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| 1 | Early Detection of Lesions of Dorsal Artery of Foot in Patients with Type 2 Diabetes Mellitus by High-frequency Ultrasonography显示文摘This study evaluated the value of high-frequency ultrasonograpy for early detection of dorsal artery of foot in patients with type 2 diabetes mellitus (MD). Eighty subjects including 40 patients with type 2 MD (T2DM group) and 40 healthy volunteers (NC group) were recruited. The in-tima-media thickness (IMT), the inner diameter and the perfusion of dorsal artery of foot were meas-ured by using high-frequency ultrasonograpy. Meanwhile, the parameters of vascular elasticity, including stiffness parameter (β), pressure-strain elastic modulus (Eρ), arterial compliance (AC), aug-ment index (AI), and pulse wave conducting velocity (PWVβ) were detected by means of echo-tracking technique. The results showed that no significant difference was found in the IMT, systolic diameter (Ds), diastolic diameter (Dd) and peak systolic velocity (PSV) between T2DM and NC groups. Eρ and PWVβ were increased, and AC was decreased in T2DM group as compared with those in NC group with the differences being significant (P<0.05 for all). There was no significant difference in β and AI between T2DM and NC groups. It was concluded that high-frequency ultra-sonography in combination with echo-tracking technique is sensitive and non-invasive, and can be used for early detection of sclerosis of the lower extremity artery in patients with type 2 MD. | 张艳容 李雯静 严天慰 鲁成发 周翔 黄艳 | 2009 | Journal of Huazhong University of Science and Technology(Medical Sciences)2009，29，3： | 149 |
| 2 | DIAGNOSIS AND TREATMENT OF CESAREAN SCAR PREGNANCY显示文摘Objective To investigate the early diagnosis and treatment of cesarean scar pregnancy(CSP).Methods Clinical data of 28 patients with CSP in Peking Union Medical College Hospital from January 1994 to April 2007,including age,interval from the last cesarean delivery to diagnosis,clinical presentation,location of the lesion,process of diagnosis and treatment,outcome,and follow-up,were retrospectively analyzed.Results CSP constituted 1.05% of all ectopic pregnancies,and the ratio of CSP to pregnancy was 1∶1221.The mean age of the group was 31.4 years.Twenty-six women had only one prior cesarean delivery.The interval from the last cesarean delivery to diagnosis ranged from 4 months to 15 years.The most common presenting symptoms of CSP were amenorrhoea and vaginal bleeding.Seventeen cases were misdiagnosed as early intrauterine pregnancies and 2 were misdiagnosed as gestational trophoblastic tumor.The other 9 were diagnosed definitely before treatment.The diagnosis was made based on cesarean delivery history,gynecologic examination,ultrasound,and magnetic resonance imaging(MRI).The treatment of CSP included systemic or local methotrexate administration,conservative surgery,and hysterectomy.The conservative treatment was successful in 24 cases.All of the 28 women were cured through individual therapies.Conclusions CSP is rare and usually misdiagnosed as other diseases.Ultrasound is valuable for diagnosing CSP,and MRI can be used as an adjunct to ultrasound scan.Early diagnosis offers the options of conservative treatment and greatly improves the outcome of patients.Individual therapy is strongly recommended. | Lan-zhou Jiao Jun Zhao Xi-run Wan Xin-yan Liu Feng-zhi Feng Tong Ren Yang Xiang | 2008 | Chinese Medical Sciences Journal2008，23，1： | 65 |
| 3 | Relationship between Carotid Atherosclerosis and Cerebral Infarction显示文摘Objective To study the relationship between carotid atherosclerosis and cerebral infarction (CI). Methods Between November 2008 and March 2009,147 CI patients (CI group) and 48 patients with non-cerebrovascular diseases (control group) were enrolled from inpatients of Neurology Department of our hospital. The diagnostic criterion of thickened carotid intima was set as 1.0 mm≤intima-media thickness (IMT) <1.5 mm and that of carotid plaque was as IMT≥1.5 mm. Carotid atherosclerosis was divided into three levels: normal intima,thickened intima,and plaque formation. The color Doppler ultrasonography data of carotid