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| 1 | Enterolactone modulates the ERK/NF-κB/Snail signaling pathway in triple-negative breast cancer cell line MDA-MB-231 to revert the TGF-β-induced epithelial–mesenchymal transition显示文摘Objective:Triple-negative breast cancer(TNBC)is highly metastatic,and there is an urgent unmet need to develop novel therapeutic strategies leading to the new drug discoveries against metastasis.The transforming growth factor-β(TGF-β)is known to promote the invasive and migratory potential of breast cancer cells through induction of epithelial–mesenchymal transition(EMT)via the ERK/NF-κB/Snail signaling pathway,leading to breast cancer metastasis.Targeting this pathway to revert the EMT would be an attractive,novel therapeutic strategy to halt breast cancer metastasis.Methods:Effects of enterolactone(EL)on the cell cycle and apoptosis were investigated using flow cytometry and a cleaved caspase-3 enzyme-linked immunosorbent assay(ELISA),respectively.Effects of TGF-βinduction and EL treatment on the functional malignancy of MDA-MB-231 breast cancer cells were investigated using migration and chemo-invasion assays.The effects of EL on EMT markers and the ERK/NF-κB/Snail signaling pathway after TGF-βinduction were studied using confocal microscopy,quantitative reverse transcription polymerase chain reaction(q RT-PCR),Western blot,and flow cytometry.Results:Herein,we report that EL exhibits a significant antimetastatic effect on MDA-MB-231 cells by almost reverting the TGF-β-induced EMT in vitro.EL downregulates the mesenchymal markers N-cadherin and vimentin,and upregulates the epithelial markers E-cadherin and occludin.It represses actin stress fiber formation via inhibition of mitogen-activated protein kinase p-38(MAPK-p38)and cluster of differentiation 44(CD44).EL also suppresses ERK-1/2,NF-κB,and Snail at the m RNA and protein levels.Conclusions:Briefly,EL was found to inhibit TGF-β-induced EMT by blocking the ERK/NF-κB/Snail signaling pathway,which is a promising target for breast cancer metastasis therapy. | Aniket V.Mali Asavari A.Joshi Mahabaleshwar V.Hegde Shivajirao S.Kadam | 2018 | Cancer Biology & Medicine2018，15，2： | 6 |
| 2 | Case-specificity and Its Implications in Distribution Network Analysis with Increasing Penetration of Photovoltaic Generation显示文摘Distribution system analysis(DSA)currently faces several challenges due to inclusion of distributed energy resources(DERs),which have many characteristics,such as inherent variability,uncertainty,possibility of flexible four quadrant converter operations with distributed generation(DG),and the need for efficient operations to improve reliability of the supply system.This article argues for a high degree of case-specificity and discusses its implications in distribution networks with increasing DG penetration.The research is based on the