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	题名	作者	年代	出处	被引量
1	Primary duodenal neoplasms:A retrospective clinico-pathological analysis显示文摘AIM: To analyze the clinico-pathological spectrum of primary duodenal neoplasms. METHODS: A total of 55 primary duodenal neoplasms reported in the last 10 years after excluding ampullary and periampullary tumors were included in the study. Clinical details were noted and routine hematoxylin and eosin stained paraffin sections were studied for histological subtyping of the tumors. RESULTS: On histopathological examination primary duodenal neoplasms were categorized as: epithelial tumor in 27 cases (49.0%) including 10 cases of adenoma, 15 cases of adenocarcinoma, and 2 cases of Brunner gland adenoma; mesenchymal tumor in 9 cases (16.3%) consisting of 4 cases of gastrointestinal stromal tumor, 4 cases of smooth muscle tumor and I case of neurofibroma; lymphoproliferative tumor in 12 cases (21.8%), and neuroendocrine tumor in 7 cases (12.7%). CONCLUSION: Although non-ampullary/periampullary duodenal adenocarcinomas are rare, they constitute the largest group. Histopathological examination of primary duodenal tumors is important for correct histological subtyping.	Amanjit Bal Kusum Joshi Kim Vaiphei JD Wig	2007	World Journal of Gastroenterology2007，13，7：	10
2	Aberrant promoter methylation of p16 in colorectal adenocarcinoma in North Indian patients显示文摘AIM:To investigate p16 gene methylation and its expression in 30 patients with sporadic colorectal adenocarcinoma in a North Indian population. METHODS:Methylation specific polymerase chain reaction was used to detect p16 gene methylation and immunohistochemistry was used to study the p16 expression in 30 sporadic colorectal tumors as well as adjoining and normal tissue specimens.RESULTS:Aberrant promoter methylation of p16 gene was detected in 12(40%)tumor specimens,whereas no promoter methylation was observed in adjoining and normal tissue.Immunohistochemistry showed expression of p16 protein in 26(86.6%)colorectal tumors whereas complete loss of expression was seen in 4(13.3%)and reduced expression was observed in 12(40%)tumors. In the adjoining mucosa,expression of p16 was in 11 (36.6%)whereas no clear positivity for p16 protein was seen in normal tissue.There was a significant difference in the expression of p16 protein in tumor tissue and adjoining mucosa(P<0.001).The methylation of the p16 gene had a significant effect on the expression of p16 protein(P=0.021).There was a significant association of methylation of p16 gene with the tumor size (P=0.015)and of the loss/reduced expression of p16 protein with the proximal site of the tumor(P=0.047). Promoter methylation and expression of p16 had no relation with the survival of the patients(P>0.05). CONCLUSION:Our study demonstrated that promoter hypermethylation of the p16 gene results in loss/reduced expression of p16 protein and this loss/reduced expression may contribute to tumor enlargement.	Pooja Malhotra Rakesh Kochhar Kim Vaiphei Jai Dev Wig Safrun Mahmood	2010	World Journal of Gastrointestinal Oncology2010，2，7：	2
3	High frequency of loss of allelic integrity at Wilms' tumor suppressor gene-llocus in advanced breast tumors associated with aggressiveness of the tumor显示文摘	Gupta S Joshi K Wig JD	2009	Indian J Cancer2009，46，4：	1
4	Comparative researches on effects of sodium dodecylbenzene sulfonate and sodium dodecyl sulfate upon Lateolabraxjaponicus biomarker system 显示文摘	Wig J F YU Z M SONG X X	2005	EnvironToxicol Pharmacol2005，20，3：	1
5	Computed tomography in abdominal cocoon显示文摘	Wig JD Gupta SK	1998	J Clin Gastroenterol1998，27，3：	1
6	Dose--related effect of propofol on pancreatic enzymes and triglyceride levels in patients undergoing non-- abdominal surgery显示文摘	Pradeep K Wig J Panda N B	2009	Anaesth Intensive Care2009，37，1：	1
7	Sterilization of foodstuffs using radio frequency heating 显示文摘	Wang Y Wig T D Tang J	2003	Journal of Food Science2003，68，2：	1
8	Ni- trite-driven anaerobic methane oxidation by oxygenic bacteria 显示文摘	ETI'WIG K F BUTLER M K LE PASLIER D	2010	Nature2010，464，7288：	1
9	Aluminum phosphide ingestiona dinico - pathologic study 显示文摘	Singh S Singh D Wig N	1996	J Toxicol1996，34，7：	1
10	Knudsen forces on microcantilevers显示文摘	PASSIAN A WIG A MERIAUDEAU F	2002	Journal of Applied Physics2002，92，10：	1
11	Enteral nutrition in severe acute pancreatitis显示文摘	Doley RP Yadav TD Wig JD	2009	JOP2009，10，2：	1
12	Changes in children's competence beliefs and subjective task values a cross the elementary shool years:A three years study显示文摘	Wig A Eccles Js Yoon ks	1999	Journal of Education Paychology1999，89，6：	1
13	Adult intussusception in Northern India显示文摘	Vikas Gupta Rudra Prasad Doley Kishore Gurumoorthy Subramanya Bharathy Thakur Deen Yadav Kusum Joshi Naveen Kalra Mandeep Kang Rakesh Kochhar Jai Dev Wig	2011	International Journal of Surgery2011，，4：	1
14	Endotoxemia predictsoutcomein acute pancreatitis显示文摘	WIG JD KOCHHAR R RAY JD	1998	J Clin Gastroenterol1998，26，：	1
15	Effect of c-MYC and E2F1 gene silencing and of 5-azacytidine treatment on te- lomerase activity in pancreatic cancer-derived cell lins 显示文摘	Kumari A Srinivasan R Wig JD	2009	Pancreatology2009，9，：	1
16	Fungal infections in severe acute pancreatitis显示文摘	Kochhar R Noor MT Wig J	2011	J Gastroenterol Hepatol2011，26，6：	1
17	Minimum entropy deconvolution显示文摘	Wiggings R A	1978	Geoexploration1978，16，1：	1
18	Comparative accuracy: assessing new tests against existing diagnostic pathways显示文摘	Bossuyt P M h'wig L Craig J	2006	Br Med J2006，332，7549：	1
19	Computed tomography in abdominal cocoon显示文摘	Wig JD Gupta SK	1998	J Clin Gastroenterol1998，26，：	1
20	Immunological findings in acute and chronic pancreatitis显示文摘	Bhatnagar A Wig JD Majumdar S	2003	ANZ J Surg2003，73，12：	1

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