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| 1 | Transplantation of UC-MSCs on collagen scaffold activates follicles in dormant ovaries of POF patients with long history of infertility显示文摘Premature ovarian failure(POF) is a refractory disease for clinical treatment with the goal of restoring fertility. In this study,umbilical cord mesenchymal stem cells on a collagen scaffold(collagen/UC-MSCs) can activate primordial follicles in vitro via phosphorylation of FOXO3 a and FOXO1. Transplantation of collagen/UC-MSCs to the ovaries of POF patients rescued overall ovarian function, evidenced by elevated estradiol concentrations, improved follicular development, and increased number of antral follicles. Successful clinical pregnancy was achieved in women with POF after transplantation of collagen/UC-MSCs or UC-MSCs. In summary, collagen/UC-MSC transplantation may provide an effective treatment for POF. | Lijun Ding Guijun Yan Bin Wang Lu Xu Yan Gu Tong Ru Xiaoying Cui Lei Lei Jingyu Liu Xiaoqiang Sheng Bin Wang Chunxue Zhang Yanjun Yang Ruiwei Jiang Jianjun Zhou Na Kong Feifei Lu Huaijun Zhou Yannan Zhao Bing Chen Yali Hu Jianwu Dai Haixiang Sun | 2018 | Science China(Life Sciences)2018，61，12： | 43 |
| 2 | Genome-wide identification, expression analysis of auxin-responsive GH_3 family genes in maize(Zea mays L.) under abiotic stresses显示文摘Auxin is involved in different aspects of plant growth and development by regulating the expression of auxinresponsive family genes. As one of the three major auxinresponsive families, GH3(Gretchen Hagen3) genes participate in auxin homeostasis by catalyzing auxin conjugation and bounding free indole-3-acetic acid(IAA) to amino acids.However, how GH3 genes function in responses to abiotic stresses and various hormones in maize is largely unknown.Here, the latest updated maize(Zea mays L.) reference genome sequence was used to characterize and analyze the Zm GH3 family genes from maize. The results showed that 13 Zm GH3 genes were mapped on fi ve maize chromosomes(total10 chromosomes). Highly diversi fi ed gene structures and tissue-speci fi c expression patterns suggested the possibility of function diversi fi cation for these genes in response to environmental stresses and hormone stimuli. The expression patterns of Zm GH3 genes are responsive to several abiotic stresses(salt, drought and cadmium) and major stress-relatedhormones(abscisic acid, salicylic acid and jasmonic acid)Various environmental factors suppress auxin free IAA contents in maize roots suggesting that these abiotic stresses and hormones might alter GH3-mediated auxin levels. The respon siveness of Zm GH3 genes to a wide range of abiotic stresses and stress-related hormones suggested that Zm GH3 s are involved in maize tolerance to environmental stresses. | Shangguo Feng Runqing Yue Sun Tao Yanjun Yang Lei Zhang Mingfeng Xu Huizhong Wang Chenjia Shen | 2015 | Journal of Integrative Plant Biology2015，57，9： | 17 |
| 3 | Effects of Predeformation on the Reverse Martensitic Transformation of TiNi Shape Memory Alloy显示文摘DSC was used to study the effects of predeformation on the reverse martensitic transformation of near-equiatomic TiNi alloy. Both the start temperature A. and the finish temperature Af of the reverse transformation increased with increasing degree of predeformation, but the algebraic difference between A. and Af decreased with increasing predeformation until it reached a minimum value, then remained unchanged with further deformation. Transformation heat also increased with increasing predeformation until it reached a maximum value, then decreased with further predeformation. All the phenomena above were considered to be closely related With the release of elastic strain energy during predeformation. | Yanjun ZHENG, Lishan CUI and Fan ZHANG (Department of Materials Science and Engineering, University of Petroleum, Beijing 102200, China) Dazhi YANG (Department of Materials Engineering, Dalian University of Technology, Dalian 116024, China) | 2000 | Journal of Materials Science & Technology2000，16，6： | 13 |
