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| 1 | 广东龙窝花岗闪长质岩体的年代学、地球化学及岩石成因显示文摘龙窝岩体是南岭地区燕山早期具幔源组分贡献的花岗岩的典型代表,其主体岩性为花岗闪长岩,岩体中含有深色闪长质包体,锆石ELA-ICP-MS定年结果表明花岗闪长岩的形成年龄为169.1±2.5Ma,属中侏罗世岩浆活动的产物。地球化学特征上,该岩体铝弱过饱和(A/NKC=1.0~1.1),相对贫碱,富钾(K_2O/Na_2O=1.15~1.45),富轻稀土和大离子亲石元素(如Rb、Cs、Th、U),贫高场强元素(如Nb、Ti)。闪长质包体具有与寄主岩相似的矿物组合,但铁镁矿物含量及过渡族元素(V、CR、Co、Ni)丰度相对偏高,二者的主量和微量元素表现出混合成因的演化趋势。寄主岩与包体具有相近的Sr、Nd同位素组成,I_(Sr)和ε_(Nd)(t)值分别为0.70843~0.70995、-6.53~-8.89和0.70797~0.70882、-4.71~-9.24,均表现出壳幔混源花岗岩类岩石的特点。二元混合模拟计算显示寄主岩与包体成岩过程中地幔物质的混入比例分别为32.9%~40.4%和 31.8%~46.4%。通过对岩石产出构造背景及地质地球化学特征的综合分析,表明龙窝花岗闪长岩及其中的闪长质包体是在伸展-引张环境下,由幔源基性岩浆及其诱发的壳源长英质岩浆混合作用的产物。 | 邱检生 胡建 McInnes B I A 蒋少涌 徐夕生 Allen C M | 2004 | 岩石学报2004，20，6： | 19 |
| 2 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 3 | Existing drugs as broad-spectrum and potent inhibitors for Zika virus by targeting NS2B-NS3 interaction显示文摘Zika 病毒(ZIKV ) 的最近的爆发为治疗学加亮迫切需要。朊酶建筑群 NS2B-NS3 在 flaviviral polyprotein 处理期间起必要作用,并且因此代表一个吸引人的药目标。这里,我们开发了裂口酶识别直接指向 flavivirus NS2B-NS3 相互作用的 orthosteric 禁止者的基于互补的高产量的屏蔽试金。由屏蔽一个总数 2 816 同意了并且 investigational 药,我们识别了三个有势力候选人, temoporfin, niclosamide,和 nitazoxanide,,有 nanomolar 力量的 flavivirus NS2B-NS3 相互作用禁止者。显著地,在老鼠的在人的胎盘、神经的祖先房间的大多数有势力化合物, temoporfin,不是仅仅禁止的 ZIKV 复制,而且阻止的导致 ZIKV 的 viremia 和死亡当模特儿。结构的停靠建议 temoporfin 潜在地绑保持批评 NS2B 残余的 NS3 衣袋,因此禁止以一种非竞争的方式处理的 flaviviral polyprotein。当这些药已经在 USA 或另外的国家在另外的指示任何一个为临床的使用被同意了,他们由 ZIKV 和另外的 flaviviruses 为感染的管理代表有希望、容易开发的治疗。 | Zhong Li Matthew Brecher Yong-Qiang Deng Jing Zhang Srilatha Sakamuru Binbin Liu Ruili Huang Cheri A Koetzner Christina A Allen Susan A Jones Haiying Chen Na-Na Zhang Min Tian Fengshan Gao Qishan Lin Nilesh Banavali Jia Zhou Nathan Boles Menghang Xia Laura D Kramer Cheng-Feng Qin Hongmin Li | 2017 | Cell Research2017，27，8： | 11 |
| 4 | MoS_2纳米片/CdS纳米线复合光催化剂的制备及其光电化学和光催化活性研究(英文)显示文摘本论文通过两步水热法合成了MoS_2纳米片/CdS纳米线复合光催化剂.采用扫描电子显微镜、透射电子显微镜、X射线粉末衍射仪、拉曼光谱仪、X射线光电子能谱仪、比表面积分析仪、紫外可见漫反射光谱仪、荧光光谱方法和光电化学测试对复合光催化剂进行了表征.研究表明复合光催化剂的性能和MoS_2负载量的多少密切相关.当MoS_2的负载量为5 mol%时复合光催化剂具有最优的光学、光电化学和光催化产氢活性.与纯的CdS纳米线相比,优化后的复合光催化剂以葡萄糖和乳酸为空穴牺牲剂,光电流提高了5.5倍,光催化产氢活性提高了74倍,这主要归因于MoS_2纳米片和CdS纳米线之间的紧密接触有利于提高电荷的分离效率.为了进一步理解光电化学和光催化活性提高的机理,采用瞬态吸收光谱仪深入探究了电荷分离和转移的动力学过程.该工作不仅涉及了具有优良光电化学和光催化活性的复合光催化剂的制备方法,而且展示了葡萄糖在光解水产氢中的应用. | 王红梅 Sara Bonabi Naghadeh 李春鹤 应露 A’Lester Allen 张金中 | 2018 | Science China Materials2018，61，6： | 9 |
| 5 | Effect of semisolid microstructure on solidified phase content in 1xxx Al alloys 显示文摘 | Allen C M O'reilly K A Q and Cantor B | 2001 | Acta Materialia2001，49，： | 2 |
| 6 | Parturition and urinary incontinence in primiparas 1 1 Statistical analysis was done by Pantelis Andreou.显示文摘 | Scott A Farrell Victoria M Allen Thomas F Baskett | 2001 | Obstetrics & Gynecology2001，，3： | 2 |
| 7 | Nano-engineering block copolymer aggregates for drug delivery 显示文摘 | Allen C Eisenberg A Maysinger D | 1999 | Colloids Surf B Biointerfaces1999，16，1： | 2 |
