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| 1 | Observation of an α-synuclein liquid droplet state and its maturation into Lewy body-like assemblies显示文摘Misfoldedα-synudein is a major component of Lewy bodies,which are a hallmark of Parkinson's disease(PD).A large body of evidence shows thatα-synuclein can aggregate into amyloid fibrils,but the relationship between a-synuclein self-assembly and Lewy body formation remains unclear.Here,we show,both in vitro and in a Caenorhabditis elegans model of PD,thatα-synuclein undergoes liquid-liquid phase separation by forming a liquid droplet state,which converts into an amyloid-rich hydrogel with Lewy-body-like properties.This maturation process towards the amyloid state is delayed in the presence of model synaptic vesicles in vitro.Taken together,these results suggest that the formation of Lewy bodies may be linked to the arrested maturation ofα-synuclein condensates in the presence of lipids and other cellular components. | Maarten C.Hardenberg Tessa Sinnige Sam Casford Samuel T.Dada Chetan Poudel Elizabeth A.Robinson Monika Fuxreiter Clemens F.Kaminksi Gabriele S.Kaminski Schierle Ellen A.A.Nollen Christopher M.Dobson Michele Vendruscolo | 2021 | Journal of Molecular Cell Biology2021，13，4： | 3 |
| 2 | Electromagnetic induction mapping at varied soil moisture reveals field-scale soil textural patterns and gravel lenses显示文摘Knowledge of the spatial distribution of soil textural properties is important for determining soil moisture storage and soil hydraulic transport properties.Capturing field heterogeneity without exhaustive sampling and costly sample analysis is difficult. Our objective was to employ electromagnetic induction(EMI) mapping in low apparent electrical conductivity(EC_a) soils at varying soil water contents to capture time invariant properties such as soil texture. Georeferenced EC_ameasurements were taken using a ground conductivity meter on six different days where volumetric water content(θ_v) varied from 0.11 to 0.23. The 50 m × 50 m field included a subsurface gravelly patch in an otherwise homogeneous silt-loam alluvial soil.Ordinary block kriging predicted EC_aat unsampled areas to produce 1-m resolution maps. Temporal stability analysis was used to divide the field into three distinct EC_a regions. Subsequent ground-truthing confirmed the lowest conductivity region correlated with coarse textured soil parent materials associated with a former high-energy alluvial depositional area. Combining maps using temporal stability analysis gives the clearest image of the textural difference. These maps could be informative for modeling,experimental design, sensor placement and targeted zone management strategies in soil science, ecology, hydrology,and agricultural applications. | Hiruy ABDU David A.ROBINSON Janis BOETTINGER Scott B.JONES | 2017 | Frontiers of Agricultural Science and Engineering2017，4，2： | 2 |
| 3 | THE USE OF RELEASABLE SUTURES IN FILTRA-TION SURGERY REDUCES EARLY POST OPERA-TIVE COMPLICATIONS显示文摘Purpose: To evaluate the use of releasable sutures in filtration surgery by comparing the results and the rate of post-operative complications in eyes which underwent filtration surgery with and without releasable sutures. Methods: A retrospective evaluation of 74 eyes with glaucoma (COAG, CNAG, PXFG) of 74 patients who underwent filtration surgery in our department during 1999. All the patients included in the study had 6-12 | A.Robinson N.Blumberg M.Lusky D.Weinberger | 2003 | 国际眼科杂志2003，3，1： | 1 |
| 4 | Reversal of Fortune:Geography and Institutions in the Making of the Modem World Income Distribution显示文摘 | Daron Acemoglu Simon Johnson James A.Robinson | | 0，，04： | 1 |
| 5 | The Colonial Origins of Comparative Development:An Empirical Investigation显示文摘 | Acemoglu Daron Simon Johnson James A.Robinson | | 0，，： | 1 |
| 6 | Reversal of fortune:Geography and Institutions in the Making of the Modem World income Distribution显示文摘 | Acemoglu Daron Simon Johnson James A.Robinson | | 0，，： | 1 |
| 7 | Work Sampling:Methodological Advances and New Applications显示文摘 | Mark A.Robinson | | 0，，： | 1 |
| 8 | Promising hypotensive effect of hawthorn extract: A randomized double‐blind pilot study of mild, essential hypertension显示文摘 | Ann F.Walker GeorgiosMarakis Andrew P.Morris Paul A.Robinson | 2002 | Phytother Res2002，，1： | 1 |
| 9 | Northern Hemisphere snow extent: regional variability 1972–1994显示文摘 | AllanFrei David A.Robinson | 1999 | Int J Climatol1999，，14： | 1 |
| 10 | The Political Economy of the Kuznets Curve显示文摘 | DaronAcemoglu James A.Robinson | 2002 | Review of Development Economics2002，，2： | 1 |
| 11 | Effects of aspect on weathering: anomalous behaviour of sandstone gravestones in southeast England显示文摘 | R. B. G.Williams D. A.Robinson | 2000 | Landforms2000，，2： | 1 |
| 12 | Microsatellite differentiation between Phillip Island and mainland Australian populations of the red fox Vulpes vulpes显示文摘 | J. A.LADE N. D.MURRAY C. A.MARKS N. A.ROBINSON | 2008 | Molecular Ecology2008，，1： | 1 |
