|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Combined interventional therapies of hepatocellular carcinoma显示文摘Hepatocellular carcinoma (HCC) is one of the most commonmalignancies in the world, responsible for an estimated one million deaths annually. It has a poor prognosis due to its rapid infiltrating growth and complicating liver cirrhosis.Surgical resection, liver transplantation and cryosurgery are considered the best curative options, achieving a high rate of complete response, especially in patients with small HCC and good residual liver function. In nonsurgery, regional interventional therapies have led to a major breakthrough in the management of unresectable HCC, which include transarterial chemoembolization (TACE), percutaneous ethanol injection (PEI), radiofrequency ablation (RFA), microwave coagulation therapy (MCT), laser-induced thermotherapy (LITT), etc. As a result of the technical development of locoregional approaches for HCC during the recent decades,the range of combined interventional therapies has been continuously extended. Most combined multimodal interventional therapies reveal their enormous advantages as compared with any single therapeutic regimen alone,and play more important roles in treating unresectable HCC. | JunQian Gan-ShengFeng ThomasVogl | 2003 | World Journal of Gastroenterology2003，9，9： | 51 |
| 2 | Ultrasonography guided percutaneous radiofrequency ablation for hepatic cavernous hemangioma显示文摘AIM: Hepatic cavernous hemangioma (HCH) is the mostcommon benign tumor of the liver and its management isstill controversial. Recent successin situ radiofrequencyablation of hepatic malignancies has led us to consider usingthis technique in patients with HCH. This study was to assessthe efficacy, safety, and complications of percutaneousradiofrequency ablation (PRFA) under ultrasonographyguidance in patients with HCH.METHODS: Twelve patients (four men and eight women,age ranged 33-56 years, mean age was 41.7 years) with 15hepatic cavernous hemangiomas (2.5 cm to 9.5 cm) weretreated using the RF-2000 generator and 10-needle LeVeenelectrode percutaneously guided by B-ultrasound. Lesionslarger than 3 cm were treated by multiple overlappingablations that encompass the entire lesion as well as a rimof normal liver tissue (approximately 0.5 cm).RESULTS: All the patients who received PRFA therapy hadno severe pain, bleeding or bile leakage during and afterthe procedures. Nine to 34 months′ follow-up (mean, 21months) by ultrasound and/or spiral CT scan demonstratedthat the ablated lesions in this group were shrunk remarkably,and the shrunken range was 38-79 % (mean, 67 % per 21months). The contrast enhancement was disappeared withinthe tumor or at its periphery in all cases on spiral CT scansobtained 3 to 6 months after treatment.CONCLUSION: The results of this study suggest that PRFAtherapy is a mini-invasive, simple, safe, and effective methodfor the treatment of selected patients with HCH. | Yan Cui Li-Yan Zhou Man-Ku Dong Ping Wang Min Ji Xiao-Ou Li Chang-Wei Chen Zi-Pei Liu Yong-Jie Xu Hong-Wen Zhang Department of Hepatobiliary Surgery,Beijing 306 Hospital,Chaoyang District,Beijing 100101,China | 2003 | World Journal of Gastroenterology2003，9，9： | 43 |