exhaustive yearly simulation analyses of 132 candidate scenarios and investigates the effects of feeder-specific factors,such as geo-electric size and feeder spread,load density,and phase unbalancing.Nineteen(19)feeder variants—with phase-domain detailed modeling of all feeder components,including DGs,are subjected to increasing penetration of photovoltaic generation without altering the type and location of DGs.The objective is to analyze the role of feederspecific factors on feeder response characteristics in terms of annualized operational parameters,such as energy losses,feeder voltage profile,average power factor,and peak demand at a substation node,as well as tap-changer operations of voltage regulating equipment and their interaction with shunt compensation.Recorded annual load profiles—industrial,commercial,and residential—as well as location specific weather data are used to simulate the candidate scenarios based on three IEEE test feeders and one actual spot network in India.Results signify the consideration of feeder-specific factors in the planning exercise of grouping“similar”feeders for formulating the strategies that can improve daily operations of distribution feeders.The demonstrated case-specificity also implies that optimization algorithms for improved operations with DGs will need to be based on an integrated approach that accounts for feeder-specific factors as well as cyclic variability of DERs. | Kalpesh A.Joshi Naran M.Pindoriya | 2017 | CSEE Journal of Power and Energy Systems2017，3，1： | 4 |
| 3 | Plasma factor?VII‐activating protease antigen levels and activity are increased in ischemic stroke显示文摘 | E.HANSON S. M.KANSE A.JOSHI K.JOOD S.NILSSON C.BLOMSTRAND C.JERN | 2012 | Journal of Thrombosis and Haemostasis2012，，5： | 1 |
| 4 | Plasma factor?VII‐activating protease antigen levels and activity are increased in ischemic stroke显示文摘 | E.HANSON S. M.KANSE A.JOSHI K.JOOD S.NILSSON C.BLOMSTRAND C.JERN | 2012 | Journal of Thrombosis and Haemostasis2012，，5： | 1 |
| 5 | 2020年全球汽车发动机效率提升和排放控制的发展动向(上)显示文摘20多年来,Corning公司每年都会发表1份关于全球内燃机(ICE)驱动车辆排放法规和排放控制技术发展情况的年度回顾报告[1-2]。介绍了2020年该领域的最新进展,交通运输领域设定的通过减少化石燃料的使用量来实现减缓气候变化的目标,以及为达到这些目标各国所采用的主要技术。近年来,各国政府加快了实施零排放车辆计划的步伐。中国公布了将在2025年实现50%以上车辆需要采用混合动力的技术路线图。预计在未来一段时间内,内燃机仍是汽车动力总成的一部分。因此,在采用传统发动机的情况下,各国需要进一步采用各种技术解决方案来促使车辆达到或接近零排放的水平。目前,各国在提升汽车发动机效率、排气后处理系统、混合动力、低碳燃油,以及预测控制等方面的技术都取得了一定进步。2020年,一些发达国家还加强了限制有害污染物排放的立法。美国加利福尼亚州采纳了要求重型车氮氧化物(NOx)排放减少90%的综合性低NOx法规,并讨论了轻型车低排放车IV(LEVIV)排放法规的若干要点,车队的非甲烷有机气体(NMOG)与NOx平均排放量限值可能要求达到20mg/mile①。欧盟制订了欧七排放法规草案,并对某些重大修改项目进行了审议,其中包括收紧排放限值(含收紧直径23nm以下颗粒物的限值)、强调城区行驶工况,并全面转向以实际行驶排放测量值为基础的车辆认证。 | 朱炳全(译) | 2021 | 汽车与新动力2021，4，5： | 1 |
| 6 | Template‐Free Hydrothermal Synthesis of Single‐Crystalline Barium Titanate and Strontium Titanate Nanowires显示文摘 | Upendra A.Joshi Jae SungLee | 2005 | Small2005，，12： | 1 |