arteries in all patients were analyzed and the severity of carotid atherosclerosis was compared between the two groups. Results In the CI group,36 (24.5%) patients had normal carotid intima,22 (15.0%) had thickened carotid intima,and 89 (60.5%) had carotid plaque. In the control group,22 (45.8%) patients had normal carotid intima,4 (8.3%) had thickened carotid intima,and 22 (45.8%) had carotid plaque. The severity of carotid atherosclerosis in the CI group was higher than that in the control group (P=0.022). There was significant difference in the constitution of carotid plaque between the two groups (P=0.001); the CI group mainly had the soft plaque (55/89,61.8%),whereas the control group mainly had the hard plaque (17/22,77.3%). The first three common locations of carotid plaque in both groups were carotid bifurcation (CI group: 73.7%; control group: 64.1%),common carotid artery (CI group: 20.4%; control group: 25.6%),and internal carotid artery (CI group: 5.9%; control group: 10.3%). The location of carotid plaque between the two groups was not significantly different (P=0.438). There was no difference in the carotid inner diameter or resistance index between the two groups (P>0.05). Conclusions Carotid atherosclerosis is to some extent able to reveal the atherosclerotic condition of cerebral arteries and act as an important predictor for the risk of CI. The color Doppler ultrasonography of carotid arteries can provide a convenient way for the prevention and treatment of CI. | Guang-wen Li Guan-yi Zheng Jin-guo Li Xu-dong Sun | 2010 | Chinese Medical Sciences Journal2010，25，1： | 59 |
| 4 | PREVALENCE AND RISK FACTORS OF PERIPHERAL ARTERIAL DISEASE IN DIABETIC PATIENTS OVER 50 YEARS OLD IN CHINA显示文摘Objective To investigate the prevalence of peripheral arterial disease (PAD) in China type 2 diabetic patients and to demonstrate the relationships between putative risk factors and PAD. Methods In total 1 397 type 2 diabetic patients aged 50 years and older were enrolled and determined ankle-brachial index (ABI) and brachial-ankle pulse wave velocity (baPWV) in 15 Class III Grade A hospitals in 7 major cities of China. Results Mean patient age was 63.7±8.2 years and mean duration of diabetes mellitus was 9.39±7.4 years. Two hundreds and seventy-two (19.47%) patients were diagnosed as PAD by ABI <0.9, 122 (18.37%) in male and 150 (20.46%) in female. PAD patients had a significantly longer duration of diabetes mellitus, higher hemoglobin Alc, and a significantly lower mean body mass index than non-PAD ones. Aging, smoking, and systolic blood pressure were found to be positively related with the prevalence of PAD. In terms of lipid profiles, no variable was found to relate with PAD. Notably, baPWV showed as the same significant guiding index for PAD, almost matched with ABI. Conclusions PAD is a common complication in China type 2 diabetic patients. Therefore, PAD screening and treatment should be emphasized for diabetic patients with high risk factors. | Heng Guan Yong-jun Li Zhang-rong XU Guang-wei Li Xiao-hui Guo Zhi-min Liu Da-jin Zou Hui-li Xing Wei Liu Zheng-yan Sheng Hao-ming Tian Da-long Zhu De-min YU Wei-te Zhuang Lu-lu Chen Jian-ping Weng | 2007 | Chinese Medical Sciences Journal2007，22，2： | 41 |
| 5 | Misdiagnosis and Delayed Diagnosis for Ectopic and Heterotopic Pregnancies after In Vitro Fertilization and Embryo Transfer显示文摘This study examined the misdiagnosis and delayed diagnosis factors for ectopic pregnancy(EP)and heterotopic pregnancy(HP)after in vitro fertilization and embryo transfer(IVF-ET)in an attempt to reduce the diagnostic error.Clinical data of patients who underwent IVF-ET treatment and had clinical pregnancy from 12463 cycles were retrospectively analyzed.Their findings of serumβ-hCG test and transvaginal ultrasonography were also obtained during follow-up.These patients were divided into two groups according to the diagnosis accuracy of EP/HP:early diagnosis and misdiagnosis/delayed diagnosis.The results showed that the incidence of EP and HP was 3.8%(125/3286)and 0.8%(27/3286)respectively for IVF/ICSI-ET cycle,and 3.8%(55/1431)and 0.7%(10/1431)respectively for frozen-thawed embryo