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| 1 | Crucial steps in the natural history of inflammatory bowel disease显示文摘Inflammatory bowel diseases(IBD),including ulcerative colitis(UC) and Crohn's disease(CD),are chronic,progressive and disabling disorders.Over the last few decades,new therapeutic approaches have been introduced which have led not only to a reduction in the mortality rate but also offered the possibility of a favorable modification in the natural history of IBD.The identification of clinical,genetic and serological prognostic factors has permitted a better stratification of the disease,thus allowing the opportunity to indicate the most appropriate therapy.Early treatment with immunosuppressive drugs and biologics has offered the opportunity to change,at least in the short term,the course of the disease by reducing,in a subset of patients with IBD,hospitalization and the need for surgery.In this review,the crucial steps in the natural history of both UC and CD will be discussed,as well as the factors that may change their clinical course.The methodological requirements for high quality studies on the course and prognosis of IBD,the true impact of environmental and dietary factors on the clinical course of IBD,the clinical,serological and genetic predictors of the IBD course(in particular,which of these are rel-evant and appropriate for use in clinical practice),the impact of the various forms of medical treatment on the IBD complication rate,the role of surgery for IBD in the biologic era,the true magnitude of risk of colorectal cancer associated with IBD,as well as the mortality rate related to IBD will be stressed;all topics that are extensively discussed in separate reviews included in this issue of World Journal of Gastroenterology. | Giovanni Latella Claudio Papi | 2012 | World Journal of Gastroenterology2012，18，29： | 7 |
| 2 | 计划行为理论框架下消费者网络电影下载动力因素研究显示文摘人们对网络媒体资源尤其是电影下载的需求日益增加,针对这一市场,电影行业仍然缺乏一个可持续的商业发展模式。本文借助计划行为理论研究了消费者合法下载电影资源的动力因素,进一步发现消费者态度、社会影响、技术可行性、创新性、兼容性及过往行为等因素都对消费者的下载决定产生作用。 | Dominik Papies Michel Clement 刘建蓉 | 2009 | 文化艺术研究2009，2，2： | 3 |
| 3 | Changes in cellular mechanical properties during onset or progression of colorectal cancer显示文摘Colorectal cancer(CRC) development represents a multistep process starting with specific mutations that affect proto-oncogenes and tumour suppressor genes.These mutations confer a selective growth advantage to colonic epithelial cells that form first dysplastic crypts, and then malignant tumours and metastases. All these steps are accompanied by deep mechanical changes at the cellular and the tissue level. A growing consensus is emerging that such modifications are not merely a byproduct of the malignant progression, but they could play a relevant role in the cancer onset and accelerate its progression. In this review, we focus on recent studies investigating the role of the biomechanical signals in the initiation and the development of CRC. We show that mechanical cues might contribute to early phases of the tumour initiation by controlling the Wnt pathway, one of most important regulators of cell proliferation in various systems. We highlight how physical stimuli may be involved in the differentiation of non-invasive cells into metastatic variants and how metastatic cells modify their mechanical properties, both stiffness and adhesion, to survive the mechanical stress associated with intravasation, circulation and extravasation. A deep comprehension of these mechanical modifications may help scientist to define novel molecular targets for the cure of CRC. | Gabriele Ciasca Massimiliano Papi Eleonora Minelli Valentina Palmieri Marco De Spirito | 2016 | World Journal of Gastroenterology2016，22，32： | 3 |
| 4 | Light metal compound casting显示文摘‘Compound casting’simplifies joining processes by directly casting a metallic melt onto a solid metal substrate. A continuously metallurgic transition is very important for industrial applications, such as joint structures of spaceframe constructions in transport industry. In this project, ‘compound casting’ of light metals is investigated, aiming at weight-saving. The substrate used is a wrought aluminium alloy of type AA5xxx, containing magnesium as main alloying element. The melts are aluminium alloys, containing various alloying elements (Cu, Si, Zn), and magnesium. By replacing the natural oxygen layer with a zinc layer, the inherent wetting difficulties were avoided, and compounds with flawless interfaces were successfully produced (no contraction defects, cracks or oxides). Electron microscopy and EDX investigations as well as optical micrographs of the interfacial areas revealed their continu- ously metallic constitution. Diffusion of alloying elements leads to heat-treatable microstructures in the vicinity of the joining interfaces in Al-Al couples. This permits significant variability of mechanical properties. Without significantly cutting down on wettability, the formation of low-melting intermetallic phases (Al3Mg2 and Al12Mg17 IMPs) at the interface of Al-Mg couples was avoided by applying a protective coating to the substrate. | Konrad J. M. PAPIS Joerg F. LOEFFLER Peter J. UGGOWITZER | 2009 | Science China(Technological Sciences)2009，52，1： | 3 |