| 4 | Seasonal variation of sedimentation in the Changjiang Estuary mud area显示文摘Seasonal distributions of suspended matter and their sedimentary effect on the Changjiang Estuary mud area of the East China Sea were discussed, based on three cruise data of total suspended matter, temperature and salinity collected from the Changjiang Estuary and its adjacent area in summer and winter. The results show that the basic pattern of distributions of suspended matter in the study area is almost the same in winter and in summer. Sediments from Changjiang (Yangtze River) to the sea are chiefly trapped to the west of 123 o 15’E due to a strong obstruction of the Taiwan Warm Current. This suggests that these sediments are mainly transported and deposited in the inner shelf. The sediment supply, Taiwan Warm Current, and Zhejiang Coastal Current show a strong seasonal variation, which results in a strong seasonal variation of the sedimentary effect on this mud area. This mud area is a 'sink' of the Changjiang’s sediment discharge to the sea and its sedimentation is stronger in summer and weaker in winter. | GUO Zhigang,YANG Zuosheng,FAN Dejiang,PAN Yanjun(College of Marine Geosciences, Ocean University of China, Qingdao 266003, China) | 2003 | Journal of Geographical Sciences2003，13，3： | 8 |
| 5 | Application of deep learning in ecological resource research:Theories, methods, and challenges显示文摘Ecological resources are an important material foundation for the survival,development,and self-realization of human beings.In-depth and comprehensive research and understanding of ecological resources are beneficial for the sustainable development of human society.Advances in observation technology have improved the ability to acquire long-term,cross-scale,massive,heterogeneous,and multi-source data.Ecological resource research is entering a new era driven by big data.Traditional statistical learning and machine learning algorithms have problems with saturation in dealing with big data.Deep learning is a method for automatically extracting complex high-dimensional nonlinear features,which is increasingly used for scientific and industrial data processing because of its ability to avoid saturation with big data.To promote the application of deep learning in the field of ecological resource research,here,we first introduce the relationship between deep learning theory and research on ecological resources,common tools,and datasets.Second,applications of deep learning in classification and recognition,detection and localization,semantic segmentation,instance segmentation,and graph neural network in typical spatial discrete data are presented through three cases:species classification,crop breeding,and vegetation mapping.Finally,challenges and opportunities for the application of deep learning in ecological resource research in the era of big data are summarized by considering the characteristics of ecological resource data and the development status of deep learning.It is anticipated that the cooperation and training of cross-disciplinary talents may promote the standardization and sharing of ecological resource data,improve the universality and interpretability of algorithms,and enrich applications with the development of hardware. | Qinghua GUO Shichao JIN Min LI Qiuli YANG Kexin XU Yuanzhen JU Jing ZHANG Jing XUAN Jin LIU Yanjun SU Qiang XU Yu LIU | 2020 | Science China Earth Sciences2020，63，10： | 7 |
| 6 | PIF1 and RVE1 form a transcriptional feedback loop to control light-mediated seed germination in Arabidopsis^FA显示文摘The phytochrome B (phyB) photoreceptor plays a major role that inputs light signals to regulate seed dormancy and germination. PHYTOCHROME-INTERACTING FACTOR1 (PIF1) is a key transcription factor repressing phyB-mediated seed germination, while REVEILLE1 (RVE1) factor functions as a curial regulator in controlling both seed dormancy and ger-mination. However, the relationship between the PIF1-and RVE1-modulated signaling pathways remains mostly unknown. Here, we find that PIF1 physically interacts with RVE1. Genetic analysis indicates that RVE1 inhibition on seed germination requires PIF1;re-ciprocally, the repressive effect of PIF1 is partially de-pendent on RVE1. Strikingly, PIF1 and RVE1 directly bind to the promoter and activate the expression of each other. Furthermore, PIF1 