| 8 | Emulation of neutron irradiation effects with protons: validation of principle显示文摘 | G.S Was J.T Busby T Allen E.A Kenik A Jensson S.M Bruemmer J Gan A.D Edwards P.M Scott P.L Andreson | 2002 | Journal of Nuclear Materials2002，，2： | 2 |
| 9 | 持续血糖监测用于检测危重症患儿高血糖的前瞻性研完显示文摘目的用组织间隙持续血糖监测仪评价PICU非糖尿病患儿血糖增高程度,并与实验室间断检测血糖的方法比较,评价监测效果。设计前瞻性、观察性研究。场所西马萨诸塞州一所医学中心拥有10张床位的PICU。对象20名非糖尿病患儿,年龄1~18岁,预计需要2d以上的重症监护。干预在患儿皮下放置持续血糖监测仪,征得患儿及家属同意后,另接探头进行72h连续血糖监测并与实验室所测血糖水平进行比较。测量指标和主要结果平均每位患儿持续监测685.2h,共有16337次探头读数,43.0%读数高于125mg/dl(6.9mmol/L),27.2%高于140mg/dl(7.8mmol/L),4%高于200mg/dl(11.1mmol/L)。实验室血糖值提示升高的频度不如持续监测,且易错过血糖升高的关键时段。结论PICU患儿可出现显著血糖升高,实验室间断检测血糖可能低估此现象。 | Allen HF Rake A Roy M | 2008 | 中国小儿急救医学2008，15，2： | 2 |
| 10 | Fusion neutron and ion emission from deuterium and deuterated methane cluster plasmas显示文摘 | K W Madison P K Patel D Price A Edens, M Allen, T E Cowan, J Zweiback, T Ditmire | | 0，，： | 2 |
| 11 | Medications as a Potential Source of Exposure to Phthalates in the U.S. Population显示文摘 | Hernández-Díaz Sonia Mitchell Allen A Kelley Katherine E Calafat Antonia M Hauser Russ | 2009 | Environmental Health Perspectives2009，，2： | 2 |
| 12 | The coexistence of multiple distribution systems for financial services: The case of property-liability insurance显示文摘 | Berger Allen N Cummins J David Weiss Mary A | 1997 | Journal of Business1997，10，： | 1 |
| 13 | Pharmacokinetics and tolerability of gemifloxacin (SB- 265805) after administration of single oral doses to healthy volunteers 显示文摘 | Allen A Bygate E Oliver S | 2000 | Antimicrob Agents Chemother2000，44，6： | 1 |
| 14 | Asymptotic profile of thesteady states for an SIS epidemic patch model显示文摘 | Allen L J S Bolker B M Lou Y Nevai A L | 2007 | SIAM J Appl Math2007，，67： | 1 |
| 15 | Fine particulate matter source attribution for Southeast Texas using ^14C/^13C ratios 显示文摘 | Lemire K R Allen D T Klouda G A | 2002 | J Geophys Res2002，107，22： | 1 |
| 16 | Commitment to Organizations and Occupations:Extension and Test of a Three-Component Conceptualization显示文摘 | Meyer J P Allen N J Smith C A | 1993 | Journal of Applied Psychology1993，78，： | 1 |
| 17 | Nonlinear shear instabilities of alongshore currents over barred beaches 显示文摘 | Slinn D N Allen J S Newberger P A | 1998 | Journal of Geophysical Research1998，103，18： | 1 |
| 18 | Gastroduodenal mucus dicarbonate barrier:protection against acid and pepsin显示文摘 | Allen A Flemstrom G | 2005 | Am J Physiol Cell Physiol2005，288，： | 1 |
| 19 | Neutron Diffraction Methods for the Study of Residual Stress Fields显示文摘 | ALLEN A J HUTCHINGS M T WINDSOR C G | 1985 | Adv Phys1985，34，4： | 1 |
| 20 | Correlation of NW European Purbecj-Wealden as seen from the English type-areas显示文摘 | Allen P Wimbledon W A | 1991 | Cretaceous Research1991，12，： | 1 |
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