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| 1 | Cyclooxygenase-2 polymorphisms and the risk of esophageal adeno-or squamous cell carcinoma显示文摘AIM:To determine whether-1195 A→G and/or-765 G→C polymorphisms in Cyclooxygenase-2(COX-2 ) may have a risk modifying effect on the development of esophageal carcinoma in a Dutch Caucasian population.METHODS:Two study groups were recruited, 252 patients with esophageal carcinoma and 240 healthy controls, matched for race, age, gender and recruiting area.DNA was isolated from whole blood and used for genotyping.PCR products were digested with restriction enzymes and products were analyzed by agarose gel electrophoresis.Odds ratios(OR) and 95% confldence intervals(CI) were estimated.RESULTS:The distribution of the-1195 A→G polymorphism was signif icantly different in esophageal cancer patients compared to controls.The-1195 GG genotype resulted in a higher risk of developing esophageal adenocarcinoma(OR = 3.85, 95% CI:1.45-10.3) compared with the-1195 AA genotype as a reference.The-765 G→C genotype distribution was not different between the two groups.The GG/ GG haplotype was present more often in esophageal adenocarcinoma patients than in controls(OR = 3.45, 95% CI:1.24-9.58;with AG/AG as a reference).The same trends were observed in patients with squamous cell carcinomas, however, the results did not reach statistical signif icance.CONCLUSION:Presence of the COX-2-1195 GG genotype and of the GG/GG haplotype may result in a higher risk of developing esophageal carcinoma. | Jón O Kristinsson Paul van Westerveld Rene HM te Morsche Hennie MJ Roelofs T Wobbes Ben JM Witteman Adriaan CITL Tan Martijn GH van Oijen Jan BMJ Jansen Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，28： | 11 |
| 2 | COX-2 polymorphisms-765G→C and-1195A→G and colorectal cancer risk显示文摘AIM:To determine the possible modulating effect of the COX-2 polymorphisms,-765G→C and-1195A→G, on the risk of colorectal cancer(CRC)in a Dutch population. METHODS:This case-control study includes 326 patients with CRC and 369 age-and gender-matched controls.Genotypes of the COX-2 polymorphisms -765G→C and-1195A→G were determined by polymerase chain reaction-based restriction fragment length polymorphism.COX-2 genotypes and haplotypes were analyzed and odds ratios with 95%confi- dence intervals were estimated by logistic regression. RESULTS:The-765GG genotype was associated with an increased risk of developing CRC(OR,1.45; 95%CI,1.03-2.04).No significant difference was observed in the genotype distribution of the-1195A→ G polymorphism between patients and controls.The GG/AC haplotype was present significantly less often in patients than in controls(OR 0.44;95%CI,0.22-0.85). When the AC,AG and GG haplotypes were investigated separately,the AC haplotype showed a tendency to be less frequent in patients than in controls(OR(AG/AC)0.78; 95%CI,0.57-1.06). CONCLUSION:The-765GG genotype is associatedwith an increased risk of developing CRC and the GG/ AC haplotype seems to protect against CRC.These findings suggest a modulating role for the COX-2 polymorphisms-765G→C and-1195A→G in the development of CRC in a Dutch population. | Juliёt H Hoff Rene HM te Morsche Hennie MJ Roelofs Elise MJ van der Logt Fokko M Nagengast Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，36： | 6 |
| 3 | Judging disease activity in clinical practice in rheumatoid arthritis: first step in the development of a disease activity score 显示文摘 | van der Heijde DM van T HM van Riel PL | 1990 | Ann Rheum Dis1990，49，： | 1 |