and RVE1 coordinately regulate the transcription of many downstream genes involved in abscisic acid and gibberellin pathways. Moreover, PIF1 enhances the DNA-binding ability and transcriptional repression activity of RVE1 in regulating GIBBERELLIN 3-OXIDASE2, and RVE1 promotes PIF1's DNA-binding ability in modulating ABSCISIC ACID-INSENSITIVE3 expression. Thus, this study demon-strates that PIF1 and RVE1 form a transcriptional feedback loop that coordinately inhibits seed germi-nation, providing a mechanistic understanding of how phyB-mediated light signal is transduced to the seeds. | Liwen Yang Zhimin Jiang Yanjun Jing Rongcheng Lin | 2020 | Journal of Integrative Plant Biology2020，62，9： | 7 |
| 7 | Mechanism and kinetics study on removal of Iron from phosphoric acid by cation exchange resin显示文摘Iron element is one of the main impurities in wet-process phosphoric acid and it has a significant impact on the subsequent phosphorus chemical products. This paper studied the feasibility of using Sinco-430 cation exchange resin for iron removal from phosphoric acid. The specific surface area and the total exchange capacity of resin were 8.91 m2·g-1 and 5.18 mmol·g-1, respectively. The sorption mechanism was determined by FTIR and XPS and the results indicated that iron was combined with-SO3 H in resin. The removal process was studied as a function of temperature, H3 PO4 content and mass ratio between resin and solution. The unit mass of resin to remove iron was 0.058 g·g-1 resin when the operating parameters were T = 50 ℃, H3 PO4 content = 27.61 wt%and S/L = 0.1, respectively. Kinetics study demonstrated that pseudo-second-order reaction model fits this study best and the calculated activation energy of overall reaction is 29.10 kJ·mol-1. The overall reaction process was mainly controlled by pore diffusion. | Xinke Leng Yanjun Zhong Dehua Xu Xinlong Wang Lin Yang | 2019 | Chinese Journal of Chemical Engineering2019，27，5： | 7 |
| 8 | Characterization and mapping of a novel mutant sms1 (senescence and male sterility 1) in rice显示文摘Plant senescence plays diverse important roles in development and environmental responses.However,the molecular basis of plant senescence is remained largely unknown.A rice spontaneous mutant with the character of early senescence and male sterility (sms) was found in the breeding line NT10-748.In order to identify the gene SMS1 and the underlying mechanism,we preliminarily analyzed physiological and biochemical phenotypes of the mutant.The mutant contained lower chlorophyll content compared with the wild type control and was severe male sterile with lower pollen viability.Genetic analysis showed that the mutant was controlled by a single recessive gene.By the map-based cloning approach,we fine-mapped SMS1 to a 67 kb region between the markers Z3-4 and Z1-1 on chromosome 8 using 1,074 F2 recessive plants derived from the cross between the mutant sms1 (japonica) × Zhenshan 97 (indica),where no known gene involved in senescence or male sterility has been identified.Therefore the SMS1 gene will be a novel gene that regulates the two developmental processes.The further cloning and functional analysis of the SMS1 gene is under way. | Wenyi Yan Shenghai Ye Qingsheng Jin Longjun Zeng Yu Peng Dawei Yan Weibing Yang Donglei Yang Zuhua He Yanjun Dong Xiaoming Zhang | 2010 | Journal of Genetics and Genomics2010，37，1： | 6 |
| 9 | Au nanorods decorated TiO_(2)nanobelts with enhanced full solar spectrum photocatalytic antibacterial activity and the sterilization file cabinet application显示文摘TiO_(2)photocatalysts have been widely studied and applied for removing bacteria,but its antibacterial efficiency is limited to the ultraviolet(UV)range of the solar spectrum.In this work,we use the gold(Au)nanorods to enhance the visible and near-infrared(NIR)light absorption of TiO_(2)NBs,a typical UV light photocatalyst,thus the enhancement of its full solar spectrum(UV,visible and NIR)photocatalytic antibacterial properties is achieved.Preliminary surface plasmon resonance(SPR)enhancement photocatalytic antibacterial mechanism is suggested.On one hand,transverse and longitudinal SPR of Au NRs is beneficial for visible and NIR light utilization.On the