| 13 | Peroxisome proliferator–activated receptor α in the human breast cancer cell lines MCF‐7 and MDA‐MB‐231显示文摘 | Kate M.Suchanek Fiona J.May Jodie A.Robinson Won JaeLee Nicola A.Holman Gregory R.Monteith Sarah J.Roberts‐Thomson | 2002 | Mol. Carcinog2002，，4： | 1 |
| 14 | LPA induces osteoblast differentiation through interplay of two receptors: LPA1 and LPA4显示文摘 | Yao‐BinLiu YogendraKharode Peter V.N.Bodine Paul J.Yaworsky John A.Robinson JuliaBilliard | 2010 | J. Cell. Biochem2010，，4： | 1 |
| 15 | Towards a better understanding of pathways of multiple co-occurring erosion processes on global cropland显示文摘Soil erosion is a complex process involving multiple natural and anthropic agents,causing the deterio-ration of multiple components comprising soil health.Here,we provide an estimate of the spatial pat-terns of cropland susceptibility to erosion by sheet and rill,gully,wind,tillage,and root crops harvesting and report the co-occurrence of these processes using a multi-model approach.In addition,to give a global overview of potential future changes,we identify the locations where these multiple concurrent soil erosion processes may be expected to intersect with projected dry/wet climate changes by 2070.Of a modelled 1.48 billion hectares(B ha)of global cropland,our results indicate that 0.56 B ha(-36%of the total area)are highly susceptible(classes 4 and 5)to a single erosion process,0.27 B ha(-18%of the total area)to two processes and 0.02 B ha(1.4%of the total area)to three or more processes.An estimated 0.82 B ha of croplands are susceptible to possible increases in water(0.68 B ha)and wind(0.14 B ha)erosion.We contend that the presented set of estimates represents a basis for enhancing our founda-tional knowledge on the geography of soil erosion at the global scale.The generated insight on multiple erosion processes can be a useful starting point for decision-makers working with ex-post and ex-ante policy evaluation of the UN Sustainable Development Goal 15(Life on Land)activities.Scientifically,this work provides the hitherto most comprehensive assessment of soil erosion risks at the global scale,based on state-of-the-art models. | Pasquale Borrelli Christine Alewell Jae E.Yang Nejc Bezak Yixian Chen Ayele Almaw Fenta Arthur Nicolaus Fendrich Surya Gupta Francis Matthews Sirio Modugno Nigussie Haregeweyn David A.Robinson Florence Tan Matthias Vanmaercke Gert Verstraeten Diana C.S.Vieira Panos Panagos | 2023 | International Soil and Water Conservation Research2023，11，4： | 0 |
| 16 | Autonomous scanning probe microscopy investigations over WS_(2)and Au{111}显示文摘Individual atomic defects in 2D materials impact their macroscopic functionality.Correlating the interplay is challenging,however,intelligent hyperspectral scanning tunneling spectroscopy(STS)mapping provides a feasible solution to this technically difficult and time consuming problem.Here,dense spectroscopic volume is collected autonomously via Gaussian process regression,where convolutional neural networks are used in tandem for spectral identification.Acquired data enable defect segmentation,and a workflow is provided for machine-driven decision making during experimentation with capability for user customization.We provide a means towards autonomous experimentation for the benefit of both enhanced reproducibility and user-accessibility.Hyperspectral investigations on WS_(2)sulfur vacancy sites are explored,which is combined with local density of states confirmation on the Au{111}herringbone reconstruction.Chalcogen vacancies,pristine WS_(2),Au face-centered cubic,and Au hexagonal close-packed regions are examined and detected by machine learning methods to demonstrate the potential of artificial intelligence for hyperspectral STS mapping. | John C.Thomas Antonio Rossi Darian Smalley Luca Francaviglia Zhuohang Yu Tianyi Zhang Shalini Kumari Joshua A.Robinson Mauricio Terrones Masahiro Ishigami Eli Rotenberg Edward S.Barnard Archana Raja Ed Wong D.Frank Ogletree Marcus M.Noack Alexander Weber-Bargioni | 2022 | npj Computational Materials2022，，1： | 0 |
| 17 | Emerging Techniques for Cardiovascular PET显示文摘Positron emission tomography(PET)has been successfully applied to an increasing number of cardiovascular conditions.This review will highlight the status of cardiovascular PET,including the present state of the art and the expanding pool of clinical evidence guiding its use.Additionally,we highlight upcoming developments in the fi eld,including the development of new tracers and applications of PET to novel indications within cardiovascular medicine. | Austin A.Robinson,MD Jamieson M.Bourque,MD,MHS | 2019 | Cardiovascular Innovations and Applications2019，，B04： | 0 |
| 18 | 历史海洋生态学:研究渔业在北海底栖息生物变化中的作用显示文摘栖息在海底之上和之中的生物,即底栖生物,是一个重要的生态类群。尽管有些底栖生物(贝类)有一定经济价值,但大多数没有,因此现有的长期数据很少。我们已经确定了3个北海历史底栖生物数据源,北海是遭受多种人类影响至少几百年时间的区域海洋。每种数据集都有其局限性,但把它们一起使用就会产生一些问题。较短期内曾观测到较广泛的群落变化,而且在较长时间尺度上见到过北海规模的若干灭绝现象。灭绝的类群共有若干与渔业某种影响一致的特点,如脆弱的形态。现在我们必须把精力集中在加深我们对特定功能单元优势度变化的生态学意义的了解上,以及对那些易遭受渔业所致灭绝伤害的生境和物种的保护上。 | Leonie A.Robinson ChrisL.J.Frid 林宝法(译) | 2008 | AMBIO-人类环境杂志2008，37，5： | 0 |
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