| 5 | Mucosal healing in inflammatory bowel disease: treatment efficacy and predictive factors显示文摘 | Claudio Papi Federica Fascì Spurio Francesca Rogai Alessia Settesoldi Giovanna Margagnoni Vito Annese | 2013 | Digestive and Liver Disease2013，，： | 2 |
| 6 | Methotrexate-induced pneumonitis in a patient with Crohn’s disease显示文摘 | Giovanna Margagnoni Valeria Papi Annalisa Aratari Luca Triolo Claudio Papi | 2009 | Journal of Crohn’s and Colitis2009，，2： | 2 |
| 7 | Role of nuclear receptors in breast cancer stem cells显示文摘The recapitulation of primary tumour heterogenity and the existence of a minor sub-population of cancer cells,capable of initiating tumour growth in xenografts on serial passages, led to the hypothesis that cancer stem cells(CSCs) exist. CSCs are present in many tumours, among which is breast cancer. Breast CSCs(BCSCs) are likely to sustain the growth of the primary tumour mass, as wellas to be responsible for disease relapse and metastatic spreading. Consequently, BCSCs represent the most significant target for new drugs in breast cancer therapy. Both the hypoxic condition in BCSCs biology and proinflammatory cytokine network has gained increasing importance in the recent past. Breast stromal cells are crucial components of the tumours milieu and are a major source of inflammatory mediators. Recently, the antiinflammatory role of some nuclear receptors ligands has emerged in several diseases, including breast cancer. Therefore, the use of nuclear receptors ligands may be a valid strategy to inhibit BCSCs viability and consequently breast cancer growth and disease relapse. | Alessio Papi Marina Orlandi | 2016 | World Journal of Stem Cells2016，8，3： | 2 |
| 8 | Kangaroo method in delivery room for full-term babies显示文摘 | Gomez Papi A Baiges Nogues MT Batiste Femandez MT | 1998 | An Esp Pediatr1998，48，： | 1 |
| 9 | Phototube sensor for monitoring the quality of current collection on overhead elec- trified railways显示文摘 | BRUNO O LANDI A PAPI M | 2001 | Proceedings of the Institution of Mechanical Engineers Part F: Journal of Rail and Rapid Transit2001，215，3： | 1 |
| 10 | Relationships between promoter polymorphisms in the thymidylate synthase gene and mRNA levels in colorectal cancers显示文摘 | Maria Morganti Monica Ciantelli Beatrice Giglioni Anna L. Putignano Stefania Nobili Laura Papi Ida Landini Cristina Napoli Rosa Valanzano Fabio Cianchi Vieri Boddi Francesco Tonelli Camillo Cortesini Teresita Mazzei Maurizio Genuardi Enrico Mini | 2005 | European Journal of Cancer2005，，14： | 1 |
| 11 | Partial reversibility of air- flow limitation and increased exhaled NO and sputum eosinophilia in chronic obstructive pulmonary disease 显示文摘 | Papi A Romagnoli M Baraldo S | 2000 | American Journal of Respiratory and Critical Care Medicine2000，162，5： | 1 |
| 12 | Statistically based multiwavelet denoising显示文摘 | Bacchelli S Papi S | 2007 | Journal of Computational and Applied Mathematics2007，210，： | 1 |
| 13 | Infections and airway inflammation in chronic obstructive pulmonary disease severe exacerbations显示文摘 | Papi A Bellettato CM Braccioni F | 2006 | Am J Respir Crit Care Med2006，173，10： | 1 |
| 14 | Value of routine measurement of serum calcilonin concentrations in patients with nodular thyroid disease: a multieenter study显示文摘 | Papi G Corsello S M Cioni K | 2006 | J Endocrinol Invest2006，29，5： | 1 |
| 15 | COPD increases the risk of squamous histological subtype in smokers who develop non - small cell lung carcinoma显示文摘 | Papi A Casoni G Caramori G | 2004 | Thorax2004，59，8： | 1 |
| 16 | Infections and airway inflammation in chronic obstructive pulmonary disease severe exacerbations显示文摘 | Papi A Bellettato C M Braccioni F | 2006 | Am J Respir Crit Care Med2006，173，： | 1 |
| 17 | Mutations in the Dof zine finger genes DAG2 and DAG1 influence with opposite effects the germination of Arabidopsis seeds显示文摘 | Gualberti G Papi M Bellueci L Ricci 1 Bouehez D Camilleri C Costantino P Vittorioso P | 2002 | Plant Cell2002，14，6： | 1 |
| 18 | Matrix Metalloproteinase -2 Protein in Lung Periphery is related to COPD Progression 显示文摘 | Baraldo S Bazzan E Zanin M E Turato G Garbisa S Maestrelli P Papi A Miniati M Fabbri L M Zuin R Saetta M | 2007 | Chest2007，132，6： | 1 |
| 19 | (-)-EpigaUocate- chin-3-gallate downregulates Pg-P and BCRP in a tamoxifen resistant MCF-7 cell line 显示文摘 | Farabegoli F Papi A Bartolini G | 2010 | Phytomedicine2010，17，5： | 1 |
| 20 | Evidence of a four-hit mechanism involving SMARCB1 and NF2 in schwannomatosis-associated schwannomas 显示文摘 | Sestini R Bacci C Provenzano A Genuardi M Papi L | 2008 | Hum Mutat2008，29，： | 1 |
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