|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Nanoparticles modified by polydopamine: Working as “drug” carriers显示文摘Inspired by the mechanism of mussel adhesion,polydopamine(PDA),a versatile polymer for surface modification has been discovered.Owing to its unique properties like extraordinary adhesiveness,excellent biocompatibility,mild synthesis requirements,as well as distinctive drug loading approach,strong photothermal conversion capacity and reactive oxygen species(ROS)scavenging facility,various PDA-modified nanoparticles have been desired as drug carriers.These nanoparticles with diverse nanostructures are exploited in multifunctions,consisting of targeting,imaging,chemical treatment(CT),photodynamic therapy(PDT),photothermal therapy(PTT),tissue regeneration ability,therefore have attracted great attentions in plenty biomedical applications.Herein,recent progress of PDA-modified nanoparticle drug carriers in cancer therapy,antibiosis,prevention of inflammation,theranostics,vaccine delivery and adjuvant,tissue repair and implant materials are reviewed,including preparation of PDA-modified nanoparticle drug carriers with various nanostructures and their drug loading strategies,basic roles of PDA surface modification,etc.The advantages of PDA modification in overcoming the existing limitations of cancer therapy,antibiosis,tissue repair and the developing trends in the future of PDA-modified nanoparticle drug carriers are also discussed. | Anting Jin Yitong Wang Kaili Lin Lingyong Jiang | 2020 | Bioactive Materials2020，5，3： | 13 |
| 2 | 糖尿病足溃疡治疗研究进展显示文摘糖尿病足溃疡(DFUs)是糖尿病的严重并发症之一,具有较高的患病率和致残率。即使采用外科清创、抗感染、局部减压、适时血运重建、伤口敷料等标准治疗措施,DFUs的治愈率仍较低。因此,负压伤口治疗、高压氧疗法和控释药物治疗等已被广泛研究和应用。慢性难愈合创面是DFUs治疗的难点,新型药物控释体系能持续释放促伤口愈合药物,是目前的研究热点。DFUs患者病情复杂,需全方位、多学科管理,应根据患者的具体情况制订个体化治疗方案。 | 董家乐 牛烁 韩威 纪智礼 | 2022 | 医学综述2022，28，6： | 6 |
| 3 | Recent trends on wound management:New therapeutic choices based on polymeric carriers显示文摘Wound healing is an unmet therapeutic challenge among medical society since wound assessment and management is a complex procedure including several factors playing major role in healing process.Wounds can mainly be categorized as acute or chronic.It is well referred that the acute wound displays normal wound physiology while healing,in most cases,is seemed to progress through the normal phases of wound healing.On the other hand,a chronic wound is physiologically impaired.The main problem in wound management is that the majority of wounds are colonized with microbes,whereas this does not mean that all wounds will be infected.In this review,we address the problems that clinicians face to manage while treat acute and chronic wounds.Moreover,we demonstrate the pathophysiology,etiology,prognosis and microbiology of wounds.We further introduce the state of art in pharmaceutical technology field as part of wound management aiming to assist health professionals to overcome the current implications on wound assessment.In addition,authors review researches which included the use of gels and dermal films as wound healing agents.It can be said that natural and synthetic drugs or carriers provide promising solutions in order to meet the wound management standards.However,are the current strategies as desirable as medical society wish? | Mehmet Evren Okur Ioannis D.Karantas Zeynep Senyigit Neslihan Ustundag Okur Panoraia I.Siafaka | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，6： | 3 |
| 4 | 氧化石墨烯复合材料载药微球的制备与性能研究显示文摘背景:重度骨结核治愈率低且需要长期服药,但口服药物不良反应大。将载药缓释微球定量置于病灶处不仅可以确保药物浓度和精准治疗,还能有效调控药物释放速度,减少不良反应。目的:优化氧化石墨烯/丝素蛋白/利福平微球的制备工艺。方法:采用乳化法制备氧化石墨烯/丝素蛋白/利福平微球,在确定丝素蛋白浓度3.5%、水油比为1∶6、司盘80与石蜡比1∶10、温度为50℃、利福平与药物载体溶液比50mg∶1mL作为定量的前提下,考察不同搅拌速度(200,500,800 r/min)、不同有机溶剂与水相体积比(1∶1、4∶1、6∶1)及不同氧化石墨烯溶液与丝素溶液溶质比(0.1%,0.25%,0.5%)条件下制备出载药微球的微观形貌、载药率和包封率,确定较佳的制备工艺。结果与结论:(1)扫描电镜显示,500 r/min制备的微球大小均匀,成球性较好;有机溶剂与水相体积比为4∶1制备的微球成球效率较好;氧化石墨烯溶液与丝素溶液溶质比为0.1%制备的微球成球率较高。(2)综合载药率和包封率检测结果,再结合氧化石墨烯/丝素蛋白微球的细胞毒性实验结果,选择在搅拌速度500 r/min、有机溶剂与水相体积比为4∶1、氧化石墨烯溶液与丝素溶液溶质比为0.1%的条件下制备微球,微球的成球率高,载药量为13.5%,包封率为61%,并且该微球在体外可稳定释放药物,在96 h内累计释药量约为67.3%,药物缓控释过程由扩散和溶蚀共同作用。 | 姜朝瑞 许燕 熊莹 张旭婧 | 2022 | 中国组织工程研究2022，26，22： | 1 |
| 5 | 丝素蛋白生物材料在创面修复中的应用研究进展显示文摘丝素蛋白是一种天然纤维蛋白,具有生物相容性好、降解性能和力学性能可调、宿主炎症反应小、成本低、易制备等特性,是创面修复的理想基质材料。丝素蛋白可单独使用,也可将其同其他材料复合,制备成支架、水凝胶、膜、功能贴片和微针等不同材料,满足不同创面修复需求,调控创面修复过程,在皮肤组织工程中的应用研究急剧增加。同其他天然材料相比,丝素蛋白通过改善不同时期的细胞增殖、迁移和分化行为来促进组织再生和创面修复,表现出不同维度的独特优势。综合近年来丝素蛋白创面修复材料研究的进展,该文重点阐述丝素蛋白及其复合材料在创面修复中的作用机制和应用前景。 | 丁召召 吕强 | 2022 | 中华烧伤与创面修复杂志2022，38，10： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员