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| 1 | Superabsorbent poly(acrylic acid) and antioxidant poly(ester amide) hybrid hydrogel for enhanced wound healing显示文摘Wound healing dressing is increasingly needed in clinical owing to the large quantity of skin damage annually.Excessive reactive oxygen species(ROS)produced through internal or external environmental influences can lead to lipid peroxidation,protein denaturation,and even DNA damage,and ultimately have harmful effects on cells.Aiming to sufficiently contact with the wound microenvironment and scavenge ROS,superabsorbent poly(acrylic acid)and antioxidant poly(ester amide)(PAA/PEA)hybrid hydrogel has been developed to enhance wound healing.The physical and chemical properties of hybrid hydrogels were studied by Fourier-transform infrared(FTIR)absorption spectrum,compression,swelling,degradation,etc.Besides,the antioxidant properties of hybrid hydrogels can be investigated through the free radical scavenging experiment,and corresponding antioxidant indicators have been tested at the cellular level.Hybrid hydrogel scaffolds supported the proliferation of human umbilical vein endothelial cells and fibroblasts,as well as accelerated angiogenesis and skin regeneration in wounds.The healing properties of wounds in vivo were further assessed on mouse skin wounds.Results showed that PAA/PEA hybrid hydrogel scaffolds significantly accelerated the wound healing process through enhancing granulation formation and re-epithelialization.In summary,these superabsorbent and antioxidative hybrid hydrogels could be served as an excellent wound dressing for full-thickness wound healing. | Jianhua Zhang Junfei Hu Baoshu Chen Tianbao Zhao Zhipeng Gu | 2021 | Regenerative Biomaterials2021，8，2： | 1 |
| 2 | 无创机械通气联合噻托溴铵吸入对慢阻肺合并Ⅱ型呼衰患者的临床研究显示文摘目的研究无创机械通气和噻托溴铵联合治疗对慢阻肺合并Ⅱ型呼衰患者的临床效果。方法以周口市第一人民医院2019年1月—2021年1月入院符合纳入标准的100例患者为研究对象,两组均采用噻托溴铵粉剂吸入治疗,实验组使用无创机械通气辅助治疗。比较两组治疗前后肺功能、炎症因子、血气指标、mMRC、CAT量表评分和临床疗效。结果治疗后实验组通气指标(FEV_(1)、FVC和FEV_(1)/FVC)与对照组相比明显提高(P<0.05);治疗后实验组血气分析指标PaO_(2)和PaCO_(2)与对照组相比趋于正常水平(P<0.05);治疗后实验组炎症因子数值(TNF-α、IL-6、IL-8)显著优于对照组(P<0.05);治疗后实验组mMRC、CAT评估与对照组相比均降低(P<0.05);实验组治疗总有效率较对照组高8%。结论无创机械通气联合噻托溴铵对慢阻肺合并Ⅱ型呼衰的治疗,能够改善肺功能,降低炎症反应,恢复呼吸酸碱平衡,提高患者自主呼吸能力,对治疗慢性呼吸疾病中具有借鉴价值。 | 张明威 | 2022 | 医药论坛杂志2022，43，22： | 0 |
| 3 | 液体硅橡胶功能改性及其医学应用研究进展显示文摘液体硅橡胶具有良好的化学稳定性和生物相容性,广泛应用于医疗及医疗器械领域,然而,在实际应用中存在机械支撑强度不足、稳定性不足以及易引发感染等缺陷。因此,提升液体硅橡胶的机械强度、抗菌性、化学稳定性和生物活性是首先要解决的问题。研究发现,将各种纳米填料添加到液体硅橡胶基质中,不仅可以提高材料的力学性能,还可以将其电学和抗菌性能提高到一个较好的水平。简要总结了液体硅橡胶的分类、构建及性能改进方式,重点阐述了液体硅橡胶在医学领域应用过程中的研究现状及目前所面临的瓶颈问题。液体硅橡胶生物医学功能改性研究有望提升纳米材料在液体硅橡胶中的分散性并改善其抗菌性、稳定性和导电性,提升液体硅橡胶的应用价值并拓展其应用场景。 | 吴帅莹 蒋永和 陆治香 刘刚 | 2023 | 中国材料进展2023，42，11： | 0 |
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