| 7 | 全球汽车排放控制的最新发展动向(上)显示文摘阐述汽车尾管温室气体(GHG)和有害污染物排放控制的最新进展。详细介绍新出台和即将出台的排放法规,以及为改进发动机和排气后处理系统而开发的各种技术。报道了各主要国家通过CO2减排和车辆电动化目标来减少GHG排放的最新动向。对某些能促使CO2实现大幅减排的成熟内燃机技术作了详细评述,其中包括汽油压燃、预燃室燃烧、喷水和停缸等发动机技术的发展动向。探讨了动力总成电动化和采用先进发动机技术的协同效应。在评估各种动力总成的选择方案和强调混合动力系统在实现CO2减排中的作用时,必须进行类似于“从摇篮到坟墓”的全生命周期分析。对先进燃油在改善车辆排放中的作用及其潜力进行了分析。在有害污染物排放方面,着重论述了氮氧化物(NOx)和颗粒物的减排情况。美国加利福尼亚州正在领导1项重型卡车综合法规的制定工作,目标是使NOx排放减少90%,对该法规草案的主要内容作了介绍。工作面临的主要挑战是要在不影响CO2排放的情况下达到NOx的减排目标。为此,人们正在开展各种研究,并提出了各种技术路径。 | | 2020 | 汽车与新动力2020，3，6： | 1 |
| 8 | Metal nanoparticles as inhibitors of enzymes and toxins of multidrug-resistant Staphylococcus aureus显示文摘Staphylococcus aureus is an aerobic Gram-positive spherical bacterium known to cause a broad range of infections worldwide.It is a major cause of infective skin and soft infections and severe and life-threatening conditions,such as pneumonia,bloodstream infections,and endocarditis.The emergence of drug-resistant strains of S aureus,par-ticularly methicillin-resistant S aureus(MRSA),has become a significant concern in the healthcare community.Antibiotic-resistant S aureus is commonly acquired in hospitals and long-term care facilities.It often affects pa-tients with weakened immune systems,those undergoing invasive medical procedures,or those who have been hospitalized for extended periods.In the US,S aureus is known to cause potentially fatal illnesses,such as toxic shock syndrome(TSS)and acute-onset toxic shock syndrome(TSS),which are characterized by fever and hy-potension.It develops resistance to antibiotics through several mechanisms,such as the production of enzymes that inactivate antibiotics,target site modification,efflux pumps,and plasmid-mediated resistance.Therefore,preventing the spread of drug-resistant S aureus is needed,and there is an urgent need to explore novel ap-proaches in the development of anti-staphylococcal agents.This article reviews the principal infections caused by S aureus,major virulence factors,mechanisms of resistance development,and nanotechnology-based solutions for the control of drug-resistant S aureus. | Amruta A.Joshi Ravindra H.Patil | 2023 | Infectious Medicine2023，2，4： | 0 |
| 9 | T-lymphoid progenitor-based immunotherapies:clinical perspectives for one and all显示文摘Commentary of Moirangthem,R.D.,Ma,K.,Lizot,S.et al.A DL-4-and TNFα-based culture system to generate high numbers of non-modified or genetically modified immunotherapeutic human T-lymphoid progenitors.Cell Mol Immunol 18,1662–1676(2021). | P.Gaudeaux R.D.Moirangthem J.Paillet M.Martin-Corredera H.Sadek P.Rault A.Joshi J.Zuber T.S.Soheili O.Negre I.André | 2022 | Cellular & Molecular Immunology2022，19，12： | 0 |