| 3 | Rapid progression of hepatocellular carcinoma after Radiofrequency Ablation显示文摘To report the results of radiofrequency ablation (RFA) of hepatocellular carcinoma (HCC)in cirrhotic patients and to describe the treatment related complications (mainly the rapid intrahepatic neoplastic progression). | AndreaRuzzenente GiovannideManzoni MatteoMolfetta SilviaPachera BrunoGenco MatteoDonataccio AlfredoGuglielmi | 2004 | World Journal of Gastroenterology2004，10，8： | 42 |
| 4 | Comparison between combination therapy of percutaneous ethanol injection and radiofrequency ablation and radiofrequency ablation alone for patients with hepatocellular carcinoma显示文摘AIM: In the present study, the characteristics of PEI-RFA treatment were further elucidated by analyzing the relationship between the volume of coagulated necrosis and the energy requirement for ablation or the amount of ethanol injected into HCC.METHODS: The volume of coagulated necrosis, total energy requirement and energy requirement for coagulation of per unit volume were examined in the groups of PEI-RFA and RFA alone using the Cool-tip RF system.RESULTS: The results showed that the volume of coagulated necrosis induced was significantly larger in PEI-RFA group than in routine RFA group, when the total energy administered was comparable in both groups.In PEI-RFA, enlargement of coagulated necrosis was admitted in 3 dimensions and the amount of energy requirement per unit volume of coagulated necrosis was negatively correlated with the amount of ethanol injected into HCC.CONCLUSION: These results suggest that, compared to RFA alone, PEI-RFA enables to induce comparable coagulated necrosis with smaller energy requirement, and that PEI-RFA is likely to be less invasive than RFA alone irrespective of inducing enhanced coagulated necrosis.Thus, simple prior injection of ethanol may make RFA treatment more effective and less invasive for the treatment of patients with HCC. | Kazutaka Kurokohchi Seishiro Watanabe Tsutomu Masaki Naoki Hosomi Yoshiaki Miyauchi Takashi Himoto Yasuhiko Kimura Seiji Nakai Akihiro Deguchi Hirohito Yoneyama Shuhei Yoshida Shigeki Kuriyama | 2005 | World Journal of Gastroenterology2005，11，10： | 29 |
| 5 | Combined transarterial chemoembolization and arterial administration of Bletilla striata in treatment of liver tumor in rats显示文摘AIM: To evaluate and compare the effect of combined transarterial chemoembolization (TACE) and arterial administration of Bletilla striata (a Chinese traditionalmedicine against liver tumor) versusTACE alone for the treatment of hepatocellular carcinoma (HCC) in ACI rats.METHODS: Subcapsular implantation of a solid Morris hepatoma 3 924A (2 mm3) in the liver was carried out in 30 male ACI rats. Tumor volume (V1) was measured by magnetic resonance imaging (MRI) on day 13 after implantation. The following different agents of interventional treatment were injected after retrograde catheterization via gastroduodenal artery (on day 14), namely, (A) TACE (0.1 mg mitomycin +0.1 mi Lipiodol) + Bletilla striata (1.0 mg) (n= 10); (B) TACE + Blebilla stnata(1.0 mg) + ligation of hepatic artery (n=10),(C) TACE alone (control