other hand,Au NRs combined with TiO_(2)NBs to form the heterostructure,which can improve the photogenerated carrier separation and direct electron transfer increases the hot electron concentration while Au NRs as the electron channel can well restrain charge recombination.finally produces the high yield of radical oxygen species and exhibits a superior antibacterial efficiency.Furthermore,we design a sterilization file cabinet with Au NR/TiO_(2)NB heterostructures as the photocatalytic coating plates.Our study reveals that Au NR/TiO_(2)NB heterostructure is a potential candidate for sterilization of bacteria and archives protection. | Yingying Qin Yichen Guo Zhangqian Liang Yanjun Xue Xiaoli Zhang Lei Yang Jian Tian | 2021 | Chinese Chemical Letters2021，32，4： | 6 |
| 10 | Comparative Study of Trajectory Tracking Control for Automated Vehicles via Model Predictive Control and Robust H-infinity State Feedback Control显示文摘A comparative study of model predictive control(MPC)schemes and robust Hstate feedback control(RSC)method for trajectory tracking is proposed in this paper.The main objective of this paper is to compare MPC and RSC controllers’performance in tracking predefined trajectory under different scenarios.MPC controller is designed based on the simple longitudinal-yaw-lateral motions of a single-track vehicle with a linear tire,which is an approximation of the more realistic model of a vehicle with double-track motion with a non-linear tire mode.RSC is designed on the basis of the same method as adopted for the MPC controller to achieve a fair comparison.Then,three test cases are built in CarSim-Simulink joint platform.Specifically,the verification test is used to test the tracking accuracy of MPC and RSC controller under well road conditions.Besides,the double lane change test with low road adhesion is designed to find the maximum velocity that both controllers can carry out while guaranteeing stability.Furthermore,an extreme curve test is built where the road adhesion changes suddenly,in order to test the performance of both controllers under extreme conditions.Finally,the advantages and disadvantages of MPC and RSC under different scenarios are also discussed. | Kai Yang Xiaolin Tang Yechen Qin Yanjun Huang Hong Wang Huayan Pu | 2021 | Chinese Journal of Mechanical Engineering2021，34，4： | 6 |
| 11 | Phenformin alone or combined with gefitinib inhibits bladder cancer via AMPK and EGFR pathways显示文摘Background:In previous studies,we have shown that the combination of metformin and gefitinib inhibits the growth of bladder cancer cells.Here we examined whether the metformin analogue phenformin,either used alone or in combination with gefitinib,could inhibit growth of bladder cancer cells.Methods:The growth-inhibitory effects of phenformin and gefitinib were tested in one murine and two human bladder cancer cell lines using MTT and clonogenic assays.Effects on cell migration were assessed in a wound healing assay.Synergistic action between the two drugs was assessed using CompuSyn software.The potential involvement of AMPK and EGFR pathways in the effects of phenformin and gefitinib was explored using Western blotting.Results:In MTT and clonogenic assays,phenformin was>10-fold more potent than metformin in inhibiting bladder cancer cell growth.Phenformin also potently inhibited cell migration in wound healing assays,and promoted apop-tosis.AMPK signaling was activated;EGFR signaling was inhibited.Phenformin was synergistic with gefitinib,with the combination of drugs showing much stronger anticancer activity and apoptotic activation than phenformin alone.Conclusions:Phenformin shows potential as an effective drug against bladder cancer,either alone or in combination with gefitinib. | Yanjun Huang Sichun Zhou Caimei He Jun Deng Ting Tao Qiongli Su Kwame Oteng Darko Mei Peng Xiaoping Yang | 2018 | Cancer Communications2018，38，1： | 5 |
