Antibacterial photodynamic therapy:overview of a promising approach to fight antibiotic-resistant bacterial infections

查看全文 作　　者：Yao [1]Liu;Rong [1]Qin;Sebastian [2]A.J.Zaat;Eefjan [1]Breukink;Michal [1,3]Heger

机构地区：[1]Department of Membrane Biochemistry and Biophysics,Utrecht University,the Netherlands;[2]Department of Medical Microbiology,Academic Medical Center,University of Amsterdam,the Netherlands;[3]Department of Experimental Surgery,Academic Medical Center,University of Amsterdam,the Netherlands

出　　处：《Journal of Clinical & Translational Research》索引2015年第1卷第3期,共28页

摘　　要：Antibacterial photodynamic therapy(APDT)has drawn increasing attention from the scientific society for its potential to effectively kill multidrug-resistant pathogenic bacteria and for its low tendency to induce drug resistance that bacteria can rapidly develop against traditional antibiotic therapy.The review summarizes the mechanism of action of APDT,the photosensitizers,the barriers to PS localization,the targets,the in vitro-,in vivo-,and clinical evidence,the current developments in terms of treating Gram-positive and Gram-negative bacteria,the limitations,as well as future perspectives.Relevance for patients:A structured overview of all important aspects of APDT is provided in the context of resistant bacterial species.The information presented is relevant and accessible for scientists as well as clinicians,whose joint effort is required to ensure that this technology benefits patients in the post-antibiotic era. 关键词：ANTIBACTERIAL photodynamic therapy bacterial cell envelope PHOTOSENSITIZER non-selectivity reactive OXYGEN species SINGLET OXYGEN MULTIDRUG resistance light dose illumination

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Antibacterial photodynamic therapy:overview of a promising approach to fight antibiotic-resistant bacterial infections

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