group, n=10). Tumor volume (V2)was assessed by MRI (on day 13 after treatment) and the tumor growth ratio (V2/V1) was calculated.RESULTS: The mean tumor volume before (V1) and after (V2) treatment was 0.0355 cm3 and 0.2248 cm3 in group A,0.0374 cm3 and 0.0573 cm3 in group B, 0.0380 cm3 and 0.3674 cm3 in group C, respectively. The mean ratio (V2/V1)was 6.2791 in group A, 1.5324 in group B and 9.1382 in group C. Compared with the control group (group C), group B showed significant inhibition of tumor growth (P<0.01),while group A did not (P>0.05). None of the animals died during implantation or in the postoperative period.CONCLUSION: Combination of TACE and arterial administration of Bletilla striata plus ligation of hepatic artery is more effective than TACE alone in the treatment of HCC in rats. | JunQian DaryuschVossoughi DirkWoitaschek ElsieOppermann WolfO.Bechstein Wei-YongLi Gan-ShengFeng ThomasVogl | 2003 | World Journal of Gastroenterology2003，9，12： | 27 |
| 6 | Comparison of transcatheter arterial chemoembolization,laparoscopic radiofrequency ablation,and conservative treatment for decompensated cirrhotic patients with hepatocellular carcinoma显示文摘AIM:To compare the therapeutic effect of transcatheter arterial chemoembolization (TACE), laparoscopic radiofrequency ablation (LRFA), and conservative treatment for the therapy of decompensated liver cirrhosis patients with hepatocellular carcinomas (HCC).METHODS:Between October 2000 and July 2003, one hundred patients with histologically proven primary HCC and clinical decompensated liver cirrhosis (Child classification B or C) were included in this study. Forty patients received LRFA (LRFA group), twenty received TACE (TACE group),and forty received conservative treatment (control group).We compared the survival, recurrence, and complication rates in these three groups, making adjustment using the tumor metastastic node staging system.RESULTS:The major complication rate in the TACE group (9/20) was significantly higher than that in the LRFA group (7/40). For patients with TMN stage Ⅱ HCC, the survival rate of the LRFA group was better than that of the TACE and control groups (P=0.003) but the recurrence rates befween the LRFA and TACE groups did not differ.CONCLUSION: The LRFA group of patients had betterclinical outcomes in terms of survival and complication rates in comparison with the TACE group or conservative treatment in patients with decompensated liver cirrhosis, especially in TMN patients with stage Ⅱ HCC. LRFA is thus an appropriate alternative treatment for poor liver function among patientswith HCC. | Chung-BaoHsieh Hao-MingChang Teng-WeiChen Chung-JuengChen De-ChuanChan Jyh-CherngYu Yao-ChiLiu Tzu-MingChang Kuo-LiangShen | 2004 | World Journal of Gastroenterology2004，10，4： | 17 |