transfer(FET)cycle.Ruptured EP occurred in 28 patients due to initial misdiagnosis or delayed diagnosis.Related factors fell in 3 categories:(1)clinician factors:misunderstanding of patients’medical history,insufficient training in ultrasonography and unawareness of EP and HP;(2)patient factors:noncompliance with medical orders and lack of communication with clinicians;(3)complicated conditions of EP:atypical symptoms,delayed elevation of serumβ-hCG level,early rupture of cornual EP,asymptomatic in early gestation and pregnancy of unknown location.All the factors were interwoven,contributing to the occurrence of EP and HP.It was concluded that complicated conditions are more likely to affect the diagnosis accuracy of EP/HP after IVF-ET.Transvaginal ultrasonography should be performed at 5 weeks of gestation.Intensive follow-up including repeated ultrasonography and serial serumβ-hCG tests should be performed in patients with a suspicious diagnosis at admission. | 王琳琳 陈薪 叶德盛 刘玉东 何于夏 郭薇 陈士岭 | 2014 | Journal of Huazhong University of Science and Technology(Medical Sciences)2014，34，1： | 37 |
| 6 | A Comparative Study of High-viscosity Cement Percutaneous Vertebroplasty vs. Low-viscosity Cement Percutaneous Kyphoplasty for Treatment of Osteoporotic Vertebral Compression Fractures显示文摘The clinical effects of two different methods–high-viscosity cement percutaneous vertebroplasty(PVP) and low-viscosity cement percutaneous kyphoplasty(PKP) in the treatment of osteoporotic vertebral compression fractures(OVCFs) were investigated. From June 2010 to August 2013, 98 cases of OVCFs were included in our study. Forty-six patients underwent high-viscosity PVP and 52 patients underwent low-viscosity PKP. The occurrence of cement leakage was observed. Pain relief and functional activity were evaluated using the Visual Analog Scale(VAS) and Oswestry Disability Index(ODI), respectively. Restoration of the vertebral body height and angle of kyphosis were assessed by comparing preoperative and postoperative measurements of the anterior heights, middle heights and the kyphotic angle of the fractured vertebra. Nine out of the 54 vertebra bodies and 11 out of the 60 vertebra bodies were observed to have cement leakage in the high-viscosity PVP and low-viscosity PKP groups, respectively. The rate of cement leakage, correction of anterior vertebral height and kyphotic angles showed no significant differences between the two groups(P>0.05). Low-viscosity PKP had significant advantage in terms of the restoration of middle vertebral height as compared with the high-viscosity PVP(P<0.05). Both groups showed significant improvements in pain relief and functional capacity status after surgery(P<0.05). It was concluded that high-viscosity PVP and low-viscosity PKP have similar clinical effects in terms of the rate of cement leakage, restoration of the anterior vertebral body height, changes of kyphotic angles, functional activity, and pain relief. Low-viscosity PKP is better than high-viscosity PVP in restoring the height of the middle vertebra. | 孙凯 刘洋 彭昊 谭俊峰 张觅 郑先念 陈方舟 李明辉 | 2016 | Journal of Huazhong University of Science and Technology(Medical Sciences)2016，36，3： | 35 |
| 7 | Early Enteral Combined with Parenteral Nutrition Treatment for Severe Traumatic Brain Injury:Effects on Immune Function,Nutritional Status and Outcomes显示文摘Objective To compare the conjoint effect of enteral nutrition (EN) and parenteral nutrition (PN)with single EN or PN on immune function, nutritional status, complications and clinical outcomes of patientswith severe traumatic brain injury (STBI).Methods A prospective randomized control trial was carried out from January 2009 to May 2012 inNeurological Intensive Care Unit (NICU). Patients of STBI who met the enrolment criteria (Glasgow ComaScale score 6~8; Nutritional Risk Screening ≥3) were randomly divided into 3 groups and were administratedEN, PN or EN+PN treatments respectively. The indexes of nutritional status, immune function,complications and clinical outcomes were examined and compared statistically. | Ming-chao Fan Qiao-ling Wang Wei Fang Yun-xia Jiang Lian-di Li Peng Sun Zhi-hong Wang | 2016 | Chinese Medical Sciences Journal2016，31，4： | 37 |
