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| 1 | Hepatic portal venous gas: Physiopathology, etiology, prognosis and treatment显示文摘Hepatic portal venous gas (HPVG), an ominous radiologic sign, is associated in some cases with a severe underlying abdominal disease requiring urgent operative intervention. HPVG has been reported with increasing frequency in medical literature and usually accompanies severe or lethal conditions. The diagnosis of HPVG is usually made by plain abdominal radiography, sonography, color Doppler flow imaging or computed tomography (CT) scan. Currently, the increased use of CT scan and ultrasound in the inpatient setting allows early and highly sensitive detection of such severe illnesses and also the recognition of an increasing number of benign and non-life threatening causes of HPVG. HPVG is not by itself a surgical indication and the treatment depends mainly on the underlying disease. The prognosis is related to the pathology itself and is not influenced by the presence of HPVG. Based on a review of the literature, we discuss in this paper the pathophysiology, risk factors, radiographic findings, management, and prognosis of pathologies associated with HPVG. | Bassam Abboud Jad El Hachem Thierry Yazbeck Corinne Doumit | 2009 | World Journal of Gastroenterology2009，15，29： | 25 |
| 2 | Occult sporadic insulinoma: Localization and surgical strategy显示文摘Insulinomas continue to pose a diagnostic challenge to physicians, surgeons and radiologists alike. Most are intrapancreatic, benign and solitary. Biochemical diagnosis is obtained and imaging techniques to localize lesions continue to evolve. Surgical resection is the treatment of choice. Despite all efforts, an occult insulinoma (occult insulinoma refers to a biochemically proven tumor with indeterminate anatomical site before operation) may still be encountered. New localization preoperative techniques decreases occult cases and the knowledge of the site of the mass before surgery allows to determine whether enucleation of the tumor or pancreatic resection is likely to be required and whether the tumor is amenable to removal via a laparoscopic approach. In absence of preoperative localization and intraoperative detection of an insulinoma, blind pancreatic resection is not recommended. | Bassam Abboud Joe Boujaoude | 2008 | World Journal of Gastroenterology2008，14，5： | 21 |
| 3 | Idiopathic sclerosing encapsulating peritonitis:Abdominal cocoon显示文摘Abdominal cocoon,the idiopathic form of sclerosing encapsulating peritonitis,is a rare condition of unknown etiology that results in an intestinal obstruction due to total or partial encapsulation of the small bowel by a f ibrocollagenous membrane.Preoperative diagnosis requires a high index of clinical suspicion.The early clinical features are nonspecif ic,are often not recognized and it is diff icult to make a def inite pre-operative diagnosis.Clinical suspicion may be generated by the recurrent episodes of small intestinal obstruction combined with relevant imaging f indings and lack of other plausible etiologies.The radiological diagnosis of abdominal cocoon may now be conf idently made on computed tomography scan.Surgery is important in the management of this disease.Careful dissection and excision of the thick sac with the release of the small intestine leads to complete recovery in the vast majority of cases. | Jenny N Tannoury Bassam N Abboud | 2012 | World Journal of Gastroenterology2012，18，17： | 14 |
| 4 | Treatment options of inflammatory appendiceal masses in adults显示文摘At present, the treatment of choice for uncomplicated acute appendicitis in adults continues to be surgical. The inflammation in acute appendicitis may sometimes be enclosed by the patient's own defense mechanisms, by the formation of an inflammatory phlegmon or a circumscribed abscess. The management of these patients is controversial. Immediate appendectomy may be technically demanding. The exploration often ends up in an ileocecal resection or a right-sided hemicolectomy. Recently, the conditions for conservative management of these patients have changed due to the development of computed tomography and ultrasound, which has improved the diagnosis of enclosed inflammation and made drainage of intra-abdominal abscesses easier. New efficient antibiotics have also given new opportunities for nonsurgical treatment of complicated appendicitis. The traditional management of these patients is nonsurgical treatment followed by interval appendectomy to prevent recurrence. The need for interval appendectomy after successful nonsurgical treatment has recently been questioned because the risk of recurrence is relatively small. After successful nonsurgical treatment of an appendiceal mass, the true diagnosis is uncertain in some cases and an underlying diagnosis of cancer or Crohn's disease may be delayed. This report aims at reviewing the treatment options of patients with enclosed appendiceal inflammation, with emphasis on the success rate of nonsurgical treatment, the need for drainage of abscesses, the risk of undetected serious disease, and the need for interval appendectomy to prevent recurrence. | Jenny Tannoury Bassam Abboud | 2013 | World Journal of Gastroenterology2013，19，25： | 9 |