| 7 | Effect of arsenic trioxide on rat hepatocarcinoma and its renal cytotoxicity显示文摘AIM: To study the effect of arsenic trioxide (As2O3) on rat experimental hepatocarcinoma and its renal cytotoxicity.METHODS: The hepatocarcinoma model was established by diethaylnitrosamine perfusion in stomach of 120 Wistar rats, and the treatment began at the end of 20 weeks.Before the treatment, the rat models were randomly divided into 5 groups. In the treatment groups, three doses of As2O3 were injected into rat abdominal cavity, the total time of drug administration was 4 weeks. Cisplatin control or the blank group was injected into abdominal cavity with equal amount of cisplatin or saline at the same time,respectively. On the 7th, 14th and 28th day after the treatment, the hepatocarcinoma nodules were obtained and the morphologic changes of hepatocarcinoma cells were observed under light and electron microscopes;Immunohistochemistry (S-P methods) was employed to detect the expression of bcl-2, bax and PCNA in hepatocarcinoma tissues; flow cytometry (TUNEL assay)was used to detect the apoptosis of liver cancer cells and the change of cytokinetics. On the 28th day, the kidneys were obtained and their histologic changes were observed under light microscope, and immunohistochemistry (SP stain) was also employed to detect the expression of bcl-2and PCNA. Cisplatin and saline solution were used as the control.RESULTS: As2O3 could induce the apoptosis of rat liver cancer cells and exhibited typical morphologic changes.The incidence of apoptosis of hapatocarcinoma cells was elevated (P=0.001). The elevation was the most higher in the group of middle-dose of As2O3 (1 mg.kg-1), significantly higher than that of the other arsenic groups and the controls (P=0.001). Large dose of As2O3 (5 mg.kg-1) was able to arise the incidence of apoptosis, but also produced a large amount of necrosis and inflammatory reaction. Middle dose of As2O3 dramatically increased the cell number in G2/M phase (P=0.0001), and apoptosis happened apparently.The expression of bcl-2 and bax was related to the dose of As2O3. With the up-regulation of apoptotic incidence, the ratio of bcl-2/bak decreased. But the incidence of apoptosis was not the highest status and the ratio of bcl-2/bax was at the lowest when the highest-dose of As2O3 was used.There was significant difference among the PCNA indexes (PCNA L1) of the five groups. Of them, three arsenic groups all showed decrease of different degrees, and this downregulation was most obvious in group A. There was significant difference among the three groups (P=0.016).Under the light microscope, the rat kidney in the cisplatin group exhibited tubular epithelium swelling and degeneration, protein casts in collecting tubules; While all arsenic groups didn't show the significant changes (P=0.013).In the arsenic groups, the expression of bcl-2 in the renal tubular epithelium was increased (P=0.005), no obvious changes happened to PCNA L1. But in the group of cisplatin,the PCNA L1 increased significantly (P=0.001).CONCLUSION: AS2O3 can induce apoptosis of rat hepatocellular carcinoma cells. And there is optimum dose;too high dose will induce the cytotoxic effect, while certain dose of As2O3 is able to block the cell cycle at G2/M phase.As2O3 had the most remarkable influence on G2/M cells,and it can also induce apoptosis to cells at other phases.As2O3 can restrain the proliferation of rat hepatocellular carcinoma cells, in a dose-time dependent manner.Compared with cisplatin, As2O3 didn't show obvious renal toxicity, which was related to the increasing expression of bcl-2 in renal tubular epithelium, the inhibition of apoptosis and the anti-oxidation effects. | Shao-Shan Wang Ti Zhang Xi-Lu Wang Li Hong Department of Surgery of Dagang Hospital 300270,Tianjin,China Qing-Hui Qi Department of Chinese and Western Integral Surgery of Master Hospital of Tianjin Medical University 300052,Tianjin,China | 2003 | World Journal of Gastroenterology2003，9，5： | 17 |