| 12 | Comparison of Two Air Pollution Episodes over Northeast China in Winter 2016/17 Using Ground-Based Lidar显示文摘This study analyzes and compares aerosol properties and meteorological conditions during two air pollution episodes in 19–22(E1) and 25–26(E2) December 2016 in Northeast China. The visibility, particulate matter(PM) mass concentration, and surface meteorological observations were examined, together with the planetary boundary layer(PBL) properties and vertical profiles of aerosol extinction coefficient and volume depolarization ratio that were measured by a ground-based lidar in Shenyang of Liaoning Province, China during December 2016–January 2017.Results suggest that the low PBL height led to poor pollution dilution in E1, while the high PBL accompanied by low visibility in E2 might have been due to cross-regional and vertical air transmission. The PM mass concentration decreased as the PBL height increased in E1 while these two variables were positively correlated in E2. The enhanced winds in E2 diffused the pollutants and contributed largely to the aerosol transport. Strong temperature inversion in E1 resulted in increased PM2.5 and PM10 concentrations, and the winds in E2 favoured the southwesterly transport of aerosols from the North China Plain into the region surrounding Shenyang. The large extinction coefficient was partially attributed to the local pollution under the low PBL with high ground-surface PM mass concentrations in E1,whereas the cross-regional transport of aerosols within a high PBL and the low PM mass concentration near the ground in E2 were associated with severe aerosol extinction at high altitudes. These results may facilitate better understanding of the vertical distribution of aerosol properties during winter pollution events in Northeast China. | Yanjun MA Hujia ZHAO Yunsheng DONG Huizheng CHE Xiaoxiao LI Ye HONG Xiaolan LI Hongbin YANG Yuche LIU Yangfeng WANG Ningwei LIU Cuiyan SUN | 2018 | Journal of Meteorological Research2018，32，2： | 5 |
| 13 | Inconsistency of changes in uniaxial compressive strength and P-wave velocity of sandstone after temperature treatments显示文摘It is generally accepted that the uniaxial compressive strength(UCS)and P-wave velocity of rocks tend to decrease simultaneously with increasing temperature.However,based on a great number of statistical data and systematic analysis of the microstructure variation of rocks with temperature rising and corresponding propagation mechanism of elastic wave,the results show that(1)There are three different trends for the changes of UCS and P-wave velocity of sandstone when heated from room temperature(20C or 25C)to 800C:(i)Both the UCS and P-wave velocity decrease simultaneously;(ii)The UCS increases initially and then decreases,while the P-wave velocity decreases continuously;and(iii)The UCS increases initially and then fluctuates,while the P-wave velocity continuously decreases.(2)The UCS changes at room temperaturee400C,400Ce600C,and 600Ce800C are mainly attributed to the discrepancy of microstructure characteristics and quartz content,the transformation plasticity of clay minerals,and the balance between the thermal cementation and thermal damage,respectively.(3)The inconsistency in the trends of UCS and P-wave velocity changes is caused by the change of quartz content,phase transition of water and certain minerals. | Jinyuan Zhang Yanjun Shen Gengshe Yang Huan Zhang Yongzhi Wang Xin Hou Qiang Sun Guoyu Li | 2021 | Journal of Rock Mechanics and Geotechnical Engineering2021，13，1： | 5 |
| 14 | Functional assembly of root-associated microbial consortia improves nutrient efficiency and yield in soybean显示文摘Root-associated microbes are critical for plant growth and nutrient acquisition. However, scant information exists on optimizing communities of beneficial root-associated microbes or the mechanisms underlying their interactions with host plants. In this report, we demonstrate that rootassociated microbes are critical influencers of host plant growth and nutrient acquisition. Three synthetic communities(SynComs) were constructed based on functional screening of 1,893 microbial strains isolated from root-associated compartments of soybean plants. Functional assemblage of SynComs promoted significant plant growth and nutrient acquisition under both N/P nutrient deficiency and sufficiency conditions.Field trials further revealed that application of SynComs stably and significantly promoted plant growth, facilitated N and P acquisition, and subsequently