| 8 | EFFECT OF DL-3-N-BUTYLPHTHALIDE ON BRAIN EDEMA IN RATS SUBJECTED TO FOCAL CEREBRAL ISCHEMIA显示文摘The present study evaluated the effect of dl-3-n hutylphthalide(NBP),a novel brain protective agent,on brain edema in rats following focal ischemiet. Edema was induced by occluding the right middle cerchral artery (MCAO) ,producing permanent focal ischemia in the right eerehral hemlspheme,which developed ipsilateral brain edenaa reproduclbly. Edema was assessed 24 b after MCA occlusion by determining the brain water content from wet and dry weight measurements,and the sodium,potasslum concentrations with ionselective electrodas.In this model,NBP at the dose of 80,160 and 240 mg/kg po 15 min after MCAO prevented from brain edema in a dose-dependent manner. A significant reduction of sodium content and an increase in potassium level wee ohserved in all drug-treated groups. It showed that NBP strongly attenuated brain water entry ,sodium accumulation and potassium loss. Nimodlpine treatment (Smg/kg sc) also reduced brain edemo (P<0. 05). The mesults suggest that & strong anti-edema activity ot NBP may play an important role to contribute to the treatment ot ischemic damage. | 邓文斌 冯亦璞 | 1997 | Chinese Medical Sciences Journal1997，12，2： | 39 |
| 9 | Role of Heart-Type Fatty Acid Binding Protein in Early Detection of Acute Myocardial Infarction in Comparison with cTnI, CK-MB and Myoglobin显示文摘Heart fatty acid-binding protein (H-FABP) is supposed to be the most sensitive biomarker of early acute myocardial infarction (AMI). To evaluate the diagnostic value of H-FABP for AMI in the early stage, the plasma levels of H-FABP were measured by sandwich ELISA in 93 patients with suspected AMI at admission within 6 h after onset of chest pain and 69 normal healthy subjects. The plasma concentrations of cardiac troponin-I (cTnI), creatine kinase-MB (CK-MB) and myoglobin (Mb) were assayed at the same time by using corpuscle chemiluminescence for those patients. The patients were classified as AMI group (n=32) and non-AMI group (n=61) retrospectively. The diagnostic validity was evaluated in terms of sensitivity, specificity and receiver operating characteristic (ROC) curve analysis. The results showed the cutoff value of H-FABP for AMI was 16.8 ng/ml, and its diagnostic sensitivity for AMI was 64.29 % within 3 h and 84.38 % within 6 h after onset of chest pain, and the diagnostic specificity for non-AMI was 100 % within 3 h and 91.8 % within 6 h. H-FABP had higher sensitivity than that of cTnI and CK-MB at all time points (P<0.05), whereas there was no significant difference in specificity among the four markers. But the area under the ROC curve of H-FABP was significantly greater than that of cTnI, CK-MB and Mb within 3 h. These results revealed that H-FABP possessed high diagnostic sensitivity and specificity for AMI in early stage, especially within 3 h after onset of persistent angina pectoris. In conclusion, H-FABP can be used as a sensitive marker for AMI in the early stage. | 陈莉莉 郭小梅 杨霏 | 2004 | Journal of Huazhong University of Science and Technology(Medical Sciences)2004，24，5： | 33 |
| 10 | IT IS GASTROESOPHAGEAL REFLUX DISEASE, NOT ASTHMA: A CASE REPORT显示文摘 | Zhong-gao Wang | 2006 | Chinese Medical Sciences Journal2006，21，3： | 34 |
| 11 | Progress in the Study of Lymph Node Metastasis in Early-stage Cervical Cancer显示文摘 | Bang-xing HUANG Fang FANG | 2018 | Current Medical Science2018，38，4： | 34 |
| 12 | THE ASSOCIATION OF THE EXPRESSION OF MTA1, NM23H1 WITH THE INVASION, METASTASIS OF OVARIAN CARCINOMA显示文摘Objective. To understanding the molecular mechanisms in invasion and metastasis of the ovarian car-cinoma, we investigate a novel candidate metastasis-associated gene (MTA1) and nm23H1 mRNA ex-pression and mutation in ovarian carcinoma.Methods. Twenty primary ovarian carcinoma specimens, 20 corresponding lymph nodes and 8 normalovarian was examined for mRNA expression and mutation of MTA1 and nm23H1 genes by revere-tran-scription ploymerase chain reaction(RT-PCR) and RT-PCR-SSCP analysis. The level of the expressionwas determined by the relative optic desity (ROD) of the PCR