From NAFLD to MAFLD:a“redefining”moment for fatty liver disease

查看全文 作　　者：Kenneth [1]IZheng;Jian-Gao [2]Fan;Jun-Ping [3]Shi;Vincent Wai-Sun [4]Wong;Mohammed [5]Eslam;Jacob [5]George;Ming-Hua [1,6,7]Zheng

机构地区：[1]Department of Hepatology,MAFLD Research Center,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,Zhejiang 25000,China;[2]Department of Gastroenterology,Center for Fatty Liver,Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition,Shanghai 200065,China;[3]Department of Liver Diseases,Hangzhou Normal University Affiliated Hospital,Hangzhou,Zhejiang 311121,China;[4]Department of Medicine and Therapeutics,The Chinese University of Hong Kong,Hong Kong 999077,China;[5]Storr Liver Centre,Westmead Institute for Medical Research,Westmead Hospital and University of Sydney,Sydney 2145,Australia;[6]Institute of Hepatology,Wenzhou Medical University,Wenzhou,Zhejiang 325000,China;[7]Key Laboratory of Diagnosis and Treatment for The Development of Chronic Liver Disease in Zhejiang Province,Wenzhou,Zhejiang 325000,China.

出　　处：《Chinese Medical Journal》索引2020年第19期,共3页

基　　金：the Robert W.Storr Bequest to the Sydney Medical Foundation,University of Sydney;a National Health and Medical Research Council of Australia(NHMRC)Program Grant(No.APP1053206 and APP1149976);Project grants(No.APP1107178 and APP1108422);Ming-Hua Zheng is supported by grants from the National Natural Science Foundation of China(No.81500665);High Level Creative Talents from Department of Public Health in Zhejiang Province and Project of New Century 551 Talent Nurturing in Wenzhou. 摘　　要：The term non-alcoholic fatty liver disease(NAFLD)was coined in 1980 to characterize a disease similar to alcoholic fatty liver disease that developed in patients without a history of excessive alcohol intake.[1]Morphologically,NAFLD is characterized by excess fatty infiltration of the liver in the absence of known causes of liver disease(eg,alcohol,autoimmune liver disease,viral hepatitis,etc).The clinical manifestations of NAFLD(both hepatic and extrahepatic)depend on the outcome of complex interactions between its primary drivers including poor lifestyle habits and diet,a dysfunctional microbiota,genetic predisposition,and environmental cues that result in metabolic dysfunction and liver disease.However,bringing all patients with their markedly different clinical courses under the NAFLD umbrella belies its complexity and implies a homogeneous disease state that then negatively impacts clinical management and a deeper understanding of pathogenesis.With advances in current knowledge on the spectrum of fatty liver diseases,it is apparent that the fourdecade-old outdated term NAFLD can no longer serve to usefully describe a highly heterogeneous disease.The disease as we understand it today not only impacts patients who consume alcohol and those who do not,but also potentially impacts all patients with any form of liver disease,by acting as a disease modifier.[2] 关键词：NAFLD MORPHOLOGICAL markedly

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From NAFLD to MAFLD:a“redefining”moment for fatty liver disease

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