increased soybean yield. Among the tested communities, SynCom1 exhibited the greatest promotion effect, with yield increases of up to 36.1% observed in two field sites. Further RNA-seq implied that SynCom application systemically regulates N and P signaling networks at the transcriptional level, which leads to increased representation of important growth pathways, especially those related to auxin responses. Overall,this study details a promising strategy for constructing SynComs based on functional screening,which are capable of enhancing nutrient acquisition and crop yield through the activities of beneficial root-associated microbes. | Cunhu Wang Yanjun Li Mingjia Li Kefei Zhang Wenjing Ma Lei Zheng Hanyu Xu Baofeng Cui Ran Liu Yongqing Yang Yongjia Zhong Hong Liao | 2021 | Journal of Integrative Plant Biology2021，63，6： | 5 |
| 15 | Atomistic Surface Passivation of CH_(3)NH_(3)PbI_(3) Perovskite Single Crystals for Highly Sensitive Coplanar-Structure X-Ray Detectors显示文摘Organic-inorganic halide perovskites(OIHPs)are recognized as the promising next-generation X-ray detection materials.However,the device performance is largely limited by the ion migration issue of OIHPs.Here,we reported a simple atomistic surface passivation strategy with methylammonium iodide(MAI)to remarkably increase the ion migration activation energy of CH_(3)NH_(3)PbI_(3)single crystals.The amount of MAI deposited on the crystal surface is finely regulated by a self-assemble process to effectively suppress the metallic lead defects,while not introducing extra mobile ions,which results in significantly improved dark current stability of the coplanar-structure devices under a large electric field of 100Vmm^(-1).The X-ray detectors hence exhibit a record-high sensitivity above 700,000μC Gy^(-1)_(air) cm^(-2)under continuum X-ray irradiation with energy up to 50 keV,which enables an ultralow X-ray detection limit down to 1.5 nGy_(air)s^(-1).Our findings will allow for the dramatically reduced X-ray exposure of human bodies in medical imaging applications. | Yilong Song Liqi Li Weihui Bi Mingwei Hao Yifei Kang Anran Wang Zisheng Wang Hanming Li Xiaohui Li Yanjun Fang Deren Yang Qingfeng Dong | 2020 | Research2020，，1： | 5 |
| 16 | A widely adaptable approach to generate integration-free iPSCs from non-invasively acquired human somatic cells显示文摘 | Zhichao Ding Lina Sui Ruotong Ren Yanjun Liu Xiuling Xu Lina Fu Ruijun Bai Tingting Yuan Ying Hao Weiqi Zhang Huize Pan Wensu Liu Han Yu Concepcion Rodriguez Esteban Xiaobing Yu Ze Yang Jian Li Xiaomin Wang Juan Carlos Izpisua Belmonte Guang-Hui Liu Fei Yi Jing Qu | 2015 | Protein & Cell2015，6，5： | 5 |
| 17 | A Virulent PEDV Strain FJzz1 with Genomic Mutations and Deletions at the High Passage Level Was Attenuated in Piglets via Serial Passage In Vitro显示文摘Highly virulent porcine epidemic diarrhea virus(PEDV)strains re-emerged and circulated in China at the end of 2010,causing significant economic losses in the pork industry worldwide.To understand the genetic dynamics of PEDV during its passage in vitro,the PEDV G2 strain FJzzl was serially propagated in Vero cells for up to 200 passages.The susceptibility and adaptability of the FJzzl strain increased gradually as it was serially passaged in vitro.Sequence analysis revealed that amino acid(aa)changes were mainly concentrated in the S glycoprotein,which accounted for 72.22%-85.71%of all aa changes.A continuous aa deletion(^(55)I^(56)G^(57)E→^(55)K^(56)Δ^(57)Δ)occurred in the N-terminal domain of S1(Sl-NTD).To examine how the aa changes affected its virulence,FJzzl-F20 and FJzzl-F200 were selected to simultaneously evaluate their pathogenicity in suckling piglets.All the piglets in the FJzzl-F20-infected group showed typical diarrhea at 24 h postinfection,and the piglets died successively by 48 h postinfection.However,the clinical signs of the piglets in the FJzzl-F200-infected group were significantly weaker,and no deaths occurred.The FJzzl-F200-infected group also showed a lower level of fecal viral shedding and lower viral loads in the intestinal tissues,and no obvious histopathological lesions.TypeⅠandⅢinterferon were induced in the FJzzl-F200 infection group,together with pro-inflammatory cytokines,such as TNF-α,IL-1βand IL-8.These results indicate that the identified genetic changes may contribute to the attenuation of FJzzl strain,and the attenuated FJzzl-F200 may have the potential for developing PEDV live-attenuated vaccines. | Pengfei Chen Xiongwei Zhao Shuting Zhou Tianxing Zhou Xiangmei Tan Xia Wu Wu Tong Fei Gao Lingxue Yu Yifeng Jiang Hai Yu Zhibiao Yang Guangzhi Tong Yanjun Zhou | 2021 | Virologica Sinica2021，36，5： | 4 |