| 10 | Author Correction to:T-lymphoid progenitor-based immunotherapies:clinical perspectives for one and all显示文摘Correction to:Cellular&Molecular Immunology http://gffzzd3cc09b8251d45dfswpbqc0fffoo569vp.ffgz.tsg.suse.edu.cn/10.1038/s41423-022-00927-5,published online 30 September 2022 In this article the affliation 2 Smart Immune,Paris,France for P.Gaudeaux was missing.The original article has been corrected. | P.Gaudeaux R.D.Moirangthem J.Paillet M.Martin-Corredera H.Sadek P.Rault A.Joshi J.Zuber T.S.Soheili O.Negre I.Andre | 2022 | Cellular & Molecular Immunology2022，19，12： | 0 |
| 11 | 2020年全球汽车发动机效率提升和排放控制的发展动向(下)显示文摘以下接上部分内容。欧盟提出的排放限值将可能会对以前法规未限制的排放组分(如NH3)产生一定的影响。发动机和排气后处理系统的技术也有所进步,轻型车汽油机的有效热效率(BTE)达到了45.0%,重型车柴油机的BTE也达到了55.0%。在欧洲和中国,尽管下一轮排放法规将要求大幅度提高颗粒过滤器的过滤效率,但目前汽油机颗粒过滤器已经是轻型车的1项较成熟的技术。对于重型车,重点分析了既能满足低氮氧化物(NOx)排放要求又能提高耐久性的排放控制系统。还介绍了各种领先的NOx减排技术及其最新进展,简要论述了燃油对发动机的重要性,这些技术不仅能提高汽油压燃等先进燃烧方式的效率,也能通过采用可再生燃油或合成燃油来减少温室气体排放。未来,当车辆接近零尾气排放时,如何有效降低颗粒排放物将成为1个重要课题。 | 朱炳全(译) | 2021 | 汽车与新动力2021，4，5： | 0 |
| 12 | 车用发动机效率提升和排放控制回顾(上)显示文摘回顾了2016年车用发动机在效率提升、排放法规和排放控制技术方面取得的具有代表性的重要进展。首先,介绍车用发动机排放法规的主要发展情况,包括最新提出的欧洲实际行驶排放(RDE)法规的颗粒数(PM)排放标准,以及中国和印度2020年后将要实施的类似于欧6的排放法规。到2023年,中国的排放标准将比欧6法规收紧30%~40%。美国加里福尼亚州重型车低氮氧化物(NO_x)排放法规正在向前推进,美国环保署正在考虑提出一项拟于2023年后实施的全美统一的排放法规建议草案。美国还最终确定了2021~2027年的新一轮重型车用发动机温室气体(GHG)排放法规,要求发动机的CO_2减排5%。轻型车和重型车发动机的效率有明显提高。总结了汽油机和柴油机为满足排放标准和温室气体法规而取得的主要进展。某些轻型车汽油机设计概念能够达到的排放水平要比现今汽油直喷发动机的排放量降低10%~15%,有些甚至能降低35%之多。严格的CO_2排放法规将要求车辆采用混合动力,以及进行高性能柴油机的开发。重型车用柴油机通过采用各种可实现商用化的技术达到了高于50%的有效热效率,还提出了一些能使有效热效率达到55%的建议方案。择要介绍了稀燃NO_x控制技术(包括选择性催化还原(SCR)催化器、SCR过滤器和组合系统)的发展情况,关注的重点是它们的耐久性和如何实现大幅度减排的目标。柴油机PM减排环绕着柴油机颗粒过滤器和SCR过滤器的碳烟再生开展工作。氧化催化器的研究侧重于225~250℃时丙烷、CO和甲烷的氧化。对可能影响排放的各种因素进行了综合评述。人们对汽油机颗粒过滤器的耐久性和灰分承载量有了更好的了解。讨论了几种三效催化器的开发情况,结果显示,人们对低成本催化系统重要性的认识有所提高。最后总结了几家实验室在稀燃汽油机排放控制方面取得的进展。 | T.Johnson A.Joshi 朱炳全 | 2018 | 汽车与新动力2018，1，2： | 0 |
| 13 | 全球汽车排放控制的最新发展动向(下)显示文摘介绍了几种主要的技术方案,包括采用双尿素供给、创新的低温尿素喷射方案、停缸、先进的燃烧技术、动力总成电动化和天然气发动机等。在轻型车方面,实际行驶排放(RDE)标准似乎要想解决实验室与道路上行驶时NOx排放数据的差异,对该方面相关的数据进行了分析。目前,行业内正在对欧6后的排放法规展开讨论,探讨了新法规的可能变化和排气后处理系统的发展,焦点仍然是要减少冷起动排放。介绍了柴油机和汽油机冷起动排放的研究情况。欧洲和中国的颗粒数排放标准已促使汽油机颗粒过滤器(GPF)在这些地区被广泛应用。概要介绍了GPF技术的最新改进情况。随着排放法规的进一步收紧,对GPF过滤效率的要求将会提高,并且预计未来也会要求气道喷油发动机车辆采用GPF。 | 朱炳全(译) | 2020 | 汽车与新动力2020，3，6： | 0 |
| 14 | 车用发动机效率提升和排放控制回顾(下)显示文摘回顾了车用发动机在效率提升、排放法规和排放控制技术方面取得的具有代表性的重要进展。首先,介绍车用发动机排放法规的主要发展情况,包括最新提出的欧洲实际行驶排放(RDE)法规的颗粒数(PN)排放标准,以及中国和印度2020年后将要实施的类似于欧6的排放法规。到2023年,中国的排放标准将比欧6法规收紧30%~40%。美国加里福尼亚州重型车低氮氧化物(NOx)排放法规正在向前推进,美国环保署正在考虑提出一项拟于2023年后实施的全美统一的排放法规建议草案。美国还最终确定了2021—2027年的新一轮重型车用发动机温室气体(GHG)排放法规,要求发动机的CO_2减排5%。轻型车和重型车发动机的效率有明显提高。总结了汽油机和柴油机为满足排放标准和温室气体法规而取得的主要进展。某些轻型车汽油机设计概念能够达到的排放水平要比现今汽油直喷发动机的排放量降低10%~15%,有些甚至能降低35%之多。严格的CO_2排放法规将要求车辆采用混合动力,以及进行高性能柴油机的开发。重型车用柴油机通过采用各种可实现商用化的技术达到了高于50%的有效热效率,还提出了一些能使有效热效率达到55%的建议方案。择要介绍了稀燃NOx控制技术(包括选择性催化还原(SCR)催化器、SCR过滤器和组合系统)的发展情况,关注的重点是它们的耐久性和如何实现大幅度减排的目标。柴油机PN减排环绕着柴油机颗粒过滤器和SCR过滤器的碳烟再生开展工作。氧化催化器的研究侧重于225~250℃时丙烷、CO和甲烷的氧化。对可能影响排放的各种因素进行了综合评述。人们对汽油机颗粒过滤器的耐久性和灰分承载量有了更好的了解。讨论了几种三效催化器的开发情况,结果显示,人们对低成本催化系统重要性的认识有所提高。最后总结了几家实验室在稀燃汽油机排放控制方面取得的进展。 | T.Johnson A.Joshi 朱炳全(译) | 2018 | 汽车与新动力2018，1，3： | 0 |
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