| 4 | Transformation of diffuse β-Amyloid precursor protein and β-Amyloid deposits to plaques in the thalamus after transient occlusion of the middle cerebral artery in rats显示文摘 | Van Groen T Puurunen K Maki HM | 2005 | Stroke2005，36，： | 1 |
| 5 | Interleukin-12p40 genotype plays a role in the susceptibility to multiple sclerosis显示文摘 | van Veen T Crusius JB Schrijver HM | 2001 | Ann Neurol2001，50，： | 1 |
| 6 | The defective down regulation of fibrinolysis in haemophilia A can be restored by increasing the TAF1 plasma concentration 显示文摘 | MOSNIER LO LISMAN T VAN DEN BERG HM | 2001 | Thromb Haemost2001，86，： | 1 |
| 7 | Transform ation of diffuse beta-amyloid precursor protein and beta-amyloid deposites to plaques in the thalamus after transient occlusion of the middle cerebral artery in rats显示文摘 | Van Groen T Puurunen K Maki HM | 2005 | Stroke2005，36，： | 1 |
| 8 | Hepatocyte nuclear factor-1 alpha is required for expression but dispensable for histone acetylation of the lactase-phlorizin hydrolase gene in vivo 显示文摘 | Bosse T van Wering HM Gielen M | 2006 | Am J Physiol Gastrointest Liver Physiol2006，290，5： | 1 |
| 9 | Interleukin-12 p40 genotype plays a role in the susceptibility to multiple sclerosis显示文摘 | van Veen T Crusius JBA Schrijver HM | 2001 | Ann Neurol2001，50，10： | 1 |
| 10 | Milrinone modulates endotoxemia,systemic inflammation,and subsequent acute phase response after cardiopulmonary bypass(CPB)显示文摘 | Loick HM Van Aken H | 1999 | Anesthesiology1999，90，1： | 1 |
| 11 | Transformation of diffuse beta-amyloid precurs or protein and beta-amyloid deposites to plaques in the thalamus after transient occlusion of the middle cerebral artery in rats 显示文摘 | Van Groen T Puurunen K Maki HM | 2005 | Stroke2005，36，30： | 1 |
| 12 | A meta- analysis of clinical studies on the caries-inhibiting effect of chlorhexidine treatment显示文摘 | van Rijkom HM Truin GJ van't Hof MA | 1996 | J Dent Res1996，75，2： | 1 |
| 13 | Comparison of autologous full-thickness gingiva and skin substitutes for wound healing显示文摘 | Vriens AP Waaijman T van den Hoogenband HM | 2008 | Cell Transplant2008，17，1011： | 1 |
| 14 | Frequent adverse events after treatment for childhood-onset differentiated thyroid carcinoma: a single institute experience显示文摘 | Van Santen HM Aronson DC Vulsma T | 2004 | Eur J Cancer2004，40，11： | 1 |
| 15 | Milrinone modulates endotoxemia systemin inflammation and subsequent acute phase response after cardio pulmonary bypass(CPB)显示文摘 | Mollnoff T Loick HM Van Aken H | 1999 | Anesthesiology1999，90，1： | 1 |
| 16 | Milrinone modulates endotoxemia systemic inflammation and subsequent acute phase response after cardiopulmonary bypass (CPB) 显示文摘 | Mollnoff T Loick HM Van Aken H | 1999 | Anesthesiology1999，90，1： | 1 |
| 17 | Interferon (IFN)-beta treatment enhances CD95 and interleukin 10 expression but reduces interferon-gamma producing T cells in MS patients 显示文摘 | Rep MH Schrijver HM van Lopik T | 1999 | J Neuroimmunol1999，96，1： | 1 |
| 18 | Interferon(IFN)-beta treatment enhances CD95 and interleukin 10expression but reduces interferon-gamma producing T cells in MS patients显示文摘 | Rep MH Schrijver HM van Lopik T | 1999 | J Neuroimmunol1999，96，1： | 1 |
| 19 | Milrinone modulates endotoxemia, systemic inflammation, and subsequent acute phase response after cardiopulmonary bypass(CPB) 显示文摘 | Mollhoff T Loick HM Van Aken H | 1999 | Anesthesiology1999，90，： | 1 |
| 20 | Transformation of diffuse beta-amyloid precursor protein and beta-amyloid deposits to plaques in the thalamusafter transient occlusion of the middle cerebral artery in rats 显示文摘 | van Groen T Puurunen K Maki HM | 2005 | Stroke2005，36，7： | 1 |
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