products.Results. The frequency of MAT1 overexpression was 100%(7/7) in primary ovarian carcinoma withmetastasis but only 38.5% (5/13) in those without metastasis (P=0.0103 ). Overexpression of MAT1 wasobserved in 87.5%(6/7) of lymph nodes with metastasis but only 23%(3/13) of lymph nodes withoutmetastasis (P=0.0118). In contrast with MAT1, low expression of nm23H1 mRNA was seen in 7 of 7 o-varian carcinoma with metastasis but only in 4 of 13(30%) of those without metastassis (P=0.0043). Lownm23H1 expression was also seen in 7 of 7 lymph nodes with metastasis but only in 5 of 13 (38.5%)nonmetastatic lymph nodes (P=0.0102). The ROD ratio of MAT1 to nm23H1 increased with the develop-ment of metastasis. No mutation of MAT1 and nm23H1 genes was found by SSCP analysis.Conclusion. The mRNA expression of MTA1 and nm23H1 is positively and negatively correlated withlymph node metastasis, respectively. Expression abnormalities but not mutation of the two genes are fre-quent events related to lymph node metastasis of ovarian cancer. | 宋毅 黄光琦 贺国丽 | 2003 | Chinese Medical Sciences Journal2003，18，2： | 32 |
| 13 | EXPRESSION OF MASPIN AND KAI1 AND THEIR CLINICOPATHOLOGICAL SIGNIFICANCE IN CARCINOGENESIS AND PROGRESSION OF GASTRIC CANCER显示文摘To investigate the roles of maspin and kai1 expression in tumorigenesis and progression of gastric cancer. Methods Maspin and kai1 expressions were detected in normal gastric mucosa (n = 182), gastric dysplasia (n = 69), and gastric cancer (n = 113) by immunohisto-chemistry. Their expressions were compared with clinicopathological parameters of tumors. Relationship between maspin and kai1 expression was also concerned in gastric cancer. Results The positive rates of maspin expression were 79.8% (145/182), 75.4% (52/69), and 50.4% (57/113) in normal gastric mucosa, gastric dysplasia, and gastric cancer, while those of kai1 expression were 81.9% (149/182), 65.2% (49/69), and 58.4% (66/113) in corresponding tissues respectively. Gastric cancer less frequently expressed maspin than the normal gastric mucosa and gastric dysplasia (P < 0.05), while dysplasia and cancer showed less frequent expression of kai1 than normal mucosa (P < 0.05). Maspin expression showed negative association with invasive depth, metastasis, Lauren’s and histological classifications (P < 0.05), but not with tumor size, Borrmann’s classification, growth pattern or TNM staging (P > 0.05). Kai1 expression was negatively correlated with invasive depth, metastasis, growth pattern, Lauren’s and histo-logical classifications (P < 0.05), but not with tumor size, Borrmann’s classification or TNM staging (P > 0.05). Maspin and kai1 were collaboratively expressed in gastric cancer (P < 0.05). Conclusions Down-regulated expressions of maspin and kai1 play an important role in gastric carcinogenesis. Abnormal expression of maspin and kai1 might have inhibitory effects on invasion and metastasis of gastric cancer and act as an effe-ctive and objective marker to indicate the pathobiological behaviors of gastric cancer. | Hua-chuanZheng Meng-chunWang Jin-yiLi Xue-feiYang Jin-minSun YanXin | 2004 | Chinese Medical Sciences Journal2004，19，3： | 29 |
| 14 | Incidence and Risk Factors of Cognitive Impairment 3 Months after First-ever Stroke: A Cross-sectional Study of 5 Geographic Areas of China显示文摘This study examined the incidence, neuropsychological characteristics and risk factors of cognitive impairment 3 months after stroke in China. Five regions that differed in geography and economy in China were selected. Patients from the hospitals located in the five regions were prescreened at admission, and the demographic data, vascular risk factors and clinical characteristics of stroke were obtained. A battery of cognitive-specific domain tests was performed in the patients who failed to pass cognitive screening 3 months post stroke. Patients were diagnosed as having post-stroke cognitive impairment (PSCI) or no cognitive impairment (NCI) based on the results of the neuropsy-chological tests. Univariate analysis was performed for suspect risk factors, and significant variables were entered in multivariable logistic regression analysis. Our results