| 8 | 射频消融与手术切除治疗肝癌并发症及生存率的临床对照研究显示文摘目的探讨超声引导下射频消融治疗肝癌并发症、术后1年生存率的情况,并与传统开腹手术进行比较。方法原发性肝癌患者共159例,根据肿瘤直径大小以及肿块数目将患者分为2组:肿瘤直径≤4.0cm、单发肿瘤组44例,其中接受手术治疗29例,接受射频治疗15例;肿瘤直径>4.0cm、多发肿瘤组115例,其中接受手术治疗54例,接受射频治疗61例。手术治疗行肝叶规则或不规则切除术;射频治疗共88个肿瘤,超声引导下集束射频治疗针穿刺进入肿瘤中心,分点多次行射频治疗。应用癌症患者生活质量评估量表Quick-FLIC,信件或电话随访了解患者并发症、短期生存率及生活质量的情况。分别比较2组接受手术和射频治疗结果的差异。结果射频治疗并发症的发生率低于手术患者。肿瘤直径≤4.0cm、单发病灶组:射频和手术患者的1年生存率和生活质量没有明显差异;肿瘤直径>4.0cm、多发肿瘤组:射频治疗术后1年生存率及平均生存时间明显低于手术患者,但生存质量较手术组高。结论对于部分失去手术治疗机会或者不愿意进行手术治疗的PLC患者。 | 张隆群 王济明 | 2007 | 第三军医大学学报2007，29，5： | 15 |
| 9 | 肝细胞癌合并肝硬化病人的腹腔镜射频消融治疗显示文摘目的探讨肝细胞癌合并肝硬化病人行腹腔镜射频消融(LRFA)治疗的可行性、安全性及疗效.方法 2001年8月至2003年12月,25例肝细胞癌合并肝硬化病人在全麻下进行了LRFA治疗.男19例,女6例,平均年龄(52.2±11.9)岁.术前经超声、螺旋CT或MRI等检查共发现瘤体38个,平均肿瘤直径(3.8±1.1)cm.肿瘤均位于肝脏表面、肝左外叶或邻近胆囊等空腔脏器.肝功能均为Child A或B级.合并慢性结石性胆囊炎3例,糖尿病2例,凝血功能障碍5例.术中行腹腔镜超声检查及病理活检.结果 25例病人腹腔镜及术中超声检查共发现瘤体41个.所有病例均顺利完成LRFA治疗,同时行胆囊切除术5例.平均手术时间(72.5±27.6)min.未出现出血、胆道、胃肠道及膈肌损伤等并发症.术后1个月螺旋CT扫描证实,肿瘤完全坏死率达100%.随访6~32个月(平均18个月),1例发现肝内新病灶,3例射频治疗部位复发,l例死于肿瘤复发及肝功能衰竭.结论肝细胞癌合并肝硬化病人行LRFA治疗是安全可行的,可提高肝细胞癌射频消融治疗效果,减少并发症. | 范瑞芳 柴福录 贺冠宪 李荣梓 李红梅 史建华 曹敏丽 | 2005 | 中华肝胆外科杂志2005，11，8： | 14 |
| 10 | Surgical vs percutaneous radiofrequency ablation for hepatocellular carcinoma in dangerous locations显示文摘AIM:To compare the long-term outcome of percutaneous vs surgical radiofrequency ablation(RFA) for hepatocellular carcinoma(HCC) in dangerous locations.METHODS:One hundred and sixty-two patients with HCC in dangerous locations treated with percutaneous or surgical RFA were enrolled in this study.The patients were divided into percutaneous RFA group and surgical RFA group.After the patients were regularly followed up for a long time,their curative rate,hospital stay time,postoperative complications and 5-year local tumor progression were compared and analyzed.RESULTS:No significant difference was observed in curative rate between the two groups(91.3% vs 96.8%,P = 0.841).The hospital stay time was longer and more analgesics were required while the incidence of bile duct injury and RFA-related hemorrhage was lower in surgical RFA group than in percutaneous RFA group(P < 0.05).The local progression rate of HCC in dangerous locations was significantly lower in surgical RFA group than in percutaneous RFA group(P = 0.05).The relative risk of local tumor progression was 14.315 in percutaneous RFA group.CONCLUSION:The incidence of severe postoperative complications and local tumor progression is lower after surgical RFA than after percutaneous RFA. | Ji-Wei Huang Roberto Hernandez-Alejandro Kristopher P Croome Lu-Nan Yan Hong Wu Zhe-Yu Chen Pankaj Prasoon Yong Zeng | 2011 | World Journal of Gastroenterology2011，17，1： | 14 |
