Michael Koon Ming Kam Shie-Lee Cheah Ming Lee Li Gao Hui-Zhong Zhang Jie-Hua He Hao Jiang Pei-Qing Ma Xiao-Dong Zhu Liang Zeng Chun-Yan Chen Gang Chen Ma-Yan Huang Sha Fu Qiong Shao An-Jia Han Hai-Gang Li Chun-Kui Shao Pei-Yu Huang Chao-Nan Qian Tai-Xiang Lu Jin-Tian Li Weimin Ye Ingemar Ernberg Ho Keung Ng Joseph T.S.Wee Yi-Xin Zeng Hans-Olov Adami Anthony T.C.Chan Jian-Yong Shao | 2016 | Chinese Journal of Cancer2016，35，6： | 10 |
| 3 | Effect of dietary supplementation of xylanase on apparent ileal digestibility of nutrients,viscosity of digesta,and intestinal morphology of growing pigs fed corn and soybean meal based diet显示文摘This study was to determine apparent ileal digestibility of acid detergent fiber(ADF), neutral detergent fiber(NDF), dry matter(DM), energy, organic matter(OM), crude ash, digesta viscosity, and gut morphology in nursery pigs fed diets containing xylanase(Lohmann Animal Nutrition GmbH, Cuxhaven, Germany). The diet(61% corn, 35% soybean meal, 1% poultry fat, and 3% minerals and vitamins) was mixed with 3 levels of xylanase(0,700, and 1400 LXU/kg). Thirty-six barrows(17.6 ± 3.3 kg) received one of 3 treatment diets based on a randomized complete block design with the initial body weight(BW) as a block. Pigs were individually housed and received experimental diets twice daily(0700 and 1700 h) at a fixed amount based on BW of pigs(0.09 x BW^(0.75) kg). Pigs were fed diets for 10 d, and chromium oxide(0.3%) was added to the diets from d 6 as an indigestible external marker. Pigs were euthanized at the end of d 10 for the collection of digesta and tissues. Jejunal digesta were centrifuged to measure viscosity using a viscometer(Brookfield Engineering Laboratories, Stoughton, MA). Diets and freeze-dried ileal digesta were used to measure ADF, NDF, and chromium to calculate apparent ileal digestibility of ADFand NDF. Villus height and crypt depth of jejunum were measured using a microscope(Fisher Scientific, Hampton, NH). Data were analyzed using polynomial contrasts in the MIXED procedure of SAS version 9.3(SAS Inc., Cary, NC, USA). Morphological measurements and ileal ADF digestibility were not affected by increasing xylanase. However, increasing xylanase supplementation from 0 to 1400 LXU/kg enhanced ileal digestibility of NDF(P < 0.042, linear) from 27.9 to 40.3%,DM(P < 0.006, linear) from 55.4 to 64.6%, OM(P < 0.006, linear) from 59.2 to 67.7%, and energy(P < 0.003,linear) from 58.8 to 68.0%. Viscosity of jejunal digesta decreased(P < 0.023) in a non-linear manner from 2.9 to 2.5 centipoises(cP). In conclusion, the usage of xylanase in corn and soybean meal based pig diets linearly enhanced digestibility of nutrients and affected viscosity of digesta in a non-linear manner. | Adsos Adami Passos Inkyung Park Peter Ferket Elke von Heimendahl Sung Woo Kim | 2015 | Animal Nutrition2015，，1： | 10 |
| 4 | Osteoporosis Treatment:When to Discontinue and When to Re-start显示文摘A number of effective therapies for the treatment of osteoporosis have become available in recent years.However,uncertainty exists regarding their long-term use and effectiveness.Bisphosphonate treatment,unlike hormone replacement,denosumab or teriparatide,is associated with benefits extended even after treatment discontinuation.The extended benefits are most apparent for alendronate(ALN)and zoledronate(ZOL).A drug holiday might be considered in patients at low-moderate risk and who have been fully compliant with treatment,and who have had a response to treatment.In patients at low-moderate risk of fractures the decision to consider a drug holiday should be balanced also with the safety profile of each treatment. | Silvano Adami Luca Idolazzi Elena Fracassi Davide Gatti Maurizio Rossini | 2013 | Bone Research2013，1，4： | 6 |
| 5 | Noninvasive methods for prediction of esophageal varices in pediatric patients with portal hypertension显示文摘AIM: To evaluate clinical and laboratory parameters for prediction of bleeding from esophageal varices (EV) in children with portal hypertension. METHODS: Retrospective study of 103 children (mean age: 10.1 ± 7.7 years), 95.1% with intrahepatic portal hypertension. All patients had no history of bleeding and underwent esophagogastroduodenoscopy for EV screening. We recorded variceal size (F1, F2 and F3), red-color signs and portal gastropathy, according to the Japanese Research Society for Portal Hypertension classification. Patients were classified into two groups: with and without EV. Seven noninvasive markers were evaluated as potential predictors of EV: (1) platelet count; (2) spleen size z score, expressed as a standard deviation score relative to normal values for age; (3)platelet count to spleen size z score ratio; (4) platelets count to spleen size (cm) ratio; (5) the clinical prediction rule (CPR); (6) the aspartate aminotransferase to platelet ratio index (APRI); and (7) the risk score. RESULTS: Seventy-one children had EV on first endoscopy. On univariate analysis, spleen size, platelets, CPR, risk score, APRI, and platelet count to spleen size z score ratio showed significant associations. The best noninvasive predictors of EV were platelet count [area under the receiver operating characteristic curve (AUROC) 0.82; 95%CI: 0.73-0.91], platelet: spleen size z score (AUROC 0.78; 95%CI: 0.67-0.88), CPR (AUROC 0.77; 95%CI: 0.64-0.89), and risk score (AUROC 0.77; 95%CI: 0.66-0.88). A logistic regression model was applied with EV as the dependent variable and corrected by albumin, bilirubin and spleen size z score. Children with a CPR < 114 were 20.7-fold more likely to have EV compared to children with CPR > 114. A risk score > -1.2 increased the likelihood of EV (odds ratio 7.47; 95%CI: 2.06-26.99). CONCLUSION: Children with portal hypertension with a CPR below 114 and a risk score greater than -1.2 are more likely to have present EV. Therefore, these two tests can be helpful in selecting children for endoscopy. | Marina Rossato Adami Cristina Targa Ferreira Carlos Oscar Kieling Vania Hirakata Sandra Maria Gonalves Vieira | 2013 | World Journal of Gastroenterology2013，19，13： | 4 |
| 6 | 双磷酸盐关节腔内注射用于治疗膝关节骨关节炎显示文摘膝关节骨关节炎是造成残疾的主要原因之一,对55岁以上的人群的10%造成影响。既往多中心研究发现,关节腔内注射氯膦酸二钠(双磷酸盐的一种)可显著改善膝关节骨关节炎患者疼痛和功能,其疗效与透明质酸相当。本研究进一步评定了在膝关节骨关节炎的患者中,关节腔内氯膦酸二钠注射的有效性和患者对上述治疗的耐受性。 | Rossini M Adami S Fracassi E 吴毅 | 2015 | 中国康复2015，30，5： | 4 |
| 7 | From bariatric to metabolic surgery:Looking for a'diseasemodifier'surgery for type 2 diabetes显示文摘In this review the recent evolution of the comprehension of clinical and metabolic consequences of bariatric surgery is depicted. At the beginning bariatric surgery aim was a significant and durable weight loss. Later on, it became evident that bariatric surgery was associated with metabolic changes, activated by unknown pathways, partially or totally independent of weight loss. Paradigm of this 'metabolic' surgery is its effects on type 2 diabetes mellitus(T2DM). In morbid obese subjects it was observed a dramatic metabolic response leading to decrease blood glucose, till diabetes remission, before the achievement of clinically significant weight loss, opening the avenue to search for putative antidiabetic 'intestinal' factors. Both proximal duodenal(still unknown) and distal(GLP1) signals have been suggested as hormonal effectors of surgery on blood glucose decrease. Despite these findings T2 DM remission was never considered a primary indication for bariatric surgery but only a secondary one. Recently T2 DM remission in obese subjects with body mass index(BMI) greater than 35 has become a primary aim for surgery. This change supports the idea that 'metabolic surgery' definition could more appropriate than bariatric, allowing to explore the possibility that metabolic surgery could represent a 'disease modifier' for T2 DM. Therefore, several patients have undergone surgery with a primary aim of a definitive cure of T2 DM and today this surgery can be proposed as an alternative therapy. How much surgery can be considered truly metabolic is still unknown. To be truly 'metabolic' it should be demonstrated that surgery could cause T2 DM remission not only in subjects with BMI > 35 but also with BMI < 35 or even < 30. Available evidence on this topic is discussed in this mini-review. | Renzo Cordera Gian Franco Adami | 2016 | World Journal of Diabetes2016，7，2： | 3 |
| 8 | A prospective study of obesity and cancer risk (Sweden)显示文摘 | Alicja Wolk Gloria Gridley Malin Svensson Olof Nyrén Joseph K. McLaughlin Joseph F. Fraumeni Hans-Olov Adami | 2001 | Cancer Causes and Control2001，，1： | 2 |
| 9 | Agreement and conversion formula between mini-mental state examination and montreal cognitive assessment in an outpatient sample显示文摘AIM To explore the agreement between the mini-mental state examination(MMSE) and montreal cognitive assessment(Mo CA) within community dwelling older patients attending an old age psychiatry service and to derive and test a conversion formula between the two scales.METHODS Prospective study of consecutive patients attending outpatient services.Both tests were administered by the same researcher on the same day in random order.RESULTS The total sample(n = 135) was randomly divided into two groups.One to derive a conversion rule(n = 70),and a second(n = 65) in which this rule was tested.The agreement(Pearson's r) of MMSE and Mo CA was 0.86(P < 0.001),and Lin's concordance correlation coefficient(CCC) was 0.57(95%CI:0.45-0.66).In the second sample Mo CA scores were converted to MMSE scores according to a conversion rule from the first sample which achieved agreement with the original MMSE scoresof 0.89(Pearson's r,P < 0.001) and CCC of 0.88(95%CI:0.82-0.92).CONCLUSION Although the two scales overlap considerably,the agreement is modest.The conversion rule derived herein demonstrated promising accuracy and warrants further testing in other populations. | Luqman Helmi David Meagher Edmond O'Mahony Donagh O'Neill Owen Mulligan Sutha Murthy Geraldine McCarthy Dimitrios Adamis | 2016 | World Journal of Psychiatry2016，6，3： | 2 |
| 10 | Cancer risk in patients with diabetes mellitus显示文摘 | Hans-Olov Adami Joseph McLaughlin Anders Ekbom Christian Berne Debra Silverman David Hacker Ingemar Persson | 1991 | Cancer Causes and Control1991，，5： | 2 |
| 11 | 未来变速箱面临的挑战显示文摘现代传动系统必需满足大的燃油经济性、较少的有害气体排放和日益增大的舒适性等要求。本文提出了可有助于达到这些目的方法。它可实现最佳的高效的自动变速箱和最佳的传动系操纵。 | ZF Fredrichshafen AG Prof. Dr. P. Adamis,Dr. G. Gruschow | 1996 | 传动技术1996，21，2： | 2 |
| 12 | 显示文摘 | Ram M K Adami M Faraci P | 2000 | Polymer2000，41，： | 1 |
| 13 | A new frequency detector for orthogonal multicarrier transmission techniques显示文摘 | Adami O | 1995 | Proc Ieee Veh Technol1995，，25： | 1 |
| 14 | The role of vascular endothelial growth factor in ocular health and disease显示文摘 | Adamis AP Shima DT | 2005 | Retina2005，25，2： | 1 |
| 15 | Relationship be- tween lipids and bone mass in tow cohorts of healthy women and men显示文摘 | Adami S Braga V Zamboni M | 2004 | Calcif Tissue Int2004，74，： | 1 |
| 16 | Diabetes therapy and cancer risk:causal effects and other plausible explanations显示文摘 | Hemndez-Daz S Adami HO | 2010 | Diabeto-logia2010，53，5： | 1 |
| 17 | The enigmatic epidemiology of naso- pharyngeal carcinoma显示文摘 | Chang ET Adami HO | 2006 | Cancer Epidemiol Biomarkers Prev2006，15，10： | 1 |
| 18 | Pegaptanib sodium for macular edema secondary to central retinal vein occlusion显示文摘 | Wroblewski JJ Wells JA 3 rd Adamis AP | | 0，，： | 1 |
| 19 | Social and economic effects of non-ulcer dyspepsia 显示文摘 | Nyr6n O Adami HO Gustavsson S et aI | 1985 | Scand J Gastroenterol Suppl1985，109，： | 1 |
| 20 | Sensitive blood-retinal barrier breakdownquantitation using Evans blue显示文摘 | XuQ Qaum T Adamis AP | 2001 | Investigative ophthalmology & visualscience2001，，42： | 1 |
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