showed that a total of 633 patients were recruited 3 months after stroke; complete cognitive tests were performed in 577 of the stroke pa-tients. The incidence of PSCI in these Chinese patients was 30.7%. There were 129 (22.4%) patients with visuospatial impairment, 67 (11.6%) with executive impairment, 60 (10.4%) with memory impairment and 18 (3.1%) with attention impairment. The risk factors associated with PSCI were older age (odds ratio [OR] 1.76, 95% confidence interval [CI] 1.20-2.58), low education level (OR 2.45, 95% CI 1.65-3.64), depressive symptom (OR 1.69, 95% CI 1.09-2.61), obesity (OR 2.57, 95% CI 1.41-4.71), stroke severity 3 months post stroke (OR 1.62, 95%CI 1.10-2.37) and cortex lesion (OR 1.55, 95% CI 1.04-2.31). It was concluded that PSCI occurs commonly 3 months after first-ever stroke in Chinese patients. Visuospatial ability may be the most frequently impaired cognitive domain for the patients with stroke. The critical risk factors of PSCI are older age, low education level, depressive symptom, obesity, stroke severity 3 months post stroke and cortex lesion. | 张勇 张振馨 杨百渔 李延峰 张蕲 屈秋民 王延平 张世红 岳卫东 谭毓绘 张宝荣 徐涛 | 2012 | Journal of Huazhong University of Science and Technology(Medical Sciences)2012，32，6： | 29 |
| 15 | Dexmedetomidine Alleviates Pulmonary Edema by Upregulating AQP1 and AQP5 Expression in Rats with Acute Lung Injury Induced by Lipopolysaccharide显示文摘This study aims to elucidate the mechanisms by which dexmedetomidine alleviates pulmonary edema in rats with acute lung injury induced by lipopolysaccharide(LPS). Male Wistar rats were randomly divided into five groups: normal saline control(NS) group,receiving intravenous 0.9% normal saline(5 m L/kg); LPS group,receiving intravenous LPS(10 mg/kg); small-dose dexmedetomidine(S) group,treated with a small dose of dexmedetomidine(0.5 μg·kg-1·h-1); medium-dose dexmedetomidine(M) group,treated with a medium dose of dexmedetomidine(2.5 μg·kg-1·h-1); high-dose dexmedetomidine(H) group,treated with a high dose of dexmedetomidine(5 μg·kg-1·h-1). The rats were sacrificed 6 h after intravenous injection of LPS or NS,and the lungs were removed for evaluating histological characteristics and determining the lung wet/dry weight ratio(W/D). The levels of tumor necrosis factor-alpha(TNF-α) and interleukin-1β(IL-1β) in the lung tissues were assessed by enzyme-linked immunosorbent assay(ELISA). The m RNA and protein expression levels of aquaporin-1(AQP1) and aquaporin-5(AQP5) were detected by RT-PCR,immunohistochemistry,and Western blotting. The lung tissues from the LPS groups were significantly damaged,which were less pronounced in the H group but not in the small-dose dexmedetomidine group or medium-dose dexmedetomidine group. The W/D and the concentrations of TNF-α and IL-1β in the pulmonary tissues were increased in the LPS group as compared with those in NS group,which were reduced in the H group but not in S group or M group(P<0.01). The expression of AQP1 and AQP5 was lower in the LPS group than in the NS group,and significantly increased in the H group but not in the S group or M group(P<0.01). Our findings suggest that dexmedetomidine may alleviate pulmonary edema by increasing the expression of AQP-1 and AQP-5. | 姜远旭 戴中亮 张雪萍 赵伟 黄强 高利昆 | 2015 | Journal of Huazhong University of Science and Technology(Medical Sciences)2015，35，5： | 30 |
| 16 | Application and Prospect of Mixed Reality Technology in Medical Field显示文摘Mixed reality(MR)technology is a new digital holographic image technology,which appears in the field of graphics after virtual reality(VR)and augmented reality(AR)technology,a new interdisciplinary frontier.As a new generation of technology,MR has attracted great attention of clinicians in recent years.The emergence of MR will bring about revolutionary changes in medical education training,medical research,medical communication,and clinical treatment.At present,MR technology has become the popular frontline information technology for medical applications.With the popularization of digital technology in the medical field,the development prospects of MR are inestimable.The purpose of this review article is to introduce the application of MR technology in the medical field and prospect its trend in the future. | Hong-zhi HU Xiao-bo FENG Zeng-wu SHAO Mao XIE Song XU Xing-huo WU Zhe-wei YE | 2019 | Current Medical Science2019，39，1： | 29 |