| 11 | Multi-modality treatment of colorectal liver metastases显示文摘Liver metastases synchronously or metachronously occur in approximately 50% of colorectal cancer patients. Multimodality comprehensive treatment is the best therapeutic strategy for these patients. However, the optimal pattern of multimodality therapy is still controversial, and it raises several signif icant concerns. Liver resection is the most important treatment for colorectal liver metastases. The defi nition of resectability has shifted to focus on the completion of R0 resection and normal liver function maintenance. The role of neoadjuvant and adjuvant chemotherapy still needs to be clarified. The management of either progression or complete remission during neoadjuvant chemotherapy is challenging. The optimal sequencing of surgery and chemotherapy in synchronous colorectal liver metastases patients is still unclear. Conversional chemotherapy, portal vein embolization, two-stage resection, and tumor ablation are effective approaches to improve resectability for initially unresectable patients. Several technical issues and concerns related to these methods need to be further explored. For patients with def initely unresectable liver disease, the necessity of resecting the primary tumor is still debatable, and evaluatingand predicting the eff icacy of targeted therapy deserve further investigation. This review discusses different patterns and important concerns of multidisciplinary treatment of colorectal liver metastases. | Guo-Xiang Cai San-Jun Cai | 2012 | World Journal of Gastroenterology2012，18，1： | 14 |
| 12 | 肝硬化胰岛素抵抗及血清生长激素水平的研究显示文摘目的:研究肝硬化患者胰岛素抵抗和血清生长激素(GH)水平的关系.方法:选择肝硬化患者40例,按Child-Pugh分级将其分为ChildA级(16例)、B级(13例)和C级(11例),正常对照组22例,用放射免疫法测定空腹血清胰岛素和GH水平,并计算胰岛素敏感性指数(ISI);同时分析Child-Pugh分级与血胰岛素、ISI和GH的关系.结果:肝硬化患者的血清胰岛素(17.8±7.2U/L)和GH水平(3.7±2.2μg/L)较正常对照组(分别为10.1±3.4U/L和1.9±0.9μg/L)显著升高(分别是P<0.05和P<0.01),并随着Child-PughA,B,C分级的升高而升高;而肝硬化患者ISI显著低于正常对照组(0.017±0.010vs0.025±0.014,P<0.05),并随着Child-PughA,B,C分级的升高而降低;肝硬化C级的空腹血清胰岛素(23.6±10.1U/L)和GH水平(4.7±2.6μg/L)显著高于肝硬化A级(分别为13.8±4.5U/L和3.1±1.4μg/L)而肝硬化C级的ISI(0.012±0.007)显著低于肝硬化A级(0.019±0.011);肝硬化患者的Child-Pugh积分与胰岛素水平呈正相关(r=0.428,P<0.01),与GH水平呈正相关(r=0.376,P<0.05),与ISI呈负相关(r=-0.333,P<0.05);ISI与GH呈负相关(r=0.388,P<0.05);合并腹水、肝性脑病和肝癌的患者的血清胰岛素、GH水平较合并上消化道出血的患者显著升高(P<0.05).结论:肝硬化患者存在着高胰岛素血症、胰岛素抵抗和高GH症,他们均与肝功能的损伤程度有关. | 张卫卫 王学清 李岩 | 2002 | 世界华人消化杂志2002，10，10： | 12 |
| 13 | 手术切除与经皮射频消融在小肝癌治疗中的价值探讨显示文摘目的评价手术切除与经皮射频消融(PRFA)在小肝癌治疗中的价值。方法我院小肝癌患者99例分为两组,分别给于手术切除和PRFA,对两组术后不良反应、术后1年复发率进行比较。结果两组患者术后不良反应,包括术后体温恢复时间,ALT升高例数,胆红素升高例数,经比较无差异;对于直径≤3cm的肿瘤,手术治疗与PRFA治疗组患者术后1年的肿瘤复发率差异没有显著性;但是直径3~5cm的肿瘤,手术治疗组在术后1年的肿瘤复发率明显低于PRFA治疗组。结论手术治疗与PRFA均是一种创伤小、恢复快、安全性高的治疗方法 ,对于肿瘤直径≤3cm的,两者疗效等同;对于肿瘤直径3~5cm的,以手术治疗为宜。 | 黄学伟 邹正东 | 2010 | 西南军医2010，12，3： | 11 |
| 14 | 立体定向放疗联合热疗及索拉非尼治疗复发及转移性肝癌的疗效分析显示文摘目的:探讨γ-体部立体定向放疗(stereotactic body radiation therapy withγ-knife,γ-SBRT)联合热疗及靶向药物索拉非尼(sorafenib)治疗复发及转移性肝癌的效果。方法:自2007年8月至2009年12月,收治71例肝癌治疗后复发及转移患者。39例行γ-SBRT联合热疗,32例γ-SBRT联合热疗及索拉非尼治疗。结果:治疗后3个月总有效率为83.1%(59/71)。γ-SBRT+热疗组的1、3年局部控制率分别为41.0%(16/39)、18.0%(7/39));γ-SBRT+热疗+索拉非尼组的1、3年局部控制率分别为56.3%(18/32)、28.1%(9/32)。γ-SBRT+热疗组的1、3年OS分别为41.2%(16/39)、17.9%(7/39),1、3年PFS分别为38.5%(15/39)、15.4%(6/39);γ-SBRT+热疗+索拉非尼组的1、3年OS分别为62.5%(20/32)、28.1%(9/32),1、3年PFS分别为59.4%(19/32)、25.0%(9/32),经Log-rank检验两组的OS、PFS差异无显著性。结论:采用γ-SBRT联合热疗及索拉非尼对转移及复发性肝癌进行治疗是较有效的治疗方法。治疗过程安全,多数患者能耐受治疗。 | 康静波 赵向飞 聂青 张丽萍 朱奇 李启亮 王仁秋 | 2013 | 中国肿瘤临床2013，40，20： | 10 |