| 18 | SERS-based mercury ion detections:principles,strategies and recent advances显示文摘Mercury ion(Hg^(2+)),known as one of the highly toxic and soluble heavy metal ions,is causing serious environmental pollution and irreversible damage to the health.It is urgent to develop some rapid and ultrasensitive methods for detecting trace mercury ions in the environment especially drink water.Surface-enhanced Raman scattering(SERS)is considered as a novel and powerful optical analysis technique since it has the significant advantages of ultra-sensitivity and high specificity.In recent years,the SERS technique and its application in the detection of Hg^(2+)have become more prevalent and compelling.This review provides an overall survey of the development of SERS-based Hg^(2+)detections and presents a summary relating to the basic principles,detection strategies,recent advances and current challenges of SERS for Hg^(2+)detections. | chunyuan song boyue yang yanjun yang lianhui wang | 2016 | Science China Chemistry2016，59，1： | 4 |
| 19 | Single-Step Organization of Plasmonic Gold Metamaterials with Self-Assembled DNA Nanostructures显示文摘Self-assembled DNA nanostructures hold great promise as nanoscale templates for organizing nanoparticles(NPs)with nearatomistic resolution.However,large-scale organization of NPs with high yield is highly desirable for nanoelectronics and nanophotonic applications.Here,we design fve-strand DNA tiles that can readily self-assemble into well-organized micrometerscale DNA nanostructures.By organizing gold nanoparticles(AuNPs)on these self-assembled DNA nanostructures,we realize the fabrication of one-and two-dimensional Au nanostructures in single steps.We further demonstrate the one-pot synthesis of Au metamaterials for highly amplifed surface-enhanced Raman Scattering(SERS).Tis single-step and high-yield strategy thus holds great potential for fabricating plasmonic metamaterials. | Shaokang Ren Jun Wang Chunyuan Song Qian Li Yanjun Yang Nan Teng Shao Su Dan Zhu Wei Huang Jie Chao Lianhui Wang Chunhai Fan | 2019 | Research2019，，1： | 4 |
| 20 | The Evening Complex and the Chromatin-Remodeling Factor PICKLE Coordinately Control Seed Dormancy by Directly Repressing DOG1 in Arabidopsis显示文摘Primary seed dormancy is acquired during seed development and maturation,which is important for plant fitness and survival.DELAY OF GERMINATION1(DOG1)plays a critical role in inducing seed dormancy.DOG1 expression increases rapidly during seed development,but the precise mechanism underlying this process remains elusive.In this study,we showed that mutants with a loss or reduced function of the chromatin-remodeling factor PICKLE(PKL)exhibit increased seed dormancy.PKL associates with DOG1 chromatin and inhibits its transcription.We found that PKL physically interacts with LUX ARRHYTHMO(LUX),a member of the evening complex(EC)of the circadian clock.Furthermore,LUX directly binds to a specific coding sequence of DOG1,and DOG1 acts genetically downstream of PKL and LUX.Mutations in either LUX or EARLY FLOWERING3(ELF3)encoding another member of the EC led to increased DOG1 expression and enhanced seed dormancy.Surprisingly,these phenotypes were abolished when the parent plants were grown under continuous light.In addition,we observed that loss of function of either PKL or LUX decreased H3K27me3 levels at the DOG1 locus.Taken together,our study reveals a regulatory mechanism in which EC proteins coordinate with PKL to transmit circadian signals for directly regulating DOG1 expression and seed dormancy during seed development. | Ping Zha Shuangrong Liu Yang Li Tingting Ma Liwen Yang Yanjun Jing Rongcheng Lin | 2020 | Plant Communications2020，1，2： | 3 |
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