| 17 | VAGINAL HYSTERECTOMY FOR PATIENTS WITH MODERATELY ENLARGED UTERUS OF BENIGN LESIONS显示文摘Objective To evaluate the possibility of vaginal hysterectomy for patients with moderately enlarged uterus of benign lesions. Methods One hundred and seventeen women with benign uterine diseases underwent vaginal hysterectomy. These patients were divided into two groups according to uterine weight. Group Ⅰ contained 60 patients with uterine enlargement to a weight of 200 to 750 g, and group Ⅱ contained 57 patients with uterine weight of less than 200 g. Uterine morcellation was performed in some cases. The peri-operative data in both groups were analyzed. Results In group Ⅰ, 59 cases underwent transvaginal hysterectomy successfully, except 1 case con-verted to abdominal operation and the uterine morcellation was performed in 21 women. In group Ⅱ, all patients successfully underwent transvaginal hysterectomy without any assistance of special technique. The mean uterine weight of group Ⅰ was significantly heavier than that of group Ⅱ(280.18 ± 100.40 g vs 146.48 ± 35.19 g). The mean operating time was significantly longer for group Ⅰ than that for group Ⅱ(83.93 ± 26.26 minutes vs 35.22 ± 20.55 minutes). There were no significant differences in blood loss and complications between groupⅠ and group Ⅱ. There was no injury of urinary bladder or rectum, and no vaginal vault infection. Conclusions Vaginal hysterectomy of moderately enlarged uterus can be safely and effectively performed by experienced operators. In some cases, in order to reduce the uterine volume, uterine mor-cellation should be used to shorten operative time, reduce the bleeding, and lower the postoperative complications. | 李志刚 冷金花 郎景和 唐家龄 | 2004 | Chinese Medical Sciences Journal2004，19，1： | 30 |
| 18 | Expression of Survivin, CyclinD1, p21^(WAF1), Caspase-3 in Cervical Cancer and Its Relation with Prognosis显示文摘The implications of Survivin, CyclinD1, p21 WAF1, Caspase-3 in the development, progression and prognosis in cervical cancer were investigated. By using immunohistochemical SP method, the expression of Survivin, CyclinD1, p21 WAF1, Caspase-3 was detected in 41 cases of cervical cancer, 17 cases of cervical intraepithelial neoplasia (CIN) and 10 cases of normal tissues, and their relation with pathological grade, clinical stage, metastasis and survival time was analyzed. The results showed that the positive expression rate of Survivin, CyclinD1 in cervical cancer was significantly higher than in CIN group and normal control group (P<0.05). The median survival time in the patients with cervical cancer positive for Survivin and CyclinD1 was significantly shorter than in those with negative expression (P<0.05). The expression of both Survivin and CyclinD1 was not related with tumor grade, clinical stage and metastasis (P>0.05). The positive expression rate of p21 WAF1, Caspase-3 in cervical cancer was significantly lower than in CIN group and normal control group (P<0.05), and had a close relation with tumor grade (P<0.05). The expression of Survivin in cervical cancer in cervical cancer was negatively associated with that of Caspase-3 (P<0.01), but positively with that of CyclinD1 (P<0.01). Cox Multivariate analysis revealed that Survivin was the independent prognostic indicator influencing the survival time of the patients with cervical cancer (P<0.05). It was suggested that the high expression of Survivin or CyclinD1, and low expression of p21 WAF1 or Caspase-3 was closely correlated with the development of cervical cancer. Survivin and CyclinD1 could be used as a useful indicator to predict the prognosis of cervical cancer. | 卢实 张保华 王泽华 | 2005 | Journal of Huazhong University of Science and Technology(Medical Sciences)2005，25，1： | 28 |