| 15 | Gene expression profiles of hepatoma cell line HLE显示文摘AIM: To investigate the global gene expression of cancer related genes in hepatoma cell line HLE using Atlas Human Cancer Array membranes with 588 well-characterized human genes related with cancer and tumor biology.METHODS: Hybridization of cDNA blotting membrane was performed with 32P-labeled cDNA probes synthesized from RNA isolated from Human hepatoma cell line HLE and noncirrhotic normal liver which was liver transplantation donor.AtlasImage, a software specific to array, was used to analyze the result. The expression pattern of some genes identified by Atlas arrays hybridization was confirmed by reverse transcription polymerase chain reaction (RT-PCR)in 24 pairs of specimens and Northern blot of 4 pairs of specimens.RESULTS: The differential expression of cell cycle/growth regulator in hepatocellular carcinoma (HCC) showed a stronger tendency toward cell proliferation with more than 1.5-fold up-regulation of Cyclin C, ERK5, ERK6, E2F-3, TFDP2 and CK4. The anti-apoptotic factors such as Akt-1 were up-regulated, whereas the promotive genes of apoptosis such as ABL2 were down-regulated. Among oncogene/tumors suppressors, SKY was down-regulated. Some genes such as Integrin beta 8, Integrin beta 7, DNA-PK, CSPCP,byglycan, Tenacin and DNA Topo were up-regulated. A number of genes, including LAR, MEK1, eps15, TDGF1,ARHGDIA were down-regulated. In general, expression of the cancer progression genes was up-regulated, while expression of anti-cancer progression genes was downregulated. These differentially expressed genes tested with RT-PCR were in consistent with cDNA array findings.CONCLUSION: Investigation of these genes in HCC is helpful in disclosing molecular mechanism of pathogenesis and progression of HCC. For the first time few genes were discovered in HCC. Further study is required for the precise relationship between the altered genes and their correlation with the pathogenesis of HCC. | Lian-XinLiu Zhi-HuaLiu Hong-ChiJiang Wei-HuiZhang Shu-YiQi JieHu Xiu-QinWang MinWu | 2003 | World Journal of Gastroenterology2003，9，4： | 10 |
| 16 | Efficacy and feasibility of radiofrequency ablation for decompensated cirrhotic patients with hepatocellular carcinoma显示文摘背景有肝功能的补偿不全的大多数 HCC 病人失去了机会外科或 interventional 治疗。这研究的目的是在对待 hepatocellular 评估 radiofrequency 脱离( RFA )的可行性和结果有差的肝的癌( HCC )病人工作(孩子呸类 C ),谁不对外科或肝的动脉 chemo-embolization.Methods 合适 13 个 HCC 病人(肿瘤的数字是 17 )与孩子呸 C 的肝功能(分数:10.2 獳扩敬洠 ' 炭鷽螞h楷拺?慰瑲慩汬? 瑡牴扩瑵摥琠? 桴 ? 潤湷敲畧慬楴湯漠 ? 湥潤桴汥湩? | WU Jin-yu YANG Wei CUI Ming YIN Shan-shan GAO Wen WU Wei YAN Kun CHEN Min-hua | 2010 | Chinese Medical Journal2010，，15： | 7 |
| 17 | Local recurrence is an important prognostic factor of hepatocellular carcinoma显示文摘AIM: To clarify the importance of complete treatment by PEIT.METHODS: A total of 140 previously untreated cases of HCC were enrolled in this study from 1988 to 2002. The inclusion criteria were: a solitary tumor less than 4 cm in diameter or multiple tumors, fewer than four in number and less than 3 cm in diameter, without extrahepatic metastasis or vessel invasion. As general principles for the treatment