| 5 | Acute mesenteric ischemia after cardio-pulmonary bypass surgery显示文摘Acute mesenteric ischemia (AMI) is a highly-lethal surgical emergency. Several pathophysiologic events (arterial obstruction, venous thrombosis and diffuse vasospasm) lead to a sudden decrease in mesenteric blood flow. Ischemia/reperfusion syndrome of the intestine is responsible for systemic abnormalities, leading to multi-organ failure and death. Early diagnosis is difficult because the clinical presentation is subtle, and the biological and radiological diagnostic tools lack sensitivity and specificity. Therapeutic options vary from conservative resuscitation, medical treatment, endovascular techniques and surgical resection and revascularization. A high index of suspicion is required for diagnosis, and prompt treatment is the only hope of reducing the mortality rate. Studies are in progress to provide more accurate diagnostic tools for early diagnosis. AMI can complicate the post-operative course of patients following cardio-pulmonary bypass (CPB). Several factors contribute to the systemic hypo-perfusion state, which is the most frequent pathophysiologic event. In this particular setting, the clinical presentation of AMI can be misleading, while the laboratory and radiological diagnostic tests often produce inconclusive results. The management strategies are controversial, but early treatment is critical for saving lives. Based on the experience of our team, we consider prompt exploratory laparotomy, irrespective of the results of the diagnostic tests, isthe only way to provide objective assessment and adequate treatment, leading to dramatic reduction in the mortality rate. | Bassam Abboud Ronald Daher Joe Boujaoude | 2008 | World Journal of Gastroenterology2008，14，35： | 9 |
| 6 | Consequences of dysthyroidism on the digestive tract and viscera显示文摘Thyroid hormones def ine basal metabolism throughout the body, particularly in the intestine and viscera. Gastrointestinal manifestations of dysthyroidism are numerous and involve all portions of the tract. Thyroid hormone action on motility has been widely studied, but more complex pathophysiologic mechanisms have been indicated by some studies although these are not fully understood. Both thyroid hormone excess and def iciency can have similar digestive manifestations, such as diarrhea, although the mechanism is different in each situation. The liver is the most affected organ in both hypo-and hyperthyroidism. Specifi c digestive diseases may be associated with autoimmune thyroid processes, such as Hashimoto's thyroiditis and Grave's disease. Among them, celiac sprue and primary biliary cirrhosis are the most frequent although a clear common mechanism has never been proven. Overall, thyroid-related digestive manifestations were described decades ago but studies are still needed in order to conf irm old concepts or elucidate undiscovered mechanisms. All practitioners must be aware of digestive symptoms due to dysthyroidism in order to avoid misdiagnosis of rare but potentially lethal situations. | Ronald Daher Thierry Yazbeck Joe Bou Jaoude Bassam Abboud | 2009 | World Journal of Gastroenterology2009，15，23： | 9 |
| 7 | Digestive manifestations of parathyroid disorders显示文摘The parathyroid glands are the main regulator of plasma calcium and have a direct influence on the digestive tract.Parathyroid disturbances often result in unknown long-standing symptoms.The main manifestation of hypoparathyroidism is steatorrhea due to a deficit in exocrine pancreas secretion.The association with celiac sprue may contribute to malabsorption.Hyperparathyroidism causes smooth-muscle atony,with upper and lower gastrointestinal symptoms such as nausea,heartburn and constipation.Hyperparathyroidism and peptic ulcer were strongly linked before the advent of proton pump inhibitors.Nowadays,this association remains likely only in the particular context of multiple endocrine neoplasia type 1/Zollinger-Ellison syndrome.In contrast to chronic pancreatitis,acute pancreatitis due to primary hyperparathyroidism is one of the most studied topics.The causative effect of high calcium level is confirmed and the distinction from secondary hyperparathyroidism is mandatory.The digestive manifestations of parathyroid malfunction are often overlooked and serum calcium level must be included in the routine workup for abdominal symptoms. | Bassam Abboud Ronald Daher Joe Boujaoude | 2011 | World Journal of Gastroenterology2011，17，36： | 2 |
| 8 | Use of locking plates in the treatment of proximal humerus fractures显示文摘 | Eric T. Ricchetti William J. Warrender Joseph A. Abboud | 2010 | Journal of Shoulder and Elbow Surgery2010，，2： | 2 |
| 9 | A novel mammalian iron-regulated protein in- volved in intracellular iron metabolism 显示文摘 | Abboud S Halle DJ | 2000 | J Biol Chem2000，275，19： | 1 |
| 10 | Expression of transforming growth factor-β and type IV collagen in early streptozotocin-lnduced diabetes 显示文摘 | Park IS Kiyomoto H Abboud SL | 1997 | Diabetes1997，46，5： | 1 |
| 11 | Ultrasound guidance for vas- cular access显示文摘 | Abboud P A Kendall J L | 2004 | Emerg Med Clin North Am2004，22，3： | 1 |
| 12 | P - selectin gene polymorphisms and risk of coronary heart disease among Tuni- sians 显示文摘 | GHAZOUANI L ABBOUD N KHLIFA S B | 2009 | J Thromb Thrombolysis2009，28，3： | 1 |
| 13 | Mesangial cell biology显示文摘 | Abboud HE | 2012 | Exp Cell Res2012，318，9： | 1 |
| 14 | Chronic myelogenons leuke- mia显示文摘 | O'Brien S Abboud CN Akhtari M | 2012 | J Natl Compr Canc Netw2012，10，1： | 1 |
| 15 | A randomized,double-blind,placebo-controlled study to assess the efficacy and safety of cinacalcet HCl in participants with CKD not receiving dialysis显示文摘 | Chonchol M Locatelli F Abboud HE | | 0，，： | 1 |
| 16 | Simulations of ductile fracture in an idealized ship grounding scenario using phenomenological damage and cohesive zone models 显示文摘 | Woelke P B Shields M D Abboud N N | 2013 | Computational Materials Science2013，80，： | 1 |
| 17 | Drug-induced liver injury显示文摘 | Abboud G Kaplowitz N | 2007 | Drug Saf2007，30，4： | 1 |
| 18 | Non-recurrent inferior laryngeal nerve inthyroid surgery : report of three cases and review of the literature显示文摘 | Abboud B Aouad R | 2004 | J Laryngol Otol2004，118，2： | 1 |
| 19 | Acute myeloid leukemia显示文摘 | O′Donnell MR Abboud CN Altman J | 2012 | J Natl Compr Canc Netw2012，10，8： | 1 |
| 20 | Polymorphisms of hu- man platelet alloantigens HPA-1 and HPA-2 associated with severe coronary artery disease 显示文摘 | Abboud N Amin H Ghazouani L | 2010 | Cardiovasc Pathol2010，19，5： | 1 |
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