| 19 | CLINICAL APPLICATION OF BODY DIFFUSION WEIGHTED MR IMAGING IN THE DIAGNOSIS AND PREOPERATIVE N STAGING OF CERVICAL CANCER显示文摘Objective To evaluate the clinical impact of body diffusion weighted imaging (DWI) on the diagnosis and preoperative N staging of cervical cancer. Methods Twenty-four patients (mean age 37.9 years old) with proved cervical cancer by cervical biopsy and 24 female patients with other suspected pelvic abnormalities received preoperative body DWI scan. Results of body DWI were compared with pathological findings. The apparent diffusion coefficient (ADC) values of normal cervix and different pathological types of cervical cancer were compared. ADC value of normal or inflammatory lymph nodes was also compared with that of metastatic ones. Student's t test was used for statistical analysis. Results There were 5 adenocarcinomas and 19 epitheliomas showed with biopsy results, and DWI showed 21 cervical lesions out of them (87.5%). ADC values of the normal cervix (n = 24), epithelioma (n = 19), and adenocar- cinoma (n = 5) were (1.73 ± 0.31) ×10-3, (0.88 ± 0.22) ×10-3, and (1.08 ± 0.12) ×10-3 mm2/s, respectively. Statistical analysis showed significant difference in ADC value between normal cervical tissue and either tumor tissues (both P < 0.01). In patients had lymphadenectomy (n = 24), totally 67 lymph nodes including 16 metastatic lymph nodes were pathologically analyzed, and DWI showed 66 (98.5%) out of them. ADC values of normal/inflammatory and metastatic lymph nodes were (1.07 ± 0.16) ×10-3 and (0.77 ± 0.13) ×10-3 mm2/s (P < 0.01). Receiver operating characteristic (ROC) curve of ADC value of metastatic lymph node showed that area under curve was 0.961. Conclusions ADC value in cervical carcinoma is lower than that in normal cervix, and ADC may have predictive value in subtype discrimination. ADC value may improve the preoperative characterization of lymph node metastasis. And at least abdominal and pelvic DWI scan is suggested for N staging evaluation in such patients. | Hua-dan Xue Shuo Li Fei Sun Hong-yi Sun Zheng-yu Jin Jia-xin Yang Mei Yu | 2008 | Chinese Medical Sciences Journal2008，23，3： | 28 |
| 20 | Serum HIF-1α and VEGF Levels Pre-and Post-TACE in Patients with Primary Liver Cancer显示文摘Objective To investigate the expression levels of serum hypoxia inducible factor 1 alpha(HIF-1α) and vascular endothelial growth factor(VEGF) pre-and post-transcatheter arterial chemoembolization(TACE) in patients with primary liver cancer(PLC),and correlations between prognosis factors and serum HIF-1α as well as VEGF levels.Methods Forty consecutive patients fulfilling diagnostic criteria for PLC undergoing TACE from March 2008 to May 2009 were enrolled into the study.The serum HIF-1α and VEGF levels of PLC patients pre-and 1 day,1 week,1 month post-TACE were analyzed using ELISA,and compared with that of 20 healthy volunteers.Patients were divided into complete response(CR) and partial response(PR),stable disease(SD),progressive disease(PD) groups according to the therapeutic efficacy.Pearson correlation was used to analyze the correlation between different clinical variables and serum HIF-1α and VEGF levels before TACE,and correlation between serum HIF-1α and VEGF levels was also evaluated.Results The expression levels of serum HIF-1α and VEGF in PLC patients were 154.94±83.29 and 264.00±148.10 pg/mL pre-TACE,and both of them were significantly higher than those in control group(23.84±8.15 and 69.78±21.42 pg/mL,all P<0.01).One day after TACE,both serum HIF-1α(570.64± 230.87 pg/mL) and VEGF levels(362.07±102.25 pg/mL) reached the peak values(all P<0.01).One week post-TACE,expression levels of them were decreased(198.62±92.11 and 283.52±145.46 pg/mL respectively),but still significantly higher than those before TACE(all P<0.01).The levels of both HIF-1α(133.96±57.02 vs.255.74±123.44 pg/mL) and VEGF(150.96±84.89 vs.368.95±161.90 pg/mL) in CR group 1 month post-TACE were significantly lower than those in PR+SD+PD group(all P<0.01).The level of serum HIF-1α was positively correlated with serum VEGF level(r=0.42,P<0.001).Both serum HIF-1α and VEGF levels were observed to be correlated with portal vein tumor thrombi(P<0.05) and metastasis(P<0.05). | Zhong-zhi Jia Guo-min Jiang Yao-liang Feng | 2011 | Chinese Medical Sciences Journal2011，26，3： | 28 |
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