of HCC, the patients underwent transcatheter arterial chemoembolization (TACE) prior to PEIT. After the initial treatment of the patients,ultrasonography and computed tomography were performed, and measurement of serum levels of α-fetoprotein (AFP) was determined. When tumor recurrences were detected, PEIT and/or TACE were repeated whenever the hepatic functional reserve of the patient permitted. We then analyzed the variables that could influence prognosis, including tumor size and number, the serum levels of AFP, the parameters of hepatic function (albumin, bilirubin, ALT, hepaplastin test,platelet number, and indocyanine green retention at 15min [ICG-R15]), combined therapy with TACE, distant recurrence, and local recurrence.RESULTS: Univariate analysis identified the ICG test,serum levels of AFP and albumin, tumor size and number,and local recurrence, but not distant recurrence, as significant prognostic variables. In multivariate analysis using those five parameters, the ICG test, tumor size, tumor number,and local recurrence were identified as significant prognostic factors. In both univariate and multivariate analyses, the relative risk for the ICG test was the highest, followed by local recurrence.CONCLUSION: We found that local recurrence is an independent prognostic factor of HCC, indicating that achieving complete treatment for HCC on first treatment is important for improving the prognosis of patients with HCC. | Eiichirou Arimura Kazuhiro Kotoh Makoto Nakamuta Shusuke Morizono Munechika Enjoji Hajime Nawata | 2005 | World Journal of Gastroenterology2005，11，36： | 7 |
| 18 | 术中超声在原发性肝癌手术以及射频消融中的应用显示文摘目的探讨术中超声在原发性肝癌手术切除以及射频消融治疗中的作用。方法对45例原发性肝癌患者行术中超声检查并将其结果与术前经腹超声检查进行对比,观察术中超声在原发性肝癌手术切除以及射频消融治疗中的作用。结果45例原发性肝癌患者共有肿瘤瘤灶60个,术前超声、术中超声诊断符合率分别为78.30%、95.00%,术中超声高于术前超声检查(P=0.0072)。对直径0.5~2.0cm的肿瘤瘤灶检出率术中超声为100%,高于术前超声的63.00%(P=0.012)。对术中未触及的8个瘤灶于术中超声引导下行肝脏局部切除术。对14个不宜手术切除的瘤灶行术中超声引导下射频消融治疗并短期随访观察,有效率为85.70%。结论术中超声可提高肝癌小瘤灶的检出率,减少漏诊以及误诊,并可在术中对无法触及以及不宜手术切除的瘤灶行术中超声引导的肿瘤切除以及射频消融治疗,具有很高的实用价值。 | 高军喜 姚兰辉 | 2008 | 中国介入影像与治疗学2008，5，1： | 7 |
| 19 | 射频及手术切除在小肝癌治疗中价值的探讨显示文摘目的 :评价射频及手术切除在小肝癌治疗中的价值。方法 :分别对我院肝内科及肝外科随机选取的 2 0 0 3年采用射频和手术切除治疗小肝癌的病例各 10 0例 ,对两组在住院费用、住院天数、肝功能恢复时间、术后 1年复发率及并发症等方面进行比较。结果 :射频治疗组患者术后肝功能恢复时间为 9.0 9± 4 .5 9d ,少于手术组 10 .5 5± 3.0 9d(P <0 .0 1) ;射频治疗组患者术后并发症 (发热 ,黄疸 )比手术组患者明显少 (P <0 .0 0 1) ,且持续时间短 ;对于直径 3.0cm以下的肿瘤 ,射频治疗组患者术后 1年的肿瘤复发率等同于手术组 (p >0 .0 5 ) ,而直径在 3.0~ 5 .0cm的肿瘤 ,射频治疗组患者术后 1年的肿瘤复发率明显高于手术组 (P <0 .0 1) ;射频治疗组患者平均住院费用是 2 35 0 4 .2 8± 4 936 .6 2元 ,手术组为 2 2 6 6 3.6 6± 394 9.6 1元。两组基本相当 (p >0 .0 5 ) ;射频治疗组患者平均住院天数为 14 .4 9± 7.6 1d ,少于手术组 17.5 8± 4 .87d(P <0 .0 1)。结论射频治疗是一种创伤小、恢复快、安全性高的治疗方法 ,其对于 3cm以下的肿瘤的疗效等同于手术切除。且其治疗费用与手术切除相当。严格掌握射频治疗的指征是降低术后复发的关键。 | 李立新 叶胜龙 杨毕伟 干育红 任正刚 夏景林 王艳红 张博恒 | 2004 | 中国临床医学2004，11，6： | 5 |
| 20 | 射频消融治疗食管不典型增生的临床研究显示文摘目的探讨内镜染色指示下射频消融术治疗食管不典型增生的疗效和安全性。方法对内镜检查发现食管有可疑病灶的病人用2%碘溶液食管染色后,在染色指示下多点取活检,经病理诊断为不典型增生,超声内镜检查病变局限于黏膜层者,在染色内镜直视下从病灶周围0.3￣0.5cm处开始先射频点灼上下左右四点以标记切除范围,然后自病灶边缘向中心规律的射频消融治疗,功率为35W,每个接触部位治疗时间3、4s,将病灶及周围0.3￣0.5cm以内黏膜及黏膜下层碳化为止。结果45例食管不典型增生(轻度13例、中度17例、重度15例)患者经一次染色内镜下射频消融治疗,随访6周~3年,所有病人痊愈,未发生出血、穿孔并发症。结论射频消融术可作为阻断食管癌变发生发展的首先方法。 | 王强 吴清明 童强 李胜保 张卫国 王小虎 | 2006 | 中国现代医学杂志2006，16，24： | 4 |
您所在的机构暂